cyclin-dependent kinase inhibitor p21

サイクリン依存性キナーゼ阻害因子p21

WordNet

1. limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
2. control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
3. limit the range or extent of; "Contact between the young was inhibited by strict social customs"
4. relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
5. addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
6. contingent on something else (同)dependant, qualified
7. (of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
8. a substance that retards or stops an activity
9. an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
10. the basic unit of money in Papua New Guinea

PrepTutorEJDIC

1. 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
2. 『頼っている』,依存している,従属している / 扶養される人(家族)
3. 抑制する人(物) / 化学反応抑制剤

UpToDate Contents

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English Journal

• Assessing Cell Cycle Independent Function of the CDK Inhibitor p21(CDKN¹A) in DNA Repair.

• Dutto I1, Tillhon M, Prosperi E.
• Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1336:123-39. doi: 10.1007/978-1-4939-2926-9_11.
• The cyclin-dependent kinase (CDK) inhibitor p21(CDKN1A) is a small protein that is able to regulate many important cell functions, often independently of its activity of CDK inhibitor. In addition to cell cycle, this protein regulates cell transcription, apoptosis, cell motility, and DNA repair. In
• PMID 26231713

• Promyelocytic leukemia zinc finger mediates glucocorticoid-induced cell cycle arrest in the chondroprogenitor cell line ATDC5.

• Naito M1, Vongsa S2, Tsukune N3, Ohashi A2, Takahashi T2.
• Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Dec 5;417:114-23. doi: 10.1016/j.mce.2015.09.026. Epub 2015 Sep 28.
• Glucocorticoids (GCs) affect the proliferation of growth plate chondrocytes. In this study, we investigated the role of the GC-inducible promyelocytic leukemia zinc finger (PLZF) gene in chondrocyte differentiation by using the chondrogenic cell line ATDC5. PLZF overexpression suppressed cell cycle
• PMID 26419928

• A novel dual EGFR/HER2 inhibitor KU004 induces cell cycle arrest and apoptosis in HER2-overexpressing cancer cells.

• Tian C1, Ding P1, Yuan Z1, Li H1, Zhao Y1, Sun L2,3, Guo Q2,3, Wang Z2,3, Sun L1,4, Zhang L5,6,7, Jiang Z8,9,10.
• Apoptosis : an international journal on programmed cell death.Apoptosis.2015 Dec;20(12):1599-612. doi: 10.1007/s10495-015-1164-7.
• Human epidermal growth factor receptor 2 (HER2) is a validated therapeutic target in cancer therapy, and HER2 protein-tyrosine kinase inhibitors have attracted considerable attention in the field of searching for novel anticancer drug candidates. In this study, we investigated the anticancer effect
• PMID 26437915

Japanese Journal

• The Severity of Internal Carotid Artery Stenosis is Associated with the Cyclin-Dependent Kinase Inhibitor 2A Gene Expression

• Bayoglu Burcu,Arslan Caner,Gode Safa,Kaya Dagistanli Fatma,Arapi Berk,Burc Deser Serkan,Dirican Ahmet,Cengiz Mujgan
• Journal of Atherosclerosis and Thrombosis 21(7), 659-671, 2014
• … Aim: The INK4b-ARF-INK4a locus in the chromosome 9p21 region is known to play an important role in the development of atherosclerosis. … The INK4/ARF transcript p16INK4a inhibits the activity of the cyclin-dependent kinases CDK4/CDK6 and arrests cell-cycle progression. …
• NAID 130004677961

• DNAメチル化阻害剤ゼブラリンによるヒト肝細胞癌に対する細胞毒性

• 中村 和昭,中林 一彦,秦 健一郎,田上 昭人
• 日本毒性学会学術年会 40.1(0), 150522, 2013
• … 一方，ゼブラリンはcyclin-dependent kinase 2 (CDK2)発現およびretinoblastoma protein (Rb)発現を低下させ，p21WAF1/CIP1 およびp53発現を亢進させた。 … これらの結果から，ゼブラリンはp44/42 MAPKリン酸化を亢進させ，p21WAF1/CIP1の発現亢進，CDK2およびRbの発現低下を介して，細胞周期停止を引き起こしていると考えられた。 …
• NAID 130004676642

• Berberine Inhibits Growth and Induces G1 Arrest and Apoptosis in Human Cholangiocarcinoma QBC939 Cells

• He Wei,Wang Bin,Zhuang Yun [他],SHAO Dong,SUN Kewen,CHEN Jianping
• Journal of pharmacological sciences 119(4), 341-348, 2012-08-20
• … Here we report that in vitro treatment of human cholangiocarcinoma QBC939 cells with berberine, a naturally occurring isoquinoline alkaloid, decreased cell viability and induced cell death in a dose-dependent manner, which was associated with an increase in G1 arrest. …
• NAID 10031071516

Related Links

• The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.

1. Mol Cancer Ther. 2002 Jun;1(8):639-49. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Gartel AL(1), Tyner AL. Author information: (1)Department of Molecular Genetics, University of Illinois College ...

• CDKN1A cyclin dependent kinase inhibitor 1A [ (human)]

cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, CDK-interaction protein 1, DNA synthesis inhibitor, cyclin-dependent kinase inhibitor 1A (p21, Cip1), melanoma differentiation associated protein 6, wild-type p53 ...

• CDKN1A - Cyclin-dependent kinase inhibitor 1 - Homo ...

May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and ...

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★リンクテーブル★

リンク元	「サイクリン依存性キナーゼ阻害因子p21」
関連記事	「inhibit」「inhibitor」「dependent」「kinase」「dependent kinase」

「サイクリン依存性キナーゼ阻害因子p21」

　　[★]

英

cyclin-dependent kinase inhibitor p21

「inhibit」

　　[★]

• v.

• 抑制する、阻害する、阻止する

関

abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression

　 　 　 　

「inhibitor」

　　[★]

• n.

• 阻害剤、阻害薬、抑制薬、抑制剤、(内在性物質について)インヒビター、抑制物質

関

blocker、depressant、suppressant

　 　

「dependent」

　　[★]

• adj.

• 依存性の、依存的な、依存型の、依存の

関

depend、dependence、dependency、dependently

　 　 　 　 　

「kinase」

　　[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase 　

「dependent kinase」

　　[★]

• 依存性キナーゼ、依存性リン酸化酵素