サイクリン依存性キナーゼ阻害因子p15
WordNet
- limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
- control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
- limit the range or extent of; "Contact between the young was inhibited by strict social customs"
- relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
- addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
- contingent on something else (同)dependant, qualified
- (of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
- a substance that retards or stops an activity
- an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
- the basic unit of money in Papua New Guinea
PrepTutorEJDIC
- 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
- 『頼っている』,依存している,従属している / 扶養される人(家族)
- 抑制する人(物) / 化学反応抑制剤
UpToDate Contents
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English Journal
- Genetic alterations of RD(INK4/ARF) enhancer in human cancer cells.
- Li J1, Knobloch TJ, Poi MJ, Zhang Z, Davis AT, Muscarella P, Weghorst CM.
- Molecular carcinogenesis.Mol Carcinog.2014 Mar;53(3):211-8. doi: 10.1002/mc.21965. Epub 2012 Oct 12.
- Recent identification of an enhancer element, RD(INK4/ARF) (RD), in the prominent INK4/ARF locus provides a novel mechanism to simultaneously regulate the transcription of p15(INK4B) (p15), p14(ARF) , and p16(INK4A) (p16) tumor suppressor genes. While genetic inactivation of p15, p14(ARF) , and p16
- PMID 23065809
- Arterial territory-specific phosphorylated retinoblastoma protein species and CDK2 promote differences in the vascular smooth muscle cell response to mitogens.
- Lange M1, Fujikawa T1, Koulova A1, Kang S1, Griffin MJ1, Lassaletta AD2, Erat A3, Tobiasch E4, Bianchi C2, Elmadhun N2, Sellke FW2, Usheva A1.
- Cell cycle (Georgetown, Tex.).Cell Cycle.2014 Jan 15;13(2):315-23. doi: 10.4161/cc.27056. Epub 2013 Nov 12.
- Despite recent advances in medical procedures, cardiovascular disease remains a clinical challenge and the leading cause of mortality in the western world. The condition causes progressive smooth muscle cell (SMC) dedifferentiation, proliferation, and migration that contribute to vascular restenosis
- PMID 24240190
- Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell cycle control and apoptosis.
- Köhler UA1, Kurinna S, Schwitter D, Marti A, Schäfer M, Hellerbrand C, Speicher T, Werner S.
- Hepatology (Baltimore, Md.).Hepatology.2013 Dec 6. doi: 10.1002/hep.26964. [Epub ahead of print]
- The Nrf2 transcription factor is a key regulator of the antioxidant defense system, and pharmacological activation of Nrf2 is a promising strategy for prevention of toxin-induced liver damage. However, the consequences of Nrf2 activation on liver regeneration have not been determined. To address thi
- PMID 24310875
Japanese Journal
- Inhibition of L-Type Amino Acid Transporter Modulates the Expression of Cell Cycle Regulatory Factors in KB Oral Cancer Cells
- Kim Chun Sung,Moon In-Sung,Park Ju-Hyun,Shin Woo-Cheol,Chun Hong Sung,Lee Sook-Young,Kook Joong-Ki,Kim Heung-Joong,Park Joo-Cheol,Endou Hitoshi,Kanai Yoshikatsu,Lee Byung-Kwon,Kim Do Kyung
- Biological and Pharmaceutical Bulletin 33(7), 1117-1121, 2010
- … The purpose of this study was to examine the effect of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), an inhibitor of L-type amino acid transporters, on the cell growth suppression in KB human oral cancer cells and to study the roles of cell cycle regulatory factors in the BCH-induced growth inhibition. … The expression of cyclin D3 was remarkably decreased by BCH treatment. …
- NAID 130000300273
- Identification of progenitor cells that gives rise to hair cells
- MALGRANGE Brigitte,VAN DE WATER Thomas R.,MOONEN Gustave,LEFEBVRE Philippe P.
- Otology Japan 15(2), 108-113, 2005-05-25
- … Cultured immature nestin positive cells present in the newborn rat organ of Corti at the level of the great epithelial ridge can proliferate and subsequently differentiate into HCs and SCs together with the detection of nestin (+) cells in vivo at the spiral limbus in the P15 mature organ of Corti.<BR>As a second approach, we have looked for the possibility of existing epithelial cells of the organ of Corti to differentiate into HCs. …
- NAID 10029379655
Related Links
- This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex ...
- Gene ID: 12579, updated on 17-Mar-2015 Summary Other designations cyclin-dependent kinase 4 inhibitor B, cyclin-dependent kinase inhibitor p15, cyclin-dependent kinase inhibitor p15INK4b, cyclin-dependent kinase inhibitor protein, ...
★リンクテーブル★
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- 英
- cyclin-dependent kinase inhibitor p15
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- 関
- abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression
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- 関
- blocker、depressant、suppressant
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- 関
- depend、dependence、dependency、dependently
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キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase
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