塩酸クロルヘキシジン
- 関
- chlorhexidine、chlorhexidine gluconate、Hibitane
WordNet
- a long-lasting liquid antiseptic; used by surgeons to wash their hands before performing surgery
- a complex consisting of an organic base in association with hydrogen chloride
UpToDate Contents
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English Journal
- Inhibition of biofilm formation and antibacterial properties of a silver nano-coating on human dentine.
- Besinis A1, De Peralta T, Handy RD.Author information 1School of Biomedical and Biological Sciences, The University of Plymouth , Plymouth PL4 8AA , UK.AbstractThe survival of pathogenic bacteria in the oral cavity depends on their successful adhesion to dental surfaces and their ability to develop into biofilms, known as dental plaque. Bacteria from the dental plaque are responsible for the development of dental caries, gingivitis, periodontitis, stomatitis and peri-implantitis. Certain metal nanoparticles have been suggested for infection control and the management of the oral biofilm. Here, it is shown that application of a silver nano-coating directly on dentine can successfully prevent the biofilm formation on dentine surfaces as well as inhibit bacterial growth in the surrounding media. This silver nano-coating was found to be stable (>98.8%) and to maintain its integrity in biological fluids. Its antibacterial activity was compared to silver nitrate and the widely used clinical antiseptic, chlorhexidine. The bacterial growth and cell viability were quantitatively assessed by measuring the turbidity, proportion of live and dead cells and lactate production. All three bioassays showed that silver nanoparticles and silver nitrate dentine coatings were equally highly bactericidal (>99.5%), while inhibiting bacterial adhesion. However, the latter caused significant dentine discolouration (ΔE* = 50.3). The chlorhexidine coating showed no antibacterial effect. Thus, silver nanoparticles may be a viable alternative to both chlorhexidine and silver nitrate, protecting from dental plaque and secondary caries when applied as a dentine coating, while they may provide the platform for creating anti-biofilm surfaces in medical devices and other biomedical applications.
- Nanotoxicology.Nanotoxicology.2014 Nov;8(7):745-54. doi: 10.3109/17435390.2013.825343. Epub 2013 Aug 7.
- The survival of pathogenic bacteria in the oral cavity depends on their successful adhesion to dental surfaces and their ability to develop into biofilms, known as dental plaque. Bacteria from the dental plaque are responsible for the development of dental caries, gingivitis, periodontitis, stomatit
- PMID 23875717
- Cytotoxicity and genotoxicity of chlorhexidine on macrophages in vitro.
- Li YC1, Kuan YH, Lee SS, Huang FM, Chang YC.Author information 1Department of Pharmacology, Chung Shan Medical University, Taichung, Taiwan.AbstractChlorhexidine (CHX) is the most widely used antiseptic for wound, skin disinfection, and dental hygiene. The aim of this study is to investigate the possible correlation between CHX-induced cytogenotoxicity and alterations in normal cell cycle on RAW264.7 macrophages. The cytotoxicity, mechanism of cell death, mitotic activity, and reactive oxygen species (ROS) generation were determined by tetrazolium bromide reduction assay, flow cytometry, cytokinesis-block proliferation index, and superoxide dismutase-inhibitable reduction of ferricytochrome c, respectively. The genotoxicity was measured using comet assay and cytokinesis-block micronucleus assay. The cytotoxicity of CHX in RAW264.7 cells presented a dose- and time-dependent manner (p < 0.05). The mode of cell death shifted from apoptosis to necrosis when the dosage of CHX increased. The genotoxicity of CHX in RAW264.7 cells had shown DNA damage in a dose-dependent manner (p < 0.05). Prolongation of cell cycle and the increase of ROS generation also expressed in a dose-dependent manner (p < 0.05). Taken together, the data suggested that CHX-induced cytotoxicity and genotoxicity on macrophages may be via ROS generation. © 2012 Wiley Periodicals, Inc. Environ Toxicol 29: 452-458, 2014.
- Environmental toxicology.Environ Toxicol.2014 Apr;29(4):452-8. doi: 10.1002/tox.21771. Epub 2012 Apr 4.
- Chlorhexidine (CHX) is the most widely used antiseptic for wound, skin disinfection, and dental hygiene. The aim of this study is to investigate the possible correlation between CHX-induced cytogenotoxicity and alterations in normal cell cycle on RAW264.7 macrophages. The cytotoxicity, mechanism of
- PMID 22488977
- The Effectiveness of Routine Daily Chlorhexidine Gluconate Bathing in Reducing Klebsiella pneumoniae Carbapenemase-Producing Enterobacteriaceae Skin Burden among Long-Term Acute Care Hospital Patients.
- Lin MY1, Lolans K, Blom DW, Lyles RD, Weiner S, Poluru KB, Moore N, Hines DW, Weinstein RA, Hayden MK.Author information 1Department of Medicine, Rush University Medical Center, Chicago, Illinois.AbstractWe evaluated the effectiveness of daily chlorhexidine gluconate (CHG) bathing in decreasing skin carriage of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae (KPC) among long-term acute care hospital patients. CHG bathing reduced KPC skin colonization, particularly when CHG skin concentrations greater than or equal to 128 μg/mL were achieved.
- Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America.Infect Control Hosp Epidemiol.2014 Apr;35(4):440-2. doi: 10.1086/675613.
- We evaluated the effectiveness of daily chlorhexidine gluconate (CHG) bathing in decreasing skin carriage of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae (KPC) among long-term acute care hospital patients. CHG bathing reduced KPC skin colonization, particularly when CHG skin conc
- PMID 24602954
Japanese Journal
- In vitro Algaecide Effect of Disinfectants on Prototheca zopfii Genotypes 1 and 2
- SOBUKAWA Hideto,WATANABE Mitsuhiro,KANO Rui [他],ITO Takaaki,ONOZAKI Masanobu,HASEGAWA Atsuhiko,KAMATA Hiroshi
- Journal of Veterinary Medical Science 73(11), 1527-1529, 2011
- … The minimal algaecide concentration (MAC) of alkyldiaminoethylglycine hydrochloride, chlorhexidine, dioxide chlorine, povidone iodine and sodium hypochlorous acid against 10 isolates and the type strain (SAG2063T) of P. … This in vitro study indicated that alkyldiaminoethylglycine hydrochloride, chlorhexidine, povidone iodine and sodium hypochlorous acid, but not dioxide chlorine, are effective against both genotypes of P. …
- NAID 130000862402
- Susceptibility of Biofilm Escherichia coli, Salmonella Enteritidis and Staphylococcus aureus to Detergents and Sanitizers
- UEDA SHIGEKO,KUWABARA YOSHIHIRO
- Biocontrol science 12(4), 149-153, 2007-12-10
- … Benzalkonium chloride, alkyldiaminoethyl glycine hydrochloride, chlorhexidine digluconate, and polyhexamethylenebiganide inactivated the great majority of <I>E. …
- NAID 10020171521
- Susceptibilities of Methicillin-Resistant Staphylococcus aureus Isolates to Seven Biocides(Microbiology)
- Narui Koji,Takano Mitsuo,Noguchi Norihisa [他],SASATSU Masanori
- Biological & pharmaceutical bulletin 30(3), 585-587, 2007-03-01
- … However, at 5 min exposure of sodium hypochlorite, benzalkonium chloride, alkyldiaminoethylglycine hydrochloride, and chlorhexidine digluconate some strains showed higher MBC values than the user concentrations. …
- NAID 110006239209
Related Links
- Chlorhexidine hydrochloride. 2. Uses : Available as a solution to clean and treat wounds or burns. 3. How This Medicine Works : Rapid bactericidal action and has a persistent antimicrobial effect against a wide range or microorganisms. 4.
★リンクテーブル★
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- グルコン酸
- 英
- chlorhexidine
- JAN
- 塩酸クロルヘキシジン chlorhexidine hydrochloride、(JANなし)グルコン酸クロルヘキシジン chlorhexidine gluconate
- 商
- アセスクリン、イワコール、ウエルアップ、ウェルマッチ、オールカット、グルクロ、グルコジン、クロヘキシン、スクラビイン、ステリクロン、デスパ、ヒビスクラブ、ヒビスコール、ヒビソフト、ヒビディール、ヒビテン・グルコネート、ヒビテン Hibitane、フェルマ、フェルマジン、ヘヴィック、ヘキザック、ヘキシジン、ベンクロジド、マスキン、ラポテック、オロナイン軟膏
- 関
- 消毒薬。外皮用殺菌消毒剤
- 皮膚手指消毒に用いる。ウイルスに対する効果は未確定(無効という事になっている)。
- グルコン酸塩を粘膜面への使用自体は可能ではあるが、稀にショック様症状(血圧低下、呼吸抑制など)を起こすことがあるので、結膜嚢の洗浄消毒以外、粘膜部位への適用ができなくなった(→グルコン酸クロルヘキシジン中毒)。
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グルコン酸クロルヘキシジン
- 関
- chlorhexidine、chlorhexidine hydrochloride
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クロルヘキシジン。chlorhexidine hydrochloride、ヒビテン Hibitane
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クロルヘキシジン
- 関
- chlorhexidine gluconate、chlorhexidine hydrochloride
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塩酸塩、ハイドロクロライド