cAMP response element-binding protein

• cAMP応答配列結合タンパク質、サイクリックAMP応答配列結合タンパク質

関

CRE-binding protein、CREB、CREB protein、cyclic AMP response element-binding protein

WordNet

1. give an artificially banal or sexual quality to
2. temporary living quarters specially built by the army for soldiers; "wherever he went in the camp the men were grumbling" (同)encampment, cantonment, bivouac
3. shelter for persons displaced by war or political oppression or for religious beliefs (同)refugee camp
4. a site where care and activities are provided for children during the summer months; "city kids get to see the country at a summer camp" (同)summer camp
5. a penal institution (often for forced labor); "China has many camps for political prisoners"
6. temporary lodgings in the country for travelers or vacationers; "level ground is best for parking and camp areas"
7. a group of people living together in a camp; "the whole camp laughed at his mistake"
8. something that is considered amusing not because of its originality but because of its unoriginality; "the living room was pure camp"
9. establish or set up a camp (同)camp down
10. providing sophisticated amusement by virtue of having artificially (and vulgarly) mannered or banal or sentimental qualities; "they played up the silliness of their roles for camp effect"; "campy Hollywood musicals of the 1940s" (同)campy
11. live in or as if in a tent; "Can we go camping again this summer?"; "The circus tented near the town"; "The houseguests had to camp in the living room" (同)encamp, camp out, bivouac, tent
12. a straight line that generates a cylinder or cone
13. one of four substances thought in ancient and medieval cosmology to constitute the physical universe; "the alchemists believed that there were four elements"
14. the situation in which you are happiest and most effective; "in your element"
15. the most favorable environment for a plant or animal; "water is the element of fishes"
16. executed with proper legal authority; "a binding contract"
17. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
18. strip sewn over or along an edge for reinforcement or decoration
19. the capacity to attract and hold something
20. a result; "this situation developed in response to events in Africa"
21. a phrase recited or sung by the congregation following a versicle by the priest or minister
22. the manner in which an electrical or mechanical device responds to an input signal or a range of input signals
23. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

PrepTutorEJDIC

1. 〈C〉(軍隊・登山隊・探検隊などの)『野営地』 / 〈C〉〈U〉野営のテント,仮設小屋 / 〈U〉野営,キャンプ[生活];軍隊生活 / 〈C〉夏季キャンプ場,サマーキャンプ / 《集合的に》野営する人たち,キャンプする人たち / 〈C〉(主義・信条などを同じくする)同志たち,同じ陣営;同じ立場 / 『野営する』,キャンプ生活を送る《+『out』》
2. =homosexual / (男性が)女々しい / すたれた,古めかしい
3. 〈C〉(物質を構成する)元素 / 〈C〉《修飾語[句]を伴って》(…の)(基本的な)『要素』,『成分』;《しばしば複数形で》構成分子 / 〈C〉(生物に固有の)生息場所,環境;(人の)適所,本領 / 〈C〉《古》四大(しだい)[元素](自然界の基本的構成要素と考えられていた地(earth)・水(water)・風(air)・火(fire)の4大要素の一つ) / 《the elements》(雨・風・雪などの)自然力・風雨,(特に)悪天候 / 《the elements》(学問の)原理,初歩,概論
4. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
5. 〈C〉(…に対する)『返事』,『返答』《+『to』+『名』》 / 〈C〉〈U〉(…に対する)『反応』,『反響』《『to』+『名』》 / 〈C〉応答歌,応唱(牧師にならって合唱隊・会衆が短い祈り・歌を応答すること)
6. 蛋白(たんばく)質

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/14 11:22:55」(JST)

wiki en

[Wiki en表示]

Not to be confused with Clean Renewable Energy Bonds.

CREB (top) is a transcription factor capable of binding DNA (bottom) and regulating gene expression.

CREB (cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the downstream genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.

Genes whose transcription is regulated by CREB include: c-fos, the neurotrophin BDNF (Brain-derived neurotrophic factor), tyrosine hydroxylase, and many neuropeptides (such as somatostatin, enkephalin, VGF, and corticotropin-releasing hormone).

CREB is closely related in structure and function to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans. CREB is a transcription factor that has been shown to be integral in the formation of spatial memory. In recent experiments it has been demonstrated that CREB may possess therapeutic potential for patients that have Alzheimer's Disease.

CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain.

Subtypes

The following genes encode CREB or CREB-like proteins:

• CREB1 (CREB1)
• CREB2 renamed ATF4 (ATF4)
• CREB3 (CREB3)
• CREB5 (CREB5)
• CREB3L1 (CREB3L1)
• CREB3L2 (CREB3L2)
• CREB3L3 (CREB3L3)
• CREB3L4 (CREB3L4)

Structure

General structure of the CREB protein.

When activated CREB protein forms a dimer and binds to the CRE region of DNA. Hydrophobic leucine amino acids are located along the inner edge of the alpha helix. These leucine residues tightly bind to leucine residues of another CREB protein forming the dimer. This chain of leucine residues forms the leucine zipper motif. The protein also has a magnesium ion that facilitates binding to DNA.

Mechanism of action

A typical (albeit somewhat simplified) sequence of events is as follows: A signal arrives at the cell surface, activates the corresponding receptor, which leads to the production of a second messenger such as cAMP or Ca²⁺, which in turn activates a protein kinase. This protein kinase translocates to the cell nucleus, where it activates a CREB protein. The activated CREB protein then binds to a CRE region, and is then bound to by a CBP (CREB-binding protein), which coactivates it, allowing it to switch certain genes on or off. The DNA binding of CREB is mediated via its basic leucine zipper domain (bZIP domain) as depicted in the image.

Function

CREB has many functions in many different organs, and some of its functions have been studied in relation to the brain. CREB proteins in neurons are thought to be involved in the formation of long-term memories; this has been shown in the marine snail Aplysia, the fruit fly Drosophila melanogaster, in rats and in mice (see CREB in Molecular and Cellular Cognition). CREB is necessary for the late stage of long-term potentiation. CREB also has an important role in the development of drug addiction. There are activator and repressor forms of CREB. Flies genetically engineered to overexpress the inactive form of CREB lose their ability to retain long-term memory. CREB is also important for the survival of neurons, as shown in genetically engineered mice, where CREB and CREM were deleted in the brain. If CREB is lost in the whole developing mouse embryo, the mice die immediately after birth, again highlighting the critical role of CREB in promoting survival.

Disease linkage

Disturbance of CREB function in brain can contribute to the development and progression of Huntington's Disease. Abnormalities of a protein that interacts with the KID domain of CREB, the CREB-binding protein, (CBP) is associated with Rubinstein-Taybi syndrome. CREB is also thought to be involved in the growth of some types of cancer.

cAMP response element

The cAMP response element is the response element for CREB. Since the effects of protein kinase A on the synthesis of proteins work by activating CREB, the cAMP response element is responsible for modulating the effects of protein kinase A that work by protein synthesis.

See also

• CREB in Molecular and Cellular Cognition

References

1. Lauren Slater, (2005). Opening Skinner's Box: Great Psychological Experiments of the Twentieth Century. New York: W. W. Norton & Company. ISBN 0-393-32655-1. 
2. Barco A, Bailey C, Kandel E (2006). "Common molecular mechanisms in explicit and implicit memory". J. Neurochem. 97 (6): 1520–33. doi:10.1111/j.1471-4159.2006.03870.x. PMID 16805766. 
3. Conkright M, Montminy M (2005). "CREB: the unindicted cancer co-conspirator". Trends Cell Biol. 15 (9): 457–9. doi:10.1016/j.tcb.2005.07.007. PMID 16084096. 
4. Mantamadiotis T, Lemberger T, Bleckmann S, Kern H, Kretz O, Martin Villalba A, Tronche F, Kellendonk C, Gau D, Kapfhammer J, Otto C, Schmid W, Schütz G (2002). "Disruption of CREB function in brain leads to neurodegeneration". Nat. Genet. 31 (1): 47–54. doi:10.1038/ng882. PMID 11967539. 
5. Mayr B, Montminy M (2001). "Transcriptional regulation by the phosphorylation-dependent factor CREB". Nat. Rev. Mol. Cell Biol. 2 (8): 599–609. doi:10.1038/35085068. PMID 11483993. 
6. Yin J, Del Vecchio M, Zhou H, Tully T (1995). "CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila". Cell 81 (1): 107–15. doi:10.1016/0092-8674(95)90375-5. PMID 7720066. 
7. Yin J, Wallach J, Del Vecchio M, Wilder E, Zhou H, Quinn W, Tully T (1994). "Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila". Cell 79 (1): 49–58. doi:10.1016/0092-8674(94)90399-9. PMID 7923376. 

External links

• Johannessen, M., Pedersen Delghandi, M., and Moens, U. (2004) - What Turns CREB on ? - Cell Signall.; 10:1211-1227. http://www.sigtrans.org/publications/what-turns-creb-on/
• http://focus.hms.harvard.edu/2001/Oct26_2001/neuroscience.html
• CREB Protein at the US National Library of Medicine Medical Subject Headings (MeSH)
• Drosophila Cyclic-AMP response element binding protein A - The Interactive Fly
• Drosophila Cyclic-AMP response element binding protein B at 17A - The Interactive Fly

UpToDate Contents

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English Journal

• Quinaldic acid inhibits proliferation of colon cancer HT-29 cells in vitro: Effects on signaling pathways.

• Langner E1, Walczak K2, Jeleniewicz W3, Turski WA4, Rajtar G2.
• European journal of pharmacology.Eur J Pharmacol.2015 Jun 15;757:21-7. doi: 10.1016/j.ejphar.2015.02.053. Epub 2015 Mar 20.
• Quinaldic acid is presumed to be a derivative of kynurenic acid, a tryptophan metabolite with proven antiproliferative activity towards cancer cells in vitro. The aim of present study was to evaluate the activity of quinaldic acid in colon cancer cells. The antiproliferative potential of quinaldic a
• PMID 25797283

• FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca(2+) /CREB pathway.

• Liu XM1, Chan HC, Ding GL, Cai J, Song Y, Wang TT, Zhang D, Chen H, Yu MK, Wu YT, Qu F, Liu Y, Lu YC, Adashi EY, Sheng JZ, Huang HF.
• Aging cell.Aging Cell.2015 Jun;14(3):409-20. doi: 10.1111/acel.12331. Epub 2015 Mar 6.
• Increased fat mass and fat redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens and oestrogens have been observed, the exact mechanism of fat accumulation and redistribution during aging remains obscure. In this study,
• PMID 25754247

• Chronic exercise prevents repeated restraint stress-provoked enhancement of immobility in forced swimming test in ovariectomized mice.

• Han TK1, Lee JK, Leem YH.
• Metabolic brain disease.Metab Brain Dis.2015 Jun;30(3):711-8. doi: 10.1007/s11011-014-9624-2. Epub 2014 Oct 26.
• We assessed whether chronic treadmill exercise attenuated the depressive phenotype induced by restraint stress in ovariectomized mice (OVX). Immobility of OVX in the forced swimming test was comparable to that of sham mice (CON) regardless of the postoperative time. Immobility was also no difference
• PMID 25344674

Japanese Journal

• 遺伝子発現屋の脳神経科学

• 津田 正明
• 薬学雑誌. 乙号 135(4), 597-617, 2015
• … Particularly focusing on the transcription regulation of the brain-derived neurotrophic factor (BDNF) gene (Bdnf), I found that the interaction of the cAMP response element-binding protein (CREB) with the CRE sequence is important for the activity-dependent activation of the Bdnf promoter. …
• NAID 130005060826

• DA-9801 Promotes Neurite Outgrowth via ERK1/2-CREB Pathway in PC12 Cells

• Won Jong Hoon,Ahn Kyong Hoon,Back Moon Jung [他],Ha Hae Chan,Jang Ji Min,Kim Ha Hyung,Choi Sang-Zin,Son Miwon,Kim Dae Kyong
• Biological and Pharmaceutical Bulletin 38(2), 169-178, 2015
• … We found that DA-9801 elicits its effects via the mitogen-activated protein kinase (MEK) extracellular signal-regulated kinase (ERK)1/2-cAMP response element-binding protein (CREB) pathway. … Conversely, the selective p38 mitogen-activated protein kinase inhibitor SB203580 did not attenuate the DA-9801 treatment-induced increase in the percentage of neurite-bearing PC12 cells. …
• NAID 130004872243

• Blunted Behavioral and Molecular Responses to Chronic Mild Stress in Adult Rats with Experience of Infancy Maternal Separation

• Shu Chang,Xiao Ling,Tang Jihua,Wang Gaohua,Zhang Xueping,Wang Xiaoping
• The Tohoku Journal of Experimental Medicine 235(2), 81-87, 2015
• … Brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB) play critical roles during brain development to maintain neuronal function and structural integrity in adulthood. …
• NAID 130004822431

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★リンクテーブル★

リンク元	「サイクリックAMP応答配列結合タンパク質」「cAMP応答配列結合タンパク質」「cyclic AMP response element-binding protein」「CREB protein」
関連記事	「binding」「element」「binding protein」「cAMP」「response」

「サイクリックAMP応答配列結合タンパク質」

　　[★]

英

cyclic AMP response element-binding protein、cAMP response element-binding protein、CRE-binding protein、CREB protein、CREB

関

cAMP応答配列結合タンパク質、CRE結合タンパク質、サイクリックAMP応答エレメント結合タンパク質

「cAMP応答配列結合タンパク質」

　　[★]

英

cAMP response element-binding protein、CRE-binding protein、CREB

関

CRE結合タンパク質、サイクリックAMP応答エレメント結合タンパク質、サイクリックAMP応答配列結合タンパク質

「cyclic AMP response element-binding protein」

　　[★]

• サイクリックAMP応答配列結合タンパク質、サイクリックAMP応答エレメント結合タンパク質

関

cAMP response element-binding protein、CRE-binding protein、CREB、CREB protein

「CREB protein」

　　[★]

• サイクリックAMP応答配列結合タンパク質

関

cAMP response element-binding protein、CRE-binding protein、CREB、cyclic AMP response element-binding protein

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「element」

　　[★]

• n.

• 要素、成分、素。(構成)分子。(科学)元素、(数)(集合の)要素、元素、素。(行列の)要素、成分。(図形を火ｔが千都来る)要素。(文法の)要素
• (電子)素子、(光学)素子

関

basal、bases、basic、basis、component、composition、constituent、elementary、factor、fundamentals、ingredient、moiety

　 　 　 　 　

「binding protein」

　　[★]

• 結合タンパク質、結合タンパク、結合蛋白質、結合蛋白

関

BP、carrier protein、transport protein

「cAMP」

　　[★] 環状アデノシン一リン酸 サイクリックAMP 環状AMP adenosine 3',5'-cyclic monophosphate, cyclic AMP

「response」

　　[★]

• n.

• 返答、応答
• 反応、感応、反響。(刺激に対する)反応