- 関
- amino acid sequence analyses、amino acid sequence analysis、amino acid sequencing、protein sequence analysis
WordNet
- determine the order of constituents in; "They sequenced the human genome"
- a following of one thing after another in time; "the doctor saw a sequence of patients" (同)chronological sequence, succession, successiveness, chronological succession
- film consisting of a succession of related shots that develop a given subject in a movie (同)episode
- serial arrangement in which things follow in logical order or a recurrent pattern; "the sequence of names was alphabetical"; "he invented a technique to determine the sequence of base pairs in DNA"
- several repetitions of a melodic phrase in different keys
- arrange in a sequence
- the act of determining the properties of something, usually by research or calculation; "the determination of molecular structures" (同)finding
- the quality of being determined to do or achieve something; firmness of purpose; "his determination showed in his every movement"; "he is a man of purpose" (同)purpose
- deciding or controlling somethings outcome or nature; "the determination of grammatical inflections"
- street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
- any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
- having the characteristics of an acid; "an acid reaction"
- pertaining to or containing any of a group of organic compounds of nitrogen derived from ammonia (同)aminic
- the radical -NH2 (同)amino_group
PrepTutorEJDIC
- 〈U〉〈C〉(時間の上の,また因果関係のつながりによる)『連続』,続き / 〈C〉《a~》(…の)一連のもの《+『of』+『名』》 / 〈U〉(起こる)『順序』(order),筋道 / 〈C〉(…に対する)結果《+『to』+『名』》
- 〈U〉『決心』,決意,決断力 / 〈U〉(…の)『決定』,決着《+『of』+『名』》 / 〈C〉(法律上の)(…の)判決,裁決,終結《+『of』+『名』》 / 〈U〉(…の)測定[法]《+『of』+『名』》
- 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
- 配列,接続;(特に時間の)調整
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. フェニルケトン尿症の概要 overview of phenylketonuria
- 2. 乳児および小児における低血糖に対するアプローチ approach to hypoglycemia in infants and children
- 3. 先天性代謝異常：代謝性救急疾患 inborn errors of metabolism metabolic emergencies
- 4. 先天性代謝異常：分類 inborn errors of metabolism classification
- 5. コレシストキニンの生理学 physiology of cholecystokinin
English Journal
- Structure-activity relationships of peptidomimetics that inhibit PPI of HER2-HER3.
- Kanthala S1, Gauthier T, Satyanarayanajois S.Author information 1Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201.AbstractHuman epidermal growth factor receptor-2 (HER2) is a tyrosine kinase family protein receptor that is known to undergo heterodimerization with other members of the family of epidermal growth factor receptors (EGFR) for cell signaling. Overexpression of HER2 and deregulation of signaling has implications in breast, ovarian, and lung cancers. We have designed several peptidomimetics to block the HER2-mediated dimerization, resulting in antiproliferative activity for cancer cells. In this work, we have investigated the structure-activity relationships of peptidomimetic analogs of Compound 5. Compound 5 was conformationally constrained by N- and C-terminal modification and cyclization as well as by substitution with d-amino acids at the N-and C-termini. Among the compounds studied in this work, a peptidomimetic Compound 21 with d-amino acid substitution and its N- and C-termini capped with acetyl and amide functional groups and a reversed sequence compared to that of Compound 5 exhibited better antiproliferative activity in HER2-overexpressed breast, ovarian, and lung cancer cell lines. Compound 21 was further evaluated for its protein-protein interaction (PPI) inhibition ability using enzyme fragment complementation assay, proximity ligation assay, and Western blot analysis. Results suggested that Compound 21 is able to block HER2:HER3 interaction and inhibit phosphorylation of the kinase domain of HER2. The mode of binding of Compound 21 to HER2 protein was modeled using a docking method. Compound 21 seems to bind to domain IV of HER2 near the PPI site of EGFR:HER2, and HER:HER3 and inhibit PPI. © 2013 Wiley Periodicals, Inc. Biopolymers 101: 693-702, 2014.
- Biopolymers.Biopolymers.2014 Jun;101(6):693-702. doi: 10.1002/bip.22441.
- Human epidermal growth factor receptor-2 (HER2) is a tyrosine kinase family protein receptor that is known to undergo heterodimerization with other members of the family of epidermal growth factor receptors (EGFR) for cell signaling. Overexpression of HER2 and deregulation of signaling has implicati
- PMID 24222531
- Improving the representation of peptide-like inhibitor and antibiotic molecules in the Protein Data Bank.
- Dutta S1, Dimitropoulos D, Feng Z, Persikova I, Sen S, Shao C, Westbrook J, Young J, Zhuravleva MA, Kleywegt GJ, Berman HM.Author information 1RCSB Protein Data Bank, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854-8076.AbstractWith the accumulation of a large number and variety of molecules in the Protein Data Bank (PDB) comes the need on occasion to review and improve their representation. The Worldwide PDB (wwPDB) partners have periodically updated various aspects of structural data representation to improve the integrity and consistency of the archive. The remediation effort described here was focused on improving the representation of peptide-like inhibitor and antibiotic molecules so that they can be easily identified and analyzed. Peptide-like inhibitors or antibiotics were identified in over 1000 PDB entries, systematically reviewed and represented either as peptides with polymer sequence or as single components. For the majority of the single-component molecules, their peptide-like composition was captured in a new representation, called the subcomponent sequence. A novel concept called "group" was developed for representing complex peptide-like antibiotics and inhibitors that are composed of multiple polymer and nonpolymer components. In addition, a reference dictionary was developed with detailed information about these peptide-like molecules to aid in their annotation, identification and analysis. Based on the experience gained in this remediation, guidelines, procedures, and tools were developed to annotate new depositions containing peptide-like inhibitors and antibiotics accurately and consistently. © 2013 Wiley Periodicals, Inc. Biopolymers 101: 659-668, 2014.
- Biopolymers.Biopolymers.2014 Jun;101(6):659-68. doi: 10.1002/bip.22434.
- With the accumulation of a large number and variety of molecules in the Protein Data Bank (PDB) comes the need on occasion to review and improve their representation. The Worldwide PDB (wwPDB) partners have periodically updated various aspects of structural data representation to improve the integri
- PMID 24173824
- Structural characterization and bioactivity evaluation of an acidic proteoglycan extract from Ganoderma lucidum fruiting bodies for PTP1B inhibition and anti-diabetes.
- Pan D1, Wang L, Hu B, Zhou P.Author information 1Department of Macromolecular Science, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, People's Republic of China.AbstractA water-soluble PTP1B inhibitor, named FYGL-a, was fractionated for structure investigation and bioactivity evaluation. FYGL-a is an ingredient of a reported antihyperglycemia extract from Ganoderma Lucidum fruiting bodies. Composition analysis indicated that FYGL-a was a 100.2 kDa acidic proteoglycan, consisting of 85 ± 2% heteropolysaccharide chain with rhamnose, galactose, glucose, and glucuronic acid residues in a mole ratio of 1.0:3.7:3.9:2.0, and the 15 ± 2% protein moiety of FYGL-a was covalently bonded to the polysaccharide chain in O-linkage type via threonine residues. The complete sequence of FYGL-a was characterized systematically by periodate oxidation, Smith degradation, methylation analysis, (1) H & (13) C 1D NMR, and 2D NMR (HSQC, HMBC, NOESY, COSY, & TOCSY). The chemical structure of FYGL-a was determined as following, which may play special role in the competitive inhibition of PTP1B and antihyperglycemia potency. © 2013 Wiley Periodicals, Inc. Biopolymers 101: 613-623, 2014.
- Biopolymers.Biopolymers.2014 Jun;101(6):613-23. doi: 10.1002/bip.22426.
- A water-soluble PTP1B inhibitor, named FYGL-a, was fractionated for structure investigation and bioactivity evaluation. FYGL-a is an ingredient of a reported antihyperglycemia extract from Ganoderma Lucidum fruiting bodies. Composition analysis indicated that FYGL-a was a 100.2 kDa acidic proteoglyc
- PMID 24127303
Japanese Journal
- Genetic analysis and phylogenetic characterization of pandemic (H1N1) 2009 influenza viruses that found in Nagasaki, Japan
- Kawano Hiroaki,Haruyama Takahiro,Hayashi Yuji [他]
- Japanese Journal of Infectious Diseases 64(3), 195-203, 2011-05
- … SUMMARY: Isolation and determination of the nucleotide sequence of hemagglutinin (HA) of the pandemic (H1N1) 2009 influenza viruses found in Nagasaki, Japan, were conducted. … The alignment results of the predicted HA amino acid sequences of these strains compared to the known global isolates revealed 5 specific amino acid differences located within the antigenic sites. …
- NAID 40018820932
- Determination and Molecular Analysis of the Complete Genome Sequence of Two Wild-Type Rabies Viruses Isolated from a Haematophagous Bat and a Frugivorous Bat in Brazil
- MOCHIZUKI Nobuyuki,KOBAYASHI Yuki,SATO Go,HIRANO Shinji,ITOU Takuya,ITO Fumio Honma,SAKAI Takeo
- Journal of Veterinary Medical Science advpub(0), 1101250445, 2011
- … The complete nucleotide sequence identity between the BR-DR1 and BR-AL1 isolates was 97%. … The BR-DR1 and BR-AL1 isolates had some conserved functional sites revealed by the fixed isolates, whereas both isolates had unique amino acid substitutions in the antigenic region IV of the nucleocapsid gene. …
- NAID 130000444988
Related Links
- A new technique is described that permits the permethylation of acylated peptides at the 2-10 nmol level. The presence of up to 400 micrograms of sodium dodecyl sulphate per sample does not affect the reaction yields. The ...
- 1. Methods Enzymol. 1991;205:421-6. Amino acid sequence determination. Hunziker PE. PMID: 1779803 [PubMed - indexed for MEDLINE] MeSH Terms Amino Acid Sequence Animals Endopeptidases Indicators and Reagents Liver ...
Related Pictures
★リンクテーブル★
| リンク元 | 「amino acid sequence analyses」「amino acid sequence analysis」「protein sequence analysis」「アミノ酸配列決定法」「アミノ酸配列決定」 |
| 関連記事 | 「sequence」「determination」「sequencing」 |
「amino acid sequence analyses」
「amino acid sequence analysis」
「protein sequence analysis」
「アミノ酸配列決定法」
「アミノ酸配列決定」
「sequence」
- n.
- v.
- 配列決定する
- 関
- a sequence of、arrange、arrangement、array、barrage、consecutive、consequence、constellation、continually、continue、continuous、order、ordinal、outcome、output、product、result、resultant、sequencing、sequential、serial、series、thread
「determination」
- n.
「sequencing」
- n.
- 関
- sequence