acidic fibroblast growth factor

• 酸性線維芽細胞増殖因子、酸性線維芽細胞成長因子

関

aFGF、FGF-1、FGF1、fibroblast growth factor-1

WordNet

1. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
2. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
3. become attached by or as if by the process of growth; "The tree trunks had grown together"
4. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
5. cause to grow or develop; "He grows vegetables in his backyard"
6. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
7. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
8. (pathology) an abnormal proliferation of tissue (as in a tumor)
9. a progression from simpler to more complex forms; "the growth of culture"
10. something grown or growing; "a growth of hair"
11. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
12. be a contributing factor; "make things factor into a companys profitability"
13. any of the numbers (or symbols) that form a product when multiplied together
14. an independent variable in statistics
15. anything that contributes causally to a result; "a number of factors determined the outcome"
16. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
17. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
18. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
19. a concept whose truth can be proved; "scientific hypotheses are not facts"
20. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
21. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
22. street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
23. any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
24. having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

1. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
2. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
3. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
4. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
5. 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/02/10 11:42:47」(JST)

wiki en

[Wiki en表示]

This article is about fibroblast growth factor-1. For the internal ribosome entry site, see FGF-1 internal ribosome entry site (IRES).

FGF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QO3, 1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16, 1NZK, 1P63, 1PZZ, 1Q03, 1Q04, 1RG8, 1RML, 1RY7, 1YTO, 1Z2V, 1Z4S, 2AFG, 2AQZ, 2AXM, 2ERM, 2HW9, 2HWA, 2HWM, 2HZ9, 2K43, 2K4A, 2K8R, 2KI4, 2KI6, 2NTD, 2Q9X, 2RQ9, 3B9U, 3BA4, 3BA5, 3BA7, 3BAD, 3BAG, 3BAH, 3BAO, 3BAQ, 3BAU, 3BAV, 3BB2, 3CQA, 3CRG, 3CRH, 3CRI, 3CU1, 3FGM, 3FJ8, 3FJ9, 3FJA, 3FJB, 3FJC, 3FJD, 3FJE, 3FJF, 3FJH, 3FJI, 3FJJ, 3FJK, 3HOM, 3JUT, 3K1X, 3O3Q, 3OJ2, 3OJM, 3OJV, 3UD7, 3UD8, 3UD9, 3UDA, 4J23, 4Q91, 4Q9G, 4Q9P, 4QAL, 4QBC, 4QBV, 4QC4, 4XKI, 4YOL
Identifiers
Aliases	FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1, fibroblast growth factor 1
External IDs	OMIM: 131220 MGI: 95515 HomoloGene: 625 GeneCards: FGF1
Genetically Related Diseases
hypertrophic cardiomyopathy
Gene ontology Molecular function • S100 protein binding • Hsp70 protein binding • protein binding • growth factor activity • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • fibroblast growth factor receptor binding • integrin binding • 1-phosphatidylinositol-3-kinase activity • heparin binding Cellular component • cytoplasm • cytosol • proteinaceous extracellular matrix • nucleoplasm • extracellular region • cell cortex • nucleolus • nucleus • extracellular space Biological process • cell differentiation • cellular response to heat • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • organ induction • lung development • positive regulation of epithelial cell proliferation • anatomical structure morphogenesis • positive regulation of intracellular signal transduction • branch elongation involved in ureteric bud branching • positive regulation of angiogenesis • MAPK cascade • multicellular organism development • mesonephric epithelium development • angiogenesis • positive regulation of ERK1 and ERK2 cascade • regulation of endothelial cell chemotaxis to fibroblast growth factor • positive regulation of cholesterol biosynthetic process • cell proliferation • positive regulation of cell division • phosphatidylinositol-mediated signaling • positive regulation of transcription from RNA polymerase II promoter • signal transduction • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • peptidyl-tyrosine phosphorylation • positive regulation of sprouting angiogenesis • activation of MAPK activity • fibroblast growth factor receptor signaling pathway • positive regulation of cell proliferation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process • regulation of endothelial tube morphogenesis • positive regulation of cell migration • positive regulation of endothelial cell migration • activation of protein kinase B activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2246	14164
Ensembl	ENSG00000113578	ENSMUSG00000036585
UniProt	P05230	P61148
RefSeq (mRNA)	NM_000800 NM_001144892 NM_001144934 NM_001144935 NM_001257205 NM_001257206 NM_001257207 NM_001257208 NM_001257209 NM_001257210 NM_001257211 NM_001257212 NM_033136 NM_033137	NM_010197
RefSeq (protein)	NP_000791 NP_001138364 NP_001138406 NP_001138407 NP_001244134 NP_001244135 NP_001244136 NP_001244137 NP_001244138 NP_001244139 NP_001244140 NP_001244141 NP_149127 NP_149128	NP_034327.1 NP_034327
Location (UCSC)	Chr 5: 142.59 – 142.7 Mb	Chr 18: 38.84 – 38.93 Mb
PubMed search
Wikidata
View/Edit Human		View/Edit Mouse

Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene.

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described.

In mice with diet-induced diabetes, the equivalent of type 2 diabetes in humans, a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for > 2 days.

Interactions

FGF1 has been shown to interact with:

• CSNK2A2,
• CSNK2B,
• CSNK2A1,
• FIBP,
• FGFR1,
• FGFR2
• FGFR3,
• FGFR4,
• HSPA9, and
• S100A13.

See also

• Fibroblast growth factor

References

Further reading

• Yu YL, Kha H, Golden JA, Migchielsen AA, Goetzl EJ, Turck CW (Apr 1992). "An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist". The Journal of Experimental Medicine. 175 (4): 1073–80. doi:10.1084/jem.175.4.1073. PMC 2119192. PMID 1372643. 
• Chiu IM, Wang WP, Lehtoma K (May 1990). "Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1". Oncogene. 5 (5): 755–62. PMID 1693186. 
• Zhu X, Komiya H, Chirino A, Faham S, Fox GM, Arakawa T, Hsu BT, Rees DC (Jan 1991). "Three-dimensional structures of acidic and basic fibroblast growth factors". Science. 251 (4989): 90–3. doi:10.1126/science.1702556. PMID 1702556. 
• Wang WP, Quick D, Balcerzak SP, Needleman SW, Chiu IM (Sep 1991). "Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients". Oncogene. 6 (9): 1521–9. PMID 1717925. 
• Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Sep 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". The Journal of Biological Chemistry. 266 (25): 16778–85. PMID 1885605. 
• Crumley G, Dionne CA, Jaye M (Aug 1990). "The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon". Biochemical and Biophysical Research Communications. 171 (1): 7–13. doi:10.1016/0006-291X(90)91348-V. PMID 2393407. 
• Harper JW, Strydom DJ, Lobb RR (Jul 1986). "Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor". Biochemistry. 25 (14): 4097–103. doi:10.1021/bi00362a017. PMID 2427112. 
• Winkles JA, Friesel R, Burgess WH, Howk R, Mehlman T, Weinstein R, Maciag T (Oct 1987). "Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor)". Proceedings of the National Academy of Sciences of the United States of America. 84 (20): 7124–8. doi:10.1073/pnas.84.20.7124. PMC 299242. PMID 2444975. 
• Wang WP, Lehtoma K, Varban ML, Krishnan I, Chiu IM (Jun 1989). "Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues". Molecular and Cellular Biology. 9 (6): 2387–95. PMC 362312. PMID 2474753. 
• Mergia A, Tischer E, Graves D, Tumolo A, Miller J, Gospodarowicz D, Abraham JA, Shipley GD, Fiddes JC (Nov 1989). "Structural analysis of the gene for human acidic fibroblast growth factor". Biochemical and Biophysical Research Communications. 164 (3): 1121–9. doi:10.1016/0006-291X(89)91785-3. PMID 2590193. 
• Gimenez-Gallego G, Conn G, Hatcher VB, Thomas KA (Jul 1986). "The complete amino acid sequence of human brain-derived acidic fibroblast growth factor". Biochemical and Biophysical Research Communications. 138 (2): 611–7. doi:10.1016/S0006-291X(86)80540-X. PMID 3527167. 
• Gautschi P, Fràter-Schröder M, Böhlen P (Aug 1986). "Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors". FEBS Letters. 204 (2): 203–7. doi:10.1016/0014-5793(86)80812-2. PMID 3732516. 
• Gautschi-Sova P, Müller T, Böhlen P (Nov 1986). "Amino acid sequence of human acidic fibroblast growth factor". Biochemical and Biophysical Research Communications. 140 (3): 874–80. doi:10.1016/0006-291X(86)90716-3. PMID 3778488. 
• Gimenez-Gallego G, Conn G, Hatcher VB, Thomas KA (Mar 1986). "Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities". Biochemical and Biophysical Research Communications. 135 (2): 541–8. doi:10.1016/0006-291X(86)90028-8. PMID 3964259. 
• Zhao XM, Yeoh TK, Hiebert M, Frist WH, Miller GG (Nov 1993). "The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells". Transplantation. 56 (5): 1177–82. doi:10.1097/00007890-199311000-00025. PMID 7504343. 
• Pineda-Lucena A, Jiménez MA, Nieto JL, Santoro J, Rico M, Giménez-Gallego G (Sep 1994). "1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate". Journal of Molecular Biology. 242 (1): 81–98. doi:10.1006/jmbi.1994.1558. PMID 7521397. 
• Chotani MA, Payson RA, Winkles JA, Chiu IM (Feb 1995). "Human fibroblast growth factor 1 gene expression in vascular smooth muscle cells is modulated via an alternate promoter in response to serum and phorbol ester". Nucleic Acids Research. 23 (3): 434–41. doi:10.1093/nar/23.3.434. PMC 306694. PMID 7533902. 
• Opalenik SR, Shin JT, Wehby JN, Mahesh VK, Thompson JA (Jul 1995). "The HIV-1 TAT protein induces the expression and extracellular appearance of acidic fibroblast growth factor". The Journal of Biological Chemistry. 270 (29): 17457–67. doi:10.1074/jbc.270.29.17457. PMID 7542239. 
• Myers RL, Payson RA, Chotani MA, Deaven LL, Chiu IM (Feb 1993). "Gene structure and differential expression of acidic fibroblast growth factor mRNA: identification and distribution of four different transcripts". Oncogene. 8 (2): 341–9. PMID 7678925. 

UpToDate Contents

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English Journal

• Acidic pH with coordinated reduction of basic fibroblast growth factor maintains the glioblastoma stem cell-like phenotype in vitro.

• Haley EM1, Tilson SG1, Triantafillu UL1, Magrath JW1, Kim Y2.
• Journal of bioscience and bioengineering.J Biosci Bioeng.2017 May;123(5):634-641. doi: 10.1016/j.jbiosc.2016.12.006. Epub 2017 Jan 4.
• PMID 28063758

• Electrostatic Forces as Dominant Interactions Between Proteins and Polyanions: an ESI MS Study of Fibroblast Growth Factor Binding to Heparin Oligomers.

• Minsky BB1, Dubin PL1, Kaltashov IA2.
• Journal of the American Society for Mass Spectrometry.J Am Soc Mass Spectrom.2017 Apr;28(4):758-767. doi: 10.1007/s13361-017-1596-0. Epub 2017 Feb 16.
• PMID 28211013

• Strong FGFR3 staining is a marker for FGFR3 fusions in diffuse gliomas.

• Granberg KJ1, Annala M1, Lehtinen B1, Kesseli J1, Haapasalo J1, Ruusuvuori P1, Yli-Harja O1, Visakorpi T1, Haapasalo H1, Nykter M1, Zhang W1.
• Neuro-oncology.Neuro Oncol.2017 Apr 1. doi: 10.1093/neuonc/nox028. [Epub ahead of print]
• PMID 28379477

Japanese Journal

• Evaluation of the Safety and Brain-Related Tissues Distribution Characteristics of TAT-HaFGF <i>via</i> Intranasal Administration

• Biological and Pharmaceutical Bulletin 37(7), 1149-1157, 2014
• NAID 130004057422

• Basic fibroblast growth factor promotes the generation of microtubule-associated protein 2-positive cells from microglia

• Biochemical and Biophysical Research Communications 390(3), 1018-1022, 2009-12-18
• NAID 120001749557

• Enhanced Immunoreactivity for Basic Fibroblast Growth Factor (FGF2) in the Adult Rat Spinal Cord in Experimental Syringomyelia

• Nano Biomedicine 1(2), 167-175, 2009
• NAID 130004555802

Related Links

• Acidic Fibroblast Growth Factor - Welcome to GenWayBio.com

Name Acidic Fibroblast Growth Factor Related Product Names Acidic Fibroblast Growth Factor (aFGF), Human, Recombinant, E Coli; HBGF-1; Acidic fibroblast growth factor; aFGF; Beta-endothelial cell growth factor; ECGF-beta ...

• ヒトオリゴペプチドー13（aFGF: Acidic Fibroblast Growth ...

商品名: ヒトオリゴペプチドー13（aFGF: Acidic Fibroblast Growth Factor）酸性線維芽細胞成長因子 内容量: 1mg当たり35,000円（税抜き） 使用方法: 精製水に溶かして使う（1Lの水に溶かすと1ppm濃度） 形状: パウダー

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★リンクテーブル★

リンク元	「fibroblast growth factor-1」「酸性線維芽細胞成長因子」「FGF-1」
関連記事	「grow」「fact」「factor」「fibroblast」「growth」

「fibroblast growth factor-1」

　　[★]

線維芽細胞増殖因子1、線維芽細胞増殖因子-1、線維芽細胞成長因子1、線維芽細胞成長因子-1

関

acidic fibroblast growth factor、FGF-1、FGF1

「酸性線維芽細胞成長因子」

　　[★]

英

acidic fibroblast growth factor、aFGF

関

線維芽細胞増殖因子-1、線維芽細胞増殖因子1、酸性線維芽細胞増殖因子

「FGF-1」

　　[★]

• 線維芽細胞増殖因子-1

関

acidic fibroblast growth factor、FGF1、fibroblast growth factor-1

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter

　 　 　 　 　 　 　

「fibroblast」

　　[★] 線維芽細胞

同

fibroblasts, scleroderma phenotype

　

「growth」

　　[★]

• n.

• 成長