コガネバナ、コガネヤナギ
- 関
- Scutellariae radix
WordNet
- an asterid dicot genus that includes the skullcaps (同)genus Scutellaria
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/02 22:26:42」(JST)
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This article needs more medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. (July 2012) |
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| Scutellaria baicalensis |
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| Scientific classification |
| Kingdom: |
Plantae |
| (unranked): |
Angiosperms |
| (unranked): |
Eudicots |
| (unranked): |
Asterids |
| Order: |
Lamiales |
| Family: |
Lamiaceae |
| Genus: |
Scutellaria |
| Species: |
S. baicalensis |
| Binomial name |
Scutellaria baicalensis
Georgi[1] |
| Synonyms |
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Scutellaria macrantha Fisch.[1]
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Scutellaria baicalensis (or Baikal skullcap, as opposed to Scutellaria lateriflora, a skullcap native to North America) is a species of flowering plant in the Lamiaceae family.
Contents
- 1 Distribution
- 2 Traditional Chinese medicine
- 3 Pharmacology
- 4 Name confusion
- 5 See also
- 6 References
- 7 External links
Distribution
The plant is cultivated in Siberia, Mongolia, the Russian Far East, China and Korea.[1]
Traditional Chinese medicine
It is one of the 50 fundamental herbs used in traditional Chinese medicine, where it has the name huáng cen (Chinese: 黄芩).[2] As a Chinese traditional medicine, huang qin usually refers to the dried root of S. baicalensis Georgi, S. viscidula Bge., S. amoena C.H. Wright, and S. ikoninkovii Ju.
Pharmacology
Main article: Scutellaria § Constituents and pharmacology
Several chemical compounds have been isolated from the root; baicalein, baicalin, wogonin, norwogonin, oroxylin A[3] and β-sitosterol are the major ones.[4]
Name confusion
It is important to use the Latin name, as the term skullcap is used for over 200 varieties, and various ailments, each with varying degrees of effectiveness. Sometimes, Scutellaria lateriflora (North American skullcap) is mistaken for S. baicalensis. This confusion can result in the intake of the S. lateriflora variety which can be processed and contaminated with other plants at high enough levels to be of concern.[citation needed]
See also
- Piper methysticum (kava), another anxiolytic GABAergic plant
- Valeriana officinalis (valerian), a sedative GABAergic plant
References
- ^ a b c "Scutellaria baicalensis information from NPGS/GRIN". USDA. Retrieved 2008-02-19.
- ^ Zhang XW; Li WF; Li WW; Ren KH; Fan CM; Chen YY; Shen YL (2011). "Protective effects of the aqueous extract of Scutellaria baicalensis against acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells". Pharm Biol. 49 (3): 256–261. doi:10.3109/13880209.2010.501803. PMID 20979538.
- ^ Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. Hua-Bin Li and Feng Chen, Journal of Chromatography A, 13 May 2005, Volume 1074, Issues 1–2, pages 107–110, doi:10.1016/j.chroma.2005.03.088
- ^ Yang LX, Liu D, Feng XF, Cui SL, Yang JY, Tang XJ, He XR, Liu JF, Hu SL (2002). "[Determination of flavone for Scutellaria baicalensis from different areas by HPLC]". Zhongguo Zhong Yao Za Zhi (in Chinese). 27 (3): 166–70. PMID 12774393.
External links
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Wikimedia Commons has media related to Scutellaria baicalensis. |
|
Wikispecies has information related to: Scutellaria baicalensis |
- Scutellaria baicalensis List of Chemicals (Dr. Duke's Databases)
- Scutellaria baicalensis (Plants for a Future)
- Sung Mun Jung et al., Reduction of urate crystal-induced inflammation by root extracts from traditional oriental medicinal plants: elevation of prostaglandin D2 levels, Arthritis Research & Therapy, 9:R64 2007. doi:10.1186/ar2222. Considers anti-inflammatory properties of dried roots from the species Angelica sinensis (Dong Quai), Acanthopanax senticosus (now known as Eleutherococcus senticosus, or Siberian Ginseng), and Scutellaria baicalensis (Baikal Skullcap).
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Anxiolytics (N05B)
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| 5-HT1A agonists |
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|
| GABAAR PAMs |
- Benzodiazepines:
- Adinazolam
- Alprazolam
- Bromazepam
- Camazepam
- Chlordiazepoxide
- Clobazam
- Clonazepam
- Clorazepate
- Clotiazepam
- Cloxazolam
- Diazepam#
- Ethyl loflazepate
- Etizolam
- Fludiazepam
- Halazepam
- Ketazolam
- Lorazepam#
- Medazepam
- Nordazepam
- Oxazepam
- Pinazepam
- Prazepam
- Others: Alpidem‡
- Barbiturates
- Carbamates
- Chlormezanone‡
- Ethanol
- Etifoxine; Herbs:
- Kava
- Skullcap
- Valerian
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|
| α2δ VDCC blockers |
- Gabapentin
- Gabapentin enacarbil
- Phenibut
- Pregabalin
|
|
| Antidepressants |
- SSRIs
- SNRIs
- SARIs
- TCAs
- TeCAs
- MAOIs; Others: Agomelatine
- Bupropion
- Vilazodone
- Vortioxetine
|
|
| Sympatholytics |
- Beta blockers (e.g., propranolol)
- Clonidine
- Dexmedetomidine
- Guanfacine
- Prazosin
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|
| Others |
- Benzoctamine
- Cannabidiol
- Cycloserine
- Fabomotizole
- Hydroxyzine
- Kanna
- Lavender
- Lorpiprazole
- Mebicar
- Mepiprazole
- Nicotine
- Opipramol
- Oxaflozane‡
- Phenaglycodol
- Phenibut
- Picamilon
- Selank
- Tiagabine
- Tofisopam
- Validolum
|
|
GABAA receptor positive allosteric modulators
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|
| Alcohols |
- Brometone
- Butanol
- Chloralodol
- Chlorobutanol (cloretone)
- Ethanol (drinking alcohol)
- Ethchlorvynol
- Isobutanol
- Isopropanol
- Menthol
- Methanol
- Methylpentynol
- Pentanol
- Petrichloral
- Propanol
- tert-Butanol (2M2P)
- tert-Pentanol (2M2B)
- Tribromoethanol
- Trichloroethanol
- Triclofos
- Trifluoroethanol
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|
| Barbiturates |
- (-)-DMBB
- Allobarbital
- Alphenal
- Amobarbital
- Aprobarbital
- Barbexaclone
- Barbital
- Benzobarbital
- Benzylbutylbarbiturate
- Brallobarbital
- Brophebarbital
- Butabarbital/Secbutabarbital
- Butalbital
- Buthalital
- Butobarbital
- Butallylonal
- Carbubarb
- CP-1414S
- Crotylbarbital
- Cyclobarbital
- Cyclopentobarbital
- Difebarbamate
- Enallylpropymal
- Ethallobarbital
- Eterobarb
- Febarbamate
- Heptabarb
- Heptobarbital
- Hexethal
- Hexobarbital
- Metharbital
- Methitural
- Methohexital
- Methylphenobarbital
- Narcobarbital
- Nealbarbital
- Pentobarbital
- Phenallymal
- Phenobarbital
- Phetharbital
- Primidone
- Probarbital
- Propallylonal
- Propylbarbital
- Proxibarbital
- Reposal
- Secobarbital
- Sigmodal
- Spirobarbital
- Talbutal
- Tetrabamate
- Tetrabarbital
- Thialbarbital
- Thiamylal
- Thiobarbital
- Thiobutabarbital
- Thiopental
- Thiotetrabarbital
- Valofane
- Vinbarbital
- Vinylbital
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| Benzodiazepines |
|
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| Carbamates |
- Carisbamate
- Carisoprodol
- Clocental
- Cyclarbamate
- Difebarbamate
- Emylcamate
- Ethinamate
- Febarbamate
- Felbamate
- Hexapropymate
- Lorbamate
- Mebutamate
- Meprobamate
- Nisobamate
- Pentabamate
- Phenprobamate
- Procymate
- Styramate
- Tetrabamate
- Tybamate
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| Flavonoids |
- 6-Methylapigenin
- Ampelopsin (dihydromyricetin)
- Apigenin
- Baicalein
- Baicalin
- Catechin
- EGC
- EGCG
- Hispidulin
- Linarin
- Luteolin
- Rc-OMe
- Skullcap constituents (e.g., baicalin)
- Wogonin
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| Imidazoles |
- Etomidate
- Metomidate
- Propoxate
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| Kava constituents |
- 10-Methoxyyangonin
- 11-Methoxyyangonin
- 11-Hydroxyyangonin
- Desmethoxyyangonin
- 11-Methoxy-12-hydroxydehydrokavain
- 7,8-Dihydroyangonin
- Kavain
- 5-Hydroxykavain
- 5,6-Dihydroyangonin
- 7,8-Dihydrokavain
- 5,6,7,8-Tetrahydroyangonin
- 5,6-Dehydromethysticin
- Methysticin
- 7,8-Dihydromethysticin
- Yangonin
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|
| Monoureides |
- Acecarbromal
- Apronal (apronalide)
- Bromisoval
- Carbromal
- Capuride
- Ectylurea
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| Neuroactive steroids |
- Acebrochol
- Allopregnanolone (SAGE-547)
- Alfadolone
- Alfaxalone
- Anabolic steroids
- 3α-Androstanediol
- Androstenol
- Androsterone
- Cholesterol
- DHDOC
- 3α-DHP
- 5α-DHP
- 5β-DHP
- DHT
- Etiocholanolone
- Ganaxolone
- Hydroxydione
- Minaxolone
- Org 20599
- Org 21465
- P1-185
- Pregnanolone (eltanolone)
- Progesterone
- Renanolone
- SAGE-105
- SAGE-217
- SAGE-324
- SAGE-516
- SAGE-689
- SAGE-872
- Testosterone
- THDOC
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|
| Nonbenzodiazepines |
- β-Carbolines: Abecarnil
- Gedocarnil
- Harmane
- SL-651,498
- ZK-93423; Cyclopyrrolones: Eszopiclone
- Pagoclone
- Pazinaclone
- Suproclone
- Suriclone
- Zopiclone; Imidazopyridines: Alpidem
- DS-1
- Necopidem
- Saripidem
- Zolpidem; Pyrazolopyrimidines: Divaplon
- Fasiplon
- Indiplon
- Lorediplon
- Ocinaplon
- Panadiplon
- Taniplon
- Zaleplon; Others: Adipiplon
- CGS-8216
- CGS-9896
- CGS-13767
- CGS-20625
- CL-218,872
- CP-615,003
- CTP-354
- ELB-139
- GBLD-345
- JM-1232
- L-838,417
- Lirequinil (Ro41-3696)
- NS-2664
- NS-2710
- NS-11394
- Pipequaline
- ROD-188
- RWJ-51204
- SB-205,384
- SX-3228
- TGSC01AA
- TP-003
- TPA-023
- TP-13
- U-89843A
- U-90042
- Viqualine
- Y-23684
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| Phenols |
- Fospropofol
- Propofol
- Thymol
|
|
| Piperidinediones |
- Glutethimide
- Methyprylon
- Piperidione
- Pyrithyldione
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| Pyrazolopyridines |
- Cartazolate
- Etazolate
- ICI-190,622
- Tracazolate
|
|
| Quinazolinones |
- Afloqualone
- Cloroqualone
- Diproqualone
- Etaqualone
- Mebroqualone
- Mecloqualone
- Methaqualone
- Methylmethaqualone
- Nitromethaqualone
- SL-164
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| Volatiles/gases |
- Acetone
- Acetophenone
- Acetylglycinamide chloral hydrate
- Aliflurane
- Benzene
- Butane
- Butylene
- Centalun
- Chloral
- Chloral betaine
- Chloral hydrate
- Chloroform
- Cryofluorane
- Desflurane
- Dichloralphenazone
- Dichloromethane
- Diethyl ether
- Enflurane
- Ethyl chloride
- Ethylene
- Fluroxene
- Gasoline
- Halopropane
- Halothane
- Isoflurane
- Kerosine
- Methoxyflurane
- Methoxypropane
- Nitric oxide
- Nitrogen
- Nitrous oxide
- Norflurane
- Paraldehyde
- Propane
- Propylene
- Roflurane
- Sevoflurane
- Synthane
- Teflurane
- Toluene
- Trichloroethane (methyl chloroform)
- Trichloroethylene
- Vinyl ether
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| Others/unsorted |
- 3-Hydroxybutanal
- α-EMTBL
- AA-29504
- Avermectins (e.g., ivermectin)
- Bromide compounds (e.g., lithium bromide, potassium bromide, sodium bromide)
- Carbamazepine
- Chloralose
- Chlormezanone
- Clomethiazole
- DEABL
- Dihydroergolines (e.g., dihydroergocryptine, dihydroergosine, dihydroergotamine, ergoloid (dihydroergotoxine))
- DS2
- Efavirenz
- Etazepine
- Etifoxine
- Fenamates (e.g., flufenamic acid, mefenamic acid, niflumic acid, tolfenamic acid)
- Fluoxetine
- Flupirtine
- Hopantenic acid
- Lanthanum
- Lavender oil
- Lignans (e.g., 4-O-methylhonokiol, honokiol, magnolol, obovatol)
- Loreclezole
- Menthyl isovalerate (validolum)
- Monastrol
- Niacin
- Nicotinamide (niacinamide)
- Org 25,435
- Phenytoin
- Propanidid
- Retigabine (ezogabine)
- Safranal
- Seproxetine
- Stiripentol
- Sulfonylalkanes (e.g., sulfonmethane (sulfonal), tetronal, trional)
- Terpenoids (e.g., borneol)
- Topiramate
- Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol)
- Unsorted benzodiazepine site PAMs: MRK-409 (MK-0343)
- TCS-1105
- TCS-1205
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See also: GABAergics
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UpToDate Contents
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English Journal
- Topical application of Scutellaria baicalensis suppresses 2,4-dinitrochlorobenzene-induced contact dermatitis.
- Kim TW1, Choi JM2, Kim MS3, Son HY1, Lim JH4.
- Natural product research.Nat Prod Res.2016 Mar;30(6):705-9. doi: 10.1080/14786419.2015.1038812. Epub 2015 May 5.
- Allergic contact dermatitis (ACD) is a prototypic T-cell-mediated cutaneous inflammatory response. In the present study we describe the anti-allergic effect of topically applied Scutellaria bacalensis aqueous extract (WSBE) in suppressing 2,4-dinitrochlorobenzene (DNCB)-induced ACD in BALB/c mice. T
- PMID 25942587
- A novel molecularly imprinted method with computational simulation for the affinity isolation and knockout of baicalein from Scutellaria baicalensis.
- Li H1, He H1, Huang J1, Wang CZ2, Gu X1, Gao Y1, Zhang H1, Du S1, Chen L1, Yuan CS2.
- Biomedical chromatography : BMC.Biomed Chromatogr.2016 Feb;30(2):117-25. doi: 10.1002/bmc.3525. Epub 2015 Jul 21.
- A novel molecularly imprinted polymer (MIP) was synthesized by precipitation polymerization with baicalein (BAI) as the template and used as solid-phase extraction (SPE) adsorbent, aiming at the affinity isolation and selective knockout of BAI from Scutellaria baicalensis Georgi (SB). We used comput
- PMID 26037609
- A bioinformatic approach for discovery of the anti-aging effects of baicalein from Scutellaria baicalensis Georgi.
- Gao L1, Duan DD2, Zhang JQ3, Zhou YZ4, Qin XM5, Du GH6.
- Rejuvenation research.Rejuvenation Res.2016 Jan 18. [Epub ahead of print]
- Aging is one of the most complicated phenomena and is the main risk factor for age-related diseases. Based on the public aging-related gene data, we propose a computational approach to predict the anti-aging activities of compounds. This approach integrates network-pharmacology and target fishing me
- PMID 26778291
Japanese Journal
- 生薬「オウゴン」国内市場品の一酸化窒素産生抑制活性とLC/MSメタボローム解析
- 大根谷 章浩,渕野 裕之,新井 玲子,高橋 豊,和田 浩志,合田 幸広,川原 信夫
- 生薬學雜誌 67(2), 35-40, 2013-08-20
- … During the course of our studies on the profiling analysis for the crude drug, we collected various samples of scutellariae radix (Scutellaria baicalensis Georgi) from the Japanese market. …
- NAID 110009634968
- 生薬「オウゴン」国内市場品の一酸化窒素産生抑制活性とLC/MSメタボローム解析
- Baicalin From Scutellaria baicalensis Impairs Th1 Polarization Through Inhibition of Dendritic Cell Maturation
- Kim Mi Eun,Kim Hyung Keun,Park Hyeon-Young [他]
- Journal of pharmacological sciences 121(2), 148-156, 2013-02
- NAID 40019583588
Related Links
- Edit 1. Sources and Composition 1.1. Sources Scutellaria baicalensis (of the Labiatae family) is a plant sometimes referred to as Huang qin or Scutellariae radix (when referring to the root) and has usage in Traditional Chinese ...
- Scutellaria baicalensis GEORGI （ シソ科 ） 花 －写真は昭和大学薬学部薬用植物園ホームページより転載－ 中国北部からシベリア東部，朝鮮半島にかけて分布する多年草で，薬用として栽培されています．山草として人気のある ...
★リンクテーブル★
[★]
- 日
- おうごん
- 英
- Scutellaria root, baical skullcap root
- ラ
- Scutellariae radix
- 同
- オウゴン、黄ごん
- 関
- コガネバナ、Scutellaria baicalensis
- 生薬
- 健胃薬
- フラボノイド(baicalin)
- 少陽病の治療方剤である多くの黄連剤、柴胡剤に含まれる。
- 少陽病・心下痞硬型(黄連剤)
- 薬理作用：清熱作用、抗炎症作用
- 副作用：間質性肺炎、肝機能障害・黄疸、膀胱炎を表す漢方方剤の中に黄芩を含むものが比較的多い
黄芩を含む漢方方剤
参考
- *http://ja.wikipedia.org/wiki/%E3%82%B3%E3%82%AC%E3%83%8D%E3%83%90%E3%83%8A
[★]
- ラ
- Scutellaria baicalensis
- 関
- 黄岑、コガネヤナギ
[★]
- ラ
- Scutellaria baicalensis
- 関
- コガネバナ
[★]
タツナミソウ属、スクテラリア属、Scutellaria属