WordNet
- the 13th letter of the Roman alphabet (同)m
PrepTutorEJDIC
- Mach number / mark[s] / Monsieur
- Maine / Middle English / Middle East
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/01 20:22:30」(JST)
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- 1. 転移性黒色腫（メラノーマ）の分子標的療法 molecularly targeted therapy for metastatic melanoma
- 2. 黒色腫（メラノーマ）の分子生物学 the molecular biology of melanoma
- 3. 進行非小細胞肺癌に対する遺伝子型による個別治療 personalized genotype directed therapy for advanced non small cell lung cancer
- 4. 上皮成長因子受容体（EGFR）阻害剤投与に続発するざ瘡様発疹 acneiform eruption secondary to epidermal growth factor egfr inhibitors
- 5. 粘膜悪性黒色腫 mucosal melanoma
English Journal
- Effect of inhibition of the FGFR-MAPK signaling pathway on the development of ocular toxicities.
- van der Noll R, Leijen S, Neuteboom GH, Beijnen JH, Schellens JH.SourceNKI-AvL, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Department of Molecular Pathology, C2.001, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address: r.vd.noll@nki.nl.
- Cancer treatment reviews.Cancer Treat Rev.2013 Oct;39(6):664-72. doi: 10.1016/j.ctrv.2013.01.003. Epub 2013 Feb 19.
- By the introduction of molecularly targeted anti-cancer drugs, that are designed to intervene with specific pathways aberrant in cancers with distinct mutations, the type of adverse events encountered has changed greatly compared to the adverse events profile of classical chemotherapeutic agents. Oc
- PMID 23434072
- HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain.
- Ai M, Qiu S, Lu Y, Fan Z.SourceDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
- Cellular signalling.Cell Signal.2013 Sep;25(9):1754-61. doi: 10.1016/j.cellsig.2013.05.010. Epub 2013 May 22.
- Breast tumor kinase (Brk), also known as protein kinase-6 (PTK6), is a nonreceptor protein-tyrosine kinase that has a close functional relationship with the human epidermal growth factor receptor 2 (HER2). High levels of Brk were found in HER2-positive tumor specimens from patients with invasive duc
- PMID 23707532
Japanese Journal
- Sphingosylphosphorylcholine and lysosulfatide have inverse regulatory functions in monocytic cell differentiation into macrophages.
- Yamamoto Hiroshi,Naito Yuko,Okano Maho,Kanazawa Takayuki,Takematsu Hiromu,Kozutsumi Yasunori
- Archives of biochemistry and biophysics 506(1), 83-91, 2011-02-01
- … The expression of CD11b, a macrophage marker, was induced in accordance with the activation status of the Raf/MEK/ERK signaling pathway in which SPC and LSF had opposite effects. … The effects of SPC on Raf/MEK/ERK and PI3K/Akt signaling were dependent on G(i/o), whereas the SPC-induced calcium influx was dependent on G(q). …
- NAID 120002770476
Related Links
- メチルエチルケトン（methyl ethyl ketone、MEK）は、ケトンに分類される有機溶媒の 一種。示性式は CH3COC2H5、IUPAC命名法では 2-ブタノン (2-butanone)、もしくは エチルメチルケトン (ethyl methyl ketone) と表される。 ...
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★リンクテーブル★
| リンク元 | 「受容体チロシンキナーゼ」「mitogen-activated protein kinase kinase」「MAPK kinase」「マイトジェン活性化プロテインキナーゼキナーゼ」「MAPK-ERKキナーゼ」 |
| 拡張検索 | 「MEK1」「MEKキナーゼ1」「MEK kinase 1」「MEK2」「MEKK」 |
| 関連記事 | 「ME」「M」 |
「受容体チロシンキナーゼ」
- 英
- receptor tyrosine kinase receptor, tyrosine kinase RTK
- 同？
- チロシンキナーゼ受容体
カスケード
- リガンド結合→レセプターの二量体化→レセプターの細胞膜内領域を自己リン酸化
- →ホスホリパーゼC→ジアシルグリセロール→PKC→増殖因子の活性化
- →Grb2→SOS→Ras→Raf-1(MAPKKK)→MEK(MAPKK)→Erk1/Erk2(MAPK)→(核移行)→ELK1→c-fos
- →PI3キナーゼ→PI(3,4,5)P3→PDK1→PKB→増殖因子の活性化
「mitogen-activated protein kinase kinase」
MAPキナーゼキナーゼ、マイトジェン活性化プロテインキナーゼキナーゼ
「MAPK kinase」
「マイトジェン活性化プロテインキナーゼキナーゼ」
「MAPK-ERKキナーゼ」
「MEK1」
「MEKキナーゼ1」
「MEK kinase 1」
「MEK2」
「MEKK」
「ME」