出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/16 18:56:33」(JST)
Mitogen-activated protein kinase kinase kinase | |||||||||
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Identifiers | |||||||||
EC number | 2.7.11.25 | ||||||||
CAS number | 146702-84-3 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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MAP kinase kinase kinase (or MAP3K or MEKK) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase.
In humans there are at least 19 genes:
Perhaps the best characterized MAP3K are the members of the oncogenic RAF family (RAF1, BRAF, ARAF), which are effectors of mitogenic ras signaling and which activate the ERK1/2 (MAPK3/MAPK1) pathway, through activation of MEK1(MAP2K1) and MEK2(MAP2K2).
MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4).[1]
MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway.[2]
MAP3K7(TAK1)participate in regulation of transcription by transforming growth factor-beta (TGF-beta).[3]
MAPK pathway. Many of the MAP3K's here are labelled by their alternative names.
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リンク元 | 「MAPKKK」「MAPキナーゼキナーゼキナーゼ」「MEKキナーゼ」「MEK kinase」 |
拡張検索 | 「MEKK1」 |
関連記事 | 「ME」 |
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