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BAALC potentiates oncogenic ERK pathway through interactions with MEKK1 and KLF4.

Morita K1, Masamoto Y1, Kataoka K1, Koya J1, Kagoya Y1, Yashiroda H2, Sato T1,3, Murata S2, Kurokawa M1,4.
Leukemia.Leukemia.2015 Nov;29(11):2248-56. doi: 10.1038/leu.2015.137. Epub 2015 Jun 8.
Although high brain and acute leukemia, cytoplasmic (BAALC) expression is a well-characterized poor prognostic factor in acute myeloid leukemia (AML), neither the exact mechanisms by which BAALC drives leukemogenesis and drug resistance nor therapeutic approaches against BAALC-high AML have been pro
PMID 26050649

Gene-Environment Interactions Target Mitogen-activated Protein 3 Kinase 1 (MAP3K1) Signaling in Eyelid Morphogenesis.

Mongan M1, Meng Q1, Wang J1, Kao WW2, Puga A1, Xia Y3.
The Journal of biological chemistry.J Biol Chem.2015 Aug 7;290(32):19770-9. doi: 10.1074/jbc.M115.665729. Epub 2015 Jun 24.
Gene-environment interactions determine the biological outcomes through mechanisms that are poorly understood. Mouse embryonic eyelid closure is a well defined model to study the genetic control of developmental programs. Using this model, we investigated how exposure to dioxin-like environmental po
PMID 26109068

Thioredoxin Activates MKK4-NFκB Pathway in a Redox-dependent Manner to Control Manganese Superoxide Dismutase Gene Expression in Endothelial Cells.

Kundumani-Sridharan V1, Subramani J1, Das KC2.
The Journal of biological chemistry.J Biol Chem.2015 Jul 10;290(28):17505-19. doi: 10.1074/jbc.M115.660365. Epub 2015 May 31.
The mitogen-activated protein kinase kinase 4 (MKK4) is activated via phosphorylation of Ser-257 and Thr-261 by upstream MAP3Ks and activates JNK and p38 MAPKs in response to cellular stress. We show that thioredoxin (Trx), a cellular redox protein, activates MKK4 via Cys-246 and Cys-266 residues as
PMID 26028649

Onodera Yasuhito,Nam Jin-Min,Bissell Mina J.
Journal of clinical investigation 124(1), 367-384, 2014-01-02
… Overexpression of glucose transporter type 3 (GLUT3) in nonmalignant human breast cells activated known oncogenic signaling pathways, including EGFR, beta 1 integrin, MEK, and AKT, leading to loss of tissue polarity and increased growth. … The former, in turn, was mediated by pyruvate kinase M2 (PKM2) interaction with soluble adenylyl cyclase. …
NAID 120005372327

1) ゲノム不安定性・遺伝子変異に基づく子宮体癌の浸潤能獲得と分子生物学的予後不良因子の検討(シンポジウム1:腫瘍「婦人科癌の浸潤・転移機構の解明と臨床応用」,第65回日本産科婦人科学会・学術講演会講演要旨)

織田克利
日本産科婦人科學會雜誌 65(10), 2388-2401, 2013-10-01
… Endometrial cancer is also known to possess mutations frequently in Ras-PI3K (phosphatidylinositol 3'-kinase) pathway, such as PTEN and K-Ras. … The presence of a MEK inhibitor, PD98059 or U0126, sensitized the K-Ras mutant cells to NVP-BEZ235. …
NAID 110009674401

Morimoto Hiroko,Iwata Kazumi,Ogonuki Narumi,Inoue Kimiko,Ogura Atsuo,Kanatsu-Shinohara Mito,Morimoto Takeshi,Yabe-Nishimura Chihiro,Shinohara Takashi
Cell Stem Cell 12(6), 774-786, 2013-06
… Using cultured SSCs, we show that ROS are generated via the AKT and MEK signaling pathways under conditions where the growth factors glial cell line-derived neurotrophic factor and fibroblast growth factor 2 drive SSC self-renewal and, instead, stimulate self-renewal at physiological levels. …
NAID 120005285490