MAPキナーゼキナーゼ
- 関
- MAP kinase kinase、MAPK-ERK kinase、MAPKK、MEK、mitogen-activated protein kinase kinase
WordNet
- an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
- the basic unit of money in Papua New Guinea
PrepTutorEJDIC
- Massachusetts / mental age
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/05/23 04:02:49」(JST)
[Wiki en表示]
"MKK" redirects here. For other uses, see MKK (disambiguation).
Mitogen-activated protein kinase kinase |
Identifiers |
EC number |
2.7.12.2 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK).
MAP2K is classified as EC 2.7.12.2.
There are seven genes:
- MAP2K1 (a.k.a. MEK1)
- MAP2K2 (a.k.a. MEK2)
- MAP2K3 (a.k.a. MKK3)
- MAP2K4 (a.k.a. MKK4)
- MAP2K5 (a.k.a. MKK5)
- MAP2K6 (a.k.a. MKK6)
- MAP2K7 (a.k.a. MKK7)
The activators of p38 (MKK3 and MKK6), JNK (MKK4 and MKK7), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.[1] The acronym MEK derives from MAPK/ERK Kinase.[2]
Contents
- 1 Role in melanoma
- 2 See also
- 3 References
- 4 External links
Role in melanoma
MEK is a member of the MAPK signaling cascade that is activated in melanoma.[3] When MEK is inhibited, cell proliferation is blocked and apoptosis(controlled cell death) is induced.
See also
- Signal transduction
- MAP kinase
- MAP kinase kinase kinase
- MAP kinase kinase kinase kinase
References
- ^ Dérijard B, et al. (1995). "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms". Science. 267 (5198): 682–5. doi:10.1126/science.7839144. PMID 7839144.
- ^ Dwivedi, Gaurav; Kemp, Melissa L. (February 15, 2012). "Systemic Redox Regulation of Cellular Information Processing". Antioxidants & Redox Signaling. 16: 374–80. doi:10.1089/ars.2011.4034. PMC 3279717 . PMID 21939387.
- ^ Falchook, Gerald S.; Lewis, Karl D.; Infante, Jeffrey R.; Gordon, Michael S.; Vogelzang, Nicholas J.; DeMarini, Douglas J.; Fecher, Leslie A.; et al. (2012). "Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial". The Lancet Oncology. 13 (8): 782–789. doi:10.1016/S1470-2045(12)70269-3. PMC 4109286 . PMID 22805292.
External links
- Mitogen-Activated Protein Kinase Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
MAP kinase activation
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Initiation |
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MAP kinase kinase kinase (MAP3K or MKKK) |
- MAP kinase kinase kinases
- MAP3K1
- MAP3K2
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAP3K7
- MAP3K8
- RAFs
- RAF1
- ARAF
- BRAF
- KSR1
- KSR2)
- MLKs
- MAP3K12
- MAP3K13
- MAP3K9
- MAP3K10
- MAP3K11
- MAP3K7
- ZAK
- CDC7
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MAP kinase kinase (MAP2K or MKK) |
- MAP2K1
- MAP2K2
- MAP2K3
- MAP2K4
- MAP2K5
- MAP2K6
- MAP2K7
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MAP kinase |
- Extracellular signal-regulated kinases
- C-Jun N-terminal kinases
- P38 mitogen-activated protein kinases
- MAPK11
- MAPK12
- MAPK13
- MAPK14
- ERK5 kinase
- Atypical MAPKs
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Phosphatase |
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Transferases: phosphorus-containing groups (EC 2.7)
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2.7.1-2.7.4:
phosphotransferase/kinase
(PO4) |
2.7.1: OH acceptor |
- Hexo-
- Gluco-
- Fructo-
- Galacto-
- Phosphofructo-
- 1
- Liver
- Muscle
- Platelet
- 2
- Riboflavin
- Shikimate
- Thymidine
- NAD+
- Glycerol
- Pantothenate
- Mevalonate
- Pyruvate
- Deoxycytidine
- PFP
- Diacylglycerol
- Phosphoinositide 3
- Class I PI 3
- Class II PI 3
- Sphingosine
- Glucose-1,6-bisphosphate synthase
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2.7.2: COOH acceptor |
- Phosphoglycerate
- Aspartate kinase
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2.7.3: N acceptor |
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2.7.4: PO4 acceptor |
- Phosphomevalonate
- Adenylate
- Nucleoside-diphosphate
- Uridylate
- Guanylate
- Thiamine-diphosphate
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2.7.6: diphosphotransferase
(P2O7) |
- Ribose-phosphate diphosphokinase
- Thiamine diphosphokinase
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2.7.7: nucleotidyltransferase
(PO4-nucleoside) |
Polymerase |
DNA polymerase |
- DNA-directed DNA polymerase
- I
- II
- III
- IV
- V
- RNA-directed DNA polymerase
- Reverse transcriptase
- Telomerase
- DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase
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RNA nucleotidyltransferase |
- RNA polymerase/DNA-directed RNA polymerase
- RNA polymerase I
- RNA polymerase II
- RNA polymerase III
- RNA polymerase IV
- Primase
- RNA-dependent RNA polymerase
- PNPase
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Phosphorolytic
3' to 5' exoribonuclease |
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Nucleotidyltransferase |
- UTP—glucose-1-phosphate uridylyltransferase
- Galactose-1-phosphate uridylyltransferase
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Guanylyltransferase |
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Other |
- Recombinase (Integrase)
- Transposase
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2.7.8: miscellaneous |
Phosphatidyltransferases |
- CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
- CDP-diacylglycerol—serine O-phosphatidyltransferase
- CDP-diacylglycerol—inositol 3-phosphatidyltransferase
- CDP-diacylglycerol—choline O-phosphatidyltransferase
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Glycosyl-1-phosphotransferase |
- N-acetylglucosamine-1-phosphate transferase
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2.7.10-2.7.13: protein kinase
(PO4; protein acceptor) |
2.7.10: protein-tyrosine |
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2.7.11: protein-serine/threonine |
- see serine/threonine-specific protein kinases
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2.7.12: protein-dual-specificity |
- see serine/threonine-specific protein kinases
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2.7.13: protein-histidine |
- Protein-histidine pros-kinase
- Protein-histidine tele-kinase
- Histidine kinase
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Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)
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Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)
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Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
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Polo kinase (EC 2.7.11.21) |
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Cyclin-dependent kinase (EC 2.7.11.22) |
- CDK1
- CDK2
- CDKL2
- CDK3
- CDK4
- CDK5
- CDKL5
- CDK6
- CDK7
- CDK8
- CDK9
- CDK10
- CDK12
- CDC2L5
- PCTK1
- PCTK2
- PCTK3
- PFTK1
- CDC2L1
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(RNA-polymerase)-subunit kinase (EC 2.7.11.23) |
- RPS6KA5
- RPS6KA4
- P70S6 kinase
- P70-S6 Kinase 1
- RPS6KB2
- RPS6KA2
- RPS6KA3
- RPS6KA1
- RPS6KC1
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Mitogen-activated protein kinase (EC 2.7.11.24) |
- Extracellular signal-regulated
- MAPK1
- MAPK3
- MAPK4
- MAPK6
- MAPK7
- MAPK12
- MAPK15
- C-Jun N-terminal
- P38 mitogen-activated protein
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MAP3K (EC 2.7.11.25) |
- MAP kinase kinase kinases
- MAP3K1
- MAP3K2
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAP3K7
- MAP3K8
- RAFs
- MLKs
- MAP3K12
- MAP3K13
- MAP3K9
- MAP3K10
- MAP3K11
- MAP3K7
- ZAK
- CDC7
- MAP3K14
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Tau-protein kinase (EC 2.7.11.26) |
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(acetyl-CoA carboxylase) kinase (EC 2.7.11.27) |
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Tropomyosin kinase (EC 2.7.11.28) |
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29) |
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Receptor protein serine/threonine kinase (EC 2.7.11.30) |
- Bone morphogenetic protein receptors
- BMPR1
- BMPR1A
- BMPR1B
- BMPR2
- ACVR1
- ACVR1B
- ACVR1C
- ACVR2A
- ACVR2B
- ACVRL1
- Anti-Müllerian hormone receptor
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Dual-specificity kinases (EC 2.7.12)
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MAP2K |
- MAP2K1
- MAP2K2
- MAP2K3
- MAP2K4
- MAP2K5
- MAP2K6
- MAP2K7
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Enzymes
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Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
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Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
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UpToDate Contents
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English Journal
- The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis.
- Kim B1, Breton S2.
- Biology of reproduction.Biol Reprod.2016 Dec;94(1):22. doi: 10.1095/biolreprod.115.134965. Epub 2015 Dec 9.
- The initial segment (IS) in rodents is functionally and structurally distinct from other epididymal segments and plays an important role in sperm maturation. The MAPK/ERK1/2 pathway is maintained active in the IS by testicular luminal factors and plays crucial roles in the maintenance and differenti
- PMID 26658708
- Effects of urban particulate matter with high glucose on human monocytes U937.
- Zhang Y1,2, Mo Y1, Gu A3, Wan R4, Zhang Q1, Tollerud DJ1.
- Journal of applied toxicology : JAT.J Appl Toxicol.2016 Apr;36(4):586-95. doi: 10.1002/jat.3198. Epub 2015 Jul 14.
- Epidemiological studies and animal experiments have shown that individuals with preexisting diseases, such as diabetes mellitus (DM), are more susceptible to particulate matter (PM)-related cardiovascular diseases. However, the underlying mechanisms are still unclear. We hypothesized that PM and hig
- PMID 26179980
- Therapeutic effect of CNP on renal osteodystrophy by antagonizing the FGF-23/MAPK pathway.
- Hu P1, Huang BY1, Xia X1, Xuan Q2, Hu B1, Qin YH3.
- Journal of receptor and signal transduction research.J Recept Signal Transduct Res.2016 Apr;36(2):213-9. doi: 10.3109/10799893.2015.1075041. Epub 2015 Oct 13.
- Renal osteodystrophy (ROD) is highly prevalent in chronic kidney disease (CKD). Because most patients with ROD are asymptomatic in the early stage and bone biopsy remains not a routine procedure in many clinical settings; therefore, several biochemical parameters may help to identify the existence o
- PMID 26459742
Japanese Journal
- Neurite Outgrowth of PC12 Mutant Cells Induced by Orange Oil and d-Limonene via the p38 MAPK Pathway
- Shinomiya Misae,Kawamura Kenji,Tanida Emiko,Nagoshi Megumi,Motoda Hirotoshi,Kasanami Yoshiko,Hiragami Fukumi,Kano Yoshio
- Acta Medica Okayama 66(2), 111-118, 2012-04
- … Neurite outgrowth can be induced by nerve growth factor (NGF), where ERK and p38 MAPK among MAPK pathways play important roles in activating intracellular signal transduction. … We also examined by which pathways, the ERK, p38 MAPK or JNK pathway, d-limonene acts on PC12m3 cells. … After treatment with d-limonene, we observed that p38 MAPK is strongly activated in PC12m3 cells, while ERK is weakly activated. …
- NAID 120004040526
- Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells
- Seki Sayaka,Aoki Miho,Hosokawa Toshiyuki,Saito Takeshi,Masuma Runa,Komori Miyako,Kurasaki Masaaki
- Chemico-Biological Interactions 194(1), 23-30, 2011-10-15
- … As results, bisphenol-A significantly inhibited phosphorylation of CREB and ERK1/2 MAPK. …
- NAID 120003483496
Related Links
- MAPK経路とは MAP kinase(mitogen-activated protein kinase、以下MAPK)は、酵母から植物・高等動物に至るまで広く真核生物に保存されたセリン/スレオニンキナーゼであり、活性化にともなって核内へと移行することから、細胞外の ...
- 米国CST社の日本法人CSTジャパン株式会社【公式サイト】MAPK カスケード (Mitogen-Activated Protein Kinase Cascades)ページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供しております。
Related Pictures
★リンクテーブル★
[★]
MAPキナーゼキナーゼ、マイトジェン活性化プロテインキナーゼキナーゼ
- 関
- MAP kinase kinase、MAPK kinase、MAPK-ERK kinase、MAPKK、MEK
[★]
MAPK-ERKキナーゼ
- 関
- MAP kinase kinase、MAPK kinase、MAPKK、MEK、mitogen-activated protein kinase kinase
[★]
[★]
[★]
キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase