関: MAP kinase kinase、MAPK kinase、MAPKK、MEK、mitogen-activated protein kinase kinase

WordNet

an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

PrepTutorEJDIC

Massachusetts / mental age

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1. 黒色腫（メラノーマ）の分子生物学 the molecular biology of melanoma
2. 前立腺癌の分子生物学 molecular biology of prostate cancer
3. 進行非小細胞肺癌に対する遺伝子型による個別治療 personalized genotype directed therapy for advanced non small cell lung cancer
4. 進行性肝細胞癌に対する全身治療 systemic treatment for advanced hepatocellular carcinoma
5. 虚血プレコンディショニングの定義および病因 definition and pathogenesis of ischemic preconditioning

English Journal

Protoapigenone, a natural derivative of apigenin, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferase π.

Chen WY, Hsieh YA, Tsai CI, Kang YF, Chang FR, Wu YC, Wu CC.SourceSchool of Medicine and Health Sciences, Fooyin University, Kaohsiung, 83101, Taiwan.
Investigational new drugs.Invest New Drugs.2011 Dec;29(6):1347-59. Epub 2010 Aug 5.
Protoapigenone, a natural derivative of the flavonoid apigenin, has been shown to exhibit potent antitumor activity in vitro and in vivo; the precise mechanism of action, however, is not fully elucidated. In this study, we investigated and compared the mechanisms by which protoapigenone and apigenin
PMID 20686818

Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells.

Aksamitiene E, Achanta S, Kolch W, Kholodenko BN, Hoek JB, Kiyatkin A.SourceDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust St., Philadelphia, Pennsylvania 19107, USA.
Cellular signalling.Cell Signal.2011 Nov;23(11):1794-805. Epub 2011 Jun 25.
There is strong evidence that deregulation of prolactin (PRL) signaling contributes to pathogenesis and chemoresistance of breast cancer. Therefore, understanding cross-talk between distinct signal transduction pathways triggered by activation of the prolactin receptor (PRL-R), is essential for eluc
PMID 21726627

Japanese Journal

Processive phosphorylation of ERK MAP kinase in mammalian cells.

Aoki Kazuhiro,Yamada Masashi,Kunida Katsuyuki,Yasuda Shuhei,Matsuda Michiyuki
Proceedings of the National Academy of Sciences of the United States of America, 2011-07-18
… 2011-07-19.The mitogen-activated protein (MAP) kinase pathway is comprised of a three-tiered kinase cascade. … The distributive kinetic mechanism of two-site MAP kinase phosphorylation inherently generates a nonlinear switch-like response. … However, a linear graded response of MAP kinase has also been observed in mammalian cells, and its molecular mechanism remains unclear. …
NAID 120003204017

Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2

Omri Abdelfatteh El,Han Junkyu,Yamada Parida,Kawada Kiyokazu,Abdrabbah Manef Ben,Isoda Hiroko,韓畯奎,川田清和,礒田博子
Journal of ethnopharmacology 131(2), 451-458, 2010-09
… officinalis.Materials and methodsCell viability, cell differentiation, acetylcholinesterase (AChE) activity, total choline, acetylcholine (ACh) and extracellular signal-regulated kinases (ERK1/2) were determined in PC12 cells treated with extracts and HPLC-identified polyphenols of R. … U0126, inhibitor of ERK1/2, significantly reduced CA and RA effects on cell differentiation and AChE activity.ConclusionsR. …
NAID 120002598875

「mitogen-activated protein kinase kinase」

　　[★]

MAPキナーゼキナーゼ、マイトジェン活性化プロテインキナーゼキナーゼ

関: MAP kinase kinase、MAPK kinase、MAPK-ERK kinase、MAPKK、MEK

「MAPK kinase」

　　[★]

MAPキナーゼキナーゼ

関: MAP kinase kinase、MAPK-ERK kinase、MAPKK、MEK、mitogen-activated protein kinase kinase

「MAPK-ERKキナーゼ」

　　[★]

英: MAPK-ERK kinase、MEK
関: MAPキナーゼキナーゼ、マイトジェン活性化プロテインキナーゼキナーゼ

「MAPK-ERK kinase 1」

　　[★]

MAPK-ERKキナーゼ1、MAPキナーゼキナーゼ1

関: MAP kinase kinase 1、MEK1

「ERK」

　　[★]

同: [[]] extracellular-signal-regulated kinase
関: MAPキナーゼスーパーファミリーカスケード

MAPKファミリーに含まれるERKファミリーを構成
キナーゼサブドメインVIIIの活性化ループに存在するリン酸化部位の配列がTEY
セリンスレオニンキナーゼ
MAPKKであるMEK1,MEK2によってスレオニンとチロシン残基がリン酸化され、活性化される。
ERK1/2の基質

転写因子：Elk-1, Ets1, Sapla, STAT
キナーゼ：p90rsk(p90 ribosomal S6 kinase), MNK1/MNK2
cPLA2
EGF受容体
Sos
細胞骨格構成タンパク質(Map2, Tau)

ERK1
ERK2

同: extracellular-signal-regulated kinase

「MAP」

　　[★]

僧帽弁輪形成術 mitral annuloplasty
Miller assessment for Pre-schoolers
平均動脈圧 mean arterial pressure
平均気道内圧 mean airway pressure
mannitol adenine phosphate
リン酸アンモニウムマグネシウム magnesium ammonium phosphate

「ER」

　　[★]

「MA」

　　[★]

「kinase」

　　[★] キナーゼカイネースリン酸化酵素 phosphoenzyme phosphotransferase 　

リンク元	「mitogen-activated protein kinase kinase」「MAPK kinase」「MAPK-ERKキナーゼ」
拡張検索	「MAPK-ERK kinase 1」
関連記事	「ERK」「MAP」「ER」「MA」「kinase」

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MAPK-ERK kinase

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★リンクテーブル★

「mitogen-activated protein kinase kinase」

「MAPK kinase」

「MAPK-ERKキナーゼ」

「MAPK-ERK kinase 1」

「ERK」

「MAP」

「ER」

「MA」

「kinase」