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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/04 11:57:16」(JST)

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Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene.^[1]

Function

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3.

The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.

The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.^[2]

Interactions

MAP2K2 has been shown to interact with MAPK3^[3]^[4]^[5] and ARAF.^[6]

References

^ Zheng CF, Guan KL (Jun 1993). "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem 268 (15): 11435–9. PMID 8388392.
^ "Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2".
^ Marti, A; Luo Z; Cunningham C; Ohta Y; Hartwig J; Stossel T P; Kyriakis J M; Avruch J (Jan 1997). "Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. (UNITED STATES) 272 (5): 2620–8. doi:10.1074/jbc.272.5.2620. ISSN 0021-9258. PMID 9006895.
^ Butch, E R; Guan K L (Feb 1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2". J. Biol. Chem. (UNITED STATES) 271 (8): 4230–5. doi:10.1074/jbc.271.8.4230. ISSN 0021-9258. PMID 8626767.
^ Zheng, C F; Guan K L (Nov 1993). "Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases". J. Biol. Chem. (UNITED STATES) 268 (32): 23933–9. ISSN 0021-9258. PMID 8226933.
^ Yin, Xiang L; Chen She; Yan Jun; Hu Yun; Gu Jian X (Feb 2002). "Identification of interaction between MEK2 and A-Raf-1". Biochim. Biophys. Acta (Netherlands) 1589 (1): 71–6. doi:10.1016/S0167-4889(01)00188-4. ISSN 0006-3002. PMID 11909642.

External links

GeneReviews/NCBI/NIH/UW entry on Cardiofaciocutaneous Syndrome

This article on a gene on chromosome 19 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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English Journal

Xanthomonas euvesicatoria type III effector XopQ interacts with tomato and pepper 14-3-3 isoforms to suppress effector-triggered immunity.

Teper D, Salomon D, Sunitha S, Kim JG, Mudgett MB, Sessa G.SourceDepartment of Molecular Biology and Ecology of Plants, Tel Aviv University, 69978, Tel Aviv, Israel.
The Plant journal : for cell and molecular biology.Plant J.2013 Nov 26. doi: 10.1111/tpj.12391. [Epub ahead of print]
Effector-triggered immunity (ETI) to host-adapted pathogens is associated with elicitation of cell death at the infection site. The plant-pathogenic bacterium Xanthomonas euvesicatoria (Xcv) interferes with plant cellular processes by injecting effector proteins into host cells through the type III
PMID 24279912

Rapamycin Induces Mitogen-activated Protein (MAP) Kinase Phosphatase-1 (MKP-1) Expression through Activation of Protein Kinase B and Mitogen-activated Protein Kinase Kinase Pathways.

Rastogi R, Jiang Z, Ahmad N, Rosati R, Liu Y, Beuret L, Monks R, Charron J, Birnbaum MJ, Samavati L.SourceFrom the Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, Michigan 48201.
The Journal of biological chemistry.J Biol Chem.2013 Nov 22;288(47):33966-77. doi: 10.1074/jbc.M113.492702. Epub 2013 Oct 14.
Mitogen-activated protein kinase phosphatase-1 (MKP-1), also known as dual specificity phosphatase-1 (DUSP-1), plays a crucial role in the deactivation of MAPKs. Several drugs with immune-suppressive properties modulate MKP-1 expression as part of their mechanism of action. We investigated the effec
PMID 24126911

MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition.

Wagle N, Van Allen EM, Treacy DJ, Frederick DT, Cooper ZA, Taylor-Weiner A, Rosenberg M, Goetz EM, Sullivan RJ, Farlow DN, Friedrich DC, Anderka K, Perrin D, Johannessen CM, McKenna A, Cibulskis K, Kryukov G, Hodis E, Lawrence DP, Fisher S, Getz G, Gabriel SB, Carter SL, Flaherty KT, Wargo JA, Garraway LA.Source1Department of Medical Oncology, Dana-Farber Cancer Institute; 2Department of Medicine, Brigham and Women's Hospital; 3Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston; 4Broad Institute of Harvard and MIT; and 5Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts.
Cancer discovery.Cancer Discov.2013 Nov 21. [Epub ahead of print]
Treatment of BRAF-mutant melanoma with combined dabrafenib and trametinib, which target RAF and the downstream MAP-ERK kinase (MEK)1 and MEK2 kinases, respectively, improves progression-free survival and response rates compared with dabrafenib monotherapy. Mechanisms of clinical resistance to combin
PMID 24265154

Japanese Journal

MEK1 and MEK2, different regulators of the G_1/S transition

USSAR S
J Biol Chem 279, 43861-43869, 2004
NAID 30016360812

Mek2 is dispensable for mouse growth and development

BELANGER L. F.
Mol. Cell. Biol. 23, 4778-4787, 2003
NAID 30021002598

Related Pictures

Nuer Mek2雲之上2》 mek2 Fig. 7. mek2 Yaesu MEK-2 mek2 Immunohistochemistry-Paraffin: MEK2 with anti-MEK1 / MAP2K1 + MEK2

★リンクテーブル★

リンク元	「MAPキナーゼスーパーファミリーカスケード」「MAPキナーゼキナーゼ2」「MAP kinase kinase 2」
関連記事	「ME」

「MAPキナーゼスーパーファミリーカスケード」

Mitogen-activated protein kinase kinase 2
	; PDB rendering based on 1s9i.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	"lastQuery":"Chain Type: there is a Protein chain but not any DNA or RNA or Hybrid\nand\nTAXONOMY is Viruses\nand\nTAXONOMY is only Bacteria (eubacteria) with Viruses\n","hetId":null,"resultCount":4316,"structureId":null,"queryCount":3,"queryId":"E9B94ECE" {"lastQuery":"Chain Type: there is a Protein chain but not any DNA or RNA or Hybrid\nand\nTAXONOMY is Viruses\nand\nTAXONOMY is only Bacteria (eubacteria) with Viruses\n","hetId":null,"resultCount":4316,"structureId":null,"queryCount":3,"queryId":"E9B94ECE"}
Identifiers
Symbols	MAP2K2 ; MAPKK2; MEK2; MKK2; PRKMK2
External IDs	OMIM: 601263 MGI: 1346867 HomoloGene: 48591 ChEMBL: 2964 GeneCards: MAP2K2 Gene
EC number	2.7.12.2
Gene ontology
Molecular function	• nucleotide binding; • protein serine/threonine kinase activity; • protein serine/threonine kinase activity; • protein serine/threonine/tyrosine kinase activity; • protein tyrosine kinase activity; • protein binding; • ATP binding; • protein complex scaffold;
Cellular component	• extracellular region; • soluble fraction; • nucleus; • mitochondrion; • early endosome; • late endosome; • Golgi apparatus; • cytosol; • focal adhesion; • cell cortex;
Biological process	• MAPK cascade; • activation of MAPKK activity; • activation of MAPK activity; • toll-like receptor signaling pathway; • MyD88-dependent toll-like receptor signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • protein phosphorylation; • epidermal growth factor receptor signaling pathway; • small GTPase mediated signal transduction; • Ras protein signal transduction; • axon guidance; • Toll signaling pathway; • insulin receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • regulation of stress-activated MAPK cascade; • toll-like receptor 1 signaling pathway; • toll-like receptor 2 signaling pathway; • toll-like receptor 3 signaling pathway; • toll-like receptor 4 signaling pathway; • TRIF-dependent toll-like receptor signaling pathway; • innate immune response; • nerve growth factor receptor signaling pathway; • stress-activated MAPK cascade; • ERK1 and ERK2 cascade; • regulation of Golgi inheritance; • positive regulation of cell motility; • regulation of early endosome to late endosome transport;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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層	増殖因子
細胞膜	Grb2 Sos Ras
細胞質
MAPKKKK	PAK3
MAPKKK	Raf-1/A-Raf
MAPKK	B-Raf/Mos
MAPK	MEK1/MEK2
基質	ERK1/ERK2, p90rsk, MNK1/MNK2, Sos, cPLA2, EGFR, Elk-1, Ets1, Sap1a, STAT, Map2, Tau