関: MAP kinase kinase、MAPK kinase、MAPK-ERK kinase、MAPKK、MEK

WordNet

aerate (sewage) so as to favor the growth of organisms that decompose organic matter (同)aerate
make (substances) radioactive
make active or more active; "activate an old file"
make more adsorptive; "activate a metal"
rendered active; e.g. rendered radioactive or luminescent or photosensitive or conductive
(of e.g. a molecule) made reactive or more reactive (同)excited
(military) set up and placed on active assignment; "a newly activated unit"
(of sewage) treated with aeration and bacteria to aid decomposition
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
an agent that triggers mitosis

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…'を'活動的にする / …‘に'放射能を与える / 〈物質〉'を'活性化する
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/04/22 01:19:38」(JST)

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Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a kinase enzyme which phosphorylates mitogen-activated protein kinase (MAPK).

MAP2K is classified as EC 2.7.12.2.

There are seven genes:

MAP2K1 (a.k.a. MEK1)
MAP2K2 (a.k.a. MEK2)
MAP2K3 (a.k.a. MKK3)
MAP2K4 (a.k.a. MKK4)
MAP2K5 (a.k.a. MKK5)
MAP2K6 (a.k.a. MKK6)
MAP2K7 (a.k.a. MKK7)

The activators of p38 (MKK3 and MKK6), JNK (MKK4 and MKK7), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways.^[1] The acronym MEK derives from MAPK/ERK Kinase.^[2]

Role in melanoma

MEK is a member of the MAPK signaling cascade that is activated in melanoma.^[3] When MEK is inhibited, cell proliferation is blocked and apoptosis(controlled cell death) is induced.

References

^ Dérijard B, et al. (1995). "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms". Science. 267 (5198): 682–5. doi:10.1126/science.7839144. PMID 7839144.
^ Dwivedi, Gaurav; Kemp, Melissa L. (February 15, 2012). "Systemic Redox Regulation of Cellular Information Processing". Antioxidants & Redox Signaling. 16: 374–80. doi:10.1089/ars.2011.4034. PMC 3279717 . PMID 21939387.
^ Falchook, Gerald S.; Lewis, Karl D.; Infante, Jeffrey R.; Gordon, Michael S.; Vogelzang, Nicholas J.; DeMarini, Douglas J.; Fecher, Leslie A.; et al. (2012). "Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial". The Lancet Oncology. 13 (8): 782–789. doi:10.1016/S1470-2045(12)70269-3. PMC 4109286 . PMID 22805292.

External links

Mitogen-Activated Protein Kinase Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Antioxidant and anti-ageing activities of citrus-based juice mixture.

Kim DB1, Shin GH1, Kim JM1, Kim YH1, Lee JH1, Lee JS1, Song HJ2, Choe SY3, Park IJ4, Cho JH5, Lee OH6.
Food chemistry.Food Chem.2016 Mar 1;194:920-7. doi: 10.1016/j.foodchem.2015.08.094. Epub 2015 Aug 24.
The production of excessive reactive oxygen species by exposure to oxidative stress and solar radiation are primary factors in skin damage. We examined the effects of a citrus-based juice mixture and its bioactive compounds on antioxidant and anti-ageing activities in human dermal fibroblasts and ha
PMID 26471635

Leptin Effect on Acetylation and Phosphorylation of Pgc1α in Muscle Cells Associated With Ampk and Akt Activation in High-Glucose Medium.

García-Carrizo F1, Nozhenko Y1, Palou A1, Rodríguez AM1.
Journal of cellular physiology.J Cell Physiol.2016 Mar;231(3):641-9. doi: 10.1002/jcp.25109.
Leptin is crucial in energy metabolism, including muscle regulation. Peroxisome proliferator activated receptor gamma co-activator 1α (PGC1α) orchestrates energy metabolism and is tightly controlled by post-translational covalent modifications such as phosphorylation and acetylation. We aimed to f
PMID 26218179

Raf kinase inhibitor protein mediated signaling inhibits invasion and metastasis of hepatocellular carcinoma.

Wu X1, Yang Y2, Xu Z1, Li J1, Yang B1, Feng N1, Zhang Y1, Wang S3.
Biochimica et biophysica acta.Biochim Biophys Acta.2016 Feb;1860(2):384-91. doi: 10.1016/j.bbagen.2015.06.009. Epub 2015 Jun 25.
BACKGROUND: Hepatocellular carcinoma (HCC) is the most common type of liver cancer with high mortality and poor prognosis. Mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) signaling pathways have been implicated in promoting tumor cell proliferation and invasion of HCC cel
PMID 26116914

Japanese Journal

Doxycycline Hyclate Protects Lipopolysaccharide-Induced Endothelial Barrier Dysfunction by Inhibiting the Activation of p38 Mitogen-Activated Protein Kinase

Xia Jian-ling,Wang Li-qun,Wu Li-li [他]
Biological & pharmaceutical bulletin 37(12), 1882-1890, 2014-12
NAID 40020277754

Inhibition of Mitogen-Activated Protein Kinases Phosphorylation Plays an Important Role in the Anti-nociceptive Effect of Pregabalin in Zymosan-Induced Inflammatory Pain Model

Jeong Young Chan,Pyun Kihyun,Kwon Young Bae
Biological & pharmaceutical bulletin 37(10), 1694-1698, 2014-10
NAID 40020224838

Hydroxysafflor Yellow A Attenuates Small Airway Remodeling in a Rat Model of Chronic Obstructive Pulmonary Disease

Wang Yu,Xue Changjiang,Dong Fang [他]
Biological & pharmaceutical bulletin 37(10), 1591-1598, 2014-10
NAID 40020224588

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リンク元	「MAPK kinase」「マイトジェン活性化プロテインキナーゼキナーゼ」「MAPK-ERK kinase」
拡張検索	「mitogen-activated protein kinase kinase 4」「mitogen-activated protein kinase kinase 3」「mitogen-activated protein kinase kinase 5」「mitogen-activated protein kinase kinase 6」
関連記事	「activated」「activate」「kinase」「protein kinase」

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Mitogen-activated protein kinase kinase
Identifiers
EC number	2.7.12.2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
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　　[★]

MAPキナーゼキナーゼ

関: MAP kinase kinase、MAPK-ERK kinase、MAPKK、MEK、mitogen-activated protein kinase kinase

「マイトジェン活性化プロテインキナーゼキナーゼ」

　　[★]

英: mitogen-activated protein kinase kinase、MAP kinase kinase、MEK
関: MAPキナーゼキナーゼ、MAPK-ERKキナーゼ

「MAPK-ERK kinase」

　　[★]

MAPK-ERKキナーゼ

関: MAP kinase kinase、MAPK kinase、MAPKK、MEK、mitogen-activated protein kinase kinase

「mitogen-activated protein kinase kinase 4」

　　[★]

マイトジェン活性化プロテインキナーゼキナーゼ4

関: JNK kinase、MAP kinase kinase 4

「mitogen-activated protein kinase kinase 3」

　　[★]

マイトジェン活性化プロテインキナーゼキナーゼ3

関: MAP kinase kinase 3

「mitogen-activated protein kinase kinase 5」

　　[★]

マイトジェン活性化プロテインキナーゼキナーゼ5

関: MAP kinase kinase 5

「mitogen-activated protein kinase kinase 6」

　　[★]

マイトジェン活性化プロテインキナーゼキナーゼ6

関: MAP kinase kinase 6

「activated」

　　[★]

adj.

活性化の、活性化型の、賦活化の

関: activate、activated form、activation、turn on

「activate」

　　[★]

v.

活性化する、賦活化する、賦活する

関: activated、activation、turn on

「kinase」

　　[★] キナーゼカイネースリン酸化酵素 phosphoenzyme phosphotransferase 　

「protein kinase」

　　[★] プロテインキナーゼ

同: protein kinases

[1] Dérijard B, et al. (1995). "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms". Science. 267 (5198): 682–5. doi:10.1126/science.7839144. PMID 7839144.

[2] Dwivedi, Gaurav; Kemp, Melissa L. (February 15, 2012). "Systemic Redox Regulation of Cellular Information Processing". Antioxidants & Redox Signaling. 16: 374–80. doi:10.1089/ars.2011.4034. PMC 3279717 . PMID 21939387.

[3] Falchook, Gerald S.; Lewis, Karl D.; Infante, Jeffrey R.; Gordon, Michael S.; Vogelzang, Nicholas J.; DeMarini, Douglas J.; Fecher, Leslie A.; et al. (2012). "Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial". The Lancet Oncology. 13 (8): 782–789. doi:10.1016/S1470-2045(12)70269-3. PMC 4109286 . PMID 22805292.

v t e MAP kinase activation
Initiation	Mitogen
MAP kinase kinase kinase (MAP3K or MKKK)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs RAF1 ARAF BRAF KSR1 KSR2) MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7
MAP kinase kinase (MAP2K or MKK)	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7
MAP kinase	Extracellular signal-regulated kinases MAPK1 MAPK3 C-Jun N-terminal kinases MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein kinases MAPK11 MAPK12 MAPK13 MAPK14 ERK5 kinase MAPK7 Atypical MAPKs MAPK4 MAPK6 MAPK15 NLK
Phosphatase	MAPK phosphatase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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案内

mitogen-activated protein kinase kinase