- 関
- MAP kinase kinase kinase、MEK kinase、MEKK
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/28 19:11:18」(JST)
[Wiki en表示]
| Mitogen-activated protein kinase kinase kinase |
| Identifiers |
| EC number |
2.7.11.25 |
| CAS number |
146702-84-3 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
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MAP kinase kinase kinase (or MAP3K or MEKK) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase.
In humans there are at least 19 genes:
- MAP3K1 (aka MEKK1)
- MAP3K2
- MAP3K3 (aka MEKK3)
- MAP3K4
- MAP3K5 (aka ASK1)
- MAP3K6 (aka ASK2)
- MAP3K7 (aka MEKK7) (aka TAK1)
- MAP3K8 (aka TPL2 or Tpl2)
- MAP3K9
- MAP3K10
- MAP3K11 (aka MEKK11) (aka MLK3)
- MAP3K12 (aka MUK)
- MAP3K13 (aka LZK)
- MAP3K14
- MAP3K15
- MAP3K16 (aka TAO1 or TAOK1)
- MAP3K17 (aka TAO2 or TAOK2)
- RAF1
- BRAF
- ARAF
- ZAK (aka MLTK)
Perhaps the best characterized MAP3K are the members of the oncogenic RAF family (RAF1, BRAF, ARAF), which are effectors of mitogenic ras signaling and which activate the ERK1/2 (MAPK3/MAPK1) pathway, through activation of MEK1(MAP2K1) and MEK2(MAP2K2).
MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4).[1]
MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway.[2]
MAP3K7(TAK1)participate in regulation of transcription by transforming growth factor-beta (TGF-beta).[3]
Contents
- 1 Additional Images
- 2 See also
- 3 External links
- 4 References
Additional Images
-
MAPK pathway. Many of the MAP3K's here are labelled by their alternative names.
See also
- Signal transduction
- MAP kinase
- MAP kinase kinase
- MAP kinase kinase kinase kinase
External links
- MAP Kinase Kinase Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 2.7.11.25
References
- ^ Yan M et al. (1994). "Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1". Nature 372 (6508): 798–800. doi:10.1038/372798a0. PMID 7997270.
- ^ Ellinger-Ziegelbauer H et al. (1997). "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative". J Biol Chem. 272 (5): 2668–2674. doi:10.1074/jbc.272.5.2668. PMID 9006902.
- ^ Yamaguchi K et al. (1995). "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction". Science 270 (5244): 2008–2011. doi:10.1126/science.270.5244.2008. PMID 8533096.
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MAP kinase activation
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| Initiation |
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| MAP kinase kinase kinase (MAP3K or MKKK) |
- MAP kinase kinase kinases
- MAP3K1
- MAP3K2
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAP3K7
- MAP3K8
- RAFs
- RAF1
- ARAF
- BRAF
- KSR1
- KSR2)
- MLKs
- MAP3K12
- MAP3K13
- MAP3K9
- MAP3K10
- MAP3K11
- MAP3K7
- ZAK
- CDC7
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| MAP kinase kinase (MAP2K or MKK) |
- MAP2K1
- MAP2K2
- MAP2K3
- MAP2K4
- MAP2K5
- MAP2K6
- MAP2K7
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| MAP kinase |
- Extracellular signal-regulated kinases
- C-Jun N-terminal kinases
- P38 mitogen-activated protein kinases
- MAPK11
- MAPK12
- MAPK13
- MAPK14
- ERK5 kinase
- Atypical MAPKs
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| Phosphatase |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)
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Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)
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Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
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| Polo kinase (EC 2.7.11.21) |
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| Cyclin-dependent kinase (EC 2.7.11.22) |
- CDK1
- CDK2
- CDKL2
- CDK3
- CDK4
- CDK5
- CDKL5
- CDK6
- CDK7
- CDK8
- CDK9
- CDK10
- CDC2L5
- CRKRS
- PCTK1
- PCTK2
- PCTK3
- PFTK1
- CDC2L1
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| (RNA-polymerase)-subunit kinase (EC 2.7.11.23) |
- RPS6KA5
- RPS6KA4
- P70S6 kinase
- P70-S6 Kinase 1
- RPS6KB2
- RPS6KA2
- RPS6KA3
- RPS6KA1
- RPS6KC1
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| Mitogen-activated protein kinase (EC 2.7.11.24) |
- Extracellular signal-regulated
- MAPK1
- MAPK3
- MAPK4
- MAPK6
- MAPK7
- MAPK12
- MAPK15
- C-Jun N-terminal
- P38 mitogen-activated protein
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| MAP3K (EC 2.7.11.25) |
- MAP kinase kinase kinases
- MAP3K1
- MAP3K2
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAP3K7
- MAP3K8
- RAFs
- MLKs
- MAP3K12
- MAP3K13
- MAP3K9
- MAP3K10
- MAP3K11
- MAP3K7
- ZAK
- CDC7
- MAP3K14
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| Tau-protein kinase (EC 2.7.11.26) |
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| (acetyl-CoA carboxylase) kinase (EC 2.7.11.27) |
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| Tropomyosin kinase (EC 2.7.11.28) |
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| Low-density-lipoprotein receptor kinase (EC 2.7.11.29) |
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| Receptor protein serine/threonine kinase (EC 2.7.11.30) |
- Bone morphogenetic protein receptors
- BMPR1
- BMPR1A
- BMPR1B
- BMPR2
- ACVR1
- ACVR1B
- ACVR1C
- ACVR2A
- ACVR2B
- ACVRL1
- Anti-Müllerian hormone receptor
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Dual-specificity kinases (EC 2.7.12)
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| MAP2K |
- MAP2K1
- MAP2K2
- MAP2K3
- MAP2K4
- MAP2K5
- MAP2K6
- MAP2K7
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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English Journal
- Structurally unique interaction of RBD-like and PH domains is crucial for yeast pheromone signaling.
- Yerko V, Sulea T, Ekiel I, Harcus D, Baardsnes J, Cygler M, Whiteway M, Wu C.Source*Life Sciences, National Research Council, 6100 Royalmount Ave., Montreal, QC, Canada H4P 2R2. ‡Department of Chemistry and Biochemistry, Concordia University, 7141 Sherbrooke St. West, Montreal, QC, Canada, H4B 1R6 ¶Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada H3G 1Y6 §Department of Biology, McGill University, 1205 Ave. Dr. Penfield, Montreal, QC, Canada H3A 1B1 ‖Department of Medicine, Division of Experimental Medicine, McGill University, Royal Victoria Hospital, 687 Pine Ave. West, Montreal, QC, Canada H3A 1A1.
- Molecular biology of the cell.Mol Biol Cell.2012 Dec 14. [Epub ahead of print]
- The Ste5 protein forms a scaffold that associates and regulates the components of the MAP kinase cascade that controls mating-pheromone mediated signaling in the yeast Saccharomyces cerevisiae. Although it is known that the MEKK of the pathway, Ste11, associates with Ste5, details of this interactio
- PMID 23242997
- Phosphoproteomic analysis of protein kinase C signaling in Saccharomyces cerevisiae reveals Slt2 MAPK-dependent phosphorylation of eisosome core components.
- Mascaraque V, Hernaez ML, Jimenez-Sanchez M, Hansen R, Gil C, Martin H, Cid VJ, Molina M.SourceUniversidad Complutense de Madrid, Spain.
- Molecular & cellular proteomics : MCP.Mol Cell Proteomics.2012 Dec 9. [Epub ahead of print]
- The cell wall integrity (CWI) pathway of the model organism Saccharomyces cerevisiae has been thoroughly studied as a paradigm of mitogen-activated protein kinase (MAPK) pathway. It consists of a classic MAPK module comprising the Bck1 MAPKKK, two redundant MAPKKs, Mkk1 and Mkk2, and the Slt2 MAPK.
- PMID 23221999
Japanese Journal
- 6. アブシジン酸受容体PYLsのアンタゴニスト(口頭発表,植物化学調節学会第46回大会)
- 武藤 拓也,岡本 昌憲,Cutler Sean,平井 伸博,轟 泰司
- 植物化学調節学会研究発表記録集 (46), 22, 2011-10-03
- … AS6 exhibited the antagonistic effect on the PP2C assay and the ABA-responsive transgenic plants (MAPKKK18::GUS) assay, whereas the effect of AS2 was agonistic similarly to ABA. …
- NAID 110008902415
- ストレスキナーゼの新しい機能--ASKファミリーを中心として (特集 細胞内シグナル伝達の新展開)
Related Links
- 栄養・生化学辞典 - MAPKKKの用語解説 - MAPキナーゼキナーゼキナーゼ．MAPキナーゼキナーゼをリン酸エステル化する反応を触媒する酵素．細胞内信号伝達系の構成因子の一つ．
- 【課題】 本発明は、ヒトおよびマウスにおいて新規MAPKKKを提供することを課題とする。本発明はまた、ヒトやマウスにおける新規MAPKKKを阻害することで、アポトーシスに関連する疾患の安全でより効果のある予防・治療剤を提供する ...
Related Pictures
★リンクテーブル★
[★]
- 英
- receptor tyrosine kinase receptor, tyrosine kinase RTK
- 同？
- チロシンキナーゼ受容体
カスケード
- リガンド結合→レセプターの二量体化→レセプターの細胞膜内領域を自己リン酸化
- →ホスホリパーゼC→ジアシルグリセロール→PKC→増殖因子の活性化
- →Grb2→SOS→Ras→Raf-1(MAPKKK)→MEK(MAPKK)→Erk1/Erk2(MAPK)→(核移行)→ELK1→c-fos
- →PI3キナーゼ→PI(3,4,5)P3→PDK1→PKB→増殖因子の活性化
[★]
| 層
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増殖因子
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| 細胞膜
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Grb2
Sos
Ras
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| 細胞質
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| MAPKKKK
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PAK3
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| MAPKKK
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Raf-1/A-Raf
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| MAPKK
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B-Raf/Mos
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| MAPK
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MEK1/MEK2
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| 基質
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ERK1/ERK2, p90rsk, MNK1/MNK2, Sos, cPLA2, EGFR, Elk-1, Ets1, Sap1a, STAT, Map2, Tau
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[★]
- 英
- MAP kinase kinase kinase、MAPKKK、MEKK
- 関
- MEKキナーゼ
[★]
- 関
- MAP kinase kinase kinase、MAPKKK、MEKK
[★]
- 同
- MAPKKK
- 同
- MAPKKK
