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Tozasertib attenuates neuronal apoptosis via DLK/JIP3/MA2K7/JNK pathway in early brain injury after SAH in rats.

Yin C1, Huang GF2, Sun XC3, Guo Z3, Zhang JH4.
Neuropharmacology.Neuropharmacology.2016 Sep;108:316-23. doi: 10.1016/j.neuropharm.2016.04.013. Epub 2016 Apr 13.
BACKGROUND AND PURPOSE: Since tozasertib is neuroprotective for injured optic nerve, this study is intended to test whether tozasertib reduces early brain injury after subarachnoid hemorrhage (SAH) in a rat model.METHODS: Two hundred sixteen (216) male Sprague-Dawley rats were randomly subjected to
PMID 27084696

Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agents.

Sun J1, Niu Y2, Wang C1, Zhang H3, Xie B3, Xu F1, Jin H4, Peng Y3, Liang L1, Xu P5.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2016 Aug 15;24(16):3472-82. doi: 10.1016/j.bmc.2016.05.055. Epub 2016 May 30.
Enterovirus 71 (EV71) is a kind of RNA virus and one of the two causes of Hand, foot and mouth disease (HFMD). Inhibitors that target key components of Ras/Raf/MEK/ERK pathway in host cells could impair replication of EV71. A series of 3-benzyl-1,3-benzoxazine-2,4-diones were designed from a specifi
PMID 27288186

Sun T1, Wu Z1, Luo M1, Lin D1, Guo C2.
Biotechnology letters.Biotechnol Lett.2016 Aug;38(8):1375-80. doi: 10.1007/s10529-016-2117-0. Epub 2016 May 5.
OBJECTIVES: To study the binding of pranlukast to hRKIP and its regulatory role in the Raf1/MEK/ERK signal pathway.RESULTS: NMR and fluorescence experiments demonstrated hRKIP could bind pranlukast with a binding constant of 1016 mM(-1). Residues (Y81, S109 and Y181) on the conserved ligand-binding
PMID 27146207

Onodera Yasuhito,Nam Jin-Min,Bissell Mina J.
Journal of clinical investigation 124(1), 367-384, 2014-01-02
… Overexpression of glucose transporter type 3 (GLUT3) in nonmalignant human breast cells activated known oncogenic signaling pathways, including EGFR, beta 1 integrin, MEK, and AKT, leading to loss of tissue polarity and increased growth. … The former, in turn, was mediated by pyruvate kinase M2 (PKM2) interaction with soluble adenylyl cyclase. …
NAID 120005372327

竹内摂,合田征司,吉川一志,堂前英資,池尾隆,山本一世
日本歯科保存学雑誌 57(1), 1-8, 2014
… そこでわれわれは, ヒト歯髄由来線維芽細胞における炎症性サイトカインIL-1β刺激によるMMP-3の産生と, 細胞内シグナル伝達物質であるExtracellular signal-regulated kinase 1/2 (ERK1/2) について検討した. 材料と方法 : 大阪歯科大学医の倫理委員会における承認 (大歯医倫070716号) の下, 矯正治療における便宜抜去歯からヒト歯髄由来線維芽細胞を採取し, 初代培養後3∼10世代を本研究に供した. …
NAID 130003398837

1) ゲノム不安定性・遺伝子変異に基づく子宮体癌の浸潤能獲得と分子生物学的予後不良因子の検討(シンポジウム1:腫瘍「婦人科癌の浸潤・転移機構の解明と臨床応用」,第65回日本産科婦人科学会・学術講演会講演要旨)

織田克利
日本産科婦人科學會雜誌 65(10), 2388-2401, 2013-10-01
… Endometrial cancer is also known to possess mutations frequently in Ras-PI3K (phosphatidylinositol 3'-kinase) pathway, such as PTEN and K-Ras. … The presence of a MEK inhibitor, PD98059 or U0126, sensitized the K-Ras mutant cells to NVP-BEZ235. …
NAID 110009674401