- 同
- MAPKKK
- 同
- MAPKKK
WordNet
- make a map of; show or establish the features of details of; "map the surface of Venus"
- to establish a mapping (of mathematical elements or sets) (同)represent
- a diagrammatic representation of the earths surface (or part of it)
- plan, delineate, or arrange in detail; "map ones future" (同)map out
- depict as if on a map; "sorrow was mapped on the mothers face"
- explore or survey for the purpose of making a map; "We havent even begun to map the many galaxies that we know exist"
- locate within a specific region of a chromosome in relation to known DNA or gene sequences; "map the genes"
- the 13th letter of the Roman alphabet (同)m
- an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
PrepTutorEJDIC
- (1枚1枚の)『地図』;天体図 / …‘の'地図を作る;…‘を'地図にかく
- Mach number / mark[s] / Monsieur
- Massachusetts / mental age
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/04/04 21:33:38」(JST)
[Wiki en表示]
Mitogen-activated protein kinase kinase kinase |
Identifiers |
EC number |
2.7.11.25 |
CAS number |
146702-84-3 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
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MAP kinase kinase kinase (or MAP3K or MEKK) is a serine/threonine-specific protein kinase which acts upon MAP kinase kinase.
In humans there are at least 19 genes:
- MAP3K1 (aka MEKK1)
- MAP3K2
- MAP3K3 (aka MEKK3)
- MAP3K4
- MAP3K5 (aka ASK1)
- MAP3K6 (aka ASK2)
- MAP3K7 (aka MEKK7) (aka TAK1)
- MAP3K8 (aka TPL2 or Tpl2)
- MAP3K9
- MAP3K10
- MAP3K11 (aka MEKK11) (aka MLK3)
- MAP3K12 (aka MUK)
- MAP3K13 (aka LZK)
- MAP3K14
- MAP3K15
- MAP3K16 (aka TAO1 or TAOK1)
- MAP3K17 (aka TAO2 or TAOK2)
- RAF1
- BRAF
- ARAF
- ZAK (aka MLTK)
Perhaps the best characterized MAP3K are the members of the oncogenic RAF family (RAF1, BRAF, ARAF), which are effectors of mitogenic ras signaling and which activate the ERK1/2 (MAPK3/MAPK1) pathway, through activation of MEK1(MAP2K1) and MEK2(MAP2K2).
MEKK1 activates MAPK8/JNK by phosphorylation of its activator SEK1(MAP2K4).[1]
MAP3K3 directly regulates the MAPK8/JNK and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway.[2]
MAP3K7(TAK1)participate in regulation of transcription by transforming growth factor-beta (TGF-beta).[3]
Contents
- 1 Additional Images
- 2 See also
- 3 External links
- 4 References
Additional Images
-
MAPK pathway. Many of the MAP3K's here are labelled by their alternative names.
See also
- Signal transduction
- MAP kinase
- MAP kinase kinase
- MAP kinase kinase kinase kinase
External links
- MAP Kinase Kinase Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 2.7.11.25
References
- ^ Yan M et al. (1994). "Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1". Nature 372 (6508): 798–800. doi:10.1038/372798a0. PMID 7997270.
- ^ Ellinger-Ziegelbauer H et al. (1997). "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivative". J Biol Chem. 272 (5): 2668–2674. doi:10.1074/jbc.272.5.2668. PMID 9006902.
- ^ Yamaguchi K et al. (1995). "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction". Science 270 (5244): 2008–2011. doi:10.1126/science.270.5244.2008. PMID 8533096.
MAP kinase activation
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Initiation |
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MAP kinase kinase kinase (MAP3K or MKKK) |
- MAP kinase kinase kinases
- MAP3K1
- MAP3K2
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAP3K7
- MAP3K8
- RAFs
- RAF1
- ARAF
- BRAF
- KSR1
- KSR2)
- MLKs
- MAP3K12
- MAP3K13
- MAP3K9
- MAP3K10
- MAP3K11
- MAP3K7
- ZAK
- CDC7
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MAP kinase kinase (MAP2K or MKK) |
- MAP2K1
- MAP2K2
- MAP2K3
- MAP2K4
- MAP2K5
- MAP2K6
- MAP2K7
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MAP kinase |
- Extracellular signal-regulated kinases
- C-Jun N-terminal kinases
- P38 mitogen-activated protein kinases
- MAPK11
- MAPK12
- MAPK13
- MAPK14
- ERK5 kinase
- Atypical MAPKs
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Phosphatase |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)
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Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)
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Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
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Polo kinase (EC 2.7.11.21) |
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Cyclin-dependent kinase (EC 2.7.11.22) |
- CDK1
- CDK2
- CDKL2
- CDK3
- CDK4
- CDK5
- CDKL5
- CDK6
- CDK7
- CDK8
- CDK9
- CDK10
- CDC2L5
- CRKRS
- PCTK1
- PCTK2
- PCTK3
- PFTK1
- CDC2L1
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(RNA-polymerase)-subunit kinase (EC 2.7.11.23) |
- RPS6KA5
- RPS6KA4
- P70S6 kinase
- P70-S6 Kinase 1
- RPS6KB2
- RPS6KA2
- RPS6KA3
- RPS6KA1
- RPS6KC1
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Mitogen-activated protein kinase (EC 2.7.11.24) |
- Extracellular signal-regulated
- MAPK1
- MAPK3
- MAPK4
- MAPK6
- MAPK7
- MAPK12
- MAPK15
- C-Jun N-terminal
- P38 mitogen-activated protein
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MAP3K (EC 2.7.11.25) |
- MAP kinase kinase kinases
- MAP3K1
- MAP3K2
- MAP3K3
- MAP3K4
- MAP3K5
- MAP3K6
- MAP3K7
- MAP3K8
- RAFs
- MLKs
- MAP3K12
- MAP3K13
- MAP3K9
- MAP3K10
- MAP3K11
- MAP3K7
- ZAK
- CDC7
- MAP3K14
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Tau-protein kinase (EC 2.7.11.26) |
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(acetyl-CoA carboxylase) kinase (EC 2.7.11.27) |
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Tropomyosin kinase (EC 2.7.11.28) |
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Low-density-lipoprotein receptor kinase (EC 2.7.11.29) |
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Receptor protein serine/threonine kinase (EC 2.7.11.30) |
- Bone morphogenetic protein receptors
- BMPR1
- BMPR1A
- BMPR1B
- BMPR2
- ACVR1
- ACVR1B
- ACVR1C
- ACVR2A
- ACVR2B
- ACVRL1
- Anti-Müllerian hormone receptor
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Dual-specificity kinases (EC 2.7.12)
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MAP2K |
- MAP2K1
- MAP2K2
- MAP2K3
- MAP2K4
- MAP2K5
- MAP2K6
- MAP2K7
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- Sepsis protects the myocardium and other organs from subsequent ischaemic/reperfusion injury via a MAPK-dependent mechanism.
- Walshe CM1, Laffey JG, Kevin L, O'Toole D.
- Intensive care medicine experimental.Intensive Care Med Exp.2015 Dec;3(1):35. doi: 10.1186/s40635-014-0035-9. Epub 2015 Jan 31.
- BACKGROUND: Sepsis has been shown to precondition the intact heart against ischaemia/reperfusion (IR) injury, and prior endotoxin exposure of cells in in vitro models has shown evidence of protection against subsequent simulated ischaemia. Our aim in this study is to validate these findings and furt
- PMID 26215802
- Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.
- Carthy JM1, Sundqvist A1, Heldin A1, van Dam H1,2, Kletsas D3, Heldin CH1, Moustakas A1,4.
- Journal of cellular physiology.J Cell Physiol.2015 Dec;230(12):3084-92. doi: 10.1002/jcp.25049.
- Transforming growth factor-β (TGF-β) is a multifunctional cytokine which stimulates the differentiation of fibroblasts into myofibroblasts. Myofibroblasts are critical for normal wound healing, but also accumulate pathologically in a number of chronic inflammatory conditions where they are key con
- PMID 26096876
- Simultaneous suppression of the MAP kinase and NF-κB pathways provides a robust therapeutic potential for thyroid cancer.
- Tsumagari K1, Abd Elmageed ZY1, Sholl AB2, Friedlander P3, Abdraboh M4, Xing M5, Boulares AH6, Kandil E7.
- Cancer letters.Cancer Lett.2015 Nov 1;368(1):46-53. doi: 10.1016/j.canlet.2015.07.011. Epub 2015 Jul 21.
- The MAP kinase and NF-κB signaling pathways play an important role in thyroid cancer tumorigenesis. We aimed to examine the therapeutic potential of dually targeting the two pathways using AZD6244 and Bortezomib in combination. We evaluated their effects on cell proliferation, cell-cycle progressio
- PMID 26208433
Japanese Journal
- Keratinocyte wound healing activity of galactoglycerolipids from the fern Ophioglossum vulgatum L.
- Clericuzio Marco,Burlando Bruno,Gandini Giulio [他]
- Journal of natural medicines 68(1), 31-37, 2014
- NAID 40019919732
- Astragaloside Ⅳ Inhibits Doxorubicin-Induced Cardiomyocyte Apoptosis Mediated by Mitochondrial Apoptotic Pathway via Activating the PI3K/Akt Pathway
- Jia Yuanyuan,Zuo Daiying,Li Zengqiang [他],Liu Hanmo,Dai Zhengning,Cai Jiayi,Pang Lili,Wu Yingliang
- Chemical and Pharmaceutical Bulletin 62(1), 45-53, 2014
- … Furthermore, AS-IV substantially reduced the mitochondrial reactive oxygen species (ROS) production and lactate dehydrogenase (LDH), creatine kinase-MB isoenzyme (CK-MB) and cytochrome c (CytC) release, and restored the reduced ATP level, succinate dehydrogenase (SDH) and ATP synthase activities induced by DOX, suggesting that AS-IV significantly attenuated DOX-induced mitochondrial damage and dysfunction. …
- NAID 130003381803
- 病原菌エフェクターによるPAMPs誘導抵抗性の抑制機構
Related Links
- ライフサイエンスシソーラス: MAPキナーゼキナーゼキナーゼ MAP Kinase Kinase Kinase MAPキナーゼキナーゼキナーゼ (MAP Kinase Kinase Kinase) を Google Scholar, Entrez, Google, Wikipedia で検索 同義語(異表記): ...
- CST signaling pathway diagrams allow you to click on individual nodes to find research resources or product information. You can also download the pathway ... Overview of MAP Kinase Signaling Mitogen-activated protein kinases ...
Related Pictures
★リンクテーブル★
[★]
- 関
- MAP kinase kinase kinase、MEK kinase、MEKK
[★]
- 英
- MAP kinase kinase kinase、MAPKKK、MEKK
- 関
- MEKキナーゼ
[★]
- 関
- MAP kinase kinase kinase、MAPKKK、MEKK
[★]
- 関
- MEK kinase 1
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[★]
[★]
[★]
- 地図で表す、(遺伝子などを)位置づける、(遺伝子などが)位置する
- 関
- lie、locate、location、loci、locus、mapping、position、rank、sit、situated、situation、stand、topo
[★]
[★]
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キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase
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メチオニン methionine