MAO-B

MAOB

WordNet

  1. the 2nd letter of the Roman alphabet (同)b
  2. the blood group whose red cells carry the B antigen (同)type_B, group B
  3. the 13th letter of the Roman alphabet (同)m

PrepTutorEJDIC

  1. Mach number / mark[s] / Monsieur
  2. Massachusetts / mental age

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/04/11 04:20:09」(JST)

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English Journal

  • Dopamine oxidation facilitates rotenone-dependent potentiation of N-methyl-d-aspartate currents in rat substantia nigra dopamine neurons.
  • Wu YN, Johnson SW.SourceDepartment of Neurology, Oregon Health and Science University, Portland, OR 97239, USA.
  • Neuroscience.Neuroscience.2011 Nov 10;195:138-44. Epub 2011 Aug 23.
  • Rotenone is a mitochondrial poison that causes dopamine cell death and is used as a model of Parkinson's disease in rodents. Recently, we showed that rotenone augments currents evoked by N-methyl-d-aspartate (NMDA) by relieving voltage-dependent Mg(2+) block in rat substantia nigra compacta (SNC) do
  • PMID 21884756
  • Sirt1 deacetylates c-Myc and promotes c-Myc/Max association.
  • Mao B, Zhao G, Lv X, Chen HZ, Xue Z, Yang B, Liu DP, Liang CC.SourceNational Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
  • The international journal of biochemistry & cell biology.Int J Biochem Cell Biol.2011 Nov;43(11):1573-81. Epub 2011 Jul 22.
  • The c-Myc oncoprotein plays critical roles in multiple biological processes by controlling cell proliferation, apoptosis, differentiation, and metabolism. Especially, c-Myc is frequently overexpressed in many human cancers and widely involved in tumorigenesis. However, how the post-translational mod
  • PMID 21807113

Japanese Journal

  • Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in β-phenylethylamine
  • Kitaichi Yuji,Inoue Takeshi,Nakagawa Shin,Boku Shuken,Izumi Takeshi,Koyama Tsukasa
  • European Journal of Pharmacology 637(1-3), 77-82, 2010-07-10
  • … Monoamine oxidase inhibitors (MAO inhibitors) have been widely used as antidepressants. … However, it remains unclear whether a difference exists between non-selective MAO inhibitors and selective MAO-A inhibitors in terms of their antidepressant effects. …
  • NAID 120002261718
  • Antioxidant and Amine Oxidase Inhibitory Activities of Hydroxyurea
  • LIU Yuh-Hwa,WU Wen-Chun,LU Yeh-Lin,LAI Ying-Jang,HOU Wen-Chi
  • Bioscience, biotechnology, and biochemistry 74(6), 1256-1260, 2010-06-23
  • … In this study, HU was found to have antioxidant activities against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals and dose-dependent inhibitory activities against monoamine oxidase (MAO)-A, MAO-B, and semicarbazide-sensitive amine oxidase (SSAO) as compared to controls of clorgyline, deprenyl, and semicarbazide respectively. …
  • NAID 10027556452

Related Links

代表的なMAOIとして、セレギリンはMAO-Bを選択的に阻害し、RIMAはMAO-Aを阻害 する。 RIMAを服用する場合、セレギリンと ... 不調などの症状があらわれる。 またMAO- Bの働きが阻害されるとジスキネジア等の症状があらわれやすくなる可能性が高くなる。 ...


Related Pictures

570px-MAO-B_inhibitors.pngThe therapeutic potential of monoamine Slide 38. Use of MAO-B Inhibitors for Off MAO-B inhibitorr oxydase A et B gliales (MAO-A + MAO-BLeave a Reply Cancel



★リンクテーブル★
リンク元パーキンソン病治療薬」「セレギリン」「MAOB」「monoamine oxidase A」「monoamine oxidase B
関連記事B」「MA」「MAO」「M

パーキンソン病治療薬」

  [★]

antiparkinson agent, antiparkinsonism drug
パーキンソン病薬理学

ドパミン前駆体

ドパミン受容体作動薬

MAO-B阻害薬

ドパミン放出促進

中枢性抗コリン作用

ノルアドレナリン前駆体

セレギリン」

  [★]

selegiline
塩酸セレギリン selegiline hydrochloride
デプレニール deprenyl


特徴

構造

作用機序

薬理作用

  • B型モノアミン酸化酵素阻害作用
  • ドパミン再取り込み阻害作用

動態

適応

注意

禁忌

副作用

相互作用

添付文書

  • セレギリン塩酸塩錠2.5mg「マイラン」
[display]http://www.info.pmda.go.jp/go/pack/1169010F1058_1_03/1169010F1058_1_03?view=body

MAOB」

  [★]

monoamine oxidase B,MAO-B
モノアミンオキシダーゼ

monoamine oxidase A」

  [★]

モノアミン酸化酵素AモノアミンオキシダーゼA

amine oxidaseMAOMAO-AMAO-Bmonoamine oxidasemonoamine oxidase B

monoamine oxidase B」

  [★]

モノアミン酸化酵素BモノアミンオキシダーゼB

amine oxidaseMAOMAO-AMAO-Bmonoamine oxidasemonoamine oxidase A

B」

  [★]

  • Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

   

MA」

  [★]

 

MAO」

  [★] モノアミンオキシダーゼ monoamine oxidase

M」

  [★] メチオニン methionine