antiparkinson agent

• 抗パーキンソン病薬

関

antiparkinson drug、antiparkinsonian、antiparkinsonian agent、antiparkinsonian drug

WordNet

1. a substance that exerts some force or effect
2. a businessman who buys or sells for another in exchange for a commission (同)factor, broker
3. any agent or representative of a federal agency or bureau (同)federal agent
4. a representative who acts on behalf of other persons or organizations
5. an active and efficient cause; capable of producing a certain effect; "their research uncovered new disease agents"
6. how long something has existed; "it was replaced because of its age"
7. a time of life (usually defined in years) at which some particular qualification or power arises; "she was now of school age"; "tall for his eld" (同)eld
8. begin to seem older; get older; "The death of his wife caused him to age fast"
9. make older; "The death of his child aged him tremendously"

PrepTutorEJDIC

1. 『代理人』;周旋人 / 働き(作用)を起こすもの;作用物,薬剤 / (政府機関,特にFBI,CIAなどの)部員,機関員
2. 〈U〉(一般に)『年齢』,寿命;〈C〉(個々の)『年齢』,年 / 〈U〉成年(おとなとしての資格・権利を得る年齢;通例18または21歳) / 〈U〉『老齢』;《集合的に》老人たち / 〈U〉(人生の)『一時期』;〈C〉世代(generation) / 〈U〉〈C〉《しばしばA-》(歴史上の)『時代』 / 〈C〉《話》長い間 / 年をとる,ふける;〈物が〉古くなる / 〈年〉'を'とらせる;〈物〉'を'古びさせる

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/10 02:59:59」(JST)

wiki en

[Wiki en表示]

An antiparkinson, or antiparkinsonian, is a type of drug which is intended to treat and relieve the symptoms of Parkinson's disease (PD) or Parkinsonism. Most of these agents act by either increasing dopamine activity or reducing acetylcholine activity in the central nervous system (CNS).

Examples

• • Dopaminergic Precursors:

(Preferred over other medications to prevent undesirable sympathomimetic side effects)

• • • Phenylalanine
    • Tyrosine
    • L-DOPA

• • Selective monoamine oxidase B inhibitors

(To prevent the metabolism of dopamine by MAO_B and hence increase its brain levels)

• • • Selegiline
    • Rasagiline

• • COMT inhibitors

(Preventing the metabolism of dopamine by COMT and hence increase its brain levels)

• • • Entacapone
    • Tolcapone

• • Dopamine receptor agonists

(Directly increase the activity of the dopamine system)

• • • Apomorphine
    • Bromocriptine
    • Pramipexole
    • Ropinirole
    • Rotigotine

• Anticholinergics - Antimuscarinics (e.g., Benzatropine): to prevent hyperkinesia.
  • Diphenhydramine
  • Dimenhydrinate
  • Scopolamine
  • Benztropine

See also

• Acetylcholine
• Dopamine
• Parkinson's disease
• Parkinsonism

References

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. パーキンソン病の薬理学的治療 pharmacologic treatment of parkinson disease
• 2. 静脈血栓塞栓症の患者における理論的根拠と無期限の抗凝固の適応 rationale and indications for indefinite anticoagulation in patients with venous thromboembolism
• 3. 最新の診療アップデート practice changing updates
• 4. Fertility preservation in women with endometrial carcinoma
• 5. Anesthesia for adult bronchoscopy

English Journal

• Amantadine's role in the treatment of levodopa-induced dyskinesia.

• Rodnitzky RL1, Narayanan NS.
• Neurology.Neurology.2014 Jan 28;82(4):288-9. doi: 10.1212/WNL.0000000000000068. Epub 2013 Dec 26.
• Levodopa-induced dyskinesia (LID) is one of the most common, frequently dose-limiting, complications of pharmacologic therapy for Parkinson disease (PD). These typically choreiform movements, usually occurring at the time of peak levodopa effect, occur in 40% to 50% of patients after 5 years of ther
• PMID 24371305

• Non-dopaminergic treatments for motor control in Parkinson's disease.

• Fox SH.
• Drugs.Drugs.2013 Sep;73(13):1405-15. doi: 10.1007/s40265-013-0105-4.
• The pathological processes underlying Parkinson's disease (PD) involve more than dopamine cell loss within the midbrain. These non-dopaminergic neurotransmitters include noradrenergic, serotonergic, glutamatergic, and cholinergic systems within cortical, brainstem and basal ganglia regions. Several
• PMID 23917951

• A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD).

• Shaltiel-Karyo R1, Frenkel-Pinter M, Rockenstein E, Patrick C, Levy-Sakin M, Schiller A, Egoz-Matia N, Masliah E, Segal D, Gazit E.
• The Journal of biological chemistry.J Biol Chem.2013 Jun 14;288(24):17579-88. doi: 10.1074/jbc.M112.434787. Epub 2013 May 1.
• The development of disease-modifying therapy for Parkinson disease has been a main drug development challenge, including the need to deliver the therapeutic agents to the brain. Here, we examined the ability of mannitol to interfere with the aggregation process of α-synuclein in vitro and in vivo i
• PMID 23637226

Japanese Journal

• COMPARISON OF THE ELECTROENCEPHALOGRAPHIC AND MOTOR EFFECTS OF ORPHENADRINE, AN ANTIPARKINSON AGENT

• The Japanese Journal of Pharmacology 18(4), 454-470, 1968
• NAID 130000836974

Related Links

• Patent US6929801 - Antiparkinson agent, dermal penetration ...

The present invention provides a transdermal drug delivery system which comprises: a therapeutically effective amount of an antiParkinson agent; at least one dermal penetration enhancer, which is a safe skin-tolerant ester sunscreen ...

• Antiparkinson agent | Online references | cyclopaedia.net

Find information on wellness, diet, fitness, weight loss, mental health, anti-aging, conditions & diseases, drugs & medications, and more on Yahoo Health. ... BACKGROUND: Antiparkinson drugs (APDs) are the mainstay in the ...

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★リンクテーブル★

リンク元	「パーキンソン病治療薬」「抗パーキンソン病薬」「antiparkinsonian」「antiparkinsonian drug」「antiparkinson drug」
関連記事	「agent」「age」

「パーキンソン病治療薬」

　　[★]

英

antiparkinson agent, antiparkinsonism drug

関

パーキンソン病、薬理学

ドパミン前駆体

• レボドパ levodopa

ドパミン受容体作動薬

• ブロモクリプチン bromocriptine
• タリペキソール talipexole

MAO-B阻害薬

• セレギリン selegiline

ドパミン放出促進

• アマンタジン amantadine

中枢性抗コリン作用

• トリヘキシフェニジル trihexyphenidyl
• ビペリデン biperiden

ノルアドレナリン前駆体

• ドロキシドパ droxidopa

「抗パーキンソン病薬」

　　[★]

英

antiparkinsonian drug、antiparkinsonian agent、antiparkinsonian、antiparkinson drug、antiparkinson agent

関

抗パーキンソン病、抗パーキンソン剤

「antiparkinsonian」

　　[★]

• adj.

• 抗パーキンソン病の

• n.

• 抗パーキンソン病薬

関

antiparkinson agent、antiparkinson drug、antiparkinsonian agent、antiparkinsonian drug

「antiparkinsonian drug」

　　[★]

• 抗パーキンソン病薬、抗パーキンソン剤

関

antiparkinson agent、antiparkinson drug、antiparkinsonian、antiparkinsonian agent

「antiparkinson drug」

　　[★]

• 抗パーキンソン病薬

関

antiparkinson agent、antiparkinsonian、antiparkinsonian agent、antiparkinsonian drug

「agent」

　　[★]

• n.

• 代行者、代理人。代理業者
• 政府職員、官吏
• ある後位をする人、ある作用をするもの。動員、動力因、作用因。(文法)動作主。科学的変化を起こさせるもの、薬品、～剤。病原体

関

agonist、agonistic、attorney、delegate、drug、etiologic agent、fomes、fomites、mediator、pathogen、pathogenic、pharmaceutical preparation、vector、vehicle

　 　 　 　 　 　

「age」

　　[★]

• n.

• 年齢、歳

• v.

• 加齢する、熟成する

関

aged、ageing、aging、year old