selegiline hydrochloride

deprenylL-deprenylselegiline

WordNet

  1. a complex consisting of an organic base in association with hydrogen chloride

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/28 07:28:16」(JST)

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English Journal

  • The opposite effect of isotype-selective monoamine oxidase inhibitors on adipogenesis in human bone marrow mesenchymal stem cells.
  • Byun Y, Park J, Hong SH, Han MH, Park S, Jung HI, Noh M.SourceCollege of Pharmacy, Korea University, 2511 Sejong-ro, Sejong, Republic of Korea.
  • Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2013 Jun 1;23(11):3273-6. doi: 10.1016/j.bmcl.2013.03.117. Epub 2013 Apr 4.
  • Adiponectin production during adipocyte differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) can be used to evaluate the pharmacological activity of anti-diabetic drugs to improve insulin sensitivity. Monoamine oxidase (MAO) inhibitors such as phenelzine and pargyline inhibit adipo
  • PMID 23611731
  • Revelation in the neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms.
  • Naoi M, Maruyama W, Inaba-Hasegawa K.SourceDepartment of Health and Nutrition, Faculty of Psychological and Physical Science, Aichi Gakuin University, Nisshin, Aichi, Japan.
  • Expert review of neurotherapeutics.Expert Rev Neurother.2013 Jun;13(6):671-84. doi: 10.1586/ern.13.60.
  • In Parkinson's disease, cell death of dopamine neurons in the substantia nigra progresses and neuroprotective therapy is required to halt neuronal loss. In cellular and animal models, selegiline [(-)deprenyl] and rasagiline, inhibitors of type B monoamine oxidase (MAO)-B, protect neuronal cells from
  • PMID 23739004

Japanese Journal

  • Application of Assay of Platelet Monoamine Oxidase Type-B (MAO-B) Activity to the Discrimination of Selegiline Use from Methamphetamine Abuse
  • Katagi Munehiro,Tsutsumi Hiroe,Tatsuno Michiaki [他],Kamata Tohru,Nishioka Hiroshi,Miki Akihiro,Nakajima Kunio,Tsuchihashi Hitoshi
  • Journal of health science 49(3), 189-194, 2003-06-01
  • … An assay of platelet monoamine oxidase type-B (MAO-B) activity has been explored in the search for a reliable method of discriminating selegiline (SG) use from methamphetamine (MA) abuse. … MA and most of its related compounds including its precursors produced no platelet MAO-B inhibition in vitro even at their lethal levels, though SG, its specific metabolites selegiline N-oxide (SGO) and N-desmethylselegiline (DM-SG), as well as its enantiomer d-deprenyl exhibited high platelet MAO-B inhibitory potency. …
  • NAID 110003609061
  • Metabolism of Selegiline Hydrochloride, a Selective Monoamine B-type Inhibitor, in Human Liver Microsomes
  • KAMADA Takahiro,CHOW Toshio,HIROI Toyoko,IMAOKA Susumu,MORIMOTO Kazuhiko,OHDE Hironori,FUNAE Yoshihiko
  • Drug metabolism and pharmacokinetics 17(3), 199-206, 2002-08-12
  • NAID 50000598913

Related Links

se·leg·i·line hydrochloride (sə-lĕj′ə-lēn′) n. A drug that is an irreversible inhibitor of a specific type of monoamine oxidase, used in conjunction with levodopa and carbidopa to treat patients with Parkinson's disease. selegiline ...
Selegiline Hydrochloride reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). ... Drug or Food Interaction Comments Antidepressants, SSRIs (e.g., fluoxetine, fluvoxamine ...


Related Pictures

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★リンクテーブル★
リンク元セレギリン」「塩酸セレギリン」「L-deprenyl
関連記事hydrochloride

セレギリン」

  [★]

selegiline
塩酸セレギリン selegiline hydrochloride
デプレニール deprenyl


特徴

構造

作用機序

薬理作用

  • B型モノアミン酸化酵素阻害作用
  • ドパミン再取り込み阻害作用

動態

適応

注意

禁忌

副作用

相互作用

添付文書

  • セレギリン塩酸塩錠2.5mg「マイラン」
[display]http://www.info.pmda.go.jp/go/pack/1169010F1058_1_03/1169010F1058_1_03?view=body

塩酸セレギリン」

  [★]

selegiline hydrochloride
デプレニルセレギリンセレギリン塩酸塩L-デプレニル

L-deprenyl」

  [★]

L-デプレニル

deprenylselegilineselegiline hydrochloride

hydrochloride」

  [★] 塩酸塩ハイドロクロライド