WordNet
- a compound derived from ammonia by replacing hydrogen atoms by univalent hydrocarbon radicals (同)aminoalkane
- any of the enzymes that catalyze biological oxidation
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/10/19 23:34:08」(JST)
[Wiki en表示]
Ribbon representation of human diamine oxidase.
[1]
amiloride binding protein 1 (amine oxidase (copper-containing)) |
Identifiers |
Symbol |
ABP1 |
Alt. symbols |
AOC1 |
Entrez |
26 |
HUGO |
80 |
OMIM |
104610 |
RefSeq |
NM_001091 |
UniProt |
P19801 |
Other data |
EC number |
1.4.3.22 |
Locus |
Chr. 7 q34-qter |
Amine oxidase (copper-containing), also known as histaminase or diamine oxidase, is an enzyme involved in the metabolism, oxidation, and inactivation of histamine in animals. Highest content is observed in the digestive tract and placenta.
[2]
External links
- García-Martín, E; Ayuso, P; Martínez, C; Blanca, M; Agúndez, JA (May 2009). "Histamine pharmacogenomics". Pharmacogenomics 10 (5): 867–83. doi:10.2217/pgs.09.26. PMID 19450133.
- García-Martín, E; Ayuso, P; Martínez, C; Agúndez, JA (Nov 2007). "Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individuals". Clin Biochem 40 (16-17): 1339–41. doi:10.1016/j.clinbiochem.2007.07.019. PMID 17826755.
- Ayuso, P; García-Martín, E; Martínez, C; Agúndez, JA (Sep 2007). "Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activity". Pharmacogenet Genomics 17 (9): 687–93. doi:10.1097/FPC.0b013e328012b8e4. PMID 17700358.
- García-Martín, E; García-Menaya, J; Sánchez, B; Martínez, C; Rosendo, R; Agúndez, JA (Aug 2007). "Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis". Clin Exp Allergy 37 (8): 1175–82. doi:10.1111/j.1365-2222.2007.02769.x. PMID 17651147.
- García-Martin, E; Mendoza, JL; Martínez, C; Taxonera, C; Urcelay, E; Ladero, JM; de la Concha, EG; Díaz-Rubio, M; Agúndez, JA (Jan 2006). "Severity of ulcerative colitis is associated with a polymorphism at diamine oxidase gene but not at histamine N-methyltransferase gene". World J Gastroenterol 12 (4): 615–20. PMID 16489678.
- Amine Oxidase (Copper-Containing) at the US National Library of Medicine Medical Subject Headings (MeSH)
CH-NH2 oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases
|
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1.4.1: NAD/NADP acceptor |
- Glutamate dehydrogenase
- Glutamate synthase (NADPH)
|
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1.4.3: oxygen acceptor |
- D-amino acid oxidase
- Amine oxidase
- Lysyl oxidase
- Monoamine oxidase
|
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1.4.4: disulfide acceptor |
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1.4.99: other acceptors |
- D-amino acid dehydrogenase
- Amine dehydrogenase
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- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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Enzymes involved in neutrotransmission
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|
monoamine |
histidine → histamine |
anabolism: |
|
|
catabolism: |
- Histamine N-methyltransferase
- Amine oxidase
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|
|
tyrosine→dopamine→epinephrine |
anabolism: |
- Tyrosine hydroxylase
- Aromatic L-amino acid decarboxylase
- Dopamine beta hydroxylase
- Phenylethanolamine N-methyltransferase
|
|
catabolism: |
- Catechol-O-methyl transferase
- Monoamine oxidase
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|
|
glutamate→GABA |
anabolism: |
|
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catabolism: |
- 4-aminobutyrate transaminase
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|
|
tryptophan→serotonin→melatonin |
- Tryptophan hydroxylase
- Aromatic L-amino acid decarboxylase
- Acetylserotonin O-methyltransferase
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arginine→NO |
- Nitric oxide synthase (NOS1, NOS2, NOS3)
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choline→Acetylcholine |
anabolism: |
- Choline acetyltransferase
|
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catabolism: |
- Cholinesterase (Acetylcholinesterase, Butyrylcholinesterase)
|
|
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Index of the central nervous system
|
|
Description |
- Anatomy
- meninges
- cortex
- association fibers
- commissural fibers
- lateral ventricles
- basal ganglia
- diencephalon
- mesencephalon
- pons
- cerebellum
- medulla
- spinal cord
- Physiology
- Development
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|
Disease |
- Addiction
- Cerebral palsy
- Meningitis
- Demyelinating diseases
- Seizures and epilepsy
- Headache
- Stroke
- Sleep
- Congenital
- Injury
- Neoplasms and cancer
- Other
- Symptoms and signs
- head and neck
- eponymous
- lesions
- Tests
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|
Treatment |
- Procedures
- Drugs
- general anesthetics
- analgesics
- dependence
- epilepsy
- cholinergics
- migraine
- Parkinson's
- vertigo
- other
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Histaminergics
|
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Receptor
(ligands) |
H1 |
- Agonists: 2-Pyridylethylamine
- Betahistine
- Histamine
- HTMT
- UR-AK49
- Antagonists: First-generation: 4-Methyldiphenhydramine
- Alimemazine
- Antazoline
- Azatadine
- Bamipine
- Benzatropine (benztropine)
- Bepotastine
- Bromazine
- Brompheniramine
- Buclizine
- Captodiame
- Carbinoxamine
- Chlorcyclizine
- Chloropyramine
- Chlorothen
- Chlorphenamine
- Chlorphenoxamine
- Cinnarizine
- Clemastine
- Clobenzepam
- Clocinizine
- Cyclizine
- Cyproheptadine
- Dacemazine
- Decloxizine
- Deptropine
- Dexbrompheniramine
- Dexchlorpheniramine
- Dimenhydrinate
- Dimetindene
- Diphenhydramine
- Diphenylpyraline
- Doxylamine
- Embramine
- Etodroxizine
- Etybenzatropine (ethylbenztropine)
- Etymemazine
- Flunarizine
- Histapyrrodine
- Homochlorcyclizine
- Hydroxyethylpromethazine
- Hydroxyzine
- Isopromethazine
- Isothipendyl
- Meclozine
- Medrylamine
- Mepyramine (pyrilamine)
- Mequitazine
- Methafurylene
- Methapyrilene
- Methdilazine
- Moxastine
- Orphenadrine
- Oxatomide
- Oxomemazine
- Phenindamine
- Pheniramine
- Phenyltoloxamine
- Pimethixene
- Piperoxan
- Pipoxizine
- Promethazine
- Propiomazine
- Pyrrobutamine
- Talastine
- Thenalidine
- Thenyldiamine
- Thiazinamium
- Thonzylamine
- Tolpropamine
- Tripelennamine
- Triprolidine
- Second/third-generation: Acrivastine
- Alinastine
- Astemizole
- Azelastine
- Bamirastine
- Barmastine
- Bepiastine
- Bepotastine
- Bilastine
- Cabastinen
- Carebastine
- Cetirizine
- Clemastine
- Clemizole
- Clobenztropine
- Desloratadine
- Dorastine
- Ebastine
- Efletirizine
- Emedastine
- Epinastine
- Fexofenadine
- Flezelastine
- Ketotifen
- Latrepirdine
- Levocabastine
- Levocetirizine
- Linetastine
- Loratadine
- Mapinastine
- Mebhydrolin
- Mizolastine
- Moxastine
- Noberastine
- Octastine
- Olopatadine
- Perastine
- Pibaxizine
- Piclopastine
- Rocastine
- Rupatadine
- Setastine
- Talastine
- Temelastine
- Terfenadine
- Vapitadine
- Zepastine
- Non-generational: Atypical antipsychotics (e.g., aripiprazole, asenapine, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone, zotepine)
- Tetracyclic antidepressants (e.g., amoxapine, loxapine, maprotiline, mianserin, mirtazapine, oxaprotiline)
- Tricyclic antidepressants (e.g., amitriptyline, butriptyline, clomipramine, desipramine, dosulepin (dothiepin), doxepin, imipramine, iprindole, lofepramine, nortriptyline, protriptyline, trimipramine)
- Typical antipsychotics (e.g., chlorpromazine, flupenthixol, fluphenazine, loxapine, perphenazine, prochlorperazine, thioridazine, thiothixene)
- Unknown/unsorted: Belarizine
- Elbanizine
- Flotrenizine
- Napactadine
- Tagorizine
- Trelnarizine
- Trenizine
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H2 |
- Agonists: Amthamine
- Betazole
- Dimaprit
- Histamine
- HTMT
- Impromidine
- UR-AK49
- Antagonists: Bisfentidine
- Burimamide
- Cimetidine
- Dalcotidine
- Donetidine
- Ebrotidine
- Etintidine
- Famotidine
- Lafutidine
- Lamtidine
- Lavoltidine (loxtidine)
- Lupitidine
- Metiamide
- Mifentidine
- Niperotidine
- Nizatidine
- Osutidine
- Oxmetidine
- Pibutidine
- Quisultazine (quisultidine)
- Ramixotidine
- Ranitidine
- Roxatidine
- Sufotidine
- Tiotidine
- Tuvatidine
- Venritidine
- Xaltidine
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|
H3 |
- Agonists: α-Methylhistamine
- Cipralisant
- Histamine
- Imetit
- Immepip
- Immethridine
- Methimepip
- Proxyfan
- Antagonists: A-349,821
- A-423,579
- ABT-239
- ABT-652
- AZD5213
- Betahistine
- Burimamide
- Ciproxifan
- Clobenpropit
- Conessine
- Enerisant
- GSK-189,254
- Impentamine
- Iodophenpropit
- Irdabisant
- JNJ-5207852
- MK-0249
- NNC 38-1049
- PF-03654746
- Pitolisant
- SCH-79687
- Thioperamide
- VUF-5681
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H4 |
- Agonists: 4-Methylhistamine
- α-Methylhistamine
- Histamine
- VUF-8430
- Antagonists: JNJ-7777120
- Mianserin
- Thioperamide
- Toreforant
- VUF-6002
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Transporter
(inhibitors) |
VMATs |
TAAR1 inactive |
- Amiodarone
- APP
- AZIK
- Bietaserpine
- Deserpidine
- Dihydrotetrabenazine
- Efavirenz
- GBR-12935
- GZ-793A
- Ibogaine
- Ketanserin
- Lobeline
- Methoxytetrabenazine
- NBI-98854
- Reserpine
- Rose bengal
- SD-809
- Tetrabenazine
- Vanoxerine (GBR-12909)
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TAAR1 active |
- Amphetamine
- Methamphetamine
- MDMA
- Phenethylamine
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Enzyme
(inhibitors) |
HDC |
- Catechin
- Meciadanol
- Naringenin
- Tritoqualine
|
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HNMT |
- Amodiaquine
- Diphenhydramine
- Harmaline
- Metoprine
- Quinacrine
- SKF-91,488
- Tacrine
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DAO |
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Others |
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Index of the respiratory system
|
|
Description |
- Anatomy
- Physiology
- Development
|
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Disease |
- Congenital
- Neoplasms and cancer
- Chest trauma
- Infection
- common cold
- pneumonia
- tuberculosis
- Other
- Symptoms and signs
|
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Treatment |
- Procedures
- Drugs
- nasal
- throat
- obstructive airway diseases
- cough and cold
- histaminergics
- pulmonary arterial hypertension
- other
- Surgery
|
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References
- ^ PDB: 3HI7; McGrath AP, Hilmer KM, Collyer CA, Shepard EM, Elmore BO, Brown DE, Dooley DM, Guss JM (2009). "Structure and inhibition of human diamine oxidase". Biochemistry 36 (41): 9810–9822. doi:10.1021/bi9014192. PMC 2791411. PMID 19764817. ; rendered with PyMOL
- ^ Agúndez, JA; Ayuso, P; Cornejo-García, JA; Blanca, M; Torres, MJ; Doña, I; Salas, M; Blanca-López, N; Canto, G; Rondon, C; Campo, P; Laguna, JJ; Fernández, J; Martínez, C; García-Martín, E (2012). "The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs". PLOS ONE 7 (11): e47571. doi:10.1371/journal.pone.0047571. PMID 23152756.
UpToDate Contents
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English Journal
- Levels of biogenic amines in retail market fermented meat products.
- Papavergou EJ, Savvaidis IN, Ambrosiadis IA.SourceLaboratory of Food Technology, Department of Hygiene and Technology of Food of Animal Origin, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, GR 54124 Thessaloniki, Greece. Electronic address: ekpap@vet.auth.gr.
- Food chemistry.Food Chem.2012 Dec 15;135(4):2750-5. doi: 10.1016/j.foodchem.2012.07.049. Epub 2012 Jul 16.
- The qualitative and quantitative profile of biogenic amines (BA) in 50 samples of dry fermented sausages sold in Greek retail markets were determined by HPLC. Putrescine, cadaverine, tryptamine, β-phenylethylamine spermidine, spermine were analysed by UV detection after pre-column derivatization wi
- PMID 22980868
Japanese Journal
- Pentamines as Substrate for Human Spermine Oxidase
- Takao Koichi,Shirahata Akira,Samejima Keijiro,Casero Jr. Robert Anthony,Igarashi Kazuei,Sugita Yoshiaki
- Biological and Pharmaceutical Bulletin 36(3), 407-411, 2013
- … Substrate activities of various linear polyamines to human spermine oxidase (hSMO) were investigated. …
- NAID 130003382080
- Purification and Molecular Analysis of a Monoamine Oxidase Isolated from Narcissus tazetta
- CUI Zhifeng,ZHANG Yongming,INOUE Hironori,YOGO Syun,HIRASAWA Eiji
- Bioscience, Biotechnology, and Biochemistry 77(8), 1728-1733, 2013
- … Semicarbazide-sensitive amine oxidase activity was detected in Narcissus tazetta. …
- NAID 130003361196
Related Links
- amine oxidase amine oxidase (1) Amine oxidase (flavin-containing), EC 1.4.3.4 (Amine:oxygen oxidoreductase (deaminating) (flavin-containing)). (2) Amine oxidase (copper-containing), EC 1.4.3.6 (Amine:oxygen oxidoreductase ...
- The origin of mammalian plasma amine oxidases. J Neural Transm. 2007; 114(6):757-62. Epub 2007 Mar 26. [J Neural Transm. 2007] Substrate selectivity of monoamine oxidase A, monoamine oxidase B, diamine oxidase, and ...
Related Pictures
★リンクテーブル★
[★]
モノアミン酸化酵素A、モノアミンオキシダーゼA
- 関
- amine oxidase、MAO、MAO-A、MAO-B、monoamine oxidase、monoamine oxidase B
[★]
モノアミン酸化酵素B、モノアミンオキシダーゼB
- 関
- amine oxidase、MAO、MAO-A、MAO-B、monoamine oxidase、monoamine oxidase A
[★]
- 英
- amine oxidase
- 関
- モノアミン酸化酵素、モノアミン酸化酵素A、モノアミン酸化酵素B、アミン酸化酵素
[★]
- 英
- amine oxidase
- 関
- アミンオキシダーゼ
[★]
- 関
- copper-containing amine oxidase、diamine oxidase、histaminase
[★]
- 関
- copper amine oxidase、diamine oxidase、histaminase
[★]
ベンジルアミン酸化酵素、ベンジルアミンオキシダーゼ
[★]
モノアミン酸化酵素阻害薬, MAOI