WordNet

respiratory disease characterized by inflammation of the lung parenchyma (excluding the bronchi) with congestion caused by viruses or bacteria or irritants

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1. レジオネラ感染の臨床症候および診断 clinical manifestations and diagnosis of legionella infection
2. レジオネラ感染の治療および予防 treatment and prevention of legionella infection
3. レジオネラ感染の疫学および病因 epidemiology and pathogenesis of legionella infection
4. 成人における市中肺炎に対する診断的アプローチ diagnostic approach to community acquired pneumonia in adults
5. 入院を要する成人における市中肺炎の治療 treatment of community acquired pneumonia in adults who require hospitalization

Peptidylprolyl cis-trans isomerases of Legionella pneumophila: virulence, moonlighting and novel therapeutic targets.

Rasch J1, Unal CM, Steinert M.
Biochemical Society transactions.Biochem Soc Trans.2014 Dec 1;42(6):1728-33. doi: 10.1042/BST20140202.
Legionella pneumophila, typically a parasite of free-living protozoa, can also replicate in human alveolar macrophages and lung epithelial cells causing Legionnaires' disease in humans, a severe atypical pneumonia. The pathogen encodes six peptidylprolyl cis-trans isomerases (PPIases), which general
PMID 25399597

Complete and Ubiquitinated Proteome of the Legionella-Containing Vacuole within Human Macrophages.

Brukert WM1, Abu Kwaik Y.
Journal of proteome research.J Proteome Res.2014 Nov 13. [Epub ahead of print]
Within protozoa or human macrophages Legionella pneumophila evades the endosomal pathway and replicates within an ER-derived vacuole termed the Legionella-containing vacuole (LCV). The LCV membrane-localized AnkB effector of L. pneumophila is an F-box protein that mediates decoration of the LCV with
PMID 25369898

Aerosolisation of respirable droplets from a domestic spa pool: the use of MS-2 coliphage and Pseudomonas aeruginosa as markers for Legionella pneumophila.

Moore G1, Hewitt M2, Stevenson D2, Walker JT2, Bennett AM2.
Applied and environmental microbiology.Appl Environ Microbiol.2014 Nov 7. pii: AEM.02912-14. [Epub ahead of print]
Legionnaires' disease can result when droplets or aerosols containing legionella bacteria are inhaled and deposited in the lungs. A number of outbreaks have been associated with the use of a spa pool where aeration, a high water temperature and a large and variable organic load makes disinfectant le
PMID 25381233