GM-CSF receptor

• 顆粒球マクロファージコロニー刺激因子受容体、顆粒球マクロファージコロニー刺激因子レセプター、GM-CSF受容体、GM-CSFレセプター

関

granulocyte-macrophage colony-stimulating factor receptor

WordNet

1. the 3rd letter of the Roman alphabet (同)c
2. (music) the keynote of the scale of C major
3. a general-purpose programing language closely associated with the UNIX operating system
4. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
5. the 7th letter of the Roman alphabet (同)g

PrepTutorEJDIC

1. carbonの化学記号
2. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/04 21:54:03」(JST)

wiki en

[Wiki en表示]

Colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3CXE
Identifiers
Symbols	CSF2RA; CD116; CDw116; CSF2R; CSF2RAX; CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR; GMR; SMDP4
External IDs	OMIM: 425000 MGI: 1339754 HomoloGene: 48406 ChEMBL: 2020 GeneCards: CSF2RA Gene
Gene Ontology Molecular function • receptor activity • cytokine receptor activity Cellular component • extracellular region • plasma membrane • integral to plasma membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1438	12982
Ensembl	ENSG00000198223	ENSMUSG00000059326
UniProt	P15509	Q00941
RefSeq (mRNA)	NM_001161529	NM_009970
RefSeq (protein)	NP_001155001	NP_034100
Location (UCSC)	Chr X: 1.39 – 1.43 Mb	Chr 19: 61.22 – 61.23 Mb
PubMed search	[1]	[2]

The granulocyte macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on myeloblast, mature neutrophil, but not on any erythroid or megakaryocytic lineage cells.

It is associated with Surfactant metabolism dysfunction type 4.

Structure

The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor. The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.

Signal transduction

Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family. This leads to association with a Shc adaptor protein. Then Shc interacts with GRB2/SoS complex which results in activation of more downstream molecules in the pathway.

References

Further reading

• Rappold G, Willson TA, Henke A, Gough NM (1992). "Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region". Genomics 14 (2): 455–461. doi:10.1016/S0888-7543(05)80241-1. PMID 1358805. 
• Hayashida K, Kitamura T, Gorman DM et al. (1991). "Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9655–9659. doi:10.1073/pnas.87.24.9655. PMC 55231. PMID 1702217. 
• Crosier KE, Wong GG, Mathey-Prevot B et al. (1991). "A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7744–7748. doi:10.1073/pnas.88.17.7744. PMC 52379. PMID 1715577. 
• Raines MA, Liu L, Quan SG et al. (1991). "Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor". Proc. Natl. Acad. Sci. U.S.A. 88 (18): 8203–8207. doi:10.1073/pnas.88.18.8203. PMC 52475. PMID 1832774. 
• Gough NM, Gearing DP, Nicola NA et al. (1990). "Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region". Nature 345 (6277): 734–736. doi:10.1038/345734a0. PMID 1972780. 
• Ashworth A, Kraft A (1991). "Cloning of a potentially soluble receptor for human GM-CSF". Nucleic Acids Res. 18 (23): 7178–7178. doi:10.1093/nar/18.23.7178. PMC 332824. PMID 2148207. 
• Gearing DP, King JA, Gough NM, Nicola NA (1990). "Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor". EMBO J. 8 (12): 3667–76. PMC 402049. PMID 2555171. 
• DiPersio J, Billing P, Kaufman S et al. (1988). "Characterization of the human granulocyte-macrophage colony-stimulating factor receptor". J. Biol. Chem. 263 (4): 1834–41. PMID 2828352. 
• Williams WV, VonFeldt JM, Rosenbaum H et al. (1994). "Molecular cloning of a soluble form of the granulocyte-macrophage colony-stimulating factor receptor alpha chain from a myelomonocytic cell line. Expression, biologic activity, and preliminary analysis of transcript distribution". Arthritis Rheum. 37 (10): 1468–1478. doi:10.1002/art.1780371010. PMID 7945472. 
• Jubinsky PT, Laurie AS, Nathan DG et al. (1995). "Expression and function of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit". Blood 84 (12): 4174–85. PMID 7994031. 
• Hu X, Emanuel PD, Zuckerman KS (1994). "Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor". Biochim. Biophys. Acta 1223 (2): 306–308. doi:10.1016/0167-4889(94)90241-0. PMID 8086503. 
• Nakagawa Y, Kosugi H, Miyajima A et al. (1994). "Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily". J. Biol. Chem. 269 (14): 10905–12. PMID 8144676. 
• Zhao Y, Rong H, Chegini N (1996). "Expression and selective cellular localization of granulocyte-macrophage colony-stimulating factor (GM-CSF) and GM-CSF alpha and beta receptor messenger ribonucleic acid and protein in human ovarian tissue". Biol. Reprod. 53 (4): 923–930. doi:10.1095/biolreprod53.4.923. PMID 8547489. 
• Lia F, Rajotte D, Clark SC, Hoang T (1996). "A dominant negative granulocyte-macrophage colony-stimulating factor receptor alpha chain reveals the multimeric structure of the receptor complex". J. Biol. Chem. 271 (45): 28287–28293. doi:10.1074/jbc.271.45.28287. PMID 8910448. 
• Wei S, Liu JH, Epling-Burnette PK et al. (1996). "Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor". J. Immunol. 157 (11): 5155–62. PMID 8943427. 
• Soldi R, Primo L, Brizzi MF et al. (1997). "Activation of JAK2 in human vascular endothelial cells by granulocyte-macrophage colony-stimulating factor". Blood 89 (3): 863–72. PMID 9028317. 
• Matsuguchi T, Zhao Y, Lilly MB, Kraft AS (1997). "The cytoplasmic domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha subunit is essential for both GM-CSF-mediated growth and differentiation". J. Biol. Chem. 272 (28): 17450–17459. doi:10.1074/jbc.272.28.17450. PMID 9211889. 
• Rivas CI, Vera JC, Delgado-López F et al. (1998). "Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer". Blood 91 (3): 1037–43. PMID 9446667. 
• Hu X, Zuckerman KS (1998). "Cloning and sequencing of an alternative splicing-derived cDNA variant of the GM-CSF receptor alpha subunit, which encodes a truncated protein". Am. J. Hematol. 58 (2): 145–147. doi:10.1002/(SICI)1096-8652(199806)58:2<145::AID-AJH11>3.0.CO;2-A. PMID 9625584. 
• Taha RA, Leung DY, Ghaffar O et al. (1998). "In vivo expression of cytokine receptor mRNA in atopic dermatitis". J. Allergy Clin. Immunol. 102 (2): 245–250. doi:10.1016/S0091-6749(98)70093-4. PMID 9723668. 

External links

• GM-CSF Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 1. 小児における肺胞蛋白症 pulmonary alveolar proteinosis in children
• 2. 成人における肺胞蛋白症の臨床症状および病因 clinical manifestations and etiology of pulmonary alveolar proteinosis in adults
• 3. 成人における肺胞蛋白症の診断および治療 diagnosis and treatment of pulmonary alveolar proteinosis in adults
• 4. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
• 5. 骨髄造血の制御 regulation of myelopoiesis

English Journal

• Dose-response effects of TPI ASM8 in asthmatics after allergen.

• Gauvreau GM, Pageau R, Seguin R, Carballo D, Gauthier J, D'Anjou H, Campbell H, Watson R, Mistry M, Parry-Billings M, Killian K, Renzi PM.SourceMcMaster University, Hamilton, ON Topigen Pharmaceuticals Inc, a member of the Pharmaxis Ltd group., Montreal, QC University of Montreal, Montreal, QC, Canada.
• Allergy.Allergy.2011 Sep;66(9):1242-8. doi: 10.1111/j.1398-9995.2011.02638.x. Epub 2011 May 24.
• To cite this article: Gauvreau GM, Pageau R, Seguin R, Carballo D, Gauthier J, D'Anjou H, Campbell H, Watson R, Mistry M, Parry-Billings M, Killian K, Renzi PM. Dose-response effects of TPI ASM8 in asthmatics after allergen. Allergy 2011; 66: 1242-1248. ABSTRACT: Background:? TPI ASM8 contains tw
• PMID 21605124

• Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-{alpha}, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study.

• Burmester GR, Feist E, Sleeman MA, Wang B, White B, Magrini F.SourceCorrespondence to Gerd-Rudiger Burmester, Department of Rheumatology and Clinical Immunology, Charite - University Medicine Berlin, Free University and Humboldt University Berlin, Chariteplatz 1, 10117 Berlin, Germany; gerd.burmester@charite.de.
• Annals of the rheumatic diseases.Ann Rheum Dis.2011 Sep;70(9):1542-9. Epub 2011 May 25.
• OBJECTIVE: To evaluate the safety, tolerability, pharmacokinetic and pharmacodynamic profiles of mavrilimumab, a human monoclonal antibody targeting the granulocyte-macrophage colony-stimulating factor receptor-α, in subjects with rheumatoid arthritis (RA).METHODS: A randomised, double-blind, place
• PMID 21613310

Japanese Journal

• Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB.

• Tanaka Takeshi,Motoi Natsuki,Tsuchihashi Yoshiko,Tazawa Ryushi,Kaneko Chinatsu,Nei Takahito,Yamamoto Toshiyuki,Hayashi Tomayoshi,Tagawa Tsutomu,Nagayasu Takeshi,Kuribayashi Futoshi,Ariyoshi Koya,Nakata Koh,Morimoto Konosuke
• Journal of medical genetics 48(3), 205-209, 2011-03
• … Background Disruption of granulocyte/macrophage colony-stimulating factor (GM-CSF) signalling causes pulmonary alveolar proteinosis (PAP). … Rarely, genetic defects in neonatal or infant-onset PAP have been identified in CSF2RA. … However, no report has clearly identified any function-associated genetic defect in CSF2RB. … She was negative for GM-CSF autoantibody and had no underlying disease. …
• NAID 120002695916

• 慢性副鼻腔炎 : ―難治例の病態とその対応―

• 平川 勝洋
• 耳鼻咽喉科臨床 104(4), 239-247, 2011
• … Inflammatory entities, including cytokines—IL-5 and GM-CSF, chemokines such as eotaxin, and chemical mediators such as CysLTs are reportedly related to eosinophilic sinonasal mucosal inflammation. … Local and/or systemic steroids and leukotriene receptor antagonists are also recommended. …
• NAID 130000805075

Related Links

• Granulocyte macrophage colony-stimulating factor receptor ...

"Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM- CSF receptor family". Cytokine Growth Factor Rev. ... "Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region". Nature 345 (6277): ...

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★リンクテーブル★

リンク元	「顆粒球マクロファージコロニー刺激因子受容体」「顆粒球マクロファージコロニー刺激因子レセプター」「GM-CSF受容体」「GM-CSFレセプター」「granulocyte-macrophage colony-stimulating factor receptor」
関連記事	「CS」「C」「CSF」「G」「CSF receptor」

「顆粒球マクロファージコロニー刺激因子受容体」

　　[★]

英

granulocyte-macrophage colony-stimulating factor receptor、GM-CSF receptor

関

顆粒球マクロファージコロニー刺激因子レセプター、GM-CSF受容体、GM-CSFレセプター

「顆粒球マクロファージコロニー刺激因子レセプター」

　　[★]

英

granulocyte-macrophage colony-stimulating factor receptor、GM-CSF receptor

関

顆粒球マクロファージコロニー刺激因子受容体、GM-CSF受容体、GM-CSFレセプター

「GM-CSF受容体」

　　[★]

英

GM-CSF receptor

関

顆粒球マクロファージコロニー刺激因子受容体、顆粒球マクロファージコロニー刺激因子レセプター、GM-CSFレセプター

「GM-CSFレセプター」

　　[★]

英

GM-CSF receptor

関

顆粒球マクロファージコロニー刺激因子受容体、顆粒球マクロファージコロニー刺激因子レセプター、GM-CSF受容体

「granulocyte-macrophage colony-stimulating factor receptor」

　　[★]

• 顆粒球マクロファージコロニー刺激因子受容体、顆粒球マクロファージコロニー刺激因子レセプター

関

GM-CSF receptor

「CS」

　　[★]

• コケイン症候群 Cockayne syndrome
• サイクロセリン cycloserine
• 冠状静脈洞 coronary sinus
• カウデン症候群 Cowden syndrome
• 膀胱鏡 cystoscope
• 帝王切開術 帝王切開 cesarean section
• クリニカルシナリオ clinical scenario
• 頚部変形性脊椎症 cervical spondylosis

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「CSF」

　　[★]

• 脳脊髄液, cerebrospinal fluid
• コロニー刺激因子, colony stimulating factor

「G」

　　[★]

• グアニン guanine
• グアノシン guanosine
• グリシン glycine

　

「CSF receptor」

　　[★]

• コロニー刺激因子受容体

関

colony-stimulating factor receptor、CSFR