関: GRK1、rhodopsin kinase

WordNet

link together; "can we couple these proposals?" (同)couple on, couple up
two items of the same kind (同)pair, twosome, twain, brace, span, yoke, couplet, distich, duo, duet, dyad, duad
a small indefinite number; "hes coming for a couple of days"
a pair of people who live together; "a married couple from Chicago" (同)mates, match
a pair who associate with one another; "the engaged couple"; "an inseparable twosome" (同)twosome, duo, duet
(physics) something joined by two equal and opposite forces that act along parallel lines
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
a unit of force equal to the force exerted by gravity; used to indicate the force to which a body is subjected when it is accelerated (同)gee, g-force
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

PrepTutorEJDIC

(同種類の物が)『2個』《+『of』+『名』》 / 『夫婦』,男女一組 / 《話》(…の)いくらか,少数《+『of』+『名』》 / …'を'『つなぎ合わせる』;(…に)…'を'連結する《+『名』+『to』(『with』)+『名』》 / …'を'(…と)関連づける《+『名』+『with』(『to』)+『名』》 / …'を'結婚させる,〈動物〉'を'つがわせる / 〈動物〉交尾する
蛋白(たんばく)質
=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/13 16:50:30」(JST)

wiki en

Rhodopsin kinase (EC 2.7.11.14, cone opsin kinase, G-protein-coupled receptor kinase 1, GPCR kinase 1, GRK1, GRK7, opsin kinase, opsin kinase (phosphorylating), rhodopsin kinase (phosphorylating), RK, STK14) is a serine/threonine-specific protein kinase involved in phototransduction.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8] This enzyme catalyses the following chemical reaction

ATP + rhodopsin ADP + phosphorhodopsin

Mutations in rhodopsin kinase are associated with a form of night blindness called Oguchi disease.^[9]

References

^ Benovic, J.L., Mayor, F., Jr., Somers, R.L., Caron, M.G. and Lefkowitz, R.J. (1986). "Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase". Nature 321 (6073): 869–872. doi:10.1038/321869a0. PMID 3014340.
^ Shichi, H. and Somers, R.L. (1978). "Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase". J. Biol. Chem. 253 (19): 7040–7046. PMID 690139.
^ Palczewski, K., McDowell, J.H. and Hargrave, P.A. (1988). "Purification and characterization of rhodopsin kinase". J. Biol. Chem. 263 (28): 14067–14073. PMID 2844754.
^ Weller, M., Virmaux, N. and Mandel, P. (1975). "Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin". Proc. Natl. Acad. Sci. USA 72 (1): 381–385. doi:10.1073/pnas.72.1.381. PMID 164024.
^ Cha, K., Bruel, C., Inglese, J. and Khorana, H.G. (1997). "Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications". Proc. Natl. Acad. Sci. USA 94 (20): 10577–10582. doi:10.1073/pnas.94.20.10577. PMID 9380677.
^ Khani, S.C., Abitbol, M., Yamamoto, S., Maravic-Magovcevic, I. and Dryja, T.P. (1996). "Characterization and chromosomal localization of the gene for human rhodopsin kinase". Genomics 35 (3): 571–576. doi:10.1006/geno.1996.0399. PMID 8812493.
^ Chen, C.K., Zhang, K., Church-Kopish, J., Huang, W., Zhang, H., Chen, Y.J., Frederick, J.M. and Baehr, W. (2001). "Characterization of human GRK7 as a potential cone opsin kinase". Mol. Vis. 7: 305–313. PMID 11754336.
^ Willets, J.M., Challiss, R.A. and Nahorski, S.R. (2003). "Non-visual GRKs: are we seeing the whole picture?". Trends Pharmacol. Sci. 24: 626–633. doi:10.1016/j.tips.2003.10.003. PMID 14654303.
^ Yamamoto S, Sippel KC, Berson EL, Dryja TP. (1997). "Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness.". Nat Genet USA 15 (2): 175–8. doi:10.1038/ng0297-175. PMID 9020843.

External links

Rhodopsin kinase at the US National Library of Medicine Medical Subject Headings (MeSH)

This biochemistry article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ペプチドホルモンのシグナル伝達および調節 peptide hormone signal transduction and regulation
2. 収縮能障害による心不全におけるβブロッカー使用の理論的根拠および臨床試験 rationale for and clinical trials of beta blockers in heart failure due to systolic dysfunction
3. セクレチン secretin
4. 血管作動性腸管ポリペプチド vasoactive intestinal polypeptide
5. 喘息におけるβ刺激剤：長期使用に関する議論 beta agonists in asthma controversy regarding chronic use

English Journal

Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding.

Vishnivetskiy SA, Ostermaier MK, Singhal A, Panneels V, Homan KT, Glukhova A, Sligar SG, Tesmer JJ, Schertler GF, Standfuss J, Gurevich VV.Author information Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.AbstractThe effects of activating mutations associated with night blindness on the stoichiometry of rhodopsin interactions with G protein-coupled receptor kinase 1 (GRK1) and arrestin-1 have not been reported. Here we show that the monomeric form of WT rhodopsin and its constitutively active mutants M257Y, G90D, and T94I, reconstituted into HDL particles are effectively phosphorylated by GRK1, as well as two more ubiquitously expressed subtypes, GRK2 and GRK5. All versions of arrestin-1 tested (WT, pre-activated, and constitutively monomeric mutants) bind to monomeric rhodopsin and show the same selectivity for different functional forms of rhodopsin as in native disc membranes. Rhodopsin phosphorylation by GRK1 and GRK2 promotes arrestin-1 binding to a comparable extent, whereas similar phosphorylation by GRK5 is less effective, suggesting that not all phosphorylation sites on rhodopsin are equivalent in promoting arrestin-1 binding. The binding of WT arrestin-1 to phospho-opsin is comparable to the binding to its preferred target, P-Rh*, suggesting that in photoreceptors arrestin-1 only dissociates after opsin regeneration with 11-cis-retinal, which converts phospho-opsin into inactive phospho-rhodopsin that has lower affinity for arrestin-1. Reduced binding of arrestin-1 to the phospho-opsin form of G90D mutant likely contributes to night blindness caused by this mutation in humans.
Cellular signalling.Cell Signal.2013 Nov;25(11):2155-62. doi: 10.1016/j.cellsig.2013.07.009. Epub 2013 Jul 17.
The effects of activating mutations associated with night blindness on the stoichiometry of rhodopsin interactions with G protein-coupled receptor kinase 1 (GRK1) and arrestin-1 have not been reported. Here we show that the monomeric form of WT rhodopsin and its constitutively active mutants M257Y,
PMID 23872075

A 1.1Mb deletion in distal 13q deletion syndrome region with congenital heart defect and postaxial polydactyly: additional support for a CHD locus at distal 13q34 region.

Yang YF, Ai Q, Huang C, Chen JL, Wang J, Xie L, Zhang WZ, Yang JF, Tan ZP.Author information Department of Cardiothoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.Abstract13q deletion syndrome is a rare genetic disorder, especially for group 3 deletion (13q33-q34 deletion). Previously we described a patient with congenital heart defect and mental retardation and proposed that a distal 6Mb region might contain the causative gene of congenital heart defect. Here we present a new patient with congenital heart defects (CHD), hand and foot anomalies and mild mental retardation. We identified a 1.1Mb deletion at chromosome 13q34 with high resolution SNP-array BeadChips (HumanOmni1-Quad, Illumina, USA). This chromosome region contains ten annotated genes, including GRK1, TFDP1, RASA3 and GAS6. To our knowledge, this represents the smallest 13q34 deletion identified to date. Our study provides additional support that distal 13q34 deletion region might contain key gene(s) responsible for cardiac development.
Gene.Gene.2013 Oct 1;528(1):51-4. doi: 10.1016/j.gene.2013.03.145. Epub 2013 Apr 29.
13q deletion syndrome is a rare genetic disorder, especially for group 3 deletion (13q33-q34 deletion). Previously we described a patient with congenital heart defect and mental retardation and proposed that a distal 6Mb region might contain the causative gene of congenital heart defect. Here we pre
PMID 23639964

Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.

Kay CN, Ryals RC, Aslanidi GV, Min SH, Ruan Q, Sun J, Dyka FM, Kasuga D, Ayala AE, Van Vliet K, Agbandje-McKenna M, Hauswirth WW, Boye SL, Boye SE.Author information Department of Ophthalmology, University of Florida College of Medicine, Gainesville, Florida, United States of America.AbstractDevelopment of viral vectors capable of transducing photoreceptors by less invasive methods than subretinal injection would provide a major advancement in retinal gene therapy. We sought to develop novel AAV vectors optimized for photoreceptor transduction following intravitreal delivery and to develop methodology for quantifying this transduction in vivo. Surface exposed tyrosine (Y) and threonine (T) residues on the capsids of AAV2, AAV5 and AAV8 were changed to phenylalanine (F) and valine (V), respectively. Transduction efficiencies of self-complimentary, capsid-mutant and unmodified AAV vectors containing the smCBA promoter and mCherry cDNA were initially scored in vitro using a cone photoreceptor cell line. Capsid mutants exhibiting the highest transduction efficiencies relative to unmodified vectors were then injected intravitreally into transgenic mice constitutively expressing a Rhodopsin-GFP fusion protein in rod photoreceptors (Rho-GFP mice). Photoreceptor transduction was quantified by fluorescent activated cell sorting (FACS) by counting cells positive for both GFP and mCherry. To explore the utility of the capsid mutants, standard, (non-self-complementary) AAV vectors containing the human rhodopsin kinase promoter (hGRK1) were made. Vectors were intravitreally injected in wildtype mice to assess whether efficient expression exclusive to photoreceptors was achievable. To restrict off-target expression in cells of the inner and middle retina, subsequent vectors incorporated multiple target sequences for miR181, an miRNA endogenously expressed in the inner and middle retina. Results showed that AAV2 containing four Y to F mutations combined with a single T to V mutation (quadY-F+T-V) transduced photoreceptors most efficiently. Robust photoreceptor expression was mediated by AAV2(quadY-F+T-V) -hGRK1-GFP. Observed off-target expression was reduced by incorporating target sequence for a miRNA highly expressed in inner/middle retina, miR181c. Thus we have identified a novel AAV vector capable of transducing photoreceptors following intravitreal delivery to mouse. Furthermore, we describe a robust methodology for quantifying photoreceptor transduction from intravitreally delivered AAV vectors.
PloS one.PLoS One.2013 Apr 26;8(4):e62097. doi: 10.1371/journal.pone.0062097. Print 2013.
Development of viral vectors capable of transducing photoreceptors by less invasive methods than subretinal injection would provide a major advancement in retinal gene therapy. We sought to develop novel AAV vectors optimized for photoreceptor transduction following intravitreal delivery and to deve
PMID 23637972

Japanese Journal

Expression of gonadotropin-inhibitory hormone receptors in mouse pituitary gonadotroph LβT2 cells and hypothalamic gonadotropin-releasing hormone-producing GT1-7 cells

Sukhbaatar Unurjargal,Kanasaki Haruhiko,Mijiddorj Tselmeg,Oride Aki,Miyazaki Kohji
Endocrine Journal 61(1), 25-34, 2014
… In the mouse pituitary gonadotroph cell line LβT2, GnRH increased expression of the GnIH receptor, G-protein coupled receptor 74 (GPR74). … The overexpression of either constitutively active MEK kinase (MEKK) or protein kinase A (PKA) in LβT2 cells increased the expression of GPR74 mRNA. …
NAID 130004443925

Different phosphorylation rates among vertebrate cone visual pigments with different spectral sensitivities.

Tsutsui Kei,Tachibanaki Shuji,Shimauchi-Matsukawa Yoshie,Shichida Yoshinori,Kawamura Satoru
Biochemical and biophysical research communications 440(4), 630-634, 2013-11-01
… Phosphorylation by G protein-coupled receptor kinase (GRK) is essential for the rapid inactivation of light-activated visual pigment, which is the rate-limiting step of the cone photoresponse recovery in salamander. …
NAID 120005353493

Molecular properties of muscarinic acetylcholine receptors

HAGA Tatsuya
Proceedings of the Japan Academy. Ser. B, Physical and Biological Sciences 89(6), 226-256, 2013-06
NAID 40019673379

「GRK1」

G protein-coupled receptor kinase 1
Identifiers
Symbol	GRK1
Alt. symbols	RHOK
Entrez	6011
HUGO	10013
OMIM	180381
RefSeq	NM_002929
UniProt	Q15835
Other data
EC number	2.7.11.14
Locus	Chr. 13 q34

　　[★]

Gタンパク質共役受容体キナーゼ1

関: G-protein-coupled receptor kinase 1

「Gタンパク質共役受容体キナーゼ1」

　　[★]

英: G-protein-coupled receptor kinase 1、GRK1
関: ロドプシンキナーゼ

「rhodopsin kinase」

　　[★]

ロドプシンキナーゼ

関: G-protein-coupled receptor kinase 1

「couple」

　　[★]

v.

共役する、連関する、結合する、カップルする、

n.

一対

関: associate、association、bind、binding、bond、bonding、combine、conjoin、conjugate、conjugated、conjugation、conjunction、connect、connection、coupling、dock、doublet、engage、engagement、family characteristics、generation、household、join、ligate、linkage、pair、symphysial、union

「kinase」

　　[★] キナーゼカイネースリン酸化酵素 phosphoenzyme phosphotransferase 　

「G」

　　[★]

「G protein」

　　[★]

同: G proteins

同: G proteins

「Gd」

　　[★]

同: ガドリニウム造影MRI

[1] Benovic, J.L., Mayor, F., Jr., Somers, R.L., Caron, M.G. and Lefkowitz, R.J. (1986). "Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase". Nature 321 (6073): 869–872. doi:10.1038/321869a0. PMID 3014340.

[2] Shichi, H. and Somers, R.L. (1978). "Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase". J. Biol. Chem. 253 (19): 7040–7046. PMID 690139.

[3] Palczewski, K., McDowell, J.H. and Hargrave, P.A. (1988). "Purification and characterization of rhodopsin kinase". J. Biol. Chem. 263 (28): 14067–14073. PMID 2844754.

[4] Weller, M., Virmaux, N. and Mandel, P. (1975). "Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin". Proc. Natl. Acad. Sci. USA 72 (1): 381–385. doi:10.1073/pnas.72.1.381. PMID 164024.

[5] Cha, K., Bruel, C., Inglese, J. and Khorana, H.G. (1997). "Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications". Proc. Natl. Acad. Sci. USA 94 (20): 10577–10582. doi:10.1073/pnas.94.20.10577. PMID 9380677.

[6] Khani, S.C., Abitbol, M., Yamamoto, S., Maravic-Magovcevic, I. and Dryja, T.P. (1996). "Characterization and chromosomal localization of the gene for human rhodopsin kinase". Genomics 35 (3): 571–576. doi:10.1006/geno.1996.0399. PMID 8812493.

[7] Chen, C.K., Zhang, K., Church-Kopish, J., Huang, W., Zhang, H., Chen, Y.J., Frederick, J.M. and Baehr, W. (2001). "Characterization of human GRK7 as a potential cone opsin kinase". Mol. Vis. 7: 305–313. PMID 11754336.

[8] Willets, J.M., Challiss, R.A. and Nahorski, S.R. (2003). "Non-visual GRKs: are we seeing the whole picture?". Trends Pharmacol. Sci. 24: 626–633. doi:10.1016/j.tips.2003.10.003. PMID 14654303.

[9] Yamamoto S, Sippel KC, Berson EL, Dryja TP. (1997). "Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness.". Nat Genet USA 15 (2): 175–8. doi:10.1038/ng0297-175. PMID 9020843.

リンク元	「GRK1」「Gタンパク質共役受容体キナーゼ1」「rhodopsin kinase」
関連記事	「couple」「kinase」「G」「G protein」「Gd」

匿名

検索

案内

案内

G-protein-coupled receptor kinase 1