GRK1

Gタンパク質共役受容体キナーゼ1

関: G-protein-coupled receptor kinase 1

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/09/14 01:08:59」(JST)

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G protein-coupled receptor kinase 1
Identifiers
Symbol	GRK1
Alt. symbols	RHOK
Entrez	6011
HUGO	10013
OMIM	180381
RefSeq	NM_002929
UniProt	Q15835
Other data
EC number	2.7.11.14
Locus	Chr. 13 q34

Rhodopsin kinase is a serine/threonine-specific protein kinase involved in phototransduction.

See also

Rhodopsin
Beta adrenergic receptor kinase
G-protein coupled receptor kinases

External links

Rhodopsin+kinase at the US National Library of Medicine Medical Subject Headings (MeSH)

This biochemistry article is a stub. You can help Wikipedia by expanding it.

Kinases: Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1, LATS2, MAST1, MAST2, STK38, STK38L, CIT, ROCK1, SGK, SGK2, SGK3, Protein kinase B (AKT1, AKT2, AKT3), Ataxia telangiectasia mutated, Mammalian target of rapamycin, EIF-2 kinases (PKR, HRI, EIF2AK3, EIF2AK4), Wee1 (WEE1)

Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1, PDK2, PDK3

Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α (PRKAA1, PRKAA2) · β (PRKAB1, PRKAB2) · γ (PRKAG1, PRKAG2, PRKAG3)

(3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)) (EC 2.7.11.4)	BCKDK, BCKDHA, BCKDHB

(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2, IDH3A, IDH3B, IDH3G

(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4

Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase (Aurora A kinase, Aurora B kinase)

Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK, STK10

Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-

IκB kinase (EC 2.7.11.10)	CHUK, IKK2, TBK1, IKBKE, IKBKG, IKBKAP

cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A, PRKACG, PRKACB, PRKACA, PRKY

cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G, PRKG1

Protein kinase C (EC 2.7.11.13)	Protein kinase C, Protein kinase Cζ, PKC alpha, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCG, PRKCI, PRKCQ, Protein kinase N1, PKN2, PKN3,

Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase

Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase, Beta adrenergic receptor kinase-2

G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4, GRK5, GRK6

Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, MLCK, CASK, CHEK1, CHEK2, DAPK1, DAPK2, DAPK3, STK11, MAPKAPK2, MAPKAPK3, MAPKAPK5, MARK1, MARK2, MARK3, MARK4, MELK, MKNK1, MKNK2, NUAK1, NUAK2, OBSCN, PASK, PHKG1, PHKG2, PIM1, PIM2, PKD1, PRKD2, PRKD3, PSKH1, SNF1LK2, KIAA0999, STK40, SNF1LK, SNRK, SPEG, TSSK2, Kalirin, TRIB1, TRIB2, TRIB3, TRIO, Titin, DCLK1

Myosin light-chain kinase (EC 2.7.11.18)	MYLK, MYLK2, MYLK3, MYLK4

Phosphorylase kinase (EC 2.7.11.19)	PHKA1, PHKA2, PHKB, PHKG1, PHKG2

Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K, STK19

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1, PLK2, PLK3, PLK4

Cyclin-dependent kinase (EC 2.7.11.22)	CDK1, CDK2, CDKL2, CDK3, CDK4, CDK5, CDKL5, CDK6, CDK7, CDK8, CDK9, CDK10, CDC2L5, CRKRS, PCTK1, PCTK2, PCTK3, PFTK1, CDC2L1

(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5, RPS6KA4, P70S6 kinase, P70-S6 Kinase 1, RPS6KB2, RPS6KA2, RPS6KA3, RPS6KA1, RPS6KC1

Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated (MAPK1, MAPK3, MAPK4, MAPK6, MAPK7, MAPK12, MAPK15), C-Jun N-terminal (MAPK8, MAPK9, MAPK10), P38 mitogen-activated protein (MAPK11, MAPK13, MAPK14)

MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases (MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8) RAFs (ARAF, BRAF, KSR1, KSR2), MLKs (MAP3K12, MAP3K13, MAP3K9, MAP3K10, MAP3K11, MAP3K7, ZAK), CDC7, MAP3K14

Tau-protein kinase (EC 2.7.11.26)	TPK1, TTK, GSK-3

(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-

Tropomyosin kinase (EC 2.7.11.28)	-

Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-

Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors (BMPR1, BMPR1A, BMPR1B, BMPR2), ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7

B
enzm
1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
2.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
2.7.10
2.7.11-12
3.1
- - 3.1.3.48
- 2
- 3
- 4
  - 3.4.21
- 5
- 6
- 7
- 22
- 23
- 24
4.1
- 2
- 3
- 4
- 5
- 6
5.1
- 2
- 3
- 4
- 99
6.1-3
- 4
- 5-6

Eye proteins

Opsin (retinylidene protein)

visual	Rhodopsin Photopsin (OPN1LW OPN1MW/OPN1MW2 OPN1SW)

nonvisual	Melanopsin OPN3 OPN5

Crystallin

Alpha (A
B)
Beta (A1
A2
A4
B1
B2
B3)
Gamma (A
B
C
D
N
S)

Other

Arrestin
Guanylate cyclase activator
Recoverin
Rhodopsin kinase

M: EYE

anat(g/a/p)/phys/devp/prot

noco/cong/tumr, epon

proc, drug(S1A/1E/1F/1L)

English Journal

Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.

Osawa S, Jo R, Xiong Y, Reidel B, Tserentsoodol N, Arshavsky VY, Iuvone PM, Weiss ER.SourceDepartment of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599-7090, USA.
The Journal of biological chemistry.J Biol Chem.2011 Jun 10;286(23):20923-9. Epub 2011 Apr 19.
Phosphorylation of rhodopsin by G protein-coupled receptor kinase 1 (GRK1, or rhodopsin kinase) is critical for the deactivation of the phototransduction cascade in vertebrate photoreceptors. Based on our previous studies in vitro, we predicted that Ser(21) in GRK1 would be phosphorylated by cAMP-de
PMID 21504899

RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments.

Christiansen JR, Kolandaivelu S, Bergo MO, Ramamurthy V.SourceCenter for Neuroscience and Department of Ophthalmology, West Virginia University, Morgantown, WV 26505, USA.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2011 May 24;108(21):8862-6. Epub 2011 May 9.
Prenylation is the posttranslational modification of a carboxyl-terminal cysteine residue of proteins that terminate with a CAAX motif. Following prenylation, the last three amino acids are cleaved off by the endoprotease, RAS-converting enzyme 1 (RCE1), and the prenylcysteine residue is methylated.
PMID 21555557

Japanese Journal

2P-213 2種類の視物質キナーゼ(GRK1、GRK7)の活性の違いをもたらす領域の特定(光生物-視覚・光受容,第47回日本生物物理学会年会)

Seno Aki,Takemoto Norihiko,Tachibanaki Shuji,Kawamura Satoru
生物物理 49(SUPPLEMENT_1), S140, 2009-09-20
NAID 110008101789

2P-271 S-モジュリン、s26によるGRK1/GRK7制御機構(光生物・視覚,光受容(2),第46回日本生物物理学会年会)

Arinobu Daisuke,Tachibanaki Shuji,Kawamura Satoru
生物物理 48(SUPPLEMENT_1), S117, 2008-10-25
NAID 110007013769

Related Links

GRK1 Gene - GeneCards | RK Protein | RK Antibody

Complete information for GRK1 gene (protein-coding), G protein-coupled receptor kinase 1.

Related Pictures

grk1 grk1 Grotech GRK1 - Chambre de dégazage Newport F-GRK1 GRIN-ROD Lens Kit

★リンクテーブル★

リンク元	「Gタンパク質共役受容体キナーゼ1」「G-protein-coupled receptor kinase 1」
関連記事	「GRK」「GR」

「Gタンパク質共役受容体キナーゼ1」

英: G-protein-coupled receptor kinase 1、GRK1
関: ロドプシンキナーゼ

「G-protein-coupled receptor kinase 1」

Gタンパク質共役受容体キナーゼ1

関: GRK1、rhodopsin kinase

「GRK」

Gタンパク質共役受容体キナーゼ

関: G-protein-coupled receptor kinase

関: G protein receptor kinase

「GR」

グルココルチコイド受容体

関: glucocorticoid receptor

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