同: Fetomodulin, Thrombomodulin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/12 13:44:01」(JST)

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Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme.^[3] Thrombomodulin is also expressed on human mesothelial cell,^[4] monocyte and a dendritic cell subset.

Genetics and Structure

In humans, thrombomodulin is encoded by the THBD gene.^[5] The protein has a molecular mass of 74kDa, and consists of a single chain with six tandemly repeated EGF-like domains, a Serine/Threonine-rich spacer and a transmembrane domain.^[6]

Function

Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. This raises the speed of protein C activation thousandfold. Thrombomodulin-bound thrombin has procoagulant effect at the same time by inhibiting fibrinolysis by cleaving thrombin-activatable fibrinolysis inhibitor (TAFI,aka carboxypeptidase B2) into its active form.^{[citation needed]}

Thrombomodulin is a glycoprotein on the surface of endothelial cells that, in addition to binding thrombin, regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene (THBD) have also been reported to be associated with atypical hemolytic-uremic syndrome (aHUS).^{[citation needed]}

The antigen described as BDCA-3^[7] has turned out to be identical to thrombomodulin.^[8] Thus, it was revealed that this molecule also occurs on a very rare (0.02%) subset of human dendritic cells called MDC2. Its function on these cells is unknown.^{[citation needed]}

Interactions

Thrombomodulin has been shown to interact with thrombin.^[9]^[10]

References

^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ IPR001491 Thrombomodulin Accessed January 19, 2012.
^ Verhagen HJ, Heijnen-Snyder GJ, Pronk A, Vroom TM, van Vroonhoven TJ, Eikelboom BC, Sixma JJ, de Groot PG (Dec 1996). "Thrombomodulin activity on mesothelial cells: perspectives for mesothelial cells as an alternative for endothelial cells for cell seeding on vascular grafts". British Journal of Haematology. 95 (3): 542–9. doi:10.1046/j.1365-2141.1996.d01-1935.x. PMID 8943899.
^ Wen DZ, Dittman WA, Ye RD, Deaven LL, Majerus PW, Sadler JE (Jul 1987). "Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene". Biochemistry. 26 (14): 4350–7. doi:10.1021/bi00388a025. PMID 2822087.
^ Sadler JE (Jul 1997). "Thrombomodulin structure and function". Thrombosis and haemostasis. 78 (1): 392–5. PMID 9198185.
^ Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, Buck DW, Schmitz J (Dec 2000). "BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood". Journal of Immunology (Baltimore, Md. : 1950). 165 (11): 6037–46. doi:10.4049/jimmunol.165.11.6037. PMID 11086035.
^ Dzionek A, Inagaki Y, Okawa K, Nagafune J, Röck J, Sohma Y, Winkels G, Zysk M, Yamaguchi Y, Schmitz J (Dec 2002). "Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions". Human Immunology. 63 (12): 1133–48. doi:10.1016/S0198-8859(02)00752-8. PMID 12480257.
^ Bajzar L, Morser J, Nesheim M (Jul 1996). "TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex". The Journal of Biological Chemistry. 271 (28): 16603–8. doi:10.1074/jbc.271.28.16603. PMID 8663147.
^ Jakubowski HV, Owen WG (Jul 1989). "Macromolecular specificity determinants on thrombin for fibrinogen and thrombomodulin". The Journal of Biological Chemistry. 264 (19): 11117–21. PMID 2544585.

External links

GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
OMIM entries on Atypical Hemolytic-Uremic Syndrome

English Journal

Best immunohistochemical panel in distinguishing adenocarcinoma from squamous cell carcinoma of lung: tissue microarray assay in resected lung cancer specimens.

Kim MJ, Shin HC, Shin KC, Ro JY.SourceDepartment of Pathology, Yeungnam University College of Medicine, 317-1 Daemyung-5dong, Nam-gu, Daegu, 705-717, South Korea. Electronic address: mjkap@ynu.ac.kr.
Annals of diagnostic pathology.Ann Diagn Pathol.2013 Feb;17(1):85-90. doi: 10.1016/j.anndiagpath.2012.07.006. Epub 2012 Oct 4.
The emergence of the targeted therapies for non-small cell lung carcinoma (NSCLC) has generated a need for accurate histologic subtyping of NSCLC. In this study, we assessed the utility of immunohistochemical markers that could be helpful in distinction between adenocarcinoma (ADC) and squamous cell
PMID 23040737

Fcγ receptor antigen targeting potentiates cross-presentation by human blood and lymphoid tissue BDCA-3+ dendritic cells.

Flinsenberg TW, Compeer EB, Koning D, Klein M, Amelung FJ, van Baarle D, Boelens JJ, Boes M.SourceDepartments of Pediatric Immunology, and.
Blood.Blood.2012 Dec 20;120(26):5163-72. doi: 10.1182/blood-2012-06-434498. Epub 2012 Oct 23.
The reactivation of human cytomegalovirus (HCMV) poses a serious health threat to immune compromised individuals. As a treatment strategy, dendritic cell (DC) vaccination trials are ongoing. Recent work suggests that BDCA-3(+) (CD141(+)) subset DCs may be particularly effective in DC vaccination tri
PMID 23093620

Japanese Journal

Th1/Th2 関連疾患における末梢血樹状細胞サブセットの解析

林ゆめ子
Dokkyo journal of medical sciences 40(1), T13-T22, 2013-03-25
… CD1a+),mDC2( CD141+)のサブセット解析を行った.サ症群では総DC, mDC の数が有意に低下していた.mDC/pDC 比は3 群間で差がなかった.CD1a+mDC は,サ症群では対照群と差がなかったが,アトピー群ではCD1a+mDC の減少,CD1a−mDC の増加を認め,CD1a+/CD1a−mDC比は小さかった.CD141+mDC はアトピー群で有意に増加していたが,CD141−mDC 数は3 群間で有意差はなかった.CD141−/ …
NAID 110009561263

Related Pictures

CD141 ELISA Kits | Biocompare.com CD141 - MST-Design Wassertransferdruck & Lackierzubehör Anti Human CD141 Antibody, clone QBEND/40 | Bio-Rad Antibodies (formerly AbD Serotec) Art Quality Design - Présentation du Papier Aluminium Brossé CD141

★リンクテーブル★

リンク元	「thrombomodulin」
関連記事	「CD14」「CD1」

「thrombomodulin」

THBD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ADX, 1DQB, 1DX5, 1EGT, 1FGD, 1FGE, 1HLT, 1TMR, 1ZAQ, 2ADX, 3GIS
Identifiers
Aliases	THBD, AHUS6, BDCA3, CD141, THPH12, THRM, TM, thrombomodulin
External IDs	OMIM: 188040 MGI: 98736 HomoloGene: 308 GeneCards: THBD
Gene ontology
Molecular function	• calcium ion binding; • protein binding; • transmembrane signaling receptor activity; • receptor activity;
Cellular component	• integral component of membrane; • cell surface; • plasma membrane; • integral component of plasma membrane; • membrane; • apicolateral plasma membrane; • vacuolar membrane; • extracellular space;
Biological process	• hemostasis; • female pregnancy; • negative regulation of platelet activation; • response to lipopolysaccharide; • response to cAMP; • negative regulation of fibrinolysis; • blood coagulation; • response to X-ray; • leukocyte migration; • signal transduction; • negative regulation of blood coagulation;
	Sources:Amigo / QuickGO
RNA expression pattern
	; ;
	More reference expression data
Orthologs
	7056
	21824
	ENSG00000178726
	ENSMUSG00000074743
	P07204
	P15306
	NM_000361
	NM_009378
	NP_000352
	NP_033404.1; NP_033404
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★] トロンボモジュリン、CD141

「CD14」

　　[★]

同？: リポ多糖受容体 LPS受容体 lipopolysaccharide receptor, LPS receptor

単球、マクロファージ、好中球の細胞膜上に存在し、LPS-LBP複合体をTLRを共役して受容し、TNF-α、IL-1を産生するシグナルを伝達するらしい

LPSの受容 (SMB.117)

LPSはマクロファージ、単球、顆粒球、Bリンパ球と反応し、多彩な生物活性を発現する。この反応には細胞表面のToll-like receptor。TLR-4がLPSのレセブタ-としてはたらき, LPSのシグナルを細胞内へと伝達する。このTLR-4の機能不全はLPSに対する応答性を失わせる。 TLR-4のほかに, CD14やMD-2と呼ばれる分子もLPSの認識に関与している。このTLRは分子群を形成し,ペプチドグリカン,リポタンパク質DNAなどの菌体成分を認識し,感染防御に重要なシグナルを伝達する。

発現細胞

骨髄性単球細胞

機能

LPSの直接の受容体であり、Toll-like receptorとともに細胞内へのシグナル伝達に関わる。
LPS-LBP複合体の受容体　←　日本語がよく分かりません

「CD1」

　　[★]

同: leucine-6, CD1A through E

種類

CD1a, CD1b, CD1c, CD1d

発現組織

胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)

分子量

43-49

機能

MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens

[1] "Human PubMed Reference:".

[2] "Mouse PubMed Reference:".

[3] IPR001491 Thrombomodulin Accessed January 19, 2012.

[4] Verhagen HJ, Heijnen-Snyder GJ, Pronk A, Vroom TM, van Vroonhoven TJ, Eikelboom BC, Sixma JJ, de Groot PG (Dec 1996). "Thrombomodulin activity on mesothelial cells: perspectives for mesothelial cells as an alternative for endothelial cells for cell seeding on vascular grafts". British Journal of Haematology. 95 (3): 542–9. doi:10.1046/j.1365-2141.1996.d01-1935.x. PMID 8943899.

[pmid2822087-5] Wen DZ, Dittman WA, Ye RD, Deaven LL, Majerus PW, Sadler JE (Jul 1987). "Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene". Biochemistry. 26 (14): 4350–7. doi:10.1021/bi00388a025. PMID 2822087.

[6] Sadler JE (Jul 1997). "Thrombomodulin structure and function". Thrombosis and haemostasis. 78 (1): 392–5. PMID 9198185.

[pmid11086035-7] Dzionek A, Fuchs A, Schmidt P, Cremer S, Zysk M, Miltenyi S, Buck DW, Schmitz J (Dec 2000). "BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood". Journal of Immunology (Baltimore, Md. : 1950). 165 (11): 6037–46. doi:10.4049/jimmunol.165.11.6037. PMID 11086035.

[pmid12480257-8] Dzionek A, Inagaki Y, Okawa K, Nagafune J, Röck J, Sohma Y, Winkels G, Zysk M, Yamaguchi Y, Schmitz J (Dec 2002). "Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions". Human Immunology. 63 (12): 1133–48. doi:10.1016/S0198-8859(02)00752-8. PMID 12480257.

[pmid8663147-9] Bajzar L, Morser J, Nesheim M (Jul 1996). "TAFI, or plasma procarboxypeptidase B, couples the coagulation and fibrinolytic cascades through the thrombin-thrombomodulin complex". The Journal of Biological Chemistry. 271 (28): 16603–8. doi:10.1074/jbc.271.28.16603. PMID 8663147.

[pmid2544585-10] Jakubowski HV, Owen WG (Jul 1989). "Macromolecular specificity determinants on thrombin for fibrinogen and thrombomodulin". The Journal of Biological Chemistry. 264 (19): 11117–21. PMID 2544585.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

匿名

検索

案内

案内

CD141