WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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1. 血液透析装置の概要 overview of the hemodialysis apparatus
2. 成人におけるセリアック病の病因、疫学、および臨床症状 pathogenesis epidemiology and clinical manifestations of celiac disease in adults
3. 成人における発熱の病態生理および治療 pathophysiology and treatment of fever in adults
4. 嫌気性感染症における病態生理、臨床的な手がかり、および微生物の回収方法 pathophysiology clinical clues and recovery of organisms in anaerobic infections
5. 敗血症に対する治験剤および無効剤 investigational and ineffective therapies for sepsis

Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata.

Zhang SM1, Loker ES2, Sullivan JT3.
Developmental and comparative immunology.Dev Comp Immunol.2016 Mar;56:25-36. doi: 10.1016/j.dci.2015.11.008. Epub 2015 Nov 22.
The anterior pericardial wall of the snail Biomphalaria glabrata has been identified as a site of hemocyte production, hence has been named the amebocyte-producing organ (APO). A number of studies have shown that exogenous abiotic and biotic substances, including pathogen associated molecular patter
PMID 26592964

Uropathogenic Escherichia coli Engages CD14-Dependent Signaling to Enable Bladder-Macrophage-Dependent Control of Acute Urinary Tract Infection.

Carey AJ1, Sullivan MJ1, Duell BL1, Crossman DK2, Chattopadhyay D3, Brooks AJ4, Tan CK1, Crowley M2, Sweet MJ5, Schembri MA6, Ulett GC7.
The Journal of infectious diseases.J Infect Dis.2016 Feb 15;213(4):659-68. doi: 10.1093/infdis/jiv424. Epub 2015 Aug 30.
BACKGROUND: CD14, a coreceptor for several pattern recognition receptors and a widely used monocyte/macrophage marker, plays a key role in host responses to gram-negative bacteria. Despite the central role of CD14 in the inflammatory response to lipopolysaccharide and other microbial products and in
PMID 26324782

Avramescu S1, Wang DS, Lecker I, To WT, Penna A, Whissell PD, Mesbah-Oskui L, Horner RL, Orser BA.
Anesthesiology.Anesthesiology.2016 Feb;124(2):417-27. doi: 10.1097/ALN.0000000000000943.
BACKGROUND: Critically ill patients with severe inflammation often exhibit heightened sensitivity to general anesthetics; however, the underlying mechanisms remain poorly understood. Inflammation increases the number of γ-aminobutyric acid type A (GABAA) receptors expressed on the surface of neuron
PMID 26566283

Landiolol hydrochloride ameliorates acute lung injury in a rat model of early sepsis through the suppression of elevated levels of pulmonary endothelin-1

Cyclic ADP-ribose and heat regulate oxytocin release via CD38 and TRPM2 in the hypothalamus during social or psychological stress in mice

Adiponectin Inhibits LPS-Induced HMGB1 Release through an AMP Kinase and Heme Oxygenase-1-Dependent Pathway in RAW 264 Macrophage Cells

リンク元

「CD14」

LPSはマクロファージ、単球、顆粒球、Bリンパ球と反応し、多彩な生物活性を発現する。この反応には細胞表面のToll-like receptor。TLR-4がLPSのレセブタ-としてはたらき, LPSのシグナルを細胞内へと伝達する。このTLR-4の機能不全はLPSに対する応答性を失わせる。 TLR-4のほかに, CD14やMD-2と呼ばれる分子もLPSの認識に関与している。このTLRは分子群を形成し,ペプチドグリカン,リポタンパク質DNAなどの菌体成分を認識し,感染防御に重要なシグナルを伝達する。