WordNet

a long-playing phonograph record; designed to be played at 33.3 rpm (同)L-P
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
the 12th letter of the Roman alphabet (同)l

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Insight into the antimicrobial activities of coprisin isolated from the dung beetle, Copris tripartitus, revealed by structure-activity relationships.

Lee E, Kim JK, Shin S, Jeong KW, Shin A, Lee J, Lee DG, Hwang JS, Kim Y.SourceDepartment of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Institute of SMART Biotechnology, Konkuk University, Seoul 143-701, South Korea.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Feb;1828(2):271-83. doi: 10.1016/j.bbamem.2012.10.028. Epub 2012 Nov 6.
The novel 43-residue, insect defensin-like peptide coprisin, isolated from the dung beetle, Copris tripartitus, is a potent antibiotic with bacterial cell selectivity, exhibiting antimicrobial activities against Gram-positive and Gram-negative bacteria without exerting hemolytic activity against hum
PMID 23137439

Stronger Toll-like receptor 1/2, 4, and 7/8 but less 9 responses in peripheral blood mononuclear cells in non-infectious exacerbated asthmatic children.

Lee WI, Yao TC, Yeh KW, Chen LC, Ou LS, Huang JL; the PATCH Study Group.SourceDivision of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan.
Immunobiology.Immunobiology.2013 Feb;218(2):192-200. doi: 10.1016/j.imbio.2012.04.002. Epub 2012 May 22.
Toll-like receptors (TLR) initiate innate and often affect adaptive immune response. This study aimed to determine if TLR response and T regulatory cell (Treg) function in peripheral blood mononuclear cells (PBMC) correlate with clinical severity in non-infectious asthma. TLR1-9 expression and repre
PMID 22727330

Crosstalk between Toll like receptors and C5a receptor in human monocyte derived DCs suppress inflammatory cytokine production.

Zaal A, Lissenberg-Thunnissen SN, van Schijndel G, Wouters D, Ham SM, Ten Brinke A.SourceDepartment of Immunopathology, Sanquin Research and Landsteiner Laboratory, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands.
Immunobiology.Immunobiology.2013 Feb;218(2):175-80. doi: 10.1016/j.imbio.2012.02.014. Epub 2012 Mar 3.
The complement anaphylatoxin, C5a has been implicated in regulation of adaptive immune responses through modulation of APC function as shown mainly in studies in mice. C5a was shown to enhance cytokine production in immature DCs, but the effect of C5a on DC function during DC activation has not been
PMID 22559913

Effects of Chondroitin Sulfate and Its Oligosaccharides on Toll-Like Receptor-Mediated IL-6 Secretion by Macrophage-Like J774.1 Cells

JIN Miao,IWAMOTO Taku,YAMADA Kiyoshi,SATSU Hideo,TOTSUKA Mamoru,SHIMIZU Makoto
Bioscience, biotechnology, and biochemistry 75(7), 1283-1289, 2011-07-23
… The effects of two types of chondroitin sulphate (CS), CS-A and CS-C, their oligosaccharides (oligo-CSs), and disaccharides (Di-CSs) on toll-like receptor (TLR)-mediated secretion of interleukin (IL)-6 were compared using macrophage-like cell line J774.1. … IL-6 secretion in the J774.1 cells was markedly increased by Pam3CS4, LPS, and CpG, the ligands to TLR1/2, 4, and 9 respectively. …
NAID 10029329031

A new peptide motif present in the protective antigen of anthrax toxin exerts its efficiency on the cellular uptake of liposomes and applications for a dual-ligand system

Kibria Golam,Hatakeyama Hiroto,Harashima Hideyoshi
International Journal of Pharmaceutics 412(1-2), 106-114, 2011-06-30
… Domain 4 of PA (PA-D4) acts as a receptor binding site for tumor endothelial marker 8 (TEM8). … The efficiency of KYND motif on cellular association was assessed by evaluating the cellular uptake of PEGylated liposomes (PEG-LPs) in TEM8 positive and negative cells. …
NAID 120003118172

LPSはマクロファージ、単球、顆粒球、Bリンパ球と反応し、多彩な生物活性を発現する。この反応には細胞表面のToll-like receptor。TLR-4がLPSのレセブタ-としてはたらき, LPSのシグナルを細胞内へと伝達する。このTLR-4の機能不全はLPSに対する応答性を失わせる。 TLR-4のほかに, CD14やMD-2と呼ばれる分子もLPSの認識に関与している。このTLRは分子群を形成し,ペプチドグリカン,リポタンパク質DNAなどの菌体成分を認識し,感染防御に重要なシグナルを伝達する。