ビタミンK1。フィトナジオン
WordNet
- United States guitar player and singer of the blues (born in 1925) (同)B. B. King, Riley B King
- United States woman tennis player (born in 1943) (同)Billie Jean King, Billie Jean Moffitt King
- United States charismatic civil rights leader and Baptist minister who campaigned against the segregation of Blacks (1929-1968) (同)Martin Luther King, Martin Luther King Jr.
- street names for ketamine (同)jet, super acid, special K, honey oil, green, cat valium, super C
- the 11th letter of the Roman alphabet (同)k
- any of a group of organic substances essential in small quantities to normal metabolism
PrepTutorEJDIC
- Kelvin / Kindergarten / (チェスの)King / kalium(ラテン語)(=potassium)の化学記号
- 『ビタミン』,栄養素(身体の喜常な機能を維持するために少量ながら必要な有機化合物)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/28 13:16:46」(JST)
[Wiki en表示]
Phylloquinone
|
| Names |
| IUPAC name
2-methyl-3-[(2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthoquinone
|
| Other names
Vitamin K1; phytomenadione; phytonadione
|
| Identifiers |
|
CAS Number
|
84-80-0 Y |
| ChEBI |
CHEBI:18067 Y |
| ChEMBL |
ChEMBL1550 Y |
| ChemSpider |
4447652 Y |
| DrugBank |
DB01022 Y |
| Jmol interactive 3D |
Image |
| PubChem |
4812 |
| UNII |
A034SE7857 Y |
InChI
-
InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1 Y
Key: MBWXNTAXLNYFJB-NKFFZRIASA-N Y
-
InChI=1/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
Key: MBWXNTAXLNYFJB-NKFFZRIABL
|
SMILES
-
CC1=C(C(=O)c2ccccc2C1=O)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C
|
| Properties |
|
Chemical formula
|
C31H46O2 |
| Molar mass |
450.70 g/mol |
| Pharmacology |
| ATC code |
B02BA01 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
| Y verify (what is YN ?) |
| Infobox references |
|
|
Phylloquinone, also Vitamin K1, is a polycyclic aromatic ketone, based on 2-methyl-1,4-naphthoquinone, with a 3-phytyl substituent.
It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants, particularly leaves, since it functions as an electron acceptor during photosynthesis, forming part of the electron transport chain of Photosystem I.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[1]
Contents
- 1 Terminology
- 2 Biochemistry
- 3 See also
- 4 External links
- 5 References
Terminology
It is often called vitamin K,[2] phytomenadione or phytonadione. Sometimes a distinction is made with phylloquinone considered natural and phytonadione considered synthetic.[3]
A stereoisomer of phylloquinone is called vitamin k1 (note the difference in capitalization).
Biochemistry
Phylloquinone is an electron acceptor during photosynthesis, forming part of the electron transport chain of Photosystem I.
Its best-known function in animals is as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX, and X by the liver. It is also required for the formation of anticoagulant factors protein C and S. It is commonly used to treat warfarin toxicity, and as an antidote for coumatetralyl.
Vitamin K is required for bone protein formation.[4]
See also
External links
Listen to this article (info/dl)
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More spoken articles
References
- ^ "WHO Model List of Essential Medicines: 18th list" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
- ^ Haroon Y, Shearer MJ, Rahim S, Gunn WG, McEnery G, Barkhan P (June 1982). "The content of phylloquinone (vitamin K1) in human milk, cows' milk, and infant formula foods determined by high-performance liquid chromatography". J. Nutr. 112 (6): 1105–17. PMID 7086539.
- ^ "Vitamin K". Retrieved 2009-03-18.
- ^ "Vitamin K: Phylloquinone". TrackMyStack. Retrieved 23 August 2015.
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Vitamins (A11)
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|
| Fat soluble |
| A |
- α-Carotene
- β-Carotene
- Retinol#
- Tretinoin
|
|
| D |
- D2
- Ergosterol
- Ergocalciferol#
- D3
- 7-Dehydrocholesterol
- Previtamin D3
- Cholecalciferol
- 25-hydroxycholecalciferol
- Calcitriol (1,25-dihydroxycholecalciferol)
- Calcitroic acid
- D4
- D5
- D analogues
- Alfacalcidol
- Dihydrotachysterol
- Calcipotriol
- Tacalcitol
- Paricalcitol
|
|
| E |
- Tocopherol
- Tocotrienol
- Tocofersolan
|
|
| K |
- Naphthoquinone
- Phylloquinone (K1)
- Menaquinones (K2)
- Menadione (K3)‡
- Menadiol (K4)
|
|
|
| Water soluble |
| B |
- B1
- B1 analogues
- Acefurtiamine
- Allithiamine
- Benfotiamine
- Fursultiamine
- Octotiamine
- Prosultiamine
- Sulbutiamine
- B2
- B3
- B5
- Pantothenic acid
- Dexpanthenol
- Pantethine
- B6
- Pyridoxine#, Pyridoxal phosphate
- Pyridoxamine
- Pyritinol
- B7
- B9
- Folic acid
- Dihydrofolic acid
- Folinic acid
- Levomefolic acid
- B12
- Cyanocobalamin
- Hydroxocobalamin
- Methylcobalamin
- Cobamamide
- Choline
|
|
| C |
- Ascorbic acid#
- Dehydroascorbic acid
|
|
|
| Combinations |
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
|
Index of nutrition
|
|
| Description |
- Vitamins
- Cofactors
- Metal metabolism
- Fats
- metabolism
- intermediates
- lipoproteins
- Sugars
- Glycolysis
- Glycogenesis and glycogenolysis
- Fructose and galactose
|
|
| Disease |
- Vitamins
- Carbohydrate
- Lipid
- Metals
- Other
- Symptoms and signs
- Tests
|
|
| Treatment |
- Drugs
- Vitamins
- Mineral supplements
|
|
|
|
Antihemorrhagics (B02)
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|
Antihemorrhagics
(coagulation) |
| Systemic |
| Vitamin K |
- Phytomenadione (K1)
- Menadione (K3)
|
|
Coagulation
factors |
- intrinsic: IX/Nonacog alfa
- VIII/Moroctocog alfa/Turoctocog alfa
- extrinsic: VII/Eptacog alfa
- common: X
- II/Thrombin
- I/Fibrinogen
- combinations: Prothrombin complex concentrate (II, VII, IX, X, protein C and S)
|
|
Other
systemic |
- Etamsylate
- Carbazochrome
- Batroxobin
- thrombopoietin receptor agonist (Romiplostim
- Eltrombopag)
|
|
|
| Local |
- Absorbable gelatin sponge
- Oxidized cellulose
- Tetragalacturonic acid hydroxymethylester
- Thrombin
- Collagen
- Calcium alginate
- Epinephrine/Adrenalone
|
|
|
| Antifibrinolytics |
- amino acids (Aminocaproic acid
- Tranexamic acid
- Aminomethylbenzoic acid)
serpins (Aprotinin
- Alfa1 antitrypsin
- C1-inhibitor
- Camostat)
|
|
|
Index of cells from bone marrow
|
|
| Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
- heme and porphyrin
|
|
| Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
|
|
| Treatment |
- Transfusion
- Drugs
- thrombosis
- bleeding
- other
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Increased matrix stiffness promotes tumor progression of residual hepatocellular carcinoma after insufficient heat treatment.
- Zhang R1, Ma M1, Dong G1, Yao RR1, Li JH1, Zheng QD1, Dong YY1, Ma H1, Gao DM1, Cui JF1, Ren ZG1, Chen RX1.
- Cancer science.Cancer Sci.2017 Jul 12. doi: 10.1111/cas.13322. [Epub ahead of print]
- PMID 28699238
- Oral Consumption of Vitamin K2 for 8 Weeks Associated With Increased Maximal Cardiac Output During Exercise.
- McFarlin BK, Henning AL, Venable AS.
- Alternative therapies in health and medicine.Altern Ther Health Med.2017 Jul;23(4):26-32.
- Background • Vitamin K1 and K2 are not typically common in a Western diet because they are found in a variety of fermented foods. Vitamin K2 in particular has been demonstrated to restore mitochondrial function and has a key role in production of mitochondrial adenosine triphosphate. Thus, it is r
- PMID 28646812
- α-Tocopheryl Phosphate Induces VEGF Expression via CD36/PI3Kγ in THP-1 Monocytes.
- Zingg JM1, Azzi A1, Meydani M1.
- Journal of cellular biochemistry.J Cell Biochem.2017 Jul;118(7):1855-1867. doi: 10.1002/jcb.25871. Epub 2017 Mar 24.
- PMID 28059487
Japanese Journal
- ラットにおけるビタミンK<sub>1</sub>またはビタミンK<sub>2</sub>経口投与によるアルカリホスファターゼ活性への影響
- Periprocedural Anticoagulation of Patients Undergoing Pericardiocentesis for Cardiac Tamponade Complicating Catheter Ablation of Atrial Fibrillation
- Periprocedural Anticoagulation of Patients Undergoing Pericardiocentesis for Cardiac Tamponade Complicating Catheter Ablation of Atrial Fibrillation
Related Links
- 発信者 構築グループ 本文 A．ビタミンKとは？ 天然に存在するビタミンKは2種類あり、緑黄色野菜・海藻類・緑茶・植物油などに含まれるビタミンK 1 (フィロキノン) と、もうひとつは腸内細菌によっても合成されるビタミンK 2 ...
- ビタミンK1錠5（ビタミンKです。ビタミンK不足によっておこる出血を予防、改善します。 ）について主な作用 副作用 用い方と注意点を説明します
Related Pictures
★リンクテーブル★
[★]
- 英
- phytonadione
- 同
- ビタミンK1 vitamin K1、フィトメナジオン phytomenadione、フィロキノン phylloquinone
- 商
- AquaMEPHYTON, Mephyton
- ビタミンＫ１、カチーフN、ビタK1、ヒメロンK1。
- (高カロリー輸液)フルカリック、ヘパンED、ネオパレン、エルネオパ
- (高カロリー輸液用総合ビタミン剤)ネオラミン・マルチＶ、オーツカＭＶ、ダイメジン・マルチ、ネオラミン・マルチＶ、ビタジェクト
- (肝不全用経口栄養剤)アミノレバンEN、オフタルム、ケーワン
- (経腸用液)ラコール、ラコールNF、ツインライン、エレンタール、エンシュア・リキッド、ツインラインNF
- 関
- ビタミンK
適応
- ビタミンＫ欠乏症の予防及び治療
- ビタミンＫ欠乏が推定される出血
併用注意
- クマリン系抗凝血薬(ワルファリン) ← 添付文書では併用注意だが、資料によっては併用禁忌とある。
[★]
フィトメナジオン
- 関
- phylloquinone、phytonadione、vitamin K1
[★]