- 同
- TIMPs, TIMP
WordNet
- limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
- control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
- limit the range or extent of; "Contact between the young was inhibited by strict social customs"
- a soft thin (usually translucent) paper (同)tissue_paper
- part of an organism consisting of an aggregate of cells having a similar structure and function
- a substance that retards or stops an activity
PrepTutorEJDIC
- 《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
- 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
- 〈U〉〈C〉(生物体の)『組織』 / 〈U〉〈C〉『薄織物』 / 〈U〉〈C〉水を吸収する柔らかな薄紙 / 〈C〉カーボンコピー用薄紙 / 〈C〉《a ~》(…を)織り交ぜて作ったもの《+of+名》 / =tissue paper
- 抑制する人(物) / 化学反応抑制剤
- OLD French古[代]フランス語
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/17 15:14:35」(JST)
[Wiki en表示]
The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4.[1]
Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP-9) can form complexes with TIMPs when the enzymes are in the latent form.
The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP (MMP-14), a membrane-anchored MMP.
The role of the pro-MMP-9/TIMP-1 complex is still unknown.
References
- ^ Brew K, Dinakarpandian D, Nagase H (2000). "Tissue inhibitors of metalloproteinases: evolution, structure and function". Biochim Biophys Acta 1477 (1–2): 267–83. doi:10.1016/S0167-4838(99)00279-4. PMID 10708863.
- Tissue Inhibitor of Metalloproteinases at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Caries correlates strongly to salivary levels of MMP-8.
- Hedenbjörk-Lager A1, Bjørndal L, Gustafsson A, Sorsa T, Tjäderhane L, Akerman S, Ericson D.
- Caries research.Caries Res.2015;49(1):1-8. doi: 10.1159/000360625. Epub 2014 Jul 31.
- The caries process in dentin involves the degradation of both mineral and organic matrix. The demineralization has been demonstrated to be caused by bacterial acids. However, the collagen degradation is considered to be initiated by endogenous proteolytic enzymes, mainly collagenolytic matrix metall
- PMID 25096527
- Effect of psychological stress on the structure of the temporomandibular joint and the expression of MMP-3 and TIMP-3 in the cartilage in rats.
- Huang X1, Liu H1, Xiao P1, Wang Y2, Zhang H1.
- The British journal of oral & maxillofacial surgery.Br J Oral Maxillofac Surg.2014 Oct;52(8):709-14. doi: 10.1016/j.bjoms.2014.06.016. Epub 2014 Jul 21.
- Our aim was to observe the effects of psychological stress on the structure of the temporomandibular joint (TMJ), and to evaluate the expression of matrix metallopeptidase-3 (MMP-3) and tissue inhibitor of metalloproteinase-3 (TIMP-3) in condylar chondrocytes in rats. The rats were divided into 3 gr
- PMID 25060974
- Vitamin d and s-farnesylthiosalicylic Acid have a synergistic effect on hepatic stellate cells proliferation.
- Neeman R1, Abramovitch S, Sharvit E, Elad-Sfadia G, Haklai R, Kloog Y, Reif S.
- Digestive diseases and sciences.Dig Dis Sci.2014 Oct;59(10):2462-9. doi: 10.1007/s10620-014-3207-2. Epub 2014 Jun 19.
- BACKGROUND: Hepatic stellate cells (HSCs) have a key role in the formation of hepatic fibrosis. The active form of vitamin D, 1,25(OH)2D3, has been found to have antiproliferative and antifibrotic effects in various tissues including liver. Farnesylthiosalicylic acid (FTS), a novel Ras antagonist, w
- PMID 24942325
Japanese Journal
- Tissue Inhibitor of Metalloproteinase-1 Is Responsible for Residual Pleural Thickening in Pleural Tuberculosis
- Hwang Ki-Eun,Shon Young-Jun,Cha Byong-Ki,Park Mi-Jeong,Chu Min-Su,Kim Young-Jun,Jeong Eun-Taik,Kim Hak-Ryul
- The Tohoku Journal of
- … Matrix metalloproteinases (MMPs) are zinc-dependent proteinases capable of degrading all components of the extracellular matrix. … The proteolytic action of MMPs may be involved in the pathogenesis of tuberculosis. …
- NAID 130005061505
- Expression of the Matrix Metalloproteinases and the Tissue Inhibitor of Metalloproteinase Factors are Affected by Tetramethylpyrazine Treatment in a Renal Interstitial Fibrosis Rat Model
- (-)-Epigallocatechin-3-gallate Inhibits Differentiation and Matrix Metalloproteinases Expression in Osteoclasts
- Irie Yuko,Iwai Shinichi,Amano Hitoshi,Ryu Kakei,Emori Haruka,Kawakami Tomoko,Kochidaira Hidehiro,Kobayashi Yoshito,Oguchi Katsuji
- Showa Univ J Med Sci 26(1), 63-74, 2014-03
- … Several studies have reported a relationship between tea consumption and decreased risk of bone fracture. … Matrix metalloproteinases (MMPs) play an important role in the degeneration of bone and cartilage matrix. … Regulation of osteoclast activity is essential in the treatment of bone disease. … However, the effects of EGCG on osteoclasts and other MMPs are not clear. …
- NAID 120005536500
Related Links
- The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4. Overall, all MMPs are inhibited by TIMPs ...
★リンクテーブル★
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- 同
- tissue inhibitor of metalloproteinases
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- 関
- abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression
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- 関
- blocker、depressant、suppressant
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メタロプロテアーゼ
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メタロプロテアーゼ