TIMPs

同

tissue inhibitor of metalloproteinases

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/31 21:45:23」(JST)

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"TIMP" redirects here. For the drug metabolite, see Thioinosine monophosphate.

The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4.

Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP-9) can form complexes with TIMPs when the enzymes are in the latent form.

The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP (MMP-14), a membrane-anchored MMP.

The role of the pro-MMP-9/TIMP-1 complex is still unknown.

References

• Tissue+Inhibitor+of+Metalloproteinases at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 1. 肝線維症の病因 pathogenesis of hepatic fibrosis
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English Journal

• The effect of substrate modulus on the growth and function of matrix-embedded endothelial cells.

• Murikipudi S, Methe H, Edelman ER.SourceHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: sylajam@mit.edu.
• Biomaterials.Biomaterials.2013 Jan;34(3):677-84. doi: 10.1016/j.biomaterials.2012.09.079. Epub 2012 Oct 24.
• Endothelial cells (EC) are potent bioregulatory cells, modulating thrombosis, inflammation and control over mural smooth muscle cells and vascular health. The biochemical roles of EC are retained when cells are embedded within three-dimensional (3D) denatured collagen matrices. Though substrate mech
• PMID 23102623

• Elevated serum MMP-9/TIMP-1 ratio in patients with homozygous familial hypercholesterolemia: Effects of LDL-apheresis.

• Nenseter MS, Narverud I, Græsdal A, Bogsrud MP, Halvorsen B, Ose L, Aukrust P, Holven KB.SourceLipid Clinic, Oslo University Hospital Rikshospitalet, Oslo, Norway; Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway. Electronic address: marit.s.nenseter@rr-research.no.
• Cytokine.Cytokine.2013 Jan;61(1):194-8. doi: 10.1016/j.cyto.2012.09.016. Epub 2012 Nov 4.
• OBJECTIVE: Matrix degradation within an atherosclerotic plaque is an important pathogenic factor in atherosclerosis, and is largely modulated by the balance between matrix metalloproteinases (MMPs) and their endogenous inhibitors (i.e., tissue inhibitor of MMPs [TIMPs]). Familial hypercholesterolemi
• PMID 23131422

Japanese Journal

• 臨床セミナー これからの心不全バイオマーカー(第3回)拡張不全のバイオマーカー(TIMPs,P？NP)

• 柳原 清孝,山本 一博
• Fluid management renaissance 2(1), 68-73, 2012-01-00
• NAID 40019294899

• The tissue inhibitors of metalloproteinases (TIMPs) : an ancient family with structural and functional diversity

• BREW K
• Biochim. Biophys. Acta 1803, 55-71, 2010
• NAID 80020867832

• The Role of MEKK1 in Hypertrophic Cardiomyopathy

• Konhilas John P.,Boucek Dana M.,Horn Todd R.,Johnson Gary L.,Leinwand Leslie A.
• International Heart Journal 51(4), 277-284, 2010
• … Since MEKK1 is required for the induction of several tissue proteases, we tested the hypothesis that cardiac enlargement of HCM- MEKK1-/- mice was due to altered expression of urokinase-type plasminogen activator (uPA), JunB, matrix-metalloproteinase (MMP), and tissue inhibitors of MMPs (TIMPs). …
• NAID 130000299284

Related Links

• 第一ファインケミカル株式会社｜MMPs TIMPs について

第一ファインケミカルの臨床検査薬・試薬事業（MMPs TIMPs）について。 ... MT1-MMP, MT2-MMP, MT3-MMP MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-20 TIMP-1, TIMP-2, TIMP-3, TIMP-4

• Flickr: timps' Photostream

Roosikott timps 0 Müüja põlleke timps 0 Esimene karp timps 1 1 Ehe ehe timps 1 Konn timps 0 Tööproov timps 2 Rahakott timps 2 Jah, see ma olen. timps 0 Vana Müts timps 0 Minu müts timps 2 Lepatriinud timps 0 Langevarjurist ...

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関連記事	「TIMP」「TIM」

「TIMP」

　　[★]

• 6-thioinosine 5'-monophosphate
• tissue inhibitor of metalloproteinases

「TIM」

　　[★] トリオースリン酸イソメラーゼ triosephosphate isomerase