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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/22 08:06:11」(JST)
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Timp (short for Mount Timpanogos) is the second highest mountain in Utah's Wasatch Range.
Timp or TIMP may refer to:
- Timp, a colloquial word for timpani
- Tissue inhibitor of metalloproteinases, a family of proteins that act as enzyme inhibitors
- Thioinosine monophosphate, an intermediate metabolite of azathioprine
See also
UpToDate Contents
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English Journal
- Serum biomarker kinetics with three different courses of HHV-6B encephalitis.
- Kawamura Y, Nakai H, Sugata K, Asano Y, Yoshikawa T.SourceDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
- Brain & development.Brain Dev.2013 Jun;35(6):590-5. doi: 10.1016/j.braindev.2012.08.005. Epub 2012 Sep 25.
- Human herpesvirus-6B (HHV-6B) encephalitis can clinically manifest as hemorrhagic shock and encephalopathy syndrome (HSES), acute encephalopathy with biphasic seizures and late reduced diffusion (AESD), and acute necrotizing encephalopathy (ANE). To compare the underlying pathophysiology, we measure
- PMID 23018119
- Expression of tissue levels of matrix metalloproteinases and their inhibitors in breast cancer.
- Zhang M, Teng XD, Guo XX, Li ZG, Han JG, Yao L.SourceDepartment of Breast Surgery, Affiliated Third Hospital of Harbin Medical University, Harbin 150040, China.
- Breast (Edinburgh, Scotland).Breast.2013 Jun;22(3):330-4. doi: 10.1016/j.breast.2012.08.002. Epub 2012 Sep 18.
- BACKGROUND: We examined mRNA expression for MMP-2, MMP-7, MMP-9, MT1-MMP, TIMP-1, and TIMP-2 in human breast cancer tissues, and the association between their expression and clinicopathological variables.PATIENTS AND METHODS: Breast tissue samples from 120 patients with breast cancer were available
- PMID 22995648
- Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway.
- Guo C, Xu L, He Q, Liang T, Duan X, Li R.SourceGuigang City People's Hospital, The Eighth Affiliated Hospital of Guangxi Medical University, Guigang, Guangxi 537100, PR China.
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2013 Jun;56:436-42. doi: 10.1016/j.fct.2013.02.051. Epub 2013 Mar 14.
- Hepatic fibrosis (HF) is a chronic disease, which primarily leads to liver unregulated metabolism. In this study, we aimed to investigate the therapeutic effects of puerarin (PR), an active ingredient from kudzu root, on CCl4-induced HF rats. PR effectively ameliorated the liver metabolic function,
- PMID 23500774
Japanese Journal
- 正常および腫瘍細胞における核へのTIMP-1の集積について
- Relationship Between Myocardial Redox State and Matrix Metalloproteinase Activity in Patients on Left Ventricular Assist Device Support
- CARUSO Raffaele,CASELLI Chiara,BORONI Chiara,CAMPOLO Jonica,MILAZZO Filippo,CABIATI Manuela,RUSSO Claudio,PAROLINI Marina,GIANNESSI Daniela,FRIGERIO Maria,PARODI Oberdan
- Circulation journal : official journal of the Japanese Circulation Society 75(10), 2387-2396, 2011-09-25
- … Myocardial MMP-2 and -9 activities and expression, tissue inhibitor of MMP (TIMP)-1 and -4, transforming growth factor (TGF)-β1 and aminothiol concentrations were measured. … MMP-2 and -9 activities and expression were lower in the LVAD group, whereas myocardial TIMP-1 and -4 concentrations were comparable to those of MT patients. …
- NAID 10029459423
Related Links
- 金沢大学は血液の病気が起きる原因をコンピューターを使ったシミュレーション(模擬 実験)で究明する手法を開発した。多くの要因が絡み合う ... 骨髄から採取した造血 幹細胞にTIMP-3を加えると造血幹細胞が活発に増殖し血球が ...
- マトリックス金属プロテアーゼ(MMP)ファミリーに共通の内因性インヒビターであるTIMP(tissue inhibitor of meta11oproteinases)には,現在までにTIMP-1,TIMP-2,TIMP-3 およびTIMP-4の4種の存在がしられている. TIMPの一義的な機能は活性型 ...
Related Pictures
★リンクテーブル★
[★]
- 英
- 6-mercaptopurine, mercaptopunne
- ラ
- 6-mercaptopurinum
- 同
- 6-MP
- 商
- ロイケリン
- 関
- アザチオプリン、制癌薬
- GOO. 134-138,1347f
- プリン代謝拮抗薬
- 抗悪性腫瘍薬
代謝
作用機序
- 本剤は、細胞増殖に重要な意義をもつ核酸の生合成を阻害する。メルカプトプリンは細胞内でinosinic acidのチオ同族体 thioinosinic acid(TIMP)に変換し、このTIMPは主としてinosinic acid からのadenylosuccinic acid 及びxanthylic acidへの転換を阻害し、adenine, guanineribonucleotideの生合成を阻害するとされている
適応
- 白血病、悪性リンパ腫以外の腫瘍に対しては効果が少なく適応されない
注意
重大な副作用
添付文書
- http://www.info.pmda.go.jp/go/pack/4221001B1052_1_02/4221001B1052_1_02?view=body
[★]
- 英
- tissue inhibitor of metalloproteinase、TIMP
- 関
- 組織性メタロプロテアーゼ阻害因子、マトリックスメタロプロテアーゼ阻害因子
[★]
- 英
- tissue inhibitor of metalloproteinase、TIMP
- 関
- マトリックスメタロプロテアーゼ阻害因子、組織メタロプロテアーゼ阻害物質
[★]
- 英
- tissue inhibitor of metalloproteinase、TIMP
- 関
- 組織性メタロプロテアーゼ阻害因子、組織メタロプロテアーゼ阻害物質
[★]
- 関
- tissue inhibitor of metalloproteinase-1
[★]
- 関
- tissue inhibitor of metalloproteinase-2
[★]
- 関
- tissue inhibitor of metalloproteinase-3
[★]
[★]
トリオースリン酸イソメラーゼ triosephosphate isomerase
[★]
- 同
- tissue inhibitor of metalloproteinases