WordNet

establish a conditioned response
the state of (good) health (especially in the phrases `in condition or `in shape or `out of condition or `out of shape' (同)shape
a state at a particular time; "a condition (or state) of disrepair"; "the current status of the arms negotiations" (同)status
a mode of being or form of existence of a person or thing; "the human condition"
an illness, disease, or other medical problem; "a heart condition"; "a skin condition"
apply conditioner to in order to make smooth and shiny; "I condition my hair after washing it"
put into a better state; "he conditions old cars"
the procedure that is varied in order to estimate a variables effect by comparison with a control condition (同)experimental_condition
an assumption on which rests the validity or effect of something else (同)precondition, stipulation
(usually plural) a statement of what is required as part of an agreement; "the contract set out the conditions of the lease"; "the terms of the treaty were generous" (同)term
(physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"
instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"
a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going" (同)scheme
a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender" (同)system of rules
a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"
a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"
the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"
affecting an entire system; "a systemic poison"
established by conditioning or learning; "a conditioned response" (同)learned
physically fit; "exercised daily to keep herself in condition" (同)in condition
the prevailing context that influences the performance or the outcome of a process; "there were wide variations in the conditions of observation"
the set of circumstances that affect someones welfare; "hazardous working conditions"; "harsh living conditions"

PrepTutorEJDIC

〈U〉(事物の)『状態』;(人の)健康状態 / 〈C〉《通例複数形で》(周囲の)『状況』,事情,形勢 / 〈C〉(…の)条件,必要条件《+『of』(『for』)+『名』》;(条件を示す)条項 / 〈C〉(社会的)地位,身分,境遇 / 〈C〉(慢性の)病気,症状 / (…に備えて)〈体など〉'を'『適当な状態にする』,‘の'調子を整える《+『名』+『for』+『名』》 / 〈物事が〉…‘の'条件となる,…を左右する,決定する / 〈人・動物など〉'を'慣らす,適応させる
〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身
(身体・言語のように)体系の,組織の / 全身の,全身的
条件つきの / (体など)調子を整えた

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/29 22:10:29」(JST)

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[Wiki en表示]

Life-threatening disease redirects here.

A systemic disease is one that affects a number of organs and tissues, or affects the body as a whole.^[1]

Examples

Mastocytosis, including Mast Cell Activation Disorder and Eosinophilic Esophagitis
Chronic fatigue syndrome
Systemic vasculitis e.g. SLE, PAN
Sarcoidosis – a disease that mainly affects the lungs, brain, joints and eyes, found most often in young African-American women.
Diabetes mellitus – an imbalance in blood glucose (sugar) levels.
Ulcerative colitis – an inflammatory bowel disease
Hypertension (high blood pressure)
Metabolic syndrome
AIDS – a disease caused by a virus that cripples the body’s immune defenses.
Grave's disease – a thyroid disorder, most often in women, which can cause a goiter (swelling in the front part of the neck) and protruding eyes.
Systemic lupus erythematosus – a connective tissue disorder involving mainly the skin, joints and kidneys.
Rheumatoid arthritis – an inflammatory disease which mainly attacks the joints. But can also affect a person's skin, eyes, lungs and mouth.
Atherosclerosis – a hardening of the arteries
Sickle cell disease – an inherited blood disorder that can block circulation throughout the body, primarily affecting African-Americans
Myasthenia gravis

Detection

Getting a regular eye exam may play a role in identifying the signs of some systemic diseases. "The eye is composed of many different types of tissue. This unique feature makes the eye susceptible to a wide variety of diseases as well as provides insights into many body systems. Almost any part of the eye can give important clues to the diagnosis of systemic diseases. Signs of a systemic disease may be evident on the outer surface of the eye (eyelids, conjunctiva and cornea), middle of the eye and at the back of the eye (retina)."^[2]

Since 500 B.C., some researchers have also believed that the physical condition of the fingernails and toenails can indicate various systemic diseases. Careful examination of the fingernails and toenails may provide clues to underlying systemic diseases, since some diseases have been found to cause disruptions in the nail growth process. The nail plate is the hard keratin cover of the nail. The nail plate is generated by the nail matrix located just under the cuticle. As the nail grows, the area closest to becoming exposed to the outside world (distal) produces the deeper layers of the nail plate, while the part of the nail matrix deeper inside the finger (proximal) makes the superficial layers. Any disruption in this growth process can lead to an alteration in the shape and texture.

Take pitting, for example. Pitting looks like depressions in the hard part of the nail. Pitting usually is associated with psoriasis, affecting 10 to 50 percent of patients with that disorder.^[3] Pitting also may be caused by a variety of systemic diseases, including reactive arthritis and other connective tissue disorders, sarcoidosis, pemphigus, alopecia areata, and incontinentia pigmenti.^[4] Because pitting is caused by defective layering of the superficial nail plate by the proximal nail matrix, any localized dermatitis (e.g., atopic dermatitis or chemical dermatitis) that disrupts orderly growth in that area also can cause pitting.^[5]

References

^ Dorland's Illustrated Medical Dictionary,28th edition (Harcourt Brace & Company). Page 489,1653
^ "The Eye in Systemic Disease" (University of Illinois at Chicago: 2008), Available at: http://www.uic.edu/com/eye/LearningAboutVision/EyeFacts/SystemicDisease.shtml, Accessed 20 August 2009.
^ Mayeaux EJ Jr. Nail disorders. Prim Care 2000;27: 333-51.
^ Daniel CR 3d, Sams WM Jr, Scher RK. Nails in systemic disease. Dermatol Clin 1985;3:465-83.
^ Eds. ROBERT S. FAWCETT, M.D., M.S., SEAN LINFORD, M.D., and DANIEL L. STULBERG, M.D., Nail Abnormalities: Clues to Systemic Disease (American Family Physician, March 15, 2004), Available at http://www.aafp.org/afp/20040315/1417.html, Accessed 20 August 2009.

UpToDate Contents

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1. 小児における全身性炎症反応症候群（SIRS）および敗血症：定義、疫学、臨床症状、
および診断 systemic inflammatory response syndrome sirs and sepsis in children definitions epidemiology clinical manifestations and diagnosis
2. 未分化型の全身性リウマチ性（結合組織）疾患およびオーバーラップ症候群 undifferentiated systemic rheumatic connective tissue diseases and overlap syndromes
3. 全身性疾患および感染に関連した網膜血管炎 retinal vasculitis associated with systemic disorders and infections
4. 成人における全身性エリテマトーデスの診断および鑑別診断 diagnosis and differential diagnosis of systemic lupus erythematosus in adults
5. 成人における全身性硬化症（強皮症）の診断および鑑別診断 diagnosis and differential diagnosis of systemic sclerosis scleroderma in adults

English Journal

Nephrogenic systemic fibrosis risk after liver magnetic resonance imaging with gadoxetate disodium in patients with moderate to severe renal impairment: results of a prospective, open-label, multicenter study.

Lauenstein T1, Ramirez-Garrido F, Kim YH, Rha SE, Ricke J, Phongkitkarun S, Boettcher J, Gupta RT, Korpraphong P, Tanomkiat W, Furtner J, Liu PS, Henry M, Endrikat J.
Investigative radiology.Invest Radiol.2015 Dec;50(6):416-22. doi: 10.1097/RLI.0000000000000145.
OBJECTIVE: The objective of this study was to assess the risk of gadoxetate disodium in liver imaging for the development of nephrogenic systemic fibrosis (NSF) in patients with moderate to severe renal impairment.MATERIALS AND METHODS: We performed a prospective, multicenter, nonrandomized, open-la
PMID 25756684

The role of conjunctival biopsy in the diagnosis of granulomatosis with polyangiitis.

Ursea R1, De Castro D2, Bowen TJ3, Chan CC4.
Journal of ophthalmic inflammation and infection.J Ophthalmic Inflamm Infect.2015 Jan 23;5(1):1. doi: 10.1186/s12348-014-0033-9. eCollection 2015.
BACKGROUND: The purpose of this study is to describe a patient who was diagnosed with granulomatosis with polyangiitis based on conjunctival biopsy. This study is a case report and review of the literature.FINDINGS: A 48-year-old Caucasian woman presented with a 2-week history of a left eye peripher
PMID 25632308

The gut microbiota and its correlations with the central nervous system disorders.

Catanzaro R1, Anzalone M, Calabrese F, Milazzo M, Capuana M, Italia A, Occhipinti S, Marotta F.
Panminerva medica.Panminerva Med.2015 Sep;57(3):127-43. Epub 2014 Nov 12.
A mutual impact of gastrointestinal tract (GIT) and central nervous system (CNS) functions has been recognized since the mid-twentieth century. It is accepted that the so-called gut-brain axis provides a two-way homeostatic communication, through immunological, hormonal and neuronal signals. A dysfu
PMID 25390799

Japanese Journal

直腸腫瘍を契機に発見された無症状の成人右側Bochdalek孔ヘルニアの１例

加藤大,大石正博,小寺正人,山村方夫,池田秀明,水野憲治,山下裕,鈴木一則
岡山医学会雑誌 126(2), 137-141, 2014-08-01
… Because the tumor was large, laparoscopic abdominoperineal rectal amputation was performed after systemic imatinib therapy. … Adult Bochdalek hernia is a relatively rare condition, and only three (incidentally discovered) cases of asymptomatic Bochdalek hernia, including the present case, have been reported in Japan. …
NAID 120005468254

喉頭癌治療後に顕在化し,再発性多発軟骨炎が疑われた1例

福原敦朗,大島謙吾,谷野功典,峯村浩之,二階堂雄文,石井妙子,佐藤俊,横内浩,金沢賢也,石田卓,棟方充
気管支学 : 日本気管支研究会雑誌 36(4), 368-373, 2014-07-25
背景.再発性多発軟骨炎(relapsing polychondritis:RPC)とは全身の軟骨組織,特に耳介,鼻,気管に慢性炎症と変性をきたす比較的稀な疾患である.その原因としては,自己免疫学的な機序が疑われているが,明らかではない.症例.80歳男性,喉頭癌に対し喉頭全摘術が施行された.術後に放射線照射が行われたが,照射終了後より呼吸困難感と喘鳴が出現したため,当科を紹介された.ステロイドの短期 …
NAID 110009833217

口腔と全身の健康の相互関連性解明のアプローチ

山下喜久,古田美智子,清原裕
保健医療科学 63(2), 114-120, 2014-04
わが国の歯科保健対策の取り組み状況をライフステージ別に考えると,母子歯科保健や学校歯科保健に比べて,成人歯科保健対策は未だ充実しているとはいえない.しかし,2011年に「歯科口腔保健の推進に関する法律」が制定されたことで,新規歯科保健政策の中で成人における歯周病の予防管理に対する試みは新たな局面を迎えている.歯周病は局所因子である歯周病原性細菌感染を主原因とするが,全身因子や環境因子が相互に関わる …
NAID 110009808511