- 同
- SP-D
WordNet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- the 4th letter of the Roman alphabet (同)d
PrepTutorEJDIC
- 蛋白(たんばく)質
- deuteriumの化学記号
- (おもに人称代名詞・固有名詞(人名),thereの後で)had, wouldの短縮形 / (疑問文でwhere,what,whenの後で)didの短縮形;Where'd he go?=Where did he go?
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/16 04:42:20」(JST)
[Wiki en表示]
| Surfactant protein D |
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PDB rendering based on 1b08.
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| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
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1B08, 1M7L, 1PW9, 1PWB, 2GGU, 2GGX, 2ORJ, 2ORK, 2OS9, 2RIA, 2RIB, 2RIC, 2RID, 2RIE, 3DBZ, 3G81, 3G83, 3G84, 3IKN, 3IKP, 3IKQ, 3IKR, 4E52, 4M17, 4M18
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| Identifiers |
| Symbols |
SFTPD ; COLEC7; PSP-D; SFTP4; SP-D |
| External IDs |
OMIM: 178635 MGI: 109515 HomoloGene: 2272 GeneCards: SFTPD Gene |
| Gene ontology |
| Molecular function |
• protein binding
• carbohydrate binding
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| Cellular component |
• extracellular region
• proteinaceous extracellular matrix
• collagen trimer
• extracellular space
• lysosome
• endocytic vesicle
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| Biological process |
• regulation of cytokine production
• receptor-mediated endocytosis
• respiratory gaseous exchange
• negative regulation of T cell proliferation
• defense response to bacterium
• surfactant homeostasis
• negative regulation of interleukin-2 biosynthetic process
• innate immune response
• macrophage chemotaxis
• lung alveolus development
• positive regulation of phagocytosis
• reactive oxygen species metabolic process
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| Sources: Amigo / QuickGO |
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| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
6441 |
20390 |
| Ensembl |
ENSG00000133661 |
ENSMUSG00000021795 |
| UniProt |
P35247 |
P50404 |
| RefSeq (mRNA) |
NM_003019 |
NM_009160 |
| RefSeq (protein) |
NP_003010 |
NP_033186 |
| Location (UCSC) |
Chr 10:
79.94 – 79.98 Mb |
Chr 14:
41.17 – 41.19 Mb |
| PubMed search |
[1] |
[2] |
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Surfactant, pulmonary-associated protein D, also known as SFTPD or SP-D, is a protein which in humans is encoded by the SFTPD gene.[1][2]
SFTPD is an innate immune system collectin.[3][4]
Contents
- 1 Interactions
- 2 See also
- 3 References
- 4 External links
- 5 Further reading
Interactions
Surfactant protein D has been shown to interact with DMBT1,[5][6] and hemagglutinin of influenza A virus. [7]
See also
References
- ^ Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.
- ^ Lu J, Willis AC, Reid KB (June 1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J. 284. 284 ( Pt 3): 795–802. PMC 1132609. PMID 1339284.
- ^ "Entrez Gene: SFTPD surfactant, pulmonary-associated protein D".
- ^ Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME (May 2008). "Surfactant protein D alters allergic lung responses in mice and human subjects". J. Allergy Clin. Immunol. 121 (5): 1140–1147.e2. doi:10.1016/j.jaci.2008.02.011. PMID 18355911.
- ^ Tino MJ, Wright JR (April 1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". Am. J. Respir. Cell Mol. Biol. 20 (4): 759–68. doi:10.1165/ajrcmb.20.4.3439. PMID 10101009.
- ^ Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (May 1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.
- ^ Goh, Boon Chong; Rynkiewicz, Michael J.; Cafarella, Tanya R.; White, Mitchell R.; Hartshorn, Kevan L.; Allen, Kimberly; Crouch, Erika C.; Calin, Oliviana; Seeberger, Peter H. (2013-11-13). "Molecular Mechanisms of Inhibition of Influenza by Surfactant Protein D Revealed by Large-Scale Molecular Dynamics Simulation". Biochemistry 52 (47): 8527–8538. doi:10.1021/bi4010683. PMC 3927399. PMID 24224757.
External links
- Surfactant Protein D at the US National Library of Medicine Medical Subject Headings (MeSH)
Further reading
- Hansen S, Holmskov U (1998). "Structural aspects of collectins and receptors for collectins". Immunobiology 199 (2): 165–89. doi:10.1016/s0171-2985(98)80025-9. PMID 9777404.
- Lu J, Willis AC, Reid KB (1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J. 284. 284 ( Pt 3): 795–802. PMC 1132609. PMID 1339284.
- Ogasawara Y, Kuroki Y, Akino T (1992). "Pulmonary surfactant protein D specifically binds to phosphatidylinositol". J. Biol. Chem. 267 (29): 21244–9. PMID 1400434.
- Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.
- Kuroki Y, Shiratori M, Ogasawara Y, Tsuzuki A, Akino T (1991). "Characterization of pulmonary surfactant protein D: its copurification with lipids". Biochim. Biophys. Acta 1086 (2): 185–90. doi:10.1016/0005-2760(91)90006-4. PMID 1932100.
- Crouch E, Persson A, Chang D, Heuser J (1994). "Molecular structure of pulmonary surfactant protein D (SP-D)". J. Biol. Chem. 269 (25): 17311–9. PMID 8006040.
- Schaeffer E, Guillou F, Part D, Zakin MM (1993). "A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells". J. Biol. Chem. 268 (31): 23399–408. PMID 8226864.
- Kölble K, Lu J, Mole SE, Kaluz S, Reid KB (1993). "Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster". Genomics 17 (2): 294–8. doi:10.1006/geno.1993.1324. PMID 8406480.
- Crouch E, Persson A, Chang D (1993). "Accumulation of surfactant protein D in human pulmonary alveolar proteinosis". Am. J. Pathol. 142 (1): 241–8. PMC 1886847. PMID 8424457.
- Crouch E, Rust K, Veile R, Donis-Keller H, Grosso L (1993). "Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1". J. Biol. Chem. 268 (4): 2976–83. PMID 8428971.
- Rust K, Bingle L, Mariencheck W, Persson A, Crouch EC (1996). "Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids". Am. J. Respir. Cell Mol. Biol. 14 (2): 121–30. doi:10.1165/ajrcmb.14.2.8630261. PMID 8630261.
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, Koch C, Reid KB (1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". J. Biol. Chem. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.
- Botas C, Poulain F, Akiyama J, Brown C, Allen L, Goerke J, Clements J, Carlson E, Gillespie AM, Epstein C, Hawgood S (1998). "Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D". Proc. Natl. Acad. Sci. U.S.A. 95 (20): 11869–74. doi:10.1073/pnas.95.20.11869. PMC 21732. PMID 9751757.
- Håkansson K, Lim NK, Hoppe HJ, Reid KB (1999). "Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D". Structure 7 (3): 255–64. doi:10.1016/S0969-2126(99)80036-7. PMID 10368295.
- Holmskov U, Mollenhauer J, Madsen J, Vitved L, Gronlund J, Tornoe I, Kliem A, Reid KB, Poustka A, Skjodt K (1999). "Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D". Proc. Natl. Acad. Sci. U.S.A. 96 (19): 10794–9. doi:10.1073/pnas.96.19.10794. PMC 17962. PMID 10485905.
- Lausen M, Lynch N, Schlosser A, Tornoe I, Saekmose SG, Teisner B, Willis AC, Crouch E, Schwaeble W, Holmskov U (1999). "Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D". J. Biol. Chem. 274 (45): 32234–40. doi:10.1074/jbc.274.45.32234. PMID 10542261.
- Madsen J, Kliem A, Tornoe I, Skjodt K, Koch C, Holmskov U (2000). "Localization of lung surfactant protein D on mucosal surfaces in human tissues". J. Immunol. 164 (11): 5866–70. doi:10.4049/jimmunol.164.11.5866. PMID 10820266.
- Zhang L, Ikegami M, Crouch EC, Korfhagen TR, Whitsett JA (2001). "Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure". J. Biol. Chem. 276 (22): 19214–9. doi:10.1074/jbc.M010191200. PMID 11278637.
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PDB gallery
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1b08: LUNG SURFACTANT PROTEIN D (SP-D) (FRAGMENT)
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1m7l: Solution Structure of the Coiled-Coil Trimerization Domain from Lung Surfactant Protein D
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1pw9: High resolution crystal structure of an active recombinant fragment of human lung surfactant protein D
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1pwb: High resolution crystal structure of an active recombinant fragment of human lung surfactant protein D with maltose
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2ggu: crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with maltotriose
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2ggx: Crystal structure of the trimer neck and carbohydrate recognition domain of human surfactant protein D in complex with p-nitrophenyl maltoside
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2orj: crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with N-acetyl mannosamine
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2ork: crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with inositol-1-phosphate
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2os9: crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with myoinositol
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UpToDate Contents
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English Journal
- Association of type II secretory phospholipase A2 and surfactant protein D with the pulmonary oxygenation potential in patients with septic shock during polymyxin-B immobilized fiber-direct hemoperfusion.
- Ishibe Y1,2, Shibata S1,2, Takahashi G1,2, Suzuki Y1,2, Inoue Y1,2, Endo S1,2.
- Journal of clinical apheresis.J Clin Apher.2017 Oct;32(5):302-310. doi: 10.1002/jca.21507. Epub 2016 Sep 13.
- PMID 27623356
- Correlation analysis of surfactant protein A and surfactant protein D with lung function in exhaled breath condensate from lung cancer patients with and without COPD.
- Lin X1, Wu Z2, Fan Y2, Chi M2, Wang X2, Zhang X3, Sun D3.
- Molecular medicine reports.Mol Med Rep.2017 Oct;16(4):4948-4954. doi: 10.3892/mmr.2017.7182. Epub 2017 Aug 7.
- PMID 28791362
- High-dose prednisolone after intravenous methylprednisolone improves prognosis of acute exacerbation in idiopathic interstitial pneumonias.
- Arai T1,2, Tachibana K2, Sugimoto C1, Inoue Y2, Tokura S2,3, Okuma T4, Akira M3, Kitaichi M5, Hayashi S2, Inoue Y1.
- Respirology (Carlton, Vic.).Respirology.2017 Oct;22(7):1363-1370. doi: 10.1111/resp.13065. Epub 2017 May 15.
- PMID 28508494
Japanese Journal
- Pulmonary effects in workers exposed to indium metal : A cross-sectional study
- Keratinocyte Growth Factor Gene Electroporation into Skeletal Muscle as a Novel Gene Therapeutic Approach for Elastase-Induced Pulmonary Emphysema in Mice
- ATP測定法を用いたマイクロ・ナノバブルの洗浄力評価
- 共立女子短期大学生活科学科紀要 = Annual bulletin, Department of the Science of Living 58, 57-65, 2015-02
- NAID 120005598462
Related Links
- Surfactant, pulmonary-associated protein D, also known as SFTPD or SP-D, is a protein which in humans is encoded by the SFTPD gene. SFTPD is an innate immune system collectin.
- 当科ではこれまで本学生化学第一講座との共同研究により、肺サーファクタント蛋白質( Surfactant Protein; SP)であるSP-AおよびSP-Dの構造・機能の解析ならびに各種呼吸 器疾患におけるの意義や臨床応用を検討してきました。肺サーファクタントは肺胞II型 ...
★リンクテーブル★
[★]
- 英
- surfactant protein D SP-D
- 関
- KL-6, SP-A。サーファクタントプロテイン
概念
- II型肺胞上皮細胞が分泌するサーファクトプロテインの一種。
- 肺の線維化のマーカーとして用いられる。
基準値
意義
- 臨床検査データブックより引用
高値
可能性
低値
[★]
- 英
- surfactant protein
- 関
- [[]]
[★]
サーファクタントプロテインD surfactant protein D
[★]
[★]