WordNet

of, affecting, or being on or near the surface; "superficial measurements"; "the superficial area of the wall"; "a superficial wound"
of little substance or significance; "a few superficial editorial changes"; "only trivial objections" (同)trivial
concerned with or comprehending only what is apparent or obvious; not deep or penetrating emotionally or intellectually; "superficial similarities"; "a superficial mind"; "his thinking was superficial and fuzzy"; "superficial knowledge"; "the superficial report didnt give the true picture"; "only superficial differences"
any of several malignant neoplasms (usually of the skin) consisting of melanocytes (同)malignant_melanoma

PrepTutorEJDIC

表面の(にある),表面的な / (考えなどが)浅薄な,皮相的な

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/06/08 19:32:32」(JST)

wiki en

Superficial spreading melanoma (SSM) is usually characterized as the most common form of cutaneous melanoma^[2] in Caucasians. The average age at diagnosis is in the fifth decade, and it tends to occur on sun-exposed skin, especially on the backs of males and lower limbs of females.

Signs and symptoms

Often, this disease evolves from a precursor lesion, usually a dysplastic nevus. Otherwise it arises in previously normal skin. A prolonged radial growth phase, where the lesion remains thin, may eventually be followed by a vertical growth phase where the lesion becomes thick and nodular. As the risk of spread varies with the thickness, early SSM is more frequently cured than late nodular melanoma.

The microscopic hallmarks are:

Large melanocytic cells with nest formation along the dermo-epidermal junction.
Invasion of the upper epidermis in a pagetoid fashion (discohesive single cell growth).
The pattern of rete ridges is often effaced.
Invasion of the dermis by atypical, pleomorphic melanocytes
Absence of the 'maturation' typical of naevus cells
Mitoses

Treatment

Treatment is by excisional biopsy, wide local excision and possibly sentinel node biopsy. Spread of disease to local lymph nodes or distant sites (typically brain, bone, skin and lung) marks a decidedly poor prognosis.

References

^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
^ Forman SB, Ferringer TC, Peckham SJ, et al. (June 2008). "Is superficial spreading melanoma still the most common form of malignant melanoma?". J. Am. Acad. Dermatol. 58 (6): 1013–20. doi:10.1016/j.jaad.2007.10.650. PMID 18485983.

External links

Fact File from the Royal College of Pathologists of Australasia (pdf)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 黒色腫の病理学的特徴 pathologic characteristics of melanoma
2. メラノーマ：臨床的特徴および診断 melanoma clinical features and diagnosis
3. 皮膚黒色腫におけるtumor node metastasis（TNM）病期分類法およびその他の予後因子 tumor node metastasis tnm staging system and other prognostic factors in cutaneous melanoma
4. Screening and early detection of melanoma in adults and adolescents
5. 眼瞼の病変 eyelid lesions

English Journal

Clinicopathological features and prognosis of patients with de novo versus nevus-associated melanoma in Taiwan.

Sheen YS1,2, Liao YH2, Lin MH3,4, Chen JS2, Liau JY5, Liang CW5, Chang YL1,5, Chu CY2.
PloS one.PLoS One.2017 May 4;12(5):e0177126. doi: 10.1371/journal.pone.0177126. eCollection 2017.
PMID 28472158

University Hospital Waterford: 5-year experience of cutaneous melanoma.

Sehgal R1, Cheung CX2, Alradadi R2, Healy DA2, Landers R2, O'Donoghue GT2.
Irish journal of medical science.Ir J Med Sci.2017 May;186(2):309-314. doi: 10.1007/s11845-016-1531-6. Epub 2016 Nov 21.
PMID 27873142

Ureteric Obstruction From Malignant Melanoma in Both Right Double Moiety and Left Single Moiety Ureters.

March B1, Calopedos RJS2, Latif E2, Ouyang R2.
Urology.Urology.2017 May;103:e7-e8. doi: 10.1016/j.urology.2017.02.021. Epub 2017 Feb 16.
PMID 28216451

Japanese Journal

ダーモスコピーで規則的な青灰色色素小球が特徴的であった色素性 Bowen 病の 1 例

西日本皮膚科 75(3), 227-229, 2013
NAID 130004475527

症例 Dysplastic Nevi, Type C (Kraemer)に発症した表在拡大型悪性黒色腫の1例

皮膚科の臨床 53(2), 307-311, 2011-02
NAID 40018707404

自治医科大学附属病院皮膚科における悪性黒色腫121例(1998〜2008年)の統計的検討

自治医科大学紀要 32, 43-49, 2010-03-01
NAID 110007726758

Related Pictures

Skin cancer (melanoma) - NHS Superficial spreading melanoma | DermNet New Zealand superficial melanoma - pictures, photos dermoscopy: Superficial spreading melanoma

★リンクテーブル★

リンク元	「悪性黒色腫」「表在拡大型黒色腫」
関連記事	「superficial」「spreading」

「悪性黒色腫」

Superficial spreading melanoma
Other names	Superficially spreading melanoma
Specialty	Dermatology

　　[★]

英: malignant melanoma MM
同: メラノーマ melanoma
ラ: melanoma malignum
関: メラニン尿

概念

メラノサイト(神経堤由来)が癌化した悪性腫瘍
色調は多くが黒褐色。紅色調病変もありうる(無色素性黒色腫 amelanotic melanoma)　←　メラニン合成能の喪失
転移能しやすい。予後不良。　→　リンパ行性が最も頻度が高い・・・だっけ？
原発：皮膚。粘膜(口腔、鼻腔)、脈絡膜、脳軟膜、眼もありうる。

悪性黒色腫のABCDE NDE.421

頭文字	特徴
A	Asymmetry	不規則形
B	Borderline irregularity	境界不鮮明
C	Color variegation	色調多彩
D	Diameter enlargement	拡大傾向(直径6mm以上)
E	Elevation of surface	表面隆起