WordNet

place signs, as along a road; "sign an intersection"; "This road has been signed"
(medicine) any objective evidence of the presence of a disorder or disease; "there were no signs of asphyxiation"
a perceptible indication of something not immediately apparent (as a visible clue that something has happened); "he showed signs of strain"; "they welcomed the signs of spring" (同)mark
a character indicating a relation between quantities; "dont forget the minus sign"
a fundamental linguistic unit linking a signifier to that which is signified; "The bond between the signifier and the signified is arbitrary"--de Saussure
a gesture that is part of a sign language
a public display of a message; "he posted signs in all the shop windows"
engage by written agreement; "They signed two new pitchers for the next season" (同)contract, sign on, sign_up
approve and express assent, responsibility, or obligation; "All parties ratified the peace treaty"; "Have you signed your contract yet?" (同)ratify
communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" (同)signal, signalize, signalise
mark with ones signature; write ones name (on); "She signed the letter and sent it off"; "Please sign here" (同)subscribe
be engaged by a written agreement; "He signed to play the casino on Dec. 18"; "The soprano signed to sing the new opera"
communicate in sign language; "I dont know how to sign, so I could not communicate with my deaf cousin"
sound loudly and sonorously; "the bells rang" (同)peal
a toroidal shape; "a ring of ships in the harbor"; "a halo of smoke" (同)halo, annulus, doughnut, anchor ring
jewelry consisting of a circlet of precious metal (often set with jewels) worn on the finger; "she had rings on every finger"; "he noted that she wore a wedding band" (同)band
a characteristic sound; "it has the ring of sincerity"
a platform usually marked off by ropes in which contestants box or wrestle
the sound of a bell ringing; "the distinctive ring of the church bell"; "the ringing of the telephone"; "the tintinnabulation that so voluminously swells from the ringing and the dinging of the bells"--E. A. Poe (同)ringing, tintinnabulation
attach a ring to the foot of, in order to identify; "ring birds"; "band the geese to observe their migratory patterns" (同)band
make (bells) ring, often for the purposes of musical edification; "Ring the bells"; "My uncle rings every Sunday at the local church" (同)knell
small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
wearing a wedding ring; lawfully married; "a ringed wife"- Tennyson
having colored rings around the body
any malignant tumor derived from epithelial tissue; one of the four major types of cancer

PrepTutorEJDIC

(ある事実・状態・感情などの)『表れ』,印,気配,徴侯(indication);(…の)こん跡,計跡《+『of』+『名』》・『身ぶり』,手まね,合図 / 『標識』,看板 / (数学・音楽などの)記号 / (…の)『象徴』,シンボル(symbol)《+『of』+『名』》・《文》(…の)『前兆』,きざし《+『of』+『名』》・宮(きゅう)(黄道12区分の一つ) ・〈手紙・書類・作品など〉‘に'『署名する』・(…に)〈名前など〉‘を'書く《+『名』+『on』(『to』)+『名』》 / …‘を'雇う契約に署名する・…‘を'合図する,知らせる;…に合図する・署名する・契約書に署名して雇われる
『指輪』 / 『輪』,環;輪形,円形 / (円形の)サーカス演技場,公演場,競技場;(ボクシング・レスリングの)リング / 《複数形で》(体操の)つり輪 / (不法な目的で結託した)(…の)徒党,一味《+『of』+『名』》 / (原子の)環 / …を円形に取り囲む,円で囲む《+『about』(『around』,《英》『round』)+『名,』+『名』+『about』(『around』,《英》『round』)+『名』》 / 〈動物〉‘に'鼻輪(首輪,足輪)をはめる / (遊びで)…‘に'輪を投げる / 環状に動く,輪を描く
〈鐘・ベルなどが〉『鳴る』 / 《『ring』+『形』〈補〉》(…のように)聞こえる / (…を)ベルを鳴らして求める《+『for』+『名』》 / 〈音声・楽器などが〉鳴り響く;〈場所が〉(音などで)満ちる《+『with』+『名』》 / 耳鳴りがする / 〈鐘・ベルなど〉‘を'『鳴らす』 / 〈人〉‘を'(鐘などを)『鳴らして呼ぶ』;…‘を'鐘を鳴らして知らせる / 《英》…‘に'電話をかける《+『up』+『名』,+『名』+『up』》 / 《単数形で》(鐘・ベルなどの)『鳴る音,響き』《+『of』+『名』》 / 鐘(ベルなど)を鳴らすこと;ベル(など)が鳴ること / 《単数形で》(…の)固有の響き,調子,感じ《+『of』+『名』》 / 《話》電話をかけること
(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
輪にある;環状の / 指輪をはめた
がん,がん腫

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/16 05:32:22」(JST)

wiki en

Signet ring cell carcinoma (SRCC) is an epithelial malignancy characterized by the histologic appearance of signet ring cells.

It is a form of adenocarcinoma,^[1] that produces mucin. When the adenocarcinoma contains more than 50% signet rings it is referred to as a signet ring cell carcinoma.^[2] It is most often found in the glandular cells of the stomach, but it may develop in other areas of the body.^[3] e.g. the prostate,^[4] bladder, gallbladder,^[5] breast, colon,^[6] ovarian stroma and testis.^[7] It may also be seen in renal cell carcinoma. However many SRCC cases are rare. SRCC do not normally form in the lungs, stomach, or urinary bladder but there have been a few incidents where signet ring cell carcinoma has been reported in these areas. The SRCC in the stomach mainly appears in women and younger patients, while the SRCC of the urinary bladder occurs mainly in men around the ages of 38 to 83.^[8]

Some cases (not all) are inherited, and these cases are often caused by mutations in the CDH1 gene.^[9]

Mechanism

The mechanism of this malignant cancer is still unclear, however it has been found that a colon carcinoma cell known as HCC2998 causes an increase in differentiated tumor production.The reason for this increase is due to the active PI3K that were "converted to a signet ring carcinoma-like cells".^[10]

Metastases

The pattern of metastases is different for gastric signet cell carcinoma than for intestinal-type gastric carcinoma. In cases where gastric signet cell carcinoma metastasizes, it tends to spread to peritoneal metastases, lymphatic permeation of the lungs, and to the ovaries, creating Krukenberg tumors.^[11]

Histologic appearance

Signet ring cells resemble signet rings because a large vacuole full of mucin displaces the nucleus to the periphery.

Prognosis, by organ

Colorectal: In a group of 154 Japanese patients the overall median survival time was 12.7 months and the 5-year survival rate was 9.4%.^[6]

Additional images

Gastric signet ring cell carcinoma. H&E stain.

References

^ el-Zimaity HM, Itani K, Graham DY (October 1997). "Early diagnosis of signet ring cell carcinoma of the stomach: role of the Genta stain". J. Clin. Pathol. 50 (10): 867–8. doi:10.1136/jcp.50.10.867. PMC 500272. PMID 9462273.
^ "Pure Signet-ring Cell Carcinoma of Lung by Fine Needle Aspiration in a Smoking Asian American: Case Report and Literature Review" (PDF). Clinical & Experimental Pathology. pp. 1985–1990. Retrieved 2014-10-29.
^ "What is a Signet Cell Cancer?". CancerHelp UK. Cancer Research UK. Retrieved 2/12/12. Check date values in: |accessdate= (help)
^ Leong FJ, Leong AS, Swift J (1996). "Signet-ring carcinoma of the prostate". Pathol. Res. Pract. 192 (12): 1232–8; discussion 1239–41. doi:10.1016/S0344-0338(96)80156-7. PMID 9182294.
^ Jain V, Gupta K, Kudva R, Rodrigues GS (2006). "A case of ovarian metastasis of gallbladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature". Int. J. Gynecol. Cancer. 16 Suppl 1: 319–21. doi:10.1111/j.1525-1438.2006.00335.x. PMID 16515613.
^ ^a ^b Makino T, Tsujinaka T, Mishima H et al. (2006). "Primary signet-ring cell carcinoma of the colon and rectum: report of eight cases and review of 154 Japanese cases". Hepatogastroenterology 53 (72): 845–9. PMID 17153438.
^ Michal M, Hes O, Kazakov DV (2005). "Primary signet-ring stromal tumor of the testis". Virchows Arch. 447 (1): 107–10. doi:10.1007/s00428-005-1218-2. PMID 15909171.
^ "Primary Signet-Ring Cell Carcinoma of the Urinary Bladder". Cancer. pp. 1985–1990. Retrieved 2014-10-29.
^ "Office of Rare Diseases Research: Diffuse Gastric Cancer". National Institute of Health. National Institute of Health. pp. 84–85. Retrieved 12/21/11. Check date values in: |accessdate= (help)
^ "Mechanism behind signet ring cell carcinoma formation". Biochemical and Biophysical Research communications. Science direct. pp. 1231–1233. Retrieved 2014-10-21.
^ "Patterns of metastases in intestinal and diffuse types of carcinoma of the stomach". Science Direct (Elsevier) 12 (3): 237–242. 1981. doi:10.1016/S0046-8177(81)80124-4. Retrieved April 11, 2012.

External links

Signet ring cell cancer information
What is a signet cell cancer

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 大腸癌の病理および予後決定因子 pathology and prognostic determinants of colorectal cancer
2. 早期胃癌：治療、自然経過、および予後 early gastric cancer treatment natural history and prognosis
3. 原発不明の腺癌 adenocarcinoma of unknown primary site
4. 胃癌の臨床的特徴、診断、および病期分類 clinical features diagnosis and staging of gastric cancer
5. 胃癌の病理および分子学的病因 pathology and molecular pathogenesis of gastric cancer

English Journal

A rare case of concurrent signet-ring carcinoma of breast and microangiopathic hemolytic anemia.

Lara K1, Bae E2, Park H2, Hussain F2.
Journal of surgical case reports.J Surg Case Rep.2016 Sep 1;2016(9). pii: rjw132. doi: 10.1093/jscr/rjw132.
Microangiopathic hemolytic anemia (MAHA) can be an uncommon presentation of an underlying malignancy, most often due to signet-ring cell carcinoma (SRCC). Additionally, pure SRCC in a breast primary-tumor comprises <2% of all breast cancers (Shin SY, Park H, Chae SW, Woo HY. Microangiopathic hemo
PMID 27587305

The role of endoscopic ultrasound on the preoperative T staging of gastric cancer: A retrospective study.

Han C1, Lin R, Shi H, Liu J, Qian W, Ding Z, Hou X.
Medicine.Medicine (Baltimore).2016 Sep;95(36):e4580.
Endoscopic ultrasonography (EUS) is used for preoperative assessment of gastric cancer. However, recent studies suggested that EUS staging accuracy is lower than previously thought. We aimed to assess EUS efficacy and image characteristics in preoperative gastric cancer T staging.A retrospective rev
PMID 27603347

Distribution of Lgr5-positive cancer cells in intramucosal gastric signet-ring cell carcinoma.

Nakajima T1, Uehara T1, Maruyama Y2, Iwaya M1, Kobayashi Y1, Ota H1,3.
Pathology international.Pathol Int.2016 Sep;66(9):518-23. doi: 10.1111/pin.12451.
Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) is a putative intestinal stem cell marker that is also expressed in various tumors. To analyze its pathological characteristics in mucosal gastric signet-ring cell carcinoma (SRCC), we investigated Lgr5 expression in 35 intramucosal
PMID 27593551

Japanese Journal

臨床眼瞼原発の眼窩印環細胞癌例

市瀬彩,鈴木宏明,鬼頭良輔 [他]
耳鼻咽喉科臨床 105(11), 1053-1057, 2012-11
NAID 40019475861

H. pylori陰性胃癌の特徴 (特集胃癌の予防と治療 : 予防策と早期診断・治療) -- (特論)

伊藤公訓,松尾泰治,田中信治 [他]
日本臨床 70(10), 1802-1806, 2012-10
NAID 40019442821

★リンクテーブル★

リンク元	「印環細胞癌」
関連記事	「sign」「ring」「cell」

「印環細胞癌」

Signet ring cell carcinoma
	A signet ring cell carcinoma of the stomach. Signet ring cells are seen in the lower half of the image. Gastric epithelium is seen in the upper half of the image. H&E stain.
Classification and external resources
ICD-O	M8490/3
MeSH	D018279

　　[★]

英: signet ring cell carcinoma, signet-ring cell carcinoma
同: 粘液細胞性腺癌 mucocellular adenocarcinoma、印環細胞腺癌 signet ring celladenocarcinoma
関: クルーケンベルク症候群、スキルス胃癌

図：BPT.599 APT.168

印環型の腫瘍細胞による腺癌
核異型に富み、細胞質には粘液を蓄え、核は細胞の周辺に押しやられ、印環(signet ring)を形作っている。

参考

胃癌（印環細胞癌）

http://kc.hospital.okayama-u.ac.jp/~pathology/2000/pathology2000/pathologyI/gas/B-77/B-77.htm

胃癌

http://www2.odn.ne.jp/g_nexus_6/microphotographs/image23.html

国試

103I064

「sign」

　　[★]

n.

徴候、兆候、サイン、(数学)符号

関: indication、manifestation、signature、stigma、stigmata、symptom、symptomatic

「ring」

　　[★]

n.

環、リング、輪、(心臓の)弁輪

関: annulus、circle、loop、wheel

「cell」

　　[★] 細胞　　　　　　　

[pmid9462273-1] -Zimaity HM, Itani K, Graham DY (October 1997). "Early diagnosis of signet ring cell carcinoma of the stomach: role of the Genta stain". J. Clin. Pathol. 50 (10): 867–8. doi:10.1136/jcp.50.10.867. PMC 500272. PMID 9462273.

[2] "Pure Signet-ring Cell Carcinoma of Lung by Fine Needle Aspiration in a Smoking Asian American: Case Report and Literature Review" (PDF). Clinical & Experimental Pathology. pp. 1985–1990. Retrieved 2014-10-29.

[3] "What is a Signet Cell Cancer?". CancerHelp UK. Cancer Research UK. Retrieved 2/12/12. Check date values in: |accessdate= (help)

[p-4] Leong FJ, Leong AS, Swift J (1996). "Signet-ring carcinoma of the prostate". Pathol. Res. Pract. 192 (12): 1232–8; discussion 1239–41. doi:10.1016/S0344-0338(96)80156-7. PMID 9182294.

[gb-5] Jain V, Gupta K, Kudva R, Rodrigues GS (2006). "A case of ovarian metastasis of gallbladder carcinoma simulating primary ovarian neoplasm: diagnostic pitfalls and review of literature". Int. J. Gynecol. Cancer. 16 Suppl 1: 319–21. doi:10.1111/j.1525-1438.2006.00335.x. PMID 16515613.

[cr-6] Makino T, Tsujinaka T, Mishima H et al. (2006). "Primary signet-ring cell carcinoma of the colon and rectum: report of eight cases and review of 154 Japanese cases". Hepatogastroenterology 53 (72): 845–9. PMID 17153438.

[t-7] Michal M, Hes O, Kazakov DV (2005). "Primary signet-ring stromal tumor of the testis". Virchows Arch. 447 (1): 107–10. doi:10.1007/s00428-005-1218-2. PMID 15909171.

[8] "Primary Signet-Ring Cell Carcinoma of the Urinary Bladder". Cancer. pp. 1985–1990. Retrieved 2014-10-29.

[9] "Office of Rare Diseases Research: Diffuse Gastric Cancer". National Institute of Health. National Institute of Health. pp. 84–85. Retrieved 12/21/11. Check date values in: |accessdate= (help)

[10] "Mechanism behind signet ring cell carcinoma formation". Biochemical and Biophysical Research communications. Science direct. pp. 1231–1233. Retrieved 2014-10-21.

[11] "Patterns of metastases in intestinal and diffuse types of carcinoma of the stomach". Science Direct (Elsevier) 12 (3): 237–242. 1981. doi:10.1016/S0046-8177(81)80124-4. Retrieved April 11, 2012.

匿名

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案内

案内

signet ring cell carcinoma