WordNet

very bad in degree or extent; "a severe worldwide depression"; "the house suffered severe damage"
unsparing and uncompromising in discipline or judgment; "a parent severe to the pitch of hostility"- H.G.Wells; "a hefty six-footer with a rather severe mien"; "a strict disciplinarian"; "a Spartan upbringing" (同)spartan
intensely or extremely bad or unpleasant in degree or quality; "severe pain"; "a severe case of flu"; "a terrible cough"; "under wicked fire from the enemys guns"; "a wicked cough" (同)terrible, wicked
set or keep apart; "sever a relationship" (同)break_up
detached by cutting; "cut flowers"; "a severed head"; "an old tale of Anne Bolyn walking the castle walls with her poor cut-off head under her arm" (同)cut_off
inflammation of the liver caused by a virus or a toxin

PrepTutorEJDIC

(人・法律などが)『厳しい』,厳格な / (態度・表情が)厳粛な,いかめしい / (病気などが)『重い』,危険な / (様式・趣味などが)簡素な,じみな,飾りのない / (人の体に)厳しくこたえる,激しい / (試験などが)難しい,厳しい
(全体から)…‘を'切断する《+『名』+『from』+『名』》 / (いくつかの部分に)…‘を'分ける《+『名』+『in』(『into』)+『名』》 / 〈関係など〉‘を'断つ / 切れる,分かれる,分裂する
肝[臓]炎

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1. B型肝炎のマネージメントの概要および症例 overview of the management of hepatitis b and case examples
2. 成人におけるA型肝炎ウイルス感染の概要 overview of hepatitis a virus infection in adults
3. 小児および思春期におけるB型肝炎ウイルス感染の概要 overview of hepatitis b virus infection in children and adolescents
4. 小児におけるA型肝炎ウイルス感染の概要 overview of hepatitis a virus infection in children
5. D型肝炎ウイルス感染の診断 diagnosis of hepatitis d virus infection

Paradoxical attenuation of autoimmune hepatitis by oral isoniazid in wild-type and N-acetyltransferase-deficient mice.

Metushi IG1, Cai P, Vega L, Grant DM, Uetrecht J.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2014 Jun;42(6):963-73. doi: 10.1124/dmd.113.056622. Epub 2014 Mar 12.
Isoniazid (INH) treatment can cause serious liver injury and autoimmunity. There are now several lines of evidence that INH-induced liver injury is immune mediated, but this type of liver injury has not been reproduced in animals, possibly because immune tolerance is the dominant response of the liv
PMID 24623063

Reduced fibrosis in recurrent HCV with tacrolimus, azathioprine and steroids versus tacrolimus: randomised trial long term outcomes.

Manousou P1, Cholongitas E, Samonakis D, Tsochatzis E, Corbani A, Dhillon AP, Davidson J, Rodríguez-Perálvarez M, Patch D, O'Beirne J, Thorburn D, Luong T, Rolles K, Davidson B, McCormick PA, Hayes P, Burroughs AK.
Gut.Gut.2014 Jun;63(6):1005-13. doi: 10.1136/gutjnl-2013-305606. Epub 2013 Oct 16.
OBJECTIVE: Early results of a randomised trial showed reduced fibrosis due to recurrent HCV hepatitis with tacrolimus triple therapy (TT) versus monotherapy (MT) following transplantation for HCV cirrhosis. We evaluated the clinical outcomes after a median 8 years of follow-up, including differences
PMID 24131637

Protein interferon-stimulated gene 15 conjugation delays but does not overcome coronavirus proliferation in a model of fulminant hepatitis.

Ma XZ1, Bartczak A, Zhang J, He W, Shalev I, Smil D, Chen L, Phillips J, Feld JJ, Selzner N, Levy G, McGilvray I.
Journal of virology.J Virol.2014 Jun;88(11):6195-204. doi: 10.1128/JVI.03801-13. Epub 2014 Mar 19.
Coronaviruses express a deubiquitinating protein, the papain-like protease-2 (PLP2), that removes both ubiquitin and the ubiquitin-like interferon (IFN)-stimulated gene 15 (ISG15) protein from target proteins. ISG15 has antiviral activity against a number of viruses; therefore, we examined the effec
PMID 24648452

Severe Colitis Caused by Hepatic Arterial Infusion Chemotherapy with Cisplatin for Hepatocellular Carcinoma

Yamamoto Shumpei,Onishi Hideki,Oyama Atsushi,Takaki Akinobu,Okada Hiroyuki
Internal Medicine, 2020
… <p>A 78-year-old man with chronic hepatitis C underwent hepatectomy for hepatocellular carcinoma (HCC) 11 years prior to presentation. … This is the first report of severe colitis following HAIC with cisplatin. …
NAID 130007701608