changing to a lower state (a less respected state) (同)debasement
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
learning (of values or attitudes etc.) that is incorporated within yourself (同)internalisation, incorporation
A Naturally Occurring GIP Receptor Variant Undergoes Enhanced Agonist-Induced Desensitization, Which Impairs GIP Control of Adipose Insulin Sensitivity.
Mohammad S1, Patel RT1, Bruno J2, Panhwar MS3, Wen J1, McGraw TE4.
Molecular and cellular biology.Mol Cell Biol.2014 Oct 1;34(19):3618-29. doi: 10.1128/MCB.00256-14. Epub 2014 Jul 21.
Glucose-dependent insulinotropic polypeptide (GIP), an incretin hormone secreted from gastrointestinal K cells in response to food intake, has an important role in the control of whole-body metabolism. GIP signals through activation of the GIP receptor (GIPR), a G-protein-coupled receptor (GPCR). Dy
Protein kinase LKB1 promotes RAB7-mediated neuropilin-1 degradation to inhibit angiogenesis.
Okon IS, Coughlan KA, Zhang C, Moriasi C, Ding Y, Song P, Zhang W, Li G, Zou MH.
The Journal of clinical investigation.J Clin Invest.2014 Sep 2. pii: 75371. doi: 10.1172/JCI75371. [Epub ahead of print]
After internalization, transmembrane receptors (TMRs) are typically recycled back to the cell surface or targeted for degradation. Efficient TMR trafficking is critical for regulation of several processes, including signal transduction pathways, development, and disease. Here, we determined that tra
Neurotrophin receptor p75 mediates the uptake of the amyloid beta (Aβ) peptide, guiding it to lysosomes for degradation in basal forebrain cholinergic neurons.
Ovsepian SV1, Antyborzec I, O'Leary VB, Zaborszky L, Herms J, Oliver Dolly J.
A fascinating yet perhaps overlooked trait of the p75 neurotrophin receptor (p75(NTR)) is its ability to bind ligands with no obvious neurotrophic function. Using cultured basal forebrain (BF) neurons, this study demonstrates selective internalization of amyloid β (Aβ) 1-42 in conjunction with p75
Internalization and Degradation of PDGF and the PDGF Receptor. Alexander Sorkin ... type fl-receptors were able to internalize and degrade the receptor, as well as ... tivated mutant receptor also internalized and degraded both receptor and ...