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English Journal

Determination of acidic and neutral therapeutic drugs in human blood by liquid chromatography-electrospray tandem mass spectrometry.

Sørensen LK1.
Forensic science international.Forensic Sci Int.2011 Mar 20;206(1-3):119-26. doi: 10.1016/j.forsciint.2010.07.016. Epub 2010 Aug 12.
A liquid chromatography-tandem mass spectrometry method using pneumatically assisted electrospray ionisation (LC-ESI-MS/MS) was developed for the simultaneous determination of paracetamol, naproxen, ibuprofen, etodolac, diclofenac, salicylic acid, lamotrigine, carbamazepine, 10-OH-carbazepine, pheny
PMID 20708359

Computational thermochemistry of six ureas, imidazolidin-2-one, N,N'-trimethyleneurea, benzimidazolinone, parabanic acid, barbital (5,5'-diethylbarbituric acid), and 3,4,4'-trichlorocarbanilide, with an extension to related compounds.

Dávalos JZ1, Ribeiro da Silva Md, Ribeiro da Silva MA, Freitas VL, Jiménez P, Roux MV, Cabildo P, Claramunt RM, Elguero J.
The journal of physical chemistry. A.J Phys Chem A.2010 Sep 2;114(34):9237-45. doi: 10.1021/jp103514f.
A computational study of the structural and thermochemical properties of N-phenyl (open) and N-alkyl (cyclic) ureas, through the use of M05-2X and B3LYP density functional theory calculations has been carried out. The consistency of the literature experimental results has been confirmed, and using m
PMID 20681553

Kobayashi K1, Yamagami S, Higuchi T, Hosokawa M, Chiba K.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2004 Apr;32(4):468-72.
The ligand-binding domain of human pregnane X receptor (hPXR) is highly hydrophobic and flexible, allowing promiscuity in accepting structurally diverse ligands. However, little information is available regarding the critical substituents of compounds involved in the activation of hPXR. The aim of t
PMID 15039302