WordNet

the chief phagocytic leukocyte; stains with either basic or acid dyes (同)neutrophile

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/03 11:30:49」(JST)

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Neutrophilia (or neutrophil leukocytosis) describes a high number of neutrophil granulocytes in blood.^[1]

Causes[edit]

Neutrophils are the primary white blood cells that respond to a bacterial infection, so the most common cause of neutrophilia is a bacterial infection, especially pyogenic infections.^[2]

Neutrophils are also increased in any acute inflammation, so will be raised after a heart attack,^[2] other infarct or burns.^[2]

Some drugs, such as prednisone, have the same effect as cortisol and Adrenaline epinephrine, causing marginated neutrophils to enter the blood stream. Nervousness will very slightly raise the neutrophil count because of this effect.

A neutrophilia might also be the result of a malignancy. Chronic myelogenous leukemia (CML or chronic myeloid leukaemia) is a disease where the blood cells proliferate out of control. These cells may be neutrophils. Neutrophilia can also be caused by appendicitis and splenectomy.^[3]

"Left shift"[edit]

A "left shift" refers to the presence of increased proportions of younger, less well differentiated neutrophils and neutrophil-precursor cells in the blood. This generally reflects early or premature release of myeloid cells from the bone marrow, the site where neutrophils are generated. A severe neutrophilia with left shift is referred to as a leukemoid reaction. The leukocyte alkaline phosphatase (LAP) score, which refers to the amount of alkaline phosphatase per neutrophil, will increase. In a severe infection, toxic granulation changes happen to the neutrophils.

This can resemble Pelger-Huet anomaly.^[4]^[5]

References[edit]

^
‹ The template below (DorlandsDict) is being considered for deletion. See templates for discussion to help reach a consensus.›

"neutrophilia" at Dorland's Medical Dictionary
^ ^a ^b ^c Table 12-6 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.
^ "bloodandcancerclinic". Retrieved 10 April 2013.
^ Mohamed IS, Wynn RJ, Cominsky K, et al. (June 2006). "White blood cell left shift in a neonate: a case of mistaken identity". J Perinatol 26 (6): 378–80. doi:10.1038/sj.jp.7211513. PMID 16724080.
^ Shmuely H, Pitlik SD, Inbal A, Rosenfeld JB (June 1993). "Pelger-Huët anomaly mimicking 'shift to the left'". Neth J Med 42 (5–6): 168–70. PMID 8377874.

UpToDate Contents

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1. 白血球増多症および好中球増多症の定義およびメカニズム definition and mechanisms of leukocytosis and neutrophilia
2. 好中球増多症の患者へのアプローチ approach to the patient with neutrophilia
3. 好中球増多症の原因 causes of neutrophilia
4. 白血球増多症および白血球症 hyperleukocytosis and leukostasis
5. 成人における急性前骨髄球性白血病の初期治療 initial treatment of acute promyelocytic leukemia in adults

English Journal

A Comparative Study of Lung Host Defense in Murine Obesity Models. Insights into Neutrophil Function.

Ubags ND1,2, Burg E2, Antkowiak M2, Wallace AM2, Dilli E2, Bement J2, Wargo MJ3, Poynter ME2, Wouters EF1, Suratt BT2.
American journal of respiratory cell and molecular biology.Am J Respir Cell Mol Biol.2016 Aug;55(2):188-200. doi: 10.1165/rcmb.2016-0042OC.
We have shown that obesity-associated attenuation of murine acute lung injury is driven, in part, by blunted neutrophil chemotaxis, yet differences were noted between the two models of obesity studied. We hypothesized that obesity-associated impairment of multiple neutrophil functions contributes to
PMID 27128821

Outcomes of unselected patients with metastatic clear-cell renal cell carcinoma treated with first-line pazopanib therapy followed by vascular endothelial growth factor receptor tyrosine kinase inhibitors or mammalian target of rapamycin inhibitors: a single institution experience.

Matrana MR1, Bathala T2, Campbell MT3, Duran C2, Shetty A1,4, Teegavarapu P5, Kalra S1,6, Xiao L7, Atkinson B8, Corn P3, Jonasch E3, Tannir NM3.
BJU international.BJU Int.2016 Aug;118(2):264-71. doi: 10.1111/bju.13374. Epub 2015 Dec 13.
OBJECTIVE: To explore the efficacy and safety of pazopanib in a 'real-world' setting in unselected patients, as data regarding unselected patients with metastatic clear-cell renal cell carcinoma (ccRCC) treated with first-line pazopanib are limited.PATIENTS AND METHODS: We reviewed records of patien
PMID 26573089

Paediatric chronic suppurative lung disease: clinical characteristics and outcomes.

Goyal V1,2, Grimwood K3,4, Marchant JM3,5,6, Masters IB5, Chang AB3,6,7.
European journal of pediatrics.Eur J Pediatr.2016 Aug;175(8):1077-84. doi: 10.1007/s00431-016-2743-5. Epub 2016 Jun 11.
We describe the clinical, bronchoscopic, bronchoalveolar lavage (BAL) and radiographic characteristics of children whose chronic wet cough did not resolve with oral antibiotics and which led to their hospitalisation for intravenous antibiotics and airway clearance therapy. Between 2010 and 2014, med
PMID 27287408

Japanese Journal

Nephrotic Syndrome Related to Chronic Neutrophilic Leukemia

Wang Rending,Tong Hongyan,Wang Huiping,Chen Zhimin,Wang Lijun,Chen Jianghua
Internal Medicine 53(21), 2505-2509, 2014
… We herein describe the case of a 41-year-old woman who was admitted with nephrotic syndrome (NS) and severe neutrophilia and underwent a splenectomy due to splenomegaly. …
NAID 130004704941

遷延性意識障害にステロイドが著効し神経Sweet病のhuman leukocyte antigen（HLA）タイピングを示した若年性認知症の1例

仲谷利栄,那波一郎,川﨑裕子,森谷真之,Nakano Misa,巽千賀夫
臨床神経学 54(2), 130-134, 2014
症例は58歳男性である．1年前より認知機能障害が出現し他院にてアルツハイマー病と診断された．その後全身衰弱をみとめ当科入院となった．入院後突発的な発熱・炎症反応上昇・舌根沈下をともなう意識障害をくりかえし人工呼吸器管理を要した．髄液検査はしらべた範囲ではIL-6のみが22.2 pg/mlと増加していた．HLA（human leukocyte antigen）B54, Cw1が陽性であり，ステロイド …
NAID 130004505559

Prognostic Value of Bronchoalveolar Lavage in Patients with Non-HIV Pneumocystis Pneumonia

Tamai Koji,Tachikawa Ryo,Tomii Keisuke,Nagata Kazuma,Otsuka Kojiro,Nakagawa Atsushi,Otsuka Kyoko,Matsumoto Takeshi,Monden Kazuya,Takeshita Jumpei,Tanaka Kosuke,Kawamura Takahisa,Otoshi Takehiro,Fujimoto Daichi
Internal Medicine 53(11), 1113-1117, 2014
… The multivariate logistic regression analysis identified only BALF neutrophilia to be a significant prognostic factor determining in-hospital mortality. … The log-rank test showed that the patients with BALF neutrophilia (≥31%) had a significantly lower survival rate than the other patients (p=0.001). … Conclusion Only BALF neutrophilia was found to be a significant predictor of survival in patients with non-HIV PCP. …
NAID 130004466317

Related Pictures

★リンクテーブル★

リンク元	「好中球増多症」「好中球増加」「好中球増多」

「好中球増多症」

Neutrophilia
	Classification and external resources
	; Neutrophils with a segmented nuclei surrounded by erythrocytes, the intra-cellular granules are visible in the cytoplasm (Giemsa stained)
DiseasesDB	8995
eMedicine	med/3209

　　[★]

英: neutrophilia
同: 好中球増多、好中球増加、好中球増加症; 顆粒球増加症 granulocytosis、好中球性白血球増加症 neutrophilic leukocytosis
関: 白血球増多症

[show details]

好中球増加症 : 約 6,050 件 (OLM)
好中球増多症 : 約 22,000 件 (LAB)

定義

成熟好中球の絶対数が8x10³/uL以上に増加している状態

OLM 94,95

原発性

続発性

急性感染症：化膿菌など

局所性感染症
全身性感染症

中毒性疾患

代謝性の物

尿毒症、アシドーシス、子癇、痛風、Cushing症候群など

化学物質によるもの

エピネフリン、ACTH、鉛、ジギタリス、水銀、蒼鉛(ビスマス)、ケロシン

昆虫による物
異種蛋白の非経口的投与
細菌性ワクチンの投与
電気ショック

組織壊死を伴う疾患

心筋梗塞
壊疽
広範な熱傷
細菌感染
悪性腫瘍(急激に増大しているもの)
良性腫瘍(変性壊死を伴う物)

急性溶血性疾患
急性出血

特発性

国試

103G047：炎症、感染のほか、喫煙によっても増加しうる。

「好中球増加」

　　[★]

英: neutrophilia
関: 好中球増多、好中球増多症、好中球増加症

「好中球増多」

　　[★]

英: neutrophilia
関: 好中球増多症、好中球増加、好中球増加症

[1] 
‹ The template below (DorlandsDict) is being considered for deletion. See templates for discussion to help reach a consensus.›

"neutrophilia" at Dorland's Medical Dictionary

[Kumar12-6-2] Table 12-6 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.

[bloodandcancerclinic-3] "bloodandcancerclinic". Retrieved 10 April 2013.

[pmid16724080-4] Mohamed IS, Wynn RJ, Cominsky K, et al. (June 2006). "White blood cell left shift in a neonate: a case of mistaken identity". J Perinatol 26 (6): 378–80. doi:10.1038/sj.jp.7211513. PMID 16724080.

[pmid8377874-5] Shmuely H, Pitlik SD, Inbal A, Rosenfeld JB (June 1993). "Pelger-Huët anomaly mimicking 'shift to the left'". Neth J Med 42 (5–6): 168–70. PMID 8377874.

匿名

検索

案内

案内

neutrophilia