mixed function oxygenase

混合機能酸素添加酵素

関

hydroxylase、monooxygenase

WordNet

1. perform as expected when applied; "The washing machine wont go unless its plugged in"; "Does this old car still run well?"; "This old radio doesnt work anymore" (同)work, operate, go, run
2. (mathematics) a mathematical relation such that each element of a given set (the domain of the function) is associated with an element of another set (the range of the function) (同)mathematical function, single-valued function, map, mapping
3. a relation such that one thing is dependent on another; "height is a function of age"; "price is a function of supply and demand"
4. the actions and activities assigned to or required or expected of a person or group; "the function of a teacher"; "the government must do its part"; "play its role" (同)office, part, role
5. what something is used for; "the function of an auger is to bore holes"; "ballet is beautiful but what use is it?" (同)purpose, role, use
6. a formal or official social gathering or ceremony; "it was a black-tie function"
7. combine (electronic signals); "mixing sounds"
8. add as an additional element or part; "mix water into the drink" (同)mix in
9. the act of mixing together; "paste made by a mix of flour and water"; "the mixing of sound channels in the recording studio" (同)commixture, admixture, mixture, intermixture, mixing
10. an event that combines things in a mixture; "a gradual mixture of cultures" (同)mixture
11. a commercially prepared mixture of dry ingredients (同)premix
12. to bring or combine together or with something else; "resourcefully he mingled music and dance" (同)mingle, commix, unify, amalgamate
13. an oxidoreductase that catalyzes the incorporation of molecular oxygen
14. performing or able to perform its regular function; "a functioning flashlight"

PrepTutorEJDIC

1. (人・物の果たすべき)『働き』,機能,役目;《しばしば複数形で》職務 / (公式の)儀式,《話》大きな催し(集まり),式典 / (数学で)関数 / 〈機械などが〉『機能を果たす』,動く / (…の)役目をする,代用となる《+『as』+『名』》
2. 〈複数のもの〉‘を'『混ぜ合わせる』,混合する,混同する / …‘を'混ぜ合わせて作る,調合して作る / …‘を'寄せ集める,まとめる / 〈物が〉(…と)混ざる,混合する《+『with』+『名』》 / 〈人が〉(他の人と)交わる,交際する《+『with』+『名』》 / 〈C〉〈U〉混合 / 〈C〉混合物(食品,薬) / 〈C〉〈U〉(水・火を加えて即席にでき上がる)素(もと),ミックス
3. (異なった成分(要素)のものが)混ざった,混合の,混成の / 男女混合の / 人種(宗教・国籍など)が違う人々の(から成る)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/10 23:46:44」(JST)

wiki en

[Wiki en表示]

Mixed-function oxidase is the name of a family of oxidase enzymes that catalyze a reaction in which each of the two atoms of oxygen in O₂ is used for a different function in the reaction.

Oxidase is a general name for enzymes that catalyze oxidations in which molecular oxygen is the electron acceptor but oxygen atoms do not appear in the oxidized product. Often, oxygen is reduced to either water (cytochrome oxidase of the mitochondrial electron transfer chain) or hydrogen peroxide (dehydrogenation of fatty acyl-CoA in peroxisomes). Most of the oxidases are flavoproteins.

The name "mixed-function oxidase" indicates that the enzyme oxidizes two different substrate simultaneously. Desaturation of fatty acyl-CoA in vertebrates is an example of the mixed-function oxidase reaction. In the process, saturated fatty acyl-CoA and NADPH are oxidized by molecular oxygen (O₂) to produce monounsaturated fatty acyl-CoA, NADP⁺ and 2 molecules of water.

Reaction

The mixed-function oxidase reaction proceeds as follows:

AH + BH₂ + O₂ --> AOH + B + H₂O h2o as catalyst

Medical Significance

High levels of mixed-function oxidase activity has been studied for their activation effects in human colon carcinoma cell lines, to study the susceptibility to certain cancers. The research has been successful in mice but remains inconclusive in humans.

References

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 混合型クリオグロブリン血症症候群の治療 treatment of the mixed cryoglobulinemia syndrome
• 2. 成人における肺機能検査の概要 overview of pulmonary function testing in adults
• 3. 小児における肺機能検査の概要 overview of pulmonary function testing in children
• 4. 膵外分泌機能検査 pancreatic exocrine function tests
• 5. 単純性および混合性酸塩基障害 simple and mixed acid base disorders

English Journal

• Mode of action of aspirin as a chemopreventive agent.

• Dovizio M, Bruno A, Tacconelli S, Patrignani P.SourceDepartment of Neuroscience and Imaging, G. d'Annunzio University, School of Medicine, Via dei Vestini 31, Chieti, Italy.
• Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer.Recent Results Cancer Res.2013;191:39-65. doi: 10.1007/978-3-642-30331-9_3.
• Aspirin taken for several years at doses of at least 75 mg daily reduced long-term incidence and mortality due to colorectal cancer. The finding of aspirin benefit at low-doses given once daily, used for cardioprevention, locates the antiplatelet effect of aspirin at the center of its antitumor effi
• PMID 22893199

• 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) decreases progesterone synthesis through cAMP-PKA pathway and P450scc downregulation in mouse Leydig tumor cells.

• Han X, Tang R, Chen X, Xu B, Qin Y, Wu W, Hu Y, Xu B, Song L, Xia Y, Wang X.SourceState Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
• Toxicology.Toxicology.2012 Dec 8;302(1):44-50. doi: 10.1016/j.tox.2012.07.010. Epub 2012 Jul 31.
• Polybrominated diphenyl ethers (PBDEs) are commonly used as flame retardants in textiles, plastics and electronics and represent a group of persistent environmental contaminants. They have been found to accumulate in human and marine mammals. Previous studies have shown that PBDEs have endocrine-dis
• PMID 22867812

Japanese Journal

• Review and Perspective on the Use of Mixed-function Oxygenase Enzymes in Biological Monitoring

• PAYNE J. F.
• Comp. Biochem. Physiol., C 86, 233-245, 1987
• NAID 80003311395

• サツマイモ塊根組織のチトクロムP-450系酵素に関する研究

• 藤田 政之
• 香川大学農学部紀要 48, 1-60, 1986-10-31
• NAID 110000940114

• High-Performance Liquid Chromatographic Determination of 6β-Hydroxycortisol in Urine

• 小野 彪,澗田 和幸,柴田 英彦,小西 廣己,島川 治巳
• Chemical & pharmaceutical bulletin 34(6), 2522-2527, 1986-06-25
• A simple, rapid, sensitive and reproducible reversed-phase high-performance liquid chromatographic (HPLC) method was developed for the quantitative determination of urinary 6β-hydroxycortisol (6β-OHF) …
• NAID 110003626421

Related Links

• mixed function oxygenase - definition of mixed function ...

mixed func·tion ox·y·ge·nase any monooxygenase that catalyzes AH + O 2 + DH 2 → AOH + H 2 O + D. ... Changes in hepatic mixed function oxygenase (MFO) activity, plasma steroid levels and age at maturity of a white sucker ...

• mixed function oxygenase – Dictionary definition of mixed ...

Definition of mixed function oxygenase – Our online dictionary has mixed function oxygenase information from A Dictionary of Biology dictionary. Encyclopedia.com: English, psychology and medical dictionaries Search over 100 ...

Related Pictures

---

★リンクテーブル★

リンク元	「混合機能酸素添加酵素」
関連記事	「function」「mix」「mixed」

「混合機能酸素添加酵素」

　　[★]

英

mixed function oxygenase, mixed-function oxidase

同

モノオキシゲナーゼ monooxygenase

• チトクロムP450などの異物代謝酵素群

「function」

　　[★]

• n.

• 機能、(数学)関数、(化学)官能基

survival as a function of HbA1c in people with type 2 diabetes HbA1cの機能を考慮（指標に）した2型糖尿病の患者の生存（予後）

Figure 2A shows survival as a function of device removal during index hpspitalization, censored at 1 year or date of last contact. (Figure2Aはは最初の入院中における心臓デバイス除去に関する生存曲線で退院後1年もしくは最後の接触で打ち切っている)

• v.

• 機能する

関

functional、functional group、functionalise、functionalize、operate

　 　 　 　 　 　 　

「mix」

　　[★]

• 混合、混合する、混ぜる

関

admix、admixture、blend、intermingle、merge、mixture、scramble、shuffle、shuffling

　 　 　 　 　 　 　

「mixed」

　　[★]

• 混合性の

関

combined