monooxygenase

モノオキシゲナーゼ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/01 19:30:55」(JST)

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Monooxygenase
Structure of the Tetx Monooxygenase in complex with the substrate 7-Iodtetracycline.
Identifiers
Symbol	FAD_binding_3
Pfam	PF01494
InterPro	IPR002938
SCOP	2phh
SUPERFAMILY	2phh
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Monooxygenases are enzymes that incorporate one hydroxyl group into substrates in many metabolic pathways. In this reaction, the two atoms of dioxygen are reduced to one hydroxyl group and one H₂O molecule by the concomitant oxidation of NAD(P)H.

Classification

It is classified as an Oxidoreductase enzyme that catalyzes an electron transfer.

Related Structures

2XDO 2XYO 2Y6R

Human proteins containing this domain

COQ6; MICAL1; MICAL2; MICAL2PV1; MICAL2PV2; MICAL3;

References

This article incorporates text from the public domain Pfam and InterPro IPR002938

UpToDate Contents

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English Journal

• Metabolic Pathway Involved in 2-Methyl-6-Ethylaniline Degradation by Sphingobium sp. Strain MEA3-1 and Cloning of the Novel Flavin-Dependent Monooxygenase System meaBA.

• Dong W1, Chen Q1, Hou Y2, Li S1, Zhuang K1, Huang F1, Zhou J1, Li Z1, Wang J1, Fu L1, Zhang Z3, Huang Y1, Wang F4, Cui Z5.
• Applied and environmental microbiology.Appl Environ Microbiol.2015 Dec 15;81(24):8254-64. doi: 10.1128/AEM.01883-15. Epub 2015 Sep 18.
• 2-Methyl-6-ethylaniline (MEA) is the main microbial degradation intermediate of the chloroacetanilide herbicides acetochlor and metolachlor. Sphingobium sp. strain MEA3-1 can utilize MEA and various alkyl-substituted aniline and phenol compounds as sole carbon and energy sources for growth. We isola
• PMID 26386060

• Effect of PCB 126 on aryl hydrocarbon receptor 1 (AHR1) and AHR1 nuclear translocator 1 (ARNT1) mRNA expression and CYP1 monooxygenase activity in chicken (Gallus domesticus) ovarian follicles.

• Wójcik D1, Antos PA2, Katarzyńska D2, Hrabia A2, Sechman A3.
• Toxicology letters.Toxicol Lett.2015 Dec 3;239(2):73-80. doi: 10.1016/j.toxlet.2015.09.005. Epub 2015 Sep 9.
• The aim of the experiment was to study the in vitro effect of 3,3',4,4',5-pentachlorobiphenyl (PCB 126; a coplanar PCB congener) on aryl hydrocarbon receptor (AHR1) and AHR1 nuclear translocator (ARNT1) mRNA expression and the activity of CYP1 family monooxygenases in chicken ovarian follicles. Whit
• PMID 26363503

• Clustered array of ochratoxin A biosynthetic genes in Aspergillus steynii and their expression patterns in permissive conditions.

• Gil-Serna J1, Vázquez C1, González-Jaén MT2, Patiño B3.
• International journal of food microbiology.Int J Food Microbiol.2015 Dec 2;214:102-8. doi: 10.1016/j.ijfoodmicro.2015.07.020. Epub 2015 Jul 30.
• Aspergillus steynii is probably the most relevant species of section Circumdati producing ochratoxin A (OTA). This mycotoxin contaminates a wide number of commodities and it is highly toxic for humans and animals. Little is known on the biosynthetic genes and their regulation in Aspergillus species.
• PMID 26256718

Japanese Journal

• Retinol Status and Expression of Retinol-Related Proteins in Methionine-Choline Deficient Rats

• MIYAZAKI Hiroshi,TAKITANI Kimitaka,KOH Maki [他]
• Journal of nutritional science and vitaminology 60(2), 78-85, 2014-04
• NAID 40020056078

• β-Carotene 15,15'-monooxygenase 1 (BCMO1)の新しい生理的機能

• 北風 智也,原田 直樹,山地 亮一
• ビタミン 87(12), 696-699, 2013-12-25
• NAID 110009686681

• プロビタミンAからビタミンAへの転換とβ-carotene15,15'-monooxygenaseの遺伝子多型(<特集>「ビタミンと遺伝子多型」-ビタミンA-)

• 高瀬 幸子,駿河 和仁,寺島 健彦 [他],清水 正則
• ビタミン 87(10), 557-563, 2013-10-25
• … β-Carotene15,15'-monooxygenase (BCMO1) is a key enzyme in the metabolism of provitamin A carotinoids. …
• NAID 110009674993

Related Links

• Monooxygenase | definition of monooxygenase by Medical ...

Once taken up into cells, B[a]P undergoes metabolic activation by the cytochrome P450-dependent monooxygenase system and is converted to reactive, toxic metabolites that bind covalently to cellular elements such as DNA ...

• monooxygenaseの意味・用例｜英辞郎 on the WEB：アルク

monooxygenase 【名】《医》モノオキシゲナーゼ - アルクがお届けする進化するオンライン英和・和英辞書データベース。一般的な単語や連語から、イディオム、専門用語、スラングまで幅広く収録。 ... 英和・和英 対訳データオンライン ...

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★リンクテーブル★

リンク元	「7α-hydroxylase」「モノオキシゲナーゼ」「混合機能酸素添加酵素」「mixed function oxygenase」
拡張検索	「monophenol monooxygenase」「benzoate 4-monooxygenase」「camphor 5-monooxygenase」「squalene monooxygenase」「cytochrome P-450 monooxygenase system」
関連記事	「monooxygenases」

「7α-hydroxylase」

　　[★]

関

コレステロール

同

cholesterol 7-hydroxylase、cholesterol 7α-hydroxylase

• microsomal enzyme
• monooxygenase
• コレステロール + NADPH + H⁺ + O₂ －(7α-hydroxylase)→ 7α-hydroxycholesterol + NADP⁺
• 補酵素としてビタミンCを要求する？
• コレステロールの存在により反応が促進され、胆汁の存在やビタミンCの不足により反応が抑制される。

「モノオキシゲナーゼ」

　　[★]

英

monooxygenase

同

一原子酸素添加酵素、混合機能オキシダーゼ mixed function oxidase

関

シトクロムP450 cytochrome P450

「混合機能酸素添加酵素」

　　[★]

英

mixed function oxygenase, mixed-function oxidase

同

モノオキシゲナーゼ monooxygenase

• チトクロムP450などの異物代謝酵素群

「mixed function oxygenase」

　　[★] 混合機能酸素添加酵素

関

hydroxylase、monooxygenase

「monophenol monooxygenase」

　　[★]

モノフェノールモノオキシゲナーゼ

関

phenoloxidase、tyrosinase

「benzoate 4-monooxygenase」

　　[★]

安息香酸-4-モノオキシゲナーゼ

関

benzoate 4-hydroxylase

「camphor 5-monooxygenase」

　　[★]

カンファー5-モノオキシゲナーゼ

関

CYP101、P450cam

「squalene monooxygenase」

　　[★]

スクアレンモノオキシゲナーゼ

「cytochrome P-450 monooxygenase system」

　　[★] シトクロムP-450酵素系

「monooxygenases」

　　[★]

関

See also Cytochrome P450 system