mixed-function oxidase

mixed function oxygenase

WordNet

1. perform as expected when applied; "The washing machine wont go unless its plugged in"; "Does this old car still run well?"; "This old radio doesnt work anymore" (同)work, operate, go, run
2. (mathematics) a mathematical relation such that each element of a given set (the domain of the function) is associated with an element of another set (the range of the function) (同)mathematical function, single-valued function, map, mapping
3. a relation such that one thing is dependent on another; "height is a function of age"; "price is a function of supply and demand"
4. the actions and activities assigned to or required or expected of a person or group; "the function of a teacher"; "the government must do its part"; "play its role" (同)office, part, role
5. what something is used for; "the function of an auger is to bore holes"; "ballet is beautiful but what use is it?" (同)purpose, role, use
6. a formal or official social gathering or ceremony; "it was a black-tie function"
7. combine (electronic signals); "mixing sounds"
8. add as an additional element or part; "mix water into the drink" (同)mix in
9. the act of mixing together; "paste made by a mix of flour and water"; "the mixing of sound channels in the recording studio" (同)commixture, admixture, mixture, intermixture, mixing
10. an event that combines things in a mixture; "a gradual mixture of cultures" (同)mixture
11. a commercially prepared mixture of dry ingredients (同)premix
12. to bring or combine together or with something else; "resourcefully he mingled music and dance" (同)mingle, commix, unify, amalgamate
13. performing or able to perform its regular function; "a functioning flashlight"
14. any of the enzymes that catalyze biological oxidation

PrepTutorEJDIC

1. (人・物の果たすべき)『働き』,機能,役目;《しばしば複数形で》職務 / (公式の)儀式,《話》大きな催し(集まり),式典 / (数学で)関数 / 〈機械などが〉『機能を果たす』,動く / (…の)役目をする,代用となる《+『as』+『名』》
2. 〈複数のもの〉‘を'『混ぜ合わせる』,混合する,混同する / …‘を'混ぜ合わせて作る,調合して作る / …‘を'寄せ集める,まとめる / 〈物が〉(…と)混ざる,混合する《+『with』+『名』》 / 〈人が〉(他の人と)交わる,交際する《+『with』+『名』》 / 〈C〉〈U〉混合 / 〈C〉混合物(食品,薬) / 〈C〉〈U〉(水・火を加えて即席にでき上がる)素(もと),ミックス
3. (異なった成分(要素)のものが)混ざった,混合の,混成の / 男女混合の / 人種(宗教・国籍など)が違う人々の(から成る)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/18 14:35:32」(JST)

wiki en

[Wiki en表示]

Mixed-function oxidase is the name of a family of oxidase enzymes that catalyze a reaction in which each of the two atoms of oxygen in O₂ is used for a different function in the reaction.

Oxidase is a general name for enzymes that catalyze oxidations in which molecular oxygen is the electron acceptor but oxygen atoms do not appear in the oxidized product. Often, oxygen is reduced to either water (cytochrome oxidase of the mitochondrial electron transfer chain) or hydrogen peroxide (dehydrogenation of fatty acyl-CoA in peroxisomes). Most of the oxidases are flavoproteins.

The name "mixed-function oxidase" indicates that the enzyme oxidizes two different substrate simultaneously. Desaturation of fatty acyl-CoA in vertebrates is an example of the mixed-function oxidase reaction. In the process, saturated fatty acyl-CoA and NADPH are oxidized by molecular oxygen (O₂) to produce monounsaturated fatty acyl-CoA, NADP⁺ and 2 molecules of water.

Reaction

The mixed-function oxidase reaction proceeds as follows:

AH + BH₂ + O₂ --> AOH + B + H₂O h2o as catalyst

Medical Significance

High levels of mixed-function oxidase activity has been studied for their activation effects in human colon carcinoma cell lines, to study the susceptibility to certain cancers. The research has been successful in mice but remains inconclusive in humans.

References

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 慢性肉芽腫性疾患：病因、臨床症状、および診断 chronic granulomatous disease pathogenesis clinical manifestations and diagnosis
• 2. 新生児における筋緊張低下を引き起こす末梢神経および筋肉の障害に関する概要 overview of peripheral nerve and muscle disorders causing hypotonia in the newborn
• 3. 貧食細胞機能の原発性疾患：概要 primary disorders of phagocytic function an overview
• 4. 成人における肺機能検査の概要 overview of pulmonary function testing in adults
• 5. ミトコンドリアの構造、機能、および遺伝学 mitochondrial structure function and genetics

English Journal

• Cyromazine resistance in a field strain of house flies, Musca domestica L.: Resistance risk assessment and bio-chemical mechanism.

• Khan HA1, Akram W2.
• Chemosphere.Chemosphere.2016 Oct 8;167:308-313. doi: 10.1016/j.chemosphere.2016.10.018. [Epub ahead of print]
• Developing resistance management strategies for eco-friendly insecticides is essential for the management of insect pests without harming the environment. Cyromazine is a biorational insecticide with very low mammalian toxicity. Resistance to cyromazine has recently been reported in house flies from
• PMID 27728890

• High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1.

• Wang M1,2, Xu M1, Long Y1, Fargue S3, Southall N1, Hu X1, McKew JC1, Danpure CJ3, Zheng W1.
• Scientific reports.Sci Rep.2016 Sep 27;6:34060. doi: 10.1038/srep34060.
• Glycolate oxidase (GO) and alanine:glyoxylate aminotransferase (AGT) are both involved in the peroxisomal glyoxylate pathway. Deficiency in AGT function causes the accumulation of intracellular oxalate and the primary hyperoxaluria type 1 (PH1). AGT enhancers or GO inhibitors may restore the abnorma
• PMID 27670739

• Medical histories.

• Dance A.
• Nature.Nature.2016 Sep 7;537(7619):S52-3. doi: 10.1038/537S52a.
• PMID 27602739

Japanese Journal

• Effects of nitric oxide on the redox status of liver microsomes-electron spin resonance monitoring using nitroxide probes

• NAKAJIMA Yoshiki,NAKASHIMA Toshiaki,INABA Koji,SUMIDA Yoshio,YOH Takaharu,ISHIKAWA Hiroki,MITSUYOSHI Hironori,SHIMA Toshihide,SENMARU Hiroshi
• Hepatology research : the official journal of the Japan Society of Hepatology 24(1), 72-79, 2002-09-01
• NAID 50000652607

• Comparative Study on in vitro Inhibitory Effects of Heavy Metals on Rabbit Drug-Metabolizing Enzymes

• , ,
• Journal of health science 47(1), 14-20, 2001-02-01
• … Mercury was the most potent in reducing cytochrome P450 content and mixed-function oxidase activities including NADPH-cytochrome c reductase and benzo[a]pyrene hydroxylase. …
• NAID 110003641366

• AN OVERVIEW OF ANIMAL TOXICOLOGY STUDIES WITH BICALUTAMIDE (ICI 176,334)

• , , [他],
• Journal of toxicological sciences 22(2), 75-88, 1997-05-25
• … Bicalutamide causes liver enlargement and is a mixed function oxidase inducer in rodents and dogs, but not man. …
• NAID 110001803627

Related Links

• mixed function oxidase – Dictionary definition of mixed ...

mixed function oxidase An enzyme complex found in animals that oxidizes toxic compounds to render them more susceptible to metabolism and excretion. Such complexes are induced in a wide range of species following exposure ...

• Mixed function oxidase - How is Mixed function oxidase ...

Acronym Definition MFO multinational force and observers (US DoD) MFO Mathematisches Forschungsinstitut Oberwolfach (German: Oberwolfach Mathematical Research Institute; est. 1944) MFO Mixed Function Oxidase MFO

---

★リンクテーブル★

リンク元	「混合機能酸素添加酵素」
拡張検索	「mixed-function oxidases」
関連記事	「function」「mix」「mixed」

「混合機能酸素添加酵素」

　　[★]

英

mixed function oxygenase, mixed-function oxidase

同

モノオキシゲナーゼ monooxygenase

• チトクロムP450などの異物代謝酵素群

「mixed-function oxidases」

　　[★]

関

See also Cytochrome P450 system

「function」

　　[★]

• n.

• 機能、(数学)関数、(化学)官能基

survival as a function of HbA1c in people with type 2 diabetes HbA1cの機能を考慮（指標に）した2型糖尿病の患者の生存（予後）

Figure 2A shows survival as a function of device removal during index hpspitalization, censored at 1 year or date of last contact. (Figure2Aはは最初の入院中における心臓デバイス除去に関する生存曲線で退院後1年もしくは最後の接触で打ち切っている)

• v.

• 機能する

関

functional、functional group、functionalise、functionalize、operate

　 　 　 　 　 　 　

「mix」

　　[★]

• 混合、混合する、混ぜる

関

admix、admixture、blend、intermingle、merge、mixture、scramble、shuffle、shuffling

　 　 　 　 　 　 　

「mixed」

　　[★]

• 混合性の

関

combined