locus control region

• 遺伝子座調節領域

関

LCR

WordNet

1. verify by using a duplicate register for comparison; "control an account"
2. a relation of constraint of one entity (thing or person or group) by another; "measures for the control of disease"; "they instituted controls over drinking on campus"
3. a mechanism that controls the operation of a machine; "the speed controller on his turntable was not working properly"; "I turned the controls over to her" (同)controller
4. (physiology) regulation or maintenance of a function or action or reflex etc; "the timing and control of his movements were unimpaired"; "he had lost control of his sphincters"
5. the activity of managing or exerting control over something; "the control of the mob by the police was admirable"
6. a spiritual agency that is assumed to assist the medium during a seance
7. power to direct or determine; "under control"
8. the economic policy of controlling or limiting or curbing prices or wages etc.; "they wanted to repeal all the legislation that imposed economic controls"
9. exercise authoritative control or power over; "control the budget"; "Command the military forces" (同)command
10. lessen the intensity of; temper; hold in restraint; hold or keep within limits; "moderate your alcohol intake"; "hold your tongue"; "hold your temper"; "control your anger" (同)hold in, hold, contain, check, curb, moderate
11. check or regulate (a scientific experiment) by conducting a parallel experiment or comparing with another standard; "Are you controlling for the temperature?" (同)verify
12. the approximate amount of something (usually used prepositionally as in `in the region of' (同)neighborhood
13. the extended spatial location of something; "the farming regions of France"; "religions in all parts of the world"; "regions of outer space" (同)part
14. a knowledge domain that you are interested in or are communicating about; "it was a limited realm of discourse"; "here we enter the region of opinion"; "the realm of the occult" (同)realm
15. a large indefinite location on the surface of the Earth; "penguins inhabit the polar regions"
16. the set of all points or lines that satisfy or are determined by specific conditions; "the locus of points equidistant from a given point is a circle"
17. the specific site of a particular gene on its chromosome

PrepTutorEJDIC

1. 〈U〉(…に対する)『統制』,抑制,制御《+『over』(『of』+『名』) / 〈C〉《複数形で》(…を)統整する手段,統御法《+『on』(『over』)+『名』》 / 〈U〉(…を)『抑制する力』,(…の)統整力,支配力《+『over』(『of』)+『名』》 / 《複数形で》《単数扱い》(機械の)操縦装置 / 〈C〉(実験結果の)照査基準 / …'を'『支配する』,統御する,管理する,監督する / 〈感情など〉'を'『抑制する』,抑える / …'を'照らし合わせて調べる,照査する
2. (地理的な)『地域』,『地帯』;(特に広大な)地方 / 《複数形で》(宇宙などの)区分,界,属 / (身体の)部分 / (学問などの)分野,領域 / 《複数形で》(都会から離れた)地方
3. (法律用語で)場所,位置 / (数学で,点が描く)軌跡)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/12 11:18:23」(JST)

wiki en

[Wiki en表示]

Locus control regions (LCR) are defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites. The concept derives from the idea that developmental and cell lineage-specific regulation of gene expression relies not only on gene-proximal elements such as promoters, enhancers, and silencers, but also on long-range interactions of various cis-regulatory elements and dynamic chromatin alterations.

The LCR was identified over 20 years ago. In transgenic mouse studies it was determined that the LCR was required for normal regulation of beta-globin gene expression. Several models exist for how the LCR exerts its effects on transcription from a distance.

Looping model

LCR section of the DNA loops around to different extent over the desired gene of expression, so that the binding site of the transcriptional machinery (proteins) is in physical close proximity to bridge and affect the transcription of that specific gene.

References

UpToDate Contents

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• 1. 鎌状細胞貧血における臨床的ばらつき clinical variability in sickle cell anemia

English Journal

• Source of drug resistant Plasmodium falciparum in a potential malaria elimination site in Saudi Arabia.

• Al-Farsi HM, Al-Hashami ZS, Bin Dajem SM, Al-Sheikh AA, Al-Qahtani A, Beja-Pereira A, Idris MA, Babiker HA.SourceDepartment of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Oman; Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Oman.
• Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.Infect Genet Evol.2012 Aug;12(6):1253-9. Epub 2012 Mar 28.
• A major challenge to the success of malaria control program in Saudi Arabia is the high influx of expatriates and holy visitors from malaria endemic countries. In the present study we examined whether drug resistant parasite genotypes reported in Jazan region, southwest of Saudi Arabia are imported
• PMID 22709478

• Multiple independent origins of mitochondrial control region duplications in the order Psittaciformes.

• Schirtzinger EE, Tavares ES, Gonzales LA, Eberhard JR, Miyaki CY, Sanchez JJ, Hernandez A, Müeller H, Graves GR, Fleischer RC, Wright TF.SourceDepartment of Biology, New Mexico State University, Las Cruces, NM 88003, USA.
• Molecular phylogenetics and evolution.Mol Phylogenet Evol.2012 Aug;64(2):342-56. Epub 2012 Apr 20.
• Mitochondrial genomes are generally thought to be under selection for compactness, due to their small size, consistent gene content, and a lack of introns or intergenic spacers. As more animal mitochondrial genomes are fully sequenced, rearrangements and partial duplications are being identified wit
• PMID 22543055

Japanese Journal

• Genetic variation of γ-tocopherol methyltransferase gene contributes to elevated α-tocopherol content in soybean seeds

• Dwiyanti Maria S.,Yamada Tetsuya,Sato Masako,Abe Jun,Kitamura Keisuke
• BMC Plant Biology 11, 152, 2011-11-07
• … Several nucleotide polymorphisms including two nonsynonymous mutations were found in the coding region of γ-TMT3 between Ichihime and KAS, but none of which was responsible for the difference in α-tocopherol concentration. … An F5 line that was heterozygous for the region containing γ-TMT3 was self-pollinated. … From among the progeny, plants that were homozygous at the γ-TMT3 locus were chosen for further evaluation. …
• NAID 120003560608

• Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development

• Liu Wanyang,Morito Daisuke,Takashima Seiji,Mineharu Yohei,Kobayashi Hatasu,Hitomi Toshiaki,Hashikata Hirokuni,Matsuura Norio,Yamazaki Satoru,Toyoda Atsushi,Kikuta Ken-ichiro,Takagi Yasushi,Harada Kouji H.,Fujiyama Asao,Herzig Roman,Krischek Boris,Zou Liping,Kim Jeong Eun,Kitakaze Masafumi,Miyamoto Susumu,Nagata Kazuhiro,Hashimoto Nobuo,Koizumi Akio
• PLoS ONE 6(7), e22542, 2011-07-20
• … Its susceptibility locus has been mapped to 17q25.3 in Japanese families, but the susceptibility gene is unknown.Methodology/Principal FindingsGenome-wide linkage analysis in eight three-generation families with moyamoya disease revealed linkage to 17q25.3 (P<10-4). … Fine mapping demonstrated a 1.5-Mb disease locus bounded by D17S1806 and rs2280147. … There was a variant of p.N321S in PCMTD1 and p.R4810K in RNF213 in the 1.5-Mb locus of the eight index cases. …
• NAID 120003204018

• 誘導電動機新V/f一定制御系の定常及び過渡特性

• 辻 峰男,趙 暁丹,浜崎 真一
• 電気学会論文誌. D, 産業応用部門誌 = The transactions of the Institute of Electrical Engineers of Japan. D, A publication of Industry Applications Society 131(4), 624-632, 2011-04-01
• … This paper presents a new constant V/f control method for induction motors and discusses the speed characteristics for steady-state and transient operations. … In the proposed method, vector control is applied, and auto-boost voltage compensation for the voltage drop across the stator impedance and slip frequency compensation for improving speed control accuracy are included. …
• NAID 10027980708

Related Links

• βグロビン遺伝子の転写制御メカニズム (スイッチング) の解明

赤血球のヘモグロビンを構成するβグロビンの遺伝子座には、非常に強力な エンハンサー活性を有するLCR (Locus Control Region) と、複数のβ様グロビン遺伝子 が存在する。LCR 内には DNaseI 高感受性領域 (Hyper sensitive sites) が5つ存在し 、5'側から ...

Related Pictures

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★リンクテーブル★

リンク元	「LCR」「遺伝子座調節領域」
関連記事	「control」「locus」「region」

「LCR」

　　[★]

• 遺伝子座調節領域

関

locus control region

「遺伝子座調節領域」

　　[★]

英

locus control region、LCR

「control」

　　[★]

• n.

• コントロール、対照、調節、制御、支配、規制

• v.

• 管理する、調節する、制御する、規制する

関

accommodation、accommodative、adjust、adjustment、administer、administrate、administration、baffle、contrast、dominate、govern、government、manage、management、modulate、modulation、predominance、regulate、regulation、regulatory

　 　 　 　 　 　 　 　 　 　 　 　

「locus」

　　[★]

• n.

• 座位、座、遺伝子座、部位、位置

関

gene loci、gene locus、lie、locate、location、loci、map、position、rank、sit、site、sitting position、situated、situation、stand、topo

　 　 　

「region」

　　[★]

• n.

• 領域、区域、部分、地域

関

area、district、division、domain、local、moiety、part、partial、piece、portion、realm、regional、segment、segmental、territory、universe