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the 12th letter of the Roman alphabet (同)l

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lira(イタリアの貨幣単位リラ)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/11 13:50:56」(JST)

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The three letter abbreviation LCR may stand for:

Molecular biology[edit]

Leucocyanidin reductase, an enzyme in the leucocyanidin biosynthesis pathway
Ligase chain reaction, a method for DNA amplification similar to the polymerase chain reaction
Locus Control Region, a phrase used in epigenetics in molecular biology
Low copy repeats

Organizations[edit]

LifeWay Christian Resources, a Nashville, TN, USA, based Christian publisher
Ligue Communiste Révolutionnaire, a political party in France
Ligue Communiste Révolutionnaire, a political party in Belgium
Lutheran Churches of the Reformation
Log Cabin Republicans, a LGBT organization that supports the U.S. Republican Party
London and Continental Railways, a railway company based in the United Kingdom, owners of the contract to build and operate High Speed 1
Louis Christen Racing, a company, named after its owner, that manufactures sidecar road racing chassis

Other[edit]

Landing Craft Rubber, an inflatable rubber boat used to carry troops
Lake County Railroad, a railroad company based in Lakeview, Oregon, United States, owned by the Lake County government and operated by the Modoc Northern Railroad
LCR circuit
LCR (dice game), a game using dice marked with the letters L, C and R
LCR meter
Lead and copper rule, a regulation issued under the U.S. Safe Drinking Water Act
Least-cost routing, the process of selecting the path of outbound communications traffic based on cost
Left/Center/Right, a speaker designation type used in surround sound
Line Concentration Ratio in a remote concentrator
Liquidity Coverage Ratio, a global minimum liquidity standard that is part of Basel III
Loughborough Campus Radio
Low Chip Rate, one of the two transmission modes of UMTS-TDD 3G standard
Ruger LCR, a revolver made by the Ruger company
Team LCR, a motorcycle team currently competing in MotoGP
Level crossing ratio
Left, Center, Right.

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UpToDate Contents

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1. サラセミア症候群の分子病理 molecular pathology of the thalassemic syndromes
2. 健常者および患者における胎児性ヘモグロビン（ヘモグロビンF） fetal hemoglobin hemoglobin f in health and disease
3. 異常ヘモグロビン症の検査室診断 laboratory diagnosis of the hemoglobinopathies
4. 鎌状細胞貧血における臨床的ばらつき clinical variability in sickle cell anemia
5. 自動血液分析装置 automated hematology instrumentation

English Journal

A label-free and PCR-free electrochemical assay for multiplexed microRNA profiles by ligase chain reaction coupling with quantum dots barcodes.

Zhu W, Su X, Gao X, Dai Z, Zou X.Author information School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China; College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, PR China.AbstractThe profiling of microRNAs (miRNAs) is greatly significant for cellular events or disease diagnosis. Electrochemical methods for miRNAs analysis mostly can only measure one kind of miRNA, which is unambiguous to indicate the disease type and state. Here a label-free and PCR-free electrochemical method is presented for multiplexed evaluation of miRNAs in a single-tube experiment. The method is based on the combination of the high base-mismatch selectivity of ligase chain reaction (LCR) and the remarkable voltammetric signature of electrochemical QDs barcodes. Two reporting probes of RP1 and RP2 were labeled with PbS and CdS quantum dots (QDs) to prepare PbS-RP1 and CdS-RP2 conjugates, and two capture probes of CP1 and CP2 were co-immobilized on magnetic beads (MBs) to fabricate MB-CP1CP2 conjugate. The miRNAs samples were simply incubated with MB-CP1CP2, PbS-RP1, and CdS-RP2 conjugates, and then added with T4 DNA ligase. After release of the disjoined QDs barcodes from the MB-conjugates, two target miRNAs of miR-155 and miR-27b were simultaneously detected by square wave voltammetry with linear ranges of 50 fM-30 pM and 50 fM-1050 pM, and limits of detection (LODs) of 12 fM and 31 fM (S/N=3). The method fulfilled the assay in less than 70 min, and showed acceptable testing recoveries for the determination of miRNAs in biological matrix. Currently there are rare reports about electrochemical multiplexed quantification of miRNAs. The method is likely to provide a new platform for identification of multiple miRNAs in a simple way.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Mar 15;53:414-9. doi: 10.1016/j.bios.2013.10.023. Epub 2013 Oct 24.
The profiling of microRNAs (miRNAs) is greatly significant for cellular events or disease diagnosis. Electrochemical methods for miRNAs analysis mostly can only measure one kind of miRNA, which is unambiguous to indicate the disease type and state. Here a label-free and PCR-free electrochemical meth
PMID 24201005

Ligation Chain Reaction based gold nanoparticle assembly for ultrasensitive DNA detection.

Yin H, Huang X, Ma W, Xu L, Zhu S, Kuang H, Xu C.Author information State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu 214122, China; Institute of Plant Quarantine, Chinese Academy of Inspection and Quarantine, Beijing 100029, China.AbstractA simple and ultrasensitive DNA biosensor was developed utilizing the color and size changes originating from Ligation Chain Reaction (LCR)-based gold nanoparticle assembly as an indicator. Using synthetic DNA of 10-fold serial dilutions as a target, the limit of detection (LOD) was 1.5 aM with a range of DNA concentrations from 0.01 to 1000 fM by UV-vis absorption and 0.1 aM in the range of 0.01-10,000 fM by dynamic light scattering (DLS). This developed method is low-cost, rapid, and much lower LOD for the detection of specific short DNA sequences, and the results can be directly determined either by the color or by the DLS. The capability of high-throughput detection with the aid of PCR amplification apparatus can also be realized.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Feb 15;52:8-12. doi: 10.1016/j.bios.2013.07.064. Epub 2013 Aug 14.
A simple and ultrasensitive DNA biosensor was developed utilizing the color and size changes originating from Ligation Chain Reaction (LCR)-based gold nanoparticle assembly as an indicator. Using synthetic DNA of 10-fold serial dilutions as a target, the limit of detection (LOD) was 1.5 aM with a ra
PMID 24012805

Microduplications in 22q11.2 and 8q22.1 associated with mild mental retardation and generalized overgrowth.

Tarsitano M1, Ceglia C2, Novelli A3, Capalbo A3, Lombardo B4, Pastore L4, Fioretti G5, Vicari L5, Pisanti MA5, Friso P5, Cavaliere ML5.Author information 1CEINGE Advanced Biotechnology, S.c.a.r.l., Naples, Italy. Electronic address: marinatarsitano@hotmail.com.2CEINGE Advanced Biotechnology, S.c.a.r.l., Naples, Italy.3Mendel Laboratory, Casa Sollievo della Sofferenza IRCCS, Viale Regina Margherita 261, 00198 Rome, Italy.4CEINGE Advanced Biotechnology, S.c.a.r.l., Naples, Italy; Department Biochemistry and Medical Biotechnology, University of Naples "Federico II", Naples, Italy.5Service of Medical Genetics, Cardarelli Hospital, Naples, Italy.AbstractThe 22q11.2 microduplication is a genomic disorder, characterized from a variable phenotype ranging from different defects to normality. The most common microduplication of 22q11.2 is 3Mb in size, but there are also cases reported with atypical duplications between 0.8Mb and 6Mb. Here, we describe a case of a child with macrocephaly, overgrowth with advanced bone age, attention deficits, evidence of mild mental retardation and dysmorphic features. An array-CGH analysis detected a 252Kb duplication at the 22q11.2 region inherited from mother and 142Kb duplication at 8q22.1 region inherited from father. Both parents show mild dysmorphic features. The duplicated genes in chromosomes 22q and 8q are TOP3B and PGCP, respectively. We describe for the first time a patient carrying the smaller atypical 22q11.2 duplication who also presents with mild mental retardation and generalized overgrowth. This patient has an additional duplication in 8q22.1 which may act as a genomic modifier of its clinical phenotype.
Gene.Gene.2014 Feb 15;536(1):213-6. doi: 10.1016/j.gene.2013.11.051. Epub 2013 Dec 4.
The 22q11.2 microduplication is a genomic disorder, characterized from a variable phenotype ranging from different defects to normality. The most common microduplication of 22q11.2 is 3Mb in size, but there are also cases reported with atypical duplications between 0.8Mb and 6Mb. Here, we describe a
PMID 24315824

Japanese Journal

Fatigue Evaluation of Low Carbon Steel by Means of the Inductance Method Using a Pancake-Type Coil (特集 The 20th MAGDA Conference in Pacific Asia (MAGDA2011))