- 関
- gene loci、loci、locus
WordNet
- the set of all points or lines that satisfy or are determined by specific conditions; "the locus of points equidistant from a given point is a circle"
- the specific site of a particular gene on its chromosome
- (genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
- informal term for information; "give me the gen on your new line of computers"
PrepTutorEJDIC
- locusの複数形
- (法律用語で)場所,位置 / (数学で,点が描く)軌跡)
- 遺伝子
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2018/05/11 22:12:32」(JST)
[Wiki en表示]
Chromosome components:
(1) Chromatid
(2) Centromere
(3) Short (p) arm
(4) Long (q) arm
A locus (plural loci) in genetics is a fixed position on a chromosome, like the position of a gene or a marker (genetic marker).[1] Each chromosome carries many genes; human's estimated 'haploid' protein coding genes are 19,000-20,000,[2] on the 23 different chromosomes. A variant of the similar DNA sequence located at a given locus is called an allele. The ordered list of loci known for a particular genome is called a gene map. Gene mapping is the process of determining the locus for a particular biological trait.
Diploid and polyploid cells whose chromosomes have the same allele of a given gene at some locus are called homozygous with respect to that gene, while those that have different alleles of a given gene at a locus are called heterozygous with respect to that gene.[3]
Contents
- 1 Nomenclature
- 2 Centisome
- 3 See also
- 4 References
- 5 External links
Nomenclature
Cytogenetic banding nomenclature
The shorter arm of a chromosome is termed the p arm or p-arm, while the longer arm is the q arm or q-arm. The chromosomal locus of a typical gene might be written 3p22.1, where
- 3 = chromosome 3
- p = p-arm
- 22 = region 2, band 2 (read as "two, two", not "twenty-two")
- 1 = sub-band 1
Thus the entire locus of the example above would be read as "three P two two point one."
The cytogenetic bands count from the centromere out toward the telomeres.
Component |
Explanation |
3 |
The chromosome number. |
p |
The position is on the chromosome's short arm (a common apocryphal explanation is that the p stands for petit in French); q indicates the long arm (chosen as next letter in alphabet after p; alternatively it is sometimes said that q stands for queue meaning tail in French). |
22.1 |
The numbers that follow the letter represent the position on the arm: region 2, band 2, sub-band 1. The bands are visible under a microscope when chromosome is suitably stained. Each of the bands is numbered, beginning with 1 for the band nearest the centromere. Sub-bands and sub-sub-bands are visible at higher resolution. |
A range of loci is specified in a similar way. For example, the locus of gene OCA1 may be written "11q1.4-q2.1", meaning it is on the long arm of chromosome 11, somewhere in the range from sub-band 4 of region 1 to sub-band 1 of region 2.
The ends of a chromosome are labeled "pter" and "qter", and so "2qter" refers to the terminus of the long arm of chromosome 2.
Centisome
A centisome (not to be confused with a centrosome) is defined as 1% of a chromosome length.[4]
See also
- Chromosomal translocation
- Cytogenetic notation
- Karyotype
- Null allele
- International System for Human Cytogenetic Nomenclature
References
- ^ Wood, E.J. (1995). "The encyclopedia of molecular biology". Biochemical .Education. 23 (2): 1165. doi:10.1016/0307-4412(95)90659-2.
- ^ Ezkurdia, Iakes; Juan, David; Rodriguez, Jose Manuel; Frankish, Adam; Diekhans, Mark; Harrow, Jennifer; Vazquez, Jesus; Valencia, Alfonso; Tress, Michael L. (2014-11-15). "Multiple evidence strands suggest that there may be as few as 19,000 human protein-coding genes". Human Molecular Genetics. 23 (22): 5866–5878. doi:10.1093/hmg/ddu309. ISSN 1460-2083. PMC 4204768 . PMID 24939910.
- ^ "NCI Dictionary of Genetics". National Cancer Institute. Retrieved 13 December 2014.
- ^ Peter D. Karp; Monica Riley (2009-01-11), Representations of Metabolic Knowledge (PDF)
Michael, R. Cummings. (2011). Human Heredity. Belmont, California: Brooks/Cole
External links
|
Wikimedia Commons has media related to Locus (genetics). |
|
Wikidata has the property: cytogenetic location (P4196) (see talk; uses) |
- Overview at ornl.gov
- Chromosome Banding and Nomenclature from NCBI.
UpToDate Contents
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English Journal
- Identification and characterization of a rabbit novel IFN-α unlocated in genome.
- Gao M1, Liu Y2, Guo Y2, Wang Y2, Dai H2, Song Z2, Wang J2, Han W3.
- Developmental and comparative immunology.Dev Comp Immunol.2018 Jan;78:91-99. doi: 10.1016/j.dci.2017.09.016. Epub 2017 Sep 21.
- PMID 28942155
- Genetic organization of Streptococcus salivarius 24SMBc blp-like bacteriocin locus.
- Santagati M1, Scillato M2, Stefani S2.
- Frontiers in bioscience (Scholar edition).Front Biosci (Schol Ed).2018 Jan 1;10:238-247.
- PMID 28930530
- QTLepi Mapping in Arabidopsis thaliana.
- Lauss K1, Keurentjes JJB2.
- Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2018;1675:373-394. doi: 10.1007/978-1-4939-7318-7_22.
- PMID 29052203
Japanese Journal
- Non-pungency in a Japanese Chili Pepper Landrace (Capsicum annuum) is Caused by a Novel Loss-of-function Pun1 Allele
- Genetic profiling of two phenotypically distinct outbred rats derived from a colony of the Zucker fatty rats maintained at Tokyo Medical University
- A new missense mutation in the paired domain of the mouse <i>Pax3</i> gene
Related Links
- Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific ...
- 用例 2: /locus_tag に予め gap を残しておいた場合の挿入 更新前の 更新後の 登録データ 登録データ ABC_0020 ABC_0020 ABC_0021 (new gene) ABC_0030 ABC_0030 禁則: 小数 ...
★リンクテーブル★
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- 関
- gene loci、gene locus、lie、locate、location、locus、map、position、rank、sit、site、sitting position、situated、situation、stand、topo
[★]
- 英
- gene locus、gene loci、locus、loci
- 関
- 位置、遺伝子座位、座、座位、部位
[★]
- 英
- locus、loci、gene locus
- 関
- 位置、遺伝子座、遺伝子座位、座位、部位
[★]
遺伝子座位、遺伝子座
- 関
- gene locus、loci、locus
[★]
- 英
- gene locus、gene loci
- 関
- 遺伝子座、座
[★]
- 関
- gene loci、gene locus、lie、locate、location、loci、map、position、rank、sit、site、sitting position、situated、situation、stand、topo