insulin-like growth factor-I

インスリン様成長因子-I

WordNet

1. want to have; "Id like a beer now!"
2. a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
3. a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
4. equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
5. resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
6. be fond of; "I like my nephews"
7. feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
8. find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
9. cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
10. come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
11. become attached by or as if by the process of growth; "The tree trunks had grown together"
12. become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
13. cause to grow or develop; "He grows vegetables in his backyard"
14. increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
15. (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
16. (pathology) an abnormal proliferation of tissue (as in a tumor)
17. a progression from simpler to more complex forms; "the growth of culture"
18. something grown or growing; "a growth of hair"
19. vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
20. be a contributing factor; "make things factor into a companys profitability"
21. any of the numbers (or symbols) that form a product when multiplied together
22. an independent variable in statistics
23. anything that contributes causally to a result; "a number of factors determined the outcome"
24. consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
25. resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
26. an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
27. a concept whose truth can be proved; "scientific hypotheses are not facts"
28. a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
29. a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"

PrepTutorEJDIC

1. …‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
2. (外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
3. 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
4. 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
5. (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
6. 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. インスリン様成長因子 Iの生理学 physiology of insulin like growth factor i
• 2. 先端巨大症の診断 diagnosis of acromegaly
• 3. 小児における成長ホルモン欠乏症の診断 diagnosis of growth hormone deficiency in children
• 4. 成人における成長ホルモン欠乏症 growth hormone deficiency in adults
• 5. 小児における成長ホルモン欠乏症の治療 treatment of growth hormone deficiency in children

English Journal

• Circulating concentrations of insulin-like growth factor-I, insulin-like growth factor-binding protein-3, genetic polymorphisms and mammographic density in premenopausal Mexican women: Results from the ESMaestras cohort.

• Rinaldi S, Biessy C, Hernandez M, Lesueur F, Dos-Santos-Silva I, Rice MS, Lajous M, Lopez-Ridaura R, Torres-Mejía G, Romieu I.Author information International Agency for Research on Cancer (IARC), Lyon, France.AbstractThe insulin-like growth factor (IGF) axis plays an essential role in the development of the mammary gland. High circulating levels of IGF-I and of its major binding protein IGFBP3 have been related with increased mammographic density in Caucasian premenopausal women. Some common single nucleotide polymorphisms (SNPs) in genes of the IGF pathway have also been suggested to play a role in mammographic density. We conducted a cross-sectional study nested within the large Mexican ESMaestras cohort to investigate the relation between circulating levels of IGF-I, IGFBP-3, the IGF-I/IGFBP-3 ratio, five common SNPs in the IGF-1, IGFBP-3 and IGF-1R genes and mammographic density in 593 premenopausal Mexican women. Mean age at mammogram was 43.1 (standard deviation, SD = 3.7) years, and average body mass index (BMI) at recruitment was 28.5 kg/m(2) . Mean percent mammographic density was 36.5% (SD: 17.1), with mean dense tissue area of 48.3 (SD: 33.3) cm(2) . Mean IGF-I and IGFBP-3 concentrations were 15.33 (SD: 5.52) nmol/l and 114.96 (SD: 21.34) nmol/l, respectively. No significant associations were seen between percent density and biomarker concentrations, but women with higher IGF-I and IGF-I/IGFBP-3 concentrations had lower absolute dense (ptrend  = 0.03 and 0.09, respectively) and nondense tissue areas (ptrend  < 0.001 for both parameters). However, these associations were null after adjustment by BMI. SNPs in specific genes were associated with circulating levels of growth factors, but not with mammographic density features. These results do not support the hypothesis of a strong association between circulating levels of growth hormones and mammographic density in Mexican premenopausal women.
• International journal of cancer. Journal international du cancer.Int J Cancer.2014 Mar 15;134(6):1436-44. doi: 10.1002/ijc.28469. Epub 2013 Oct 5.
• The insulin-like growth factor (IGF) axis plays an essential role in the development of the mammary gland. High circulating levels of IGF-I and of its major binding protein IGFBP3 have been related with increased mammographic density in Caucasian premenopausal women. Some common single nucleotide po
• PMID 24037648

• Bovine and murine tissue expression of insulin like growth factor-I.

• Oberbauer AM1, Belanger JM2, Rincon G3, Cánovas A4, Islas-Trejo A5, Gularte-Mérida R6, Thomas MG7, Medrano JF8.Author information 1Department of Animal Science, University of California, Davis, CA, USA. Electronic address: amoberbauer@ucdavis.edu.2Department of Animal Science, University of California, Davis, CA, USA. Electronic address: jmbelanger@ucddavis.edu.3Department of Animal Science, University of California, Davis, CA, USA. Electronic address: gonzalo.rincon@zoetis.com.4Department of Animal Science, University of California, Davis, CA, USA. Electronic address: acanovas@ucdavis.edu.5Department of Animal Science, University of California, Davis, CA, USA. Electronic address: adislas@ucdavis.edu.6Department of Animal Science, University of California, Davis, CA, USA. Electronic address: rodrigo.gularte@ulg.ac.be.7Department of Animal Sciences, Colorado State University, Fort Collins, CO, USA. Electronic address: milt.Thomas@colostate.edu.8Department of Animal Science, University of California, Davis, CA, USA. Electronic address: jfmedrano@ucdavis.edu.AbstractThe genomic architecture and expression of the Igf-1 gene are complex yielding multiple IGF-I transcript isoforms with putative functional contributions to growth and metabolism. Using RNA-seq on different tissues, physiological states, and species, the breadth of transcripts expressed was determined. Tissues from pre- and post-pubertal heifers and mature mice were collected and the transcript isoforms characterized. Three different IGF-I isoforms were detected in heifers with Class 1 transcripts most abundantly expressed. The pituitary reduced IGF-I expression post-pubertally whereas the uterus increased expression. Murine IGF-I transcript expression was more diverse utilizing multiple exons, start sites, and 3'UTRs. The RNA-seq methodology to characterize expression profiles permits assessment of the transcript isoforms yielding insight into functional roles of each transcript.
• Gene.Gene.2014 Feb 10;535(2):101-5. doi: 10.1016/j.gene.2013.11.089. Epub 2013 Dec 12.
• The genomic architecture and expression of the Igf-1 gene are complex yielding multiple IGF-I transcript isoforms with putative functional contributions to growth and metabolism. Using RNA-seq on different tissues, physiological states, and species, the breadth of transcripts expressed was determine
• PMID 24333269

• Identification and expression pattern of two novel alternative splicing variants of EEF1D gene of dairy cattle.

• Xie Y1, Yang S1, Cui X1, Jiang L1, Zhang S1, Zhang Q1, Zhang Y1, Sun D2.Author information 1College of Animal Science and Technology, China Agricultural University, Beijing 100193, China; Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory of Animal Breeding, China Agricultural University, Beijing 100193, China.2College of Animal Science and Technology, China Agricultural University, Beijing 100193, China; Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory of Animal Breeding, China Agricultural University, Beijing 100193, China. Electronic address: sundx@cau.edu.cn.AbstractOur recent genome-wide association study (GWAS) has identified 105 genome-wide significant SNPs for milk production traits. Of these, one SNP (rs109661298) for milk fat percentage is located within the first intron of the bovine EEF1D gene on BTA14, thus that the EEF1D gene was considered as a novel candidate in dairy cattle. Until now, however, its genomic organization remains undetermined yet and no studies of EEF1D in relation to milk production traits have been reported. To layout the groundwork for the validation of gene function in dairy cattle, we herein investigated its expression pattern in lactating dairy cows. With rapid amplification of 5' cDNA end (5' RACE), two novel alternatively spliced transcript variants of 1202bp and 2195bp were isolated in bovine mammary in lactation, named EEF1Da and EEF1Db (GenBank: KC190039 and KC190038KC190039KC190038). Such two variants contain the different first exon from each other (exon1a vs exon1b: 294bp vs 1287bp) with no overlap and the same remaining 7 exons. Coding sequence similarity between EEF1Da and EEF1Db and three of human EEF1D transcript variants were 85-88%. With semi-quantitative and quantitative real-time RT-PCR, we found that the mRNA level of EEF1Da was similar to the overall EEF1D mRNA and much higher than EEF1Db in the mammary of lactating cows, indicating EEF1Da functions as the dominant transcript variant to encode the EEF1D protein. Tissue expression pattern showed that the mRNA expression of EEF1D and EEF1Da in mammary gland was significantly higher compared with other 7 tissues (P<0.05, P<0.01) with the exception of EEF1D between mammary and lung. Together, our findings present the first report on the alternative splicing of the bovine EEF1D gene and provided basis for further investigation on function validation of EEF1D in dairy cattle.
• Gene.Gene.2014 Jan 25;534(2):189-96. doi: 10.1016/j.gene.2013.10.061. Epub 2013 Nov 14.
• Our recent genome-wide association study (GWAS) has identified 105 genome-wide significant SNPs for milk production traits. Of these, one SNP (rs109661298) for milk fat percentage is located within the first intron of the bovine EEF1D gene on BTA14, thus that the EEF1D gene was considered as a novel
• PMID 24239553

Japanese Journal

• Receptor Tyrosine Kinases and Targeted Cancer Therapeutics (Target Therapy for Cancer : Anti-cancer Drugs Targeting Growth-Factor Signaling Molecules)

• TAKEUCHI Kenji,ITO Fumiaki
• Biological & pharmaceutical bulletin 34(12), 1774-1780, 2011-12
• NAID 40019073228

• 胎児血IGF-I, IGFBP-3ならびにVEGFの分娩ストレスによる変化に関する検討

• 松浦 玲,大槻 克文,下平 和久,千葉 博,徳中 真由美,新城 梓,大場 智洋,荒川 香,長塚 正晃,岡井 崇
• 日本周産期・新生児医学会雑誌 = Journal of Japan Society of Perinatal and Neonatal Medicine 47(1), 43-49, 2011-05-01
• NAID 10029381951

Related Links

• IGF-1: The Test | Insulin-like Growth Factor - 1

Proceeds from website advertising help sustain Lab Tests Online. AACC is a not-for-profit organization and does not endorse non-AACC products and services. ... A test for insulin-like growth factor-1 (IGF-1) may be used to help: ...

• Insulin-like growth factor 1 receptorとは - goo Wikipedia ...

The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2

Related Pictures

---

★リンクテーブル★

リンク元	「IGF-I」
関連記事	「like」「grow」「I」「fact」「factor」

「IGF-I」

　　[★] インスリン様成長因子-I insulin-like growth factor-I

「like」

　　[★]

• v.

• 好む

• prep.

• 似ている、同様の

関

alike、as well as、care for、correspond、correspondingly、equally、favor、identically、likewise、prefer、resemble、same、similar、similarly、such

　 　 　 　 　 　 　 　 　 　

「grow」

　　[★]

• v.

(過去: grew-過去分詞: grown)

• 成長する、生育する、伸びる

関

extend、growth、outgrow、outgrowth、stretch

　 　 　 　 　 　 　

「I」

　　[★]

• イソロイシン isoleucine
• イノシン inosine
• 阻害剤 inhibitor
• iodine
• ヨード iodide
• I因子 factor I

　 　 　

「fact」

　　[★]

• n.

• 事実、現状、実際、実態

関

actual、actually、in fact、in practice、indeed、practically

　 　 　 　 　

「factor」

　　[★]

• n.

• 因子、要因、要素、ファクター

関

element、elementary、factorial、parameter