heparin

ヘパリン


   

WordNet

  1. a polysaccharide produced in basophils (especially in the lung and liver) and that inhibits the activity of thrombin in coagulation of the blood; it (trade names Lipo-Hepin and Liquaemin) is used as an anticoagulant in the treatment of thrombosis and in heart surgery (同)Lipo-Hepin, Liquaemin

PrepTutorEJDIC

  1. ヘバリン(肝臓などにあり血液の凝固を防ぐ物質)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/07 22:03:42」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

  • Hemocompatible and antibacterial porous membranes with heparinized copper hydroxide nanofibers as separation layer.
  • Zhu LJ, Zhu LP, Yi Z, Jiang JH, Zhu BK, Xu YY.SourceMOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, PR China; The Engineering Research Center of Membrane and Water Treatment Technology (Ministry of Education), Zhejiang University, Hangzhou 310027, PR China.
  • Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2013 Oct 1;110:36-44. doi: 10.1016/j.colsurfb.2013.04.020. Epub 2013 Apr 28.
  • Here we report the fabrication of a novel heparinized copper hydroxide (Cu(OH)2) nanofiberous membrane with satisfying hemocompatibility and antibacterial properties. The positively charged Cu(OH)2 nanofibers were prepared in a weakly alkaline copper nitrate solution in the presence of 2-aminoethano
  • PMID 23707848
  • Regulation of intracellular pH by glycosaminoglycans.
  • Kathagen N, Prehm P.SourceInstitute of Physiological Chemistry and Pathobiochemistry, Muenster University, Hospital, Münster, Germany.
  • Journal of cellular physiology.J Cell Physiol.2013 Oct;228(10):2071-5. doi: 10.1002/jcp.24376.
  • The intracellular pH is regulated by a delicate balance of ion distribution across the plasma membrane and the physico-chemical properties of intra- and extracellular components. We analyzed the effects of glycosaminoglycans on the intracellular pH of fibroblasts by using the fluorescent pH indicato
  • PMID 23558851
  • FGFR-targeted gene delivery mediated by supramolecular assembly between β-cyclodextrin-crosslinked PEI and redox-sensitive PEG.
  • Ping Y, Hu Q, Tang G, Li J.SourceDepartment of Bioengineering, Faculty of Engineering, National University of Singapore,7 Engineering Drive 1, Singapore 117574, Singapore; Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore 117602, Singapore.
  • Biomaterials.Biomaterials.2013 Sep;34(27):6482-94. doi: 10.1016/j.biomaterials.2013.03.071. Epub 2013 Apr 17.
  • A new redox-sensitive poly(ethylene glycol) (PEG)-based gene vector specially designed to target fibroblast growth factor receptors (FGFRs) was developed by host-guest supramolecular complexation. The new vector was designed as follows: 1) A host segment was consisted of β-cyclodextrin-crosslinked
  • PMID 23602276

Japanese Journal

  • Inhibition of the prothrombinase complex on red blood cells by heparin and covalent antithrombin-heparin complex
  • Stevic Ivan,Chan Howard H. W.,Berry Leslie R. 他
  • The journal of biochemistry 153(1), 103-110, 2013-01-00
  • NAID 40019546578
  • 抗血栓療法で良好に維持している左心室腔内血栓症の犬の1例 (日本獣医師会学会学術誌) -- (小動物臨床関連部門)
  • 船山 麻理菜,寺崎 絵里,小宮山 絵梨 他
  • 日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 66(1), 52-56, 2013-01-00
  • NAID 40019538718
  • Pharmacokinetic modeling of hepatocyte growth factor in experimental animals and humans
  • Sugiura Tomoko,Takahashi Saki,Sano Kazusa,Abe Tetsushi,Fukuta Kazuhiro,Adachi Kiichi,Nakamura Toshikazu,Matsumoto Kunio,Nakamichi Noritaka,Kato Yukio
  • Journal of Pharmaceutical Sciences 102(1), 237-249, 2013-01-00
  • … A pharmacokinetic model including plasma and liver compartments was constructed, incorporating both high- and low-affinity receptors for association and subsequent endocytosis of HGF because HGF is eliminated via specific receptor c-Met and heparin-like substance. …
  • NAID 120005223453

Related Links

Disease states sensitive to heparin Heparin's effect in experimental models Clinical status Acquired immunodeficiency syndrome Reduces the ability of human immunodeficiency virus types 1 and 2 to adsorb to cultured T4 cells. [34]
Manufacturer of heparin and heparin-like glycosaminoglycans including Centaxarin (ardeparin sodium). Features scientific background and history.
HiTrap Heparin HP Columns 血液凝固タンパク質精製用HiTrapカラム 応用:血液凝固タンパク質、エンドヌクレアーゼ、リパーゼ、ステロイドレセプター、DNA結合タンパク質、成長因子 HiTrap全般に関するFAQ(製品Q&A)は下記リンク先 ...



★リンクテーブル★
リンク元ヘパリン」「heparin sodium
拡張検索heparinase」「heparin calcium」「heparinization

ヘパリン」

  [★]

heparin
ヘパリンナトリウムヘパリンカルシウム
カプロシンヘパフィルドペミロックデリバデクスノボ・ヘパリンヘパフラッシュ。(軟膏)ペセタ
血液凝固因子抗凝固薬(抗凝血薬)

構造

作用機序

薬効薬理

カプロシン注2万単位/20mL/**カプロシン注5万単位/50mL/**カプロシン注10万単位/100mL
  • 血液凝固阻止作用5~9)
  • (1) ヘパリンはO-及びN-硫酸基を持ったムコ多糖類で、その強い陰イオン活性によって蛋白質と反応し、抗凝血作用をあらわす。
  • (2) ヘパリンは、ヘパリンCo-factor(Antithrombin III)と結合することにより、種々の活性化凝固因子(トロンビン、Xa、IXa、XIa、XIIa)に対する阻害作用を促進して抗凝血作用を発揮する。

薬理作用

  • 抗凝固作用

動態

相互作用

臨床検査

  • 赤沈、血液生化学検査の採血の際、抗凝固薬として用いる。  ←  血算にはEDTA・2Kを用いる。ヘパリンを用いると血小板が凝集してしまう。

ヘパリンとワルファリンの比較

[display]http://kusuri-jouhou.com/pharmacology/myocardial-infarction.html
より
also see YN.G-96
  ワルファリン ヘパリン
投与方法 経口可能 注射のみ
in vitro 有効 有効
in vivo 有効 無効
その他 遅行性(12~36時間有する) ヘパリナーゼ(肝臓)で分解
持続性(2~5日有効)  

参考

  • カプロシン注2万単位/20mL/**カプロシン注5万単位/50mL/**カプロシン注10万単位/100mL
[display]http://www.info.pmda.go.jp/go/pack/3334400A5033_1_01/3334400A5033_1_01?view=body

heparin sodium」

  [★]

heparinheparin calcium

heparinase」

  [★]

ヘパリナーゼヘパリン分解酵素

heparin lyase

heparin calcium」

  [★]

heparinheparin sodium

heparinization」

  [★]

heparinize