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1. ヘパリンおよび低分子ヘパリンの治療使用 therapeutic use of heparin and low molecular weight heparin
2. 持続的腎代替療法中の抗凝固療法 anticoagulation for continuous renal replacement therapy
3. ヘパリン起因性血小板減少症 heparin induced thrombocytopenia
4. 静脈血栓塞栓症に対する低分子ヘパリン low molecular weight heparin for venous thromboembolic disease
5. 内科患者における静脈血栓塞栓症の予防 prevention of venous thromboembolic disease in medical patients

English Journal

Immobilization of Heparin on the Surface of Polypropylene Non-Woven Fabric for Improvement of the Hydrophilicity and Blood Compatibility.

Li R, Wang H, Wang W, Ye Y.AbstractA polypropylene non-woven fabric (PPNWF) was exposed to oxygen plasma to produce peroxides on its surface. These peroxides were used to initiate graft polymerization of acrylic acid (AA) on the surface of PPNWF. Direct heparinization was accomplished via a reaction between heparin and PP-PAA (AA grafted PPNWF) which was activated by EDC (N-ethyl-N'-[3-(dimethylamino)propyl] carbodiimide). Indirect heparinized PPNWF was prepared by grafting poly(ethylene oxide) (PEO) on a PP-PAA surface to form PP-PAA-PEO, followed by reaction with heparin which was activated by EDC before use. The surface-modified PPNWFs were characterized by attenuated total reflection Fourier transform infrared (ATR-FT-IR) spectroscopy, electron spectroscopy for chemical analysis (ESCA) and contact angle goniometry. It was found that hydrophilicity was greatly improved, as indicated by the decrease of the water contact angle from 142 to 33°. In vitro blood compatibility evaluation of modified PPNWFs, including hemolysis rate, platelet adhesion, plasma protein adsorption and activated partial thromboplastin time (APTT) was investigated. The results suggested that both heparinized PPNWFs showed lower hemolysis rates and better platelet anti-adhesion than non-heparinized controls. Furthermore, PPNWF obtained via indirect immobilization of heparin showed better hydrophilicity and blood compatibility than direct heparinization of PPNWF.
Journal of biomaterials science. Polymer edition.J Biomater Sci Polym Ed.2012 Feb 14. [Epub ahead of print]
A polypropylene non-woven fabric (PPNWF) was exposed to oxygen plasma to produce peroxides on its surface. These peroxides were used to initiate graft polymerization of acrylic acid (AA) on the surface of PPNWF. Direct heparinization was accomplished via a reaction between heparin and PP-PAA (AA gra
PMID 22333943

High mortality associated with intracardiac and intrapulmonary thromboses after cardiopulmonary bypass.

Ogawa S, Richardson JE, Sakai T, Ide M, Tanaka KA.SourceDepartment of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA.
Journal of anesthesia.J Anesth.2012 Feb;26(1):9-19. Epub 2011 Oct 19.
PURPOSE: Intrapulmonary or intracardiac thrombosis is a rare but catastrophic event following complex cardiothoracic surgery. Although there have been multiple cases reported in the literature, the causes of these events are largely unknown. In this retrospective review, we attempt to identify risk
PMID 22005756

Japanese Journal

抗血栓療法合併症例に対する呼吸器外科手術の検討

古市基彦,村松高,四万村三恵 [他]
日大医学雑誌 = Journal of Nihon University Medical Association 73(6), 248-253, 2014-12
NAID 40020316368

抗血栓療法合併症例に対する呼吸器外科手術の検討

古市基彦,村松高,四万村三恵,西井竜彦,竹下伸二,石本真一郎,田中洋子,諸岡宏明,日暮亮太,塩野元美
日大医学雑誌 73(6), 248-253, 2014
2009 年1 月から2013 年8 月までの4 年8 ヶ月で当科で施行した全身麻酔手術症例は737 例で，術前から抗血栓療法を受けていたため，周術期にヘパリン置換を要したのは28 例(3.8%) であった．周術期管理としては内服の抗血栓療法薬は術前1 週間前に入院して中止し，未分画ヘパリン持続静注でAPTT を55 から70 秒程度にコントロールした．手術6 時間前にヘパリン静注を中止した．すべ …
NAID 130005070932

Elevated white blood cell count is associated with clot formation within arterial sheaths and may be a risk factor for thromboembolic complication during transradial cerebral angiography

, ,
脳神経血管内治療 8(4), 193-197, 2014
Objectives: The transradial approach for diagnostic cerebral angiography is feasible, safe, and commonly used. To prevent neurological complications, unfractionated heparin (UFH) is often administered …
NAID 130004726279