WordNet

write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
(biology) the taxonomic group whose characteristics are used to define the next higher taxon
a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
all of the tokens of the same symbol; "the word `element contains five different types of character"
printed characters; "small type is hard to read"
identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
a plane figure with rounded sides curving inward at the top and intersecting at the bottom; conventionally used on playing cards and valentines; "he drew a heart and called it a valentine"
the courage to carry on; "he kept fighting on pure spunk"; "you havent got the heart for baseball" (同)mettle, nerve, spunk
an inclination or tendency of a certain kind; "he had a change of heart" (同)spirit
a playing card in the major suit that has one or more red hearts on it; "he led the queen of hearts"; "hearts were trumps"
the locus of feelings and intuitions; "in your heart you know it is true"; "her story would melt your bosom" (同)bosom
the hollow muscular organ located behind the sternum and between the lungs; its rhythmic contractions move the blood through the body; "he stood still, his heart thumping wildly" (同)pump, ticker
a firm rather dry variety meat (usually beef or veal); "a five-pound beef heart will serve six"
able to perceive sound
an opportunity to state your case and be heard; "they condemned him without a hearing"; "he saw that he had lost his audience" (同)audience
(law) a proceeding (usually by a court) where evidence is taken for the purpose of determining an issue of fact and reaching a decision based on that evidence
the ability to hear; the auditory faculty; "his hearing was impaired" (同)audition, auditory sense, sense of hearing, auditory modality
a session (of a committee or grand jury) in which witnesses are called and testimony is taken; "the investigative committee will hold hearings in Chicago"
executed with proper legal authority; "a binding contract"
the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
strip sewn over or along an edge for reinforcement or decoration
the capacity to attract and hold something
having an (over)abundance of flesh; "he hadnt remembered how fat she was"
a soft greasy substance occurring in organic tissue and consisting of a mixture of lipids (mostly triglycerides); "pizza has too much fat"
marked by great fruitfulness; "fertile farmland"; "a fat land"; "a productive vineyard"; "rich soil" (同)fertile, productive, rich
lucrative; "a juicy contract"; "a nice fat job" (同)juicy
having a relatively large diameter; "a fat rope"

PrepTutorEJDIC

〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
〈C〉『心臓』;胸 / 〈C〉(感情の中心をなす)『心』,気持ち / 〈U〉愛情,同情 / 〈U〉『勇気』,元気,熱意 / 《the ~》『中心』,内部,(物事の)本質,核心 / 〈C〉ハート形の物;(カードの)ハートの札
〈U〉『聴力』,聴覚〈U〉〈C〉(…を)『聞くこと』,(…の)聞き取り《+『of』+『名』》・〈C〉聞いてもらう機会,聞いてやること・聴取・聴聞会〈C〉(法廷などでの)尋問,審問,;(刑罰の減免を求める)釈明,意見陳述 / 〈U〉聞こえる距離(範囲)
義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
『脂肪』,脂肪分 / (動物の)あぶら身 / (料理用の)油,ヘット / 肥満,太り過ぎ / 『太った』,肥満した / 『脂肪の多い』 / たっぷりとはいった,分厚い / もうかる / (土地が)肥えた / …‘を'太らせる / ふとる,肥える

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/23 16:07:49」(JST)

wiki en

Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is encoded by the FABP3 gene.^[1]^[2]

Structure

The HADHB gene is located on chromosome 1, with its specific location being 1p33-p32.^[2] The gene contains 5 exons. HADHB encodes a 51.2 kDa protein that is composed of 133 amino acids; 124 peptides have been observed through mass spectrometry data.^[3]^[4]

Function

Heart-type Fatty Acid-Binding Protein (H-FABP) is a small cytoplasmic protein (15 kDa) released from cardiac myocytes following an ischemic episode.^[5] Like the nine other distinct FABPs that have been identified, H-FABP is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation.^[5] See FABP3 for biochemical details.

The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is also a candidate tumor suppressor gene for human breast cancer.^[2]

Interactions

FABP3 is known to interact with TNNI3K in the context of interacting with cardiac troponin I.^[6] The protein also interacts with , VPS28, KIAA159,^[7]NUP62,^[8] PLK1, UBC, and Xpo1.^[2]

In HIV, a synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of fatty acid binding protein 3 (FABP3) in peptide-treated PBMCs.^[9]

Clinical significance

Diagnostic potential

H-FABP is a sensitive biomarker for myocardial infarction^[10]^[11] and can be detected in the blood within one to three hours of the pain.^[12]^{[unreliable medical source?]}

The diagnostic potential of the biomarker H-FABP for heart injury was discovered in 1988 by Professor Jan Glatz (Maastricht, Netherlands).^[13] H-FABP is 20 times more specific to cardiac muscle than myoglobin,^[13] it is found at 10-fold lower levels in skeletal muscle than heart muscle and the amounts in the kidney, liver and small intestine are even lower again.^[14]^[15]

H-FABP is recommended to be measured with troponin to identify myocardial infarction and acute coronary syndrome in patients presenting with chest pain. H-FABP measured with troponin shows increased sensitivity of 20.6% over troponin at 3–6 hours following chest pain onset.^[16] This sensitivity may be explained by the high concentration of H-FABP in myocardium compared to other tissues, the stability and solubility of H-FABP, its low molecular weight; 15kDa compared to 18, 80 and 37kDa for MYO, CK-MB and cTnT respectively,^[17]^[18]^[19] its rapid release into plasma after myocardial injury - 60 minutes after an ischemic episode,^[20] and its relative tissue specificity.^[21] Similarly this study showed that measuring H-FABP in combination with troponin increased the diagnostic accuracy and with a negative predictive value of 98% could be used to identify those not suffering from MI at the early time point of 3–6 hours post chest pain onset.^[16] The effectiveness of using the combination of H-FABP with troponin to diagnose MI within 6 hours is well reported.^[22]^[23]^[24]

Prognostic potential

In addition to its diagnostic potential, H-FABP also has prognostic value. Alongside D-dimer, NT-proBNP and peak troponin T, it was the only cardiac biomarker that proved to be a statistically significant predictor of death or MI at one year. This prognostic information was independent of troponin T, ECG and clinical examination.^[23] The risk associated with raised H-FABP is dependent upon its concentration.^[25]^[26] Patients who were TnI negative but H-FABP positive had 17% increased risk of all cause mortality within one year compared to those patients who were TnI positive but H-FABP negative.^[25] Currently these TnI positive patients are prioritised for angioplasty, and the TnI negative patients are considered to be of a lower priority, yet the addition of the H-FABP test helps identify patients who are currently slipping through the net and allows physicians to more appropriately manage this hidden high risk group. If both biomarkers were negative, there is 0% mortality at 6 months, in the authors own words this “represents a particularly worthwhile clinical outcome, especially because it was observed in patients admitted into hospital for suspected ACS.” H-FABP indicates risk across the ACS spectrum including UA, NSTEMI or STEMI where low H-FABP concentrations confer low risk whereas high H-FABP concentrations indicate patients who are at a much higher risk of future events.^[25]

H-FABP in other diseases

H-FABP has been proven to significantly predict 30 day mortality in acute pulmonary embolism.^[27] H-FABP is more effective than Troponin T in risk stratifying Chronic Heart Failure patients.^[28] H-FABP is beginning to create interest with researchers who have found emerging evidence that indicates a role in differentiating between different neurodegenerative diseases.^[29]^[30]

H-FABP Point of care testing

To obtain diagnostic and prognostic information a precise and fully quantitative measurement of H-FABP is required. Commercial tests include Cardiac Array on Evidence MultiStat (Randox Laboratories Ltd.).

References

^ Phelan CM, Larsson C, Baird S, Futreal PA, Ruttledge MH, Morgan K, Tonin P, Hung H, Korneluk RG, Pollak MN, Narod SA (May 1996). "The human mammary-derived growth inhibitor (MDGI) gene: genomic structure and mutation analysis in human breast tumors". Genomics 34 (1): 63–8. doi:10.1006/geno.1996.0241. PMID 8661024.
^ ^a ^b ^c ^d "Entrez Gene: FABP3 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)".
^ ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
^ "Fatty acid-binding protein, heart". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).
^ ^a ^b Kleine AH, Glatz JF, Van Nieuwenhoven FA, Van der Vusse GJ (Oct 1992). "Release of heart fatty acid-binding protein into plasma after acute myocardial infarction in man". Molecular and Cellular Biochemistry 116 (1-2): 155–62. doi:10.1007/BF01270583. PMID 1480144.
^ Zhao Y, Meng XM, Wei YJ, Zhao XW, Liu DQ, Cao HQ, Liew CC, Ding JF (May 2003). "Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I". Journal of Molecular Medicine 81 (5): 297–304. doi:10.1007/s00109-003-0427-x. PMID 12721663.
^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
^ Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW (Jul 2009). "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair". Cell 138 (1): 63–77. doi:10.1016/j.cell.2009.06.030. PMID 19596235.
^ Denner J, Eschricht M, Lauck M, Semaan M, Schlaermann P, Ryu H, Akyüz L (2013). "Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1". PloS One 8 (1): e55199. doi:10.1371/journal.pone.0055199. PMID 23383108.
^ Tanaka T, Hirota Y, Sohmiya K, Nishimura S, Kawamura K (Apr 1991). "Serum and urinary human heart fatty acid-binding protein in acute myocardial infarction". Clinical Biochemistry 24 (2): 195–201. doi:10.1016/0009-9120(91)90571-U. PMID 2040092.
^ Watanabe K, Wakabayashi H, Veerkamp JH, Ono T, Suzuki T (May 1993). "Immunohistochemical distribution of heart-type fatty acid-binding protein immunoreactivity in normal human tissues and in acute myocardial infarct". The Journal of Pathology 170 (1): 59–65. doi:10.1002/path.1711700110. PMID 8326460.
^ Dobson R (2010-04-06). "At last, the pacemaker that lets you have a lifesaving body scan". Health. Daily Mail.
^ ^a ^b Glatz JF, van Bilsen M, Paulussen RJ, Veerkamp JH, van der Vusse GJ, Reneman RS (Jul 1988). "Release of fatty acid-binding protein from isolated rat heart subjected to ischemia and reperfusion or to the calcium paradox". Biochimica Et Biophysica Acta 961 (1): 148–52. doi:10.1016/0005-2760(88)90141-5. PMID 3260112.
^ Ghani F, Wu AH, Graff L, Petry C, Armstrong G, Prigent F, Brown M (May 2000). "Role of heart-type fatty acid-binding protein in early detection of acute myocardial infarction". Clinical Chemistry 46 (5): 718–9. PMID 10794758.
^ Pelsers MM, Hermens WT, Glatz JF (Feb 2005). "Fatty acid-binding proteins as plasma markers of tissue injury". Clinica Chimica Acta; International Journal of Clinical Chemistry 352 (1-2): 15–35. doi:10.1016/j.cccn.2004.09.001. PMID 15653098.
^ ^a ^b McMahon G, Lamont J, Curtin E, McConnell RI, Crockard M, Kurth MJ, Crean P, Fitzgerald SP (2011). "Diagnostic accuracy of H-FABP for the early diagnosis of acute myocardial infarction". American Journal of Emergency Medicine: in press.
^ Glatz JF, Kleine AH, van Nieuwenhoven FA, Hermens WT, van Dieijen-Visser MP, van der Vusse GJ (Feb 1994). "Fatty-acid-binding protein as a plasma marker for the estimation of myocardial infarct size in humans". British Heart Journal 71 (2): 135–40. doi:10.1136/hrt.71.2.135. PMC 483632. PMID 8130020.
^ Wodzig KW, Kragten JA, Hermens WT, Glatz JF, van Dieijen-Visser MP (Mar 1997). "Estimation of myocardial infarct size from plasma myoglobin or fatty acid-binding protein. Influence of renal function". European Journal of Clinical Chemistry and Clinical Biochemistry 35 (3): 191–8. doi:10.1515/cclm.1997.35.3.191. PMID 9127740.
^ Michielsen EC, Diris JH, Kleijnen VW, Wodzig WK, Van Dieijen-Visser MP (2006). "Interpretation of cardiac troponin T behaviour in size-exclusion chromatography". Clinical Chemistry and Laboratory Medicine 44 (12): 1422–7. doi:10.1515/CCLM.2006.265. PMID 17163817.
^ Van Nieuwenhoven FA, Kleine AH, Wodzig WH, Hermens WT, Kragten HA, Maessen JG, Punt CD, Van Dieijen MP, Van der Vusse GJ, Glatz JF (Nov 1995). "Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid-binding protein". Circulation 92 (10): 2848–54. doi:10.1161/01.cir.92.10.2848. PMID 7586251.
^ Alhadi HA, Fox KA (Apr 2004). "Do we need additional markers of myocyte necrosis: the potential value of heart fatty-acid-binding protein". Qjm 97 (4): 187–98. doi:10.1093/qjmed/hch037. PMID 15028848.
^ Azzazy HM, Pelsers MM, Christenson RH (Jan 2006). "Unbound free fatty acids and heart-type fatty acid-binding protein: diagnostic assays and clinical applications". Clinical Chemistry 52 (1): 19–29. doi:10.1373/clinchem.2005.056143. PMID 16269514.
^ ^a ^b McCann CJ, Glover BM, Menown IB, Moore MJ, McEneny J, Owens CG, Smith B, Sharpe PC, Young IS, Adgey JA (Dec 2008). "Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T". European Heart Journal 29 (23): 2843–50. doi:10.1093/eurheartj/ehn363. PMID 18682444.
^ Li CJ, Li JQ, Liang XF, Li XX, Cui JG, Yang ZJ, Guo Q, Cao KJ, Huang J (Mar 2010). "Point-of-care test of heart-type fatty acid-binding protein for the diagnosis of early acute myocardial infarction". Acta Pharmacologica Sinica 31 (3): 307–12. doi:10.1038/aps.2010.2. PMID 20140003.
^ ^a ^b ^c Kilcullen N, Viswanathan K, Das R, Morrell C, Farrin A, Barth JH, Hall AS (Nov 2007). "Heart-type fatty acid-binding protein predicts long-term mortality after acute coronary syndrome and identifies high-risk patients across the range of troponin values". Journal of the American College of Cardiology 50 (21): 2061–7. doi:10.1016/j.jacc.2007.08.021. PMID 18021874.
^ Viswanathan K, Kilcullen N, Morrell C, Thistlethwaite SJ, Sivananthan MU, Hassan TB, Barth JH, Hall AS (Jun 2010). "Heart-type fatty acid-binding protein predicts long-term mortality and re-infarction in consecutive patients with suspected acute coronary syndrome who are troponin-negative". Journal of the American College of Cardiology 55 (23): 2590–8. doi:10.1016/j.jacc.2009.12.062. PMID 20513600.
^ Kaczyñska A, Pelsers MM, Bochowicz A, Kostrubiec M, Glatz JF, Pruszczyk P (Sep 2006). "Plasma heart-type fatty acid binding protein is superior to troponin and myoglobin for rapid risk stratification in acute pulmonary embolism". Clinica Chimica Acta; International Journal of Clinical Chemistry 371 (1-2): 117–23. doi:10.1016/j.cca.2006.02.032. PMID 16698008.
^ Niizeki T, Takeishi Y, Arimoto T, Takabatake N, Nozaki N, Hirono O, Watanabe T, Nitobe J, Harada M, Suzuki S, Koyama Y, Kitahara T, Sasaki T, Kubota I (Mar 2007). "Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage in chronic heart failure patients". Journal of Cardiac Failure 13 (2): 120–7. doi:10.1016/j.cardfail.2006.10.014. PMID 17395052.
^ Mollenhauer B, Steinacker P, Bahn E, Bibl M, Brechlin P, Schlossmacher MG, Locascio JJ, Wiltfang J, Kretzschmar HA, Poser S, Trenkwalder C, Otto M (2007). "Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: marker candidates for dementia with Lewy bodies". Neuro-Degenerative Diseases 4 (5): 366–75. doi:10.1159/000105157. PMID 17622779.
^ Lescuyer P, Allard L, Zimmermann-Ivol CG, Burgess JA, Hughes-Frutiger S, Burkhard PR, Sanchez JC, Hochstrasser DF (Aug 2004). "Identification of post-mortem cerebrospinal fluid proteins as potential biomarkers of ischemia and neurodegeneration". Proteomics 4 (8): 2234–41. doi:10.1002/pmic.200300822. PMID 15274117.

UpToDate Contents

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1. トロポニンおよびクレアチンキナーゼ以外の心筋障害を示唆するバイオマーカー biomarkers suggesting cardiac injury other than troponins and creatine kinase
2. 非ST上昇型心筋梗塞後の有害転帰の危険因子 risk factors for adverse outcomes after non st elevation acute coronary syndromes
3. 心筋障害のバイオマーカーとしてのトロポニンおよびクレアチンキナーゼ troponins and creatine kinase as biomarkers of cardiac injury

English Journal

Urinary EGF Receptor Ligand Excretion in Patients with Autosomal Dominant Polycystic Kidney Disease and Response to Tolvaptan.

Harskamp LR1, Gansevoort RT2, Boertien WE1, van Oeveren W3, Engels GE3, van Goor H4, Meijer E1.
Clinical journal of the American Society of Nephrology : CJASN.Clin J Am Soc Nephrol.2015 Jul 31. pii: CJN.09941014. [Epub ahead of print]
BACKGROUND AND OBJECTIVES: Recent animal experiments suggest that dysregulation of the EGF receptor pathway plays a role in the pathophysiology of autosomal dominant polycystic kidney disease (ADPKD). Research on EGF receptor ligands in humans with ADPKD is lacking. EGF receptor ligands were measure
PMID 26231191

Comparison of a qualitative measurement of heart-type fatty acid-binding protein with other cardiac markers as an early diagnostic marker in the diagnosis of non-ST-segment elevation myocardial infarction.

Gerede DM1, Güleç S1, Kiliçkap M1, Kaya CT1, Vurgun VK1, Özcan ÖU1, Göksülük H1, Erol Ç1.
Cardiovascular journal of Africa.Cardiovasc J Afr.2015 Jul 14;26:1-6. doi: 10.5830/CVJA-2015-028. [Epub ahead of print]
OBJECTIVE: Heart-type fatty acid-binding protein (H-FABP) is a novel cardiac marker used in the early diagnosis of acute myocardial infarction (AMI), which shows myocyte injury. Our study aimed to compare bedside H-FABP measurements with routine creatine kinase-MB (CK-MB) and troponin I (TnI) tests
PMID 26212703

Prognostic Value of Biomarkers in Acute Non-massive Pulmonary Embolism: A Systematic Review and Meta-analysis.

Bajaj A1, Rathor P, Sehgal V, Kabak B, Shetty A, Al Masalmeh O, Hosur S.
Lung.Lung.2015 Jul 2. [Epub ahead of print]
BACKGROUND: Various biomarkers have been evaluated to risk stratify patients with acute pulmonary embolism (PE). We aimed to summarize the available evidence to compare the prognostic value of three most widely studied biomarkers in normotensive patients with acute PE.METHOD: A systematic literature
PMID 26134045

Japanese Journal

心筋マーカー迅速検出キットの比較検討

医学検査 65(3), 332-336, 2016
NAID 130005164401

全血または血漿中の心臓由来脂肪酸結合蛋白（H-FABP）迅速定量試薬「ラピッドチップ<sup>®</sup>H-FABP」の基礎的検討

医学検査 64(6), 705-712, 2015
NAID 130005119249

ヒト心臓由来脂肪酸結合蛋白（H-FABP）測定試薬『ラテックスH-FABPキット「ヤマサ」』の基礎的検討

医学検査 64(4), 495-500, 2015
NAID 130005098775

「H-FABP」

Fatty acid binding protein 3, muscle and heart
	PDB rendering based on 1g5w.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1G5W, 1HMR, 1HMS, 1HMT, 2HMB, 3RSW, 3WBG, 3WVM, 3WXQ, 4TJZ, 4TKB, 4TKH, 4TKJ, 4WBK
Identifiers
Symbols	FABP3 ; FABP11; H-FABP; M-FABP; MDGI; O-FABP
External IDs	OMIM: 134651 MGI: 95476 HomoloGene: 68379 ChEMBL: 3344 GeneCards: FABP3 Gene
Gene ontology
Molecular function	• long-chain fatty acid transporter activity; • protein binding; • cytoskeletal protein binding; • long-chain fatty acid binding; • icosatetraenoic acid binding; • oleic acid binding;
Cellular component	• extracellular space; • cytosol; • sarcoplasm; • extracellular exosome;
Biological process	• fatty acid metabolic process; • negative regulation of cell proliferation; • triglyceride catabolic process; • response to insulin; • response to drug; • cholesterol homeostasis; • small molecule metabolic process; • long-chain fatty acid import; • regulation of fatty acid oxidation; • phospholipid homeostasis; • response to fatty acid; • positive regulation of phospholipid biosynthetic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★] ヒト心臓由来脂肪酸結合蛋白 heart-type fatty acid binding protein

「heart-type fatty acid-binding protein」

　　[★] ヒト心臓由来脂肪酸結合蛋白

「binding」

　　[★]

n.

結合、バインディング

adj.

結合性の

関: affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

「type」

　　[★]

n.

型、タイプ、(生物)タイプ標本

(windows)ファイル内容表示(linux -> cat])

ex. type report_20111118.jp.htm | php a.php > report_20111118.jp.jp.jp.html

関: form、mode、pattern、type specimen、typed

「hearing」

　　[★]

n。

聴力、聴覚。聞くこと、聴取。聞こえる距離/範囲。聞いてやること、傾聴。聞いてもらうこと、発言の機会。(委員会などの)聴聞会、ヒアリング。(法)審問、尋問。

「binding protein」

　　[★]

結合タンパク質、結合タンパク、結合蛋白質、結合蛋白

関: BP、carrier protein、transport protein

「fatty」

　　[★]

adj.

脂肪性の、脂肪質の

関: adipose、aliphatic、lipogenous

[pmid8661024-1] Phelan CM, Larsson C, Baird S, Futreal PA, Ruttledge MH, Morgan K, Tonin P, Hung H, Korneluk RG, Pollak MN, Narod SA (May 1996). "The human mammary-derived growth inhibitor (MDGI) gene: genomic structure and mutation analysis in human breast tumors". Genomics 34 (1): 63–8. doi:10.1006/geno.1996.0241. PMID 8661024.

[entrez-2] "Entrez Gene: FABP3 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)".

[COPaKB-3] ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.

[url_COPaKB-4] "Fatty acid-binding protein, heart". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).

[pmid1480144-5] Kleine AH, Glatz JF, Van Nieuwenhoven FA, Van der Vusse GJ (Oct 1992). "Release of heart fatty acid-binding protein into plasma after acute myocardial infarction in man". Molecular and Cellular Biochemistry 116 (1-2): 155–62. doi:10.1007/BF01270583. PMID 1480144.

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リンク元	「H-FABP」
拡張検索	「heart-type fatty acid-binding protein」
関連記事	「binding」「type」「hearing」「binding protein」「fatty」

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heart-type fatty acid binding protein